Lauren Gerard Koch
- Associate Professor, Physiology and Pharmacology , College of Medicine and Life Sciences
Publications
selected publications
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Article (Faculty180)
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2022Age and Intrinsic Fitness Affect the Female Rotator Cuff Tendon Tissue. Biomedicines. 10.
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2022Biology: Motion is Function. Function (Oxford, England). 3:zqac030.
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2022
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2021A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo. Physiological reports. 9:e14799.
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2021Genetically determined exercise capacity affects systemic glucose response to insulin in rats. Physiological genomics. 53:395-405.
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2021Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats. Journal of Alzheimer's disease reports. 5:469-475.
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2021Low Intrinsic Aerobic Capacity Limits Recovery Response to Hindlimb Ischemia. Frontiers in cardiovascular medicine. 8:752955.
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2021Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. Frontiers in endocrinology. 12:645881.
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2021Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young. Physiology & behavior. 236:113417.
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2021SARS-CoV-2, ACE2 expression, and systemic organ invasion. Physiological genomics. 53:51-60.
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2020Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure. Physiology & behavior. 225:113048.
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2020Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation. Journal of Endocrinology. 247:39.
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2020Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award. Hypertension (Dallas, Tex. : 1979). 75:1386-1396.
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2018Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors. Obesity (Silver Spring, Md.). 26:885-894.
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2018Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental physiology. 103:1513-1523.
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2018
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2018Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. Molecular metabolism. 11:189-196.
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2016Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological genomics. 48:183-90.
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2016Rodent models for resolving extremes of exercise and health. Physiological genomics. 48:82-92.
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2015
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2015High intrinsic aerobic capacity and pomegranate juice are protective against macrophage atherogenecity: studies in high- vs. low-capacity runner (HCR vs. LCR) rats. The Journal of nutritional biochemistry. 26:1015-21.
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2015Iron-induced necrotic brain cell death in rats with different aerobic capacity. Translational stroke research. 6:215-23.
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2015
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2015Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Archiv : European journal of physiology. 467:779-88.
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2014Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Annals of clinical and translational neurology. 1:589-604.
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2014Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis. American journal of physiology. Endocrinology and metabolism. 306:E635-47.
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2014Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta physiologica (Oxford, England). 210:854-64.
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2013(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. Clinical science (London, England : 1979). 124:663-74.
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2013Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American journal of physiology. Endocrinology and metabolism. 305:E429-38.
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2013Genetic analysis of a rat model of aerobic capacity and metabolic fitness. PloS one. 8:e77588.
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2013High inborn aerobic capacity does not protect the heart following myocardial infarction. Journal of applied physiology (Bethesda, Md. : 1985). 115:1788-95.
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2013Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. American journal of physiology. Heart and circulatory physiology. 304:H729-39.
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2013Selectively bred rat model system for low and high response to exercise training. Physiological genomics. 45:606-14.
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2013Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 118:1098-105.
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2013Susceptibility to intracerebral hemorrhage-induced brain injury segregates with low aerobic capacity in rats. Neurobiology of disease. 49:22-8.
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2013Uphill running does not exacerbate collagenase-induced pathological changes in the Achilles tendon of rats selectively bred for high-capacity running. Connective tissue research. 54:386-93.
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2013Vascularity of myocardium and gastrocnemius muscle in rats selectively bred for endurance running capacity. Physiological genomics. 45:119-25.
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2012
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2012Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome. Anesthesia and analgesia. 114:297-302.
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2012Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?. Journal of applied physiology (Bethesda, Md. : 1985). 113:1403-12.
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2012Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. Journal of applied physiology (Bethesda, Md. : 1985). 113:1624-34.
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2012Selective breeding for endurance running capacity affects cognitive but not motor learning in rats. Physiology & behavior. 106:95-100.
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2011Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. American journal of physiology. Regulatory, integrative and comparative physiology. 300:R544-53.
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2011Osteoblast response to ovariectomy is enhanced in intrinsically high aerobic-capacity rats. Calcified tissue international. 88:325-35.
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2011The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of cellular physiology. 226:2235-43.
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2010
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2010Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24:4565-74.
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2010Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Hormones and behavior. 58:355-67.
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2010Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. Journal of applied physiology (Bethesda, Md. : 1985). 108:1487-96.
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2009Rat strains bred for low and high aerobic running capacity do not differ in their survival time to hemorrhage. Experimental biology and medicine (Maywood, N.J.). 234:1503-10.
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2009Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. The Journal of physiology. 587:1805-16.
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2008Aerobic metabolism underlies complexity and capacity. The Journal of physiology. 586:83-95.
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2008Body mass index measures in children with cerebral palsy related to gross motor function classification: a clinic-based study. American journal of physical medicine & rehabilitation. 87:395-403.
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2008Development of animal models to test the fundamental basis of gene-environment interactions. Obesity (Silver Spring, Md.). 16 Suppl 3:S28-32.
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2008Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. Physiological genomics. 35:213-21.
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2008Initial signaling response to acute exercise bout is similar in hearts of rats bred for divergent exercise capacities. Frontiers in bioscience : a journal and virtual library. 13:347-55.
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2008Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity. Physiology & behavior. 93:1044-54.
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2007Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. American journal of physiology. Endocrinology and metabolism. 293:E31-41.
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2007Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity. American journal of physiology. Endocrinology and metabolism. 292:E1631-6.
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2007Evolution, atmospheric oxygen, and complex disease. Physiological genomics. 30:205-8.
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2007Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. 14:319-25.
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2007Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome. Neuroscience letters. 419:178-83.
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2006Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease--a new take on an old hypothesis. Pharmacology & therapeutics. 110:71-82.
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2006Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity. Journal of applied physiology (Bethesda, Md. : 1985). 100:1765-9.
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2006Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. American journal of physiology. Heart and circulatory physiology. 291:H2933-41.
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2006Systemic oxygen transport in rats artificially selected for running endurance. Respiratory physiology & neurobiology. 151:141-50.
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2005Cardiac rehabilitation after heart transplantation in a patient with Becker's muscular dystrophy: a case report. Archives of physical medicine and rehabilitation. 86:2059-61.
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2003Selected contribution: Variation and heritability for the adaptational response to exercise in genetically heterogeneous rats. Journal of applied physiology (Bethesda, Md. : 1985). 94:1674-81.
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2003Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. Journal of applied physiology (Bethesda, Md. : 1985). 94:1682-8.
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2002Determinants of maximal O(2) uptake in rats selectively bred for endurance running capacity. Journal of applied physiology (Bethesda, Md. : 1985). 93:1265-74.
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2001Cardiac function in rats selectively bred for low- and high-capacity running. American journal of physiology. Regulatory, integrative and comparative physiology. 281:R1787-91.
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2001Cardiac performance in inbred rat genetic models of low and high running capacity. The Journal of physiology. 535:611-7.
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1999A gravimetric method for the measurement of total spontaneous activity in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 222:65-9.
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1999Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Physiological genomics. 1:63-9.
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1998Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Journal of applied physiology (Bethesda, Md. : 1985). 85:530-6.
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1994In vivo effect of naftidrofuryl on 5-hydroxytryptamine-mediated constriction in rat peripheral microcirculation. European journal of pharmacology. 254:249-55.
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1991Reflex versus autoregulatory control of hindlimb blood flow during treadmill exercise in dogs. The American journal of physiology. 260:H436-44.
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Article (Web of Science)
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2022Age and Intrinsic Fitness Affect the Female Rotator Cuff Tendon Tissue. BIOMEDICINES. 10.Full Text via DOI: 10.3390/biomedicines10020509 PMID: 35203717
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2022The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23.Full Text via DOI: 10.3390/ijms23010079 PMID: 35008516
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2021Influence of Intrinsic Aerobic Exercise Capacity and Sex on Cardiac Injury Following Acute Myocardial Ischemia and Reperfusion. FRONTIERS IN CARDIOVASCULAR MEDICINE. 8.Full Text via DOI: 10.3389/fcvm.2021.751864 PMID: 34901212
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2021Low Intrinsic Aerobic Capacity Limits Recovery Response to Hindlimb Ischemia. FRONTIERS IN CARDIOVASCULAR MEDICINE. 8.Full Text via DOI: 10.3389/fcvm.2021.752955 PMID: 34881306
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2021Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus. BRAIN BEHAVIOR AND IMMUNITY. 97:250-259.Full Text via DOI: 10.1016/j.bbi.2021.06.017 PMID: 34224822
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2021Genetically determined exercise capacity affects systemic glucose response to insulin in rats. PHYSIOLOGICAL GENOMICS. 53:395-405.Full Text via DOI: 10.1152/physiolgenomics.00014.2021 PMID: 34297615
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2021Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young. PHYSIOLOGY & BEHAVIOR. 236.Full Text via DOI: 10.1016/j.physbeh.2021.113417 PMID: 33838202
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2021Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. FRONTIERS IN ENDOCRINOLOGY. 12.Full Text via DOI: 10.3389/fendo.2021.645881 PMID: 34177798
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2021Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue. GEROSCIENCE.Full Text via DOI: 10.1007/s11357-021-00387-1 PMID: 34089174
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2021A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo. PHYSIOLOGICAL REPORTS. 9.Full Text via DOI: 10.14814/phy2.14799 PMID: 34042295
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2021Hydrocephalus Following Experimental Subarachnoid Hemorrhage in Rats with Different Aerobic Capacity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.Full Text via DOI: 10.3390/ijms22094489 PMID: 33925787
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2021Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity. CELL REPORTS. 35.Full Text via DOI: 10.1016/j.celrep.2021.109018 PMID: 33882313
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2021Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats. PHYSIOLOGY & BEHAVIOR. 230.Full Text via DOI: 10.1016/j.physbeh.2020.113280 PMID: 33285179
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2021Low responders to endurance training exhibit impaired hypertrophy and divergent biological process responses in rat skeletal muscle. EXPERIMENTAL PHYSIOLOGY.Full Text via DOI: 10.1113/EP089301 PMID: 33486778
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2021Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety. PHYSIOLOGICAL REPORTS. 9.Full Text via DOI: 10.14814/phy2.14716 PMID: 33619911
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2021Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan. NPJ AGING AND MECHANISMS OF DISEASE. 7.Full Text via DOI: 10.1038/s41514-020-00054-3 PMID: 33398019
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2021Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks. FUNCTION. 2.Full Text via DOI: 10.1093/function/zqaa029 PMID: 33363281
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2021Differential weight loss with intermittent fasting or daily calorie restriction in low‐ and high‐fitness phenotypes. EXPERIMENTAL PHYSIOLOGY. 106:1731-1742.Full Text via DOI: 10.1113/ep089434
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2021Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats. Journal of Alzheimer's Disease Reports. 5:469-475.Full Text via DOI: 10.3233/adr-200289
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2021Low responders to endurance training exhibit impaired hypertrophy and divergent biological process responses in rat skeletal muscle. EXPERIMENTAL PHYSIOLOGY. 106:714-725.Full Text via DOI: 10.1113/ep089301
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2020Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats. FRONTIERS IN ENDOCRINOLOGY. 11.Full Text via DOI: 10.3389/fendo.2020.591476 PMID: 33193103
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2020Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure. PHYSIOLOGY & BEHAVIOR. 225.Full Text via DOI: 10.1016/j.physbeh.2020.113048 PMID: 32628949
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2020Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise. NATURE METABOLISM. 2:902-+.Full Text via DOI: 10.1038/s42255-020-0240-7 PMID: 32694831
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2020Rats genetically selected for low and high aerobic capacity exhibit altered soleus muscle myofilament functions. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 318:C422-C429.Full Text via DOI: 10.1152/ajpcell.00430.2019 PMID: 31875694
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2020Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training. PHYSIOLOGICAL GENOMICS. 52:35-46.Full Text via DOI: 10.1152/physiolgenomics.00103.2019 PMID: 31790338
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2020Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. PHYSIOLOGICAL GENOMICS. 52:1-14.Full Text via DOI: 10.1152/physiolgenomics.00089.2019 PMID: 31762410
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2019Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training. DATA IN BRIEF. 27.Full Text via DOI: 10.1016/j.dib.2019.104570 PMID: 31687430
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2019Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. EXPERIMENTAL GERONTOLOGY. 125.Full Text via DOI: 10.1016/j.exger.2019.110657 PMID: 31306740
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2019Precision exercise medicine: understanding exercise response variability. BRITISH JOURNAL OF SPORTS MEDICINE. 53:1141-1153.Full Text via DOI: 10.1136/bjsports-2018-100328 PMID: 30862704
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2019Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance. ENDOCRINOLOGY. 160:1179-1192.Full Text via DOI: 10.1210/en.2019-00118 PMID: 31144719
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2018Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-35728-2
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2018Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training. PLOS ONE. 13.Full Text via DOI: 10.1371/journal.pone.0208703
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2018Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. EXPERIMENTAL PHYSIOLOGY. 103:1513-1523.Full Text via DOI: 10.1113/EP087144
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2018Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors. OBESITY. 26:885-894.Full Text via DOI: 10.1002/oby.22166
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2018Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats. NEUROSCIENCE LETTERS. 674:49-53.Full Text via DOI: 10.1016/j.neulet.2018.03.009
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2018Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. MOLECULAR METABOLISM. 11:189-196.Full Text via DOI: 10.1016/j.molmet.2018.02.009
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2018Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. EXPERIMENTAL PHYSIOLOGY. 103:1513-1523.Full Text via DOI: 10.1113/ep087144
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2018Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk. Cold Spring Harbor Perspectives in Medicine. 8:a029868.Full Text via DOI: 10.1101/cshperspect.a029868
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2018Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats. Adipocyte. 7:20-34.Full Text via DOI: 10.1080/21623945.2017.1402991
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2017A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 313:E681-E689.Full Text via DOI: 10.1152/ajpendo.00157.2017
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2017Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis. JOURNAL OF PHYSIOLOGY-LONDON. 595:4909-4926.Full Text via DOI: 10.1113/jp274281
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2017DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. CELL METABOLISM. 25:1135-1146.e7.Full Text via DOI: 10.1016/j.cmet.2017.04.008
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2017Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. FRONTIERS IN IMMUNOLOGY. 8.Full Text via DOI: 10.3389/fimmu.2017.01768
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2017Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 313:E335-E343.Full Text via DOI: 10.1152/ajpendo.00043.2017
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2017High Aerobic Capacity Mitigates Changes in the Plasma Metabolomic Profile Associated with Aging. JOURNAL OF PROTEOME RESEARCH. 16:798-805.Full Text via DOI: 10.1021/acs.jproteome.6b00796
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2017Inherent aerobic capacity-dependent differences in breast carcinogenesis. CARCINOGENESIS. 38:920-928.Full Text via DOI: 10.1093/carcin/bgx066
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2017Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings. PHYSIOLOGICAL GENOMICS. 49:733-746.Full Text via DOI: 10.1152/physiolgenomics.00081.2017
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2017Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain. Brain and Behavior. 7:e00780.Full Text via DOI: 10.1002/brb3.780
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2017Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats. SCIENTIFIC REPORTS. 7:9261.Full Text via DOI: 10.1038/s41598-017-08965-0
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2017Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 49:254-264.Full Text via DOI: 10.1249/mss.0000000000001101
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2017mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. Annals of Clinical and Translational Neurology. 4:844-858.Full Text via DOI: 10.1002/acn3.484
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2016Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 311:E749-E760.Full Text via DOI: 10.1152/ajpendo.00178.2016
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2016Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease. DIABETES. 65:3341-3351.Full Text via DOI: 10.2337/db16-0292
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2016Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression. PHYSIOLOGY & BEHAVIOR. 164:383-389.Full Text via DOI: 10.1016/j.physbeh.2016.06.006
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2016Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. EXPERIMENTAL GERONTOLOGY. 79:46-54.Full Text via DOI: 10.1016/j.exger.2016.03.015
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2016Effects of ovariectomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 310:E190-E199.Full Text via DOI: 10.1152/ajpendo.00434.2015
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2016Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 311:G166-G179.Full Text via DOI: 10.1152/ajpgi.00065.2016
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2016Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. OBESITY. 24:1929-1937.Full Text via DOI: 10.1002/oby.21564
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2016Nucleus accumbens cocaine-amphetamine regulated transcript mediates food intake during novelty conflict. PHYSIOLOGY & BEHAVIOR. 158:76-84.Full Text via DOI: 10.1016/j.physbeh.2016.02.035
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2016Ovariectomized Highly Fit Rats Are Protected against Diet-Induced Insulin Resistance. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 48:1259-1269.Full Text via DOI: 10.1249/mss.0000000000000898
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2016Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. JOURNAL OF PHYSIOLOGY-LONDON. 594:1855-1873.Full Text via DOI: 10.1113/jp271552
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2016Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats. Aging. 8:769-776.Full Text via DOI: 10.18632/aging.100929
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2016Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness. PHYSIOLOGICAL GENOMICS. 48:816-825.Full Text via DOI: 10.1152/physiolgenomics.00118.2015
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2016The rate of training response to aerobic exercise affects brain function of rats. NEUROCHEMISTRY INTERNATIONAL. 99:16-23.Full Text via DOI: 10.1016/j.neuint.2016.05.012
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2016Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. FRONTIERS IN PHYSIOLOGY. 7.Full Text via DOI: 10.3389/fphys.2016.00311
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2015Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. NEUROSCIENCE. 310:252-267.Full Text via DOI: 10.1016/j.neuroscience.2015.09.035
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2015Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLOS ONE. 10:e0126906.Full Text via DOI: 10.1371/journal.pone.0126906
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2015Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 308:R530-R542.Full Text via DOI: 10.1152/ajpregu.00401.2014
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2015High intrinsic aerobic capacity and pomegranate juice are protective against macrophage atherogenecity: studies in high- vs. low-capacity runner (HCR vs. LCR) rats. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 26:1015-1021.Full Text via DOI: 10.1016/j.jnutbio.2015.04.001
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2015Iron-Induced Necrotic Brain Cell Death in Rats with Different Aerobic Capacity. TRANSLATIONAL STROKE RESEARCH. 6:215-223.Full Text via DOI: 10.1007/s12975-015-0388-8
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2015Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity. PROTEOMICS. 15:2342-2349.Full Text via DOI: 10.1002/pmic.201400537
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2015Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation. CELL METABOLISM. 21:468-478.Full Text via DOI: 10.1016/j.cmet.2015.02.007
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2015Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 467:779-788.Full Text via DOI: 10.1007/s00424-014-1554-7
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2015Physical Activity Differentially Affects the Cecal Microbiota of Ovariectomized Female Rats Selectively Bred for High and Low Aerobic Capacity. PLOS ONE. 10:e0136150.Full Text via DOI: 10.1371/journal.pone.0136150
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2015Physical activity in adulthood: genes and mortality. SCIENTIFIC REPORTS. 5:18259.Full Text via DOI: 10.1038/srep18259
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2015Physically active rats lose more weight during calorie restriction. PHYSIOLOGY & BEHAVIOR. 139:303-313.Full Text via DOI: 10.1016/j.physbeh.2014.11.044
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2015Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction. JOURNAL OF APPLIED PHYSIOLOGY. 118:849-857.Full Text via DOI: 10.1152/japplphysiol.00797.2014
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2014Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Annals of Clinical and Translational Neurology. 1:589-604.Full Text via DOI: 10.1002/acn3.86
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2014Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity. Journal of Proteomics. 106:230-245.Full Text via DOI: 10.1016/j.jprot.2014.04.015
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2014Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. BRAIN RESEARCH BULLETIN. 107:54-60.Full Text via DOI: 10.1016/j.brainresbull.2014.07.003
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2014Eszopiclone and Dexmedetomidine Depress Ventilation in Obese Rats with Features of Metabolic Syndrome. SLEEP. 37:871-880.Full Text via DOI: 10.5665/sleep.3650
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2014Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity. PLOS ONE. 9:e114075.Full Text via DOI: 10.1371/journal.pone.0114075
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2014Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 307:E355-E364.Full Text via DOI: 10.1152/ajpendo.00093.2014
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2014Label-free profiling of skeletal muscle using high-definition mass spectrometry. PROTEOMICS. 14:2339-2344.Full Text via DOI: 10.1002/pmic.201400118
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2014Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 306:E635-E647.Full Text via DOI: 10.1152/ajpendo.00555.2013
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2014Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica. 210:854-864.Full Text via DOI: 10.1111/apha.12238
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2014Resveratrol Attenuates Exercise-Induced Adaptive Responses in Rats Selectively Bred for Low Running Performance. Dose-Response. 12:dose-response.1.Full Text via DOI: 10.2203/dose-response.13-010.radak
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2014Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity. BRAIN RESEARCH. 1572:11-17.Full Text via DOI: 10.1016/j.brainres.2014.05.014
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2013(–)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. CLINICAL SCIENCE. 124:663-674.Full Text via DOI: 10.1042/cs20120469
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2013Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair. NEUROSCIENCE. 252:326-336.Full Text via DOI: 10.1016/j.neuroscience.2013.08.020
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2013Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE. 8:e76568.Full Text via DOI: 10.1371/journal.pone.0076568
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2013Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity. PHYSIOLOGICAL GENOMICS. 45:17-25.Full Text via DOI: 10.1152/physiolgenomics.00111.2012
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2013Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 305:E429-E438.Full Text via DOI: 10.1152/ajpendo.00544.2012
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2013Genetic Analysis of a Rat Model of Aerobic Capacity and Metabolic Fitness. PLOS ONE. 8:e77588.Full Text via DOI: 10.1371/journal.pone.0077588
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2013High inborn aerobic capacity does not protect the heart following myocardial infarction. JOURNAL OF APPLIED PHYSIOLOGY. 115:1788-1795.Full Text via DOI: 10.1152/japplphysiol.00312.2013
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2013Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 304:H729-H739.Full Text via DOI: 10.1152/ajpheart.00638.2012
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2013Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 305:H403-H409.Full Text via DOI: 10.1152/ajpheart.00317.2013
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2013Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks. DIABETES. 62:2717-2727.Full Text via DOI: 10.2337/db13-0062
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2013Resveratrol enhances exercise training responses in rats selectively bred for high running performance. FOOD AND CHEMICAL TOXICOLOGY. 61:53-59.Full Text via DOI: 10.1016/j.fct.2013.01.051
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2013Selectively bred rat model system for low and high response to exercise training. PHYSIOLOGICAL GENOMICS. 45:606-614.Full Text via DOI: 10.1152/physiolgenomics.00021.2013
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2013Susceptibility to intracerebral hemorrhage-induced brain injury segregates with low aerobic capacity in rats. NEUROBIOLOGY OF DISEASE. 49:22-28.Full Text via DOI: 10.1016/j.nbd.2012.08.014
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2013Uphill running does not exacerbate collagenase-induced pathological changes in the Achilles tendon of rats selectively bred for high-capacity running. Connective Tissue Research. 54:386-393.Full Text via DOI: 10.3109/03008207.2013.848201
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2013Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon. BMC Musculoskeletal Disorders. 14:90.Full Text via DOI: 10.1186/1471-2474-14-90
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2013Vascularity of myocardium and gastrocnemius muscle in rats selectively bred for endurance running capacity. PHYSIOLOGICAL GENOMICS. 45:119-125.Full Text via DOI: 10.1152/physiolgenomics.00110.2012
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2012Brain Activation Patterns at Exhaustion in Rats That Differ in Inherent Exercise Capacity. PLOS ONE. 7:e45415.Full Text via DOI: 10.1371/journal.pone.0045415
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2012Determination of Minimum Alveolar Concentration for Isoflurane and Sevoflurane in a Rodent Model of Human Metabolic Syndrome. ANESTHESIA AND ANALGESIA. 114:297-302.Full Text via DOI: 10.1213/ane.0b013e31823ede22
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2012Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?. JOURNAL OF APPLIED PHYSIOLOGY. 113:1403-1412.Full Text via DOI: 10.1152/japplphysiol.00788.2012
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2012Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome. Molecular Medicine. 18:1481-1490.Full Text via DOI: 10.2119/molmed.2012.00351
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2012Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2emission capacities without major shifts in myosin heavy chain isoform. JOURNAL OF APPLIED PHYSIOLOGY. 113:1624-1634.Full Text via DOI: 10.1152/japplphysiol.01475.2011
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2012Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 302:H1667-H1682.Full Text via DOI: 10.1152/ajpheart.01027.2011
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2012Rats Bred for Low Aerobic Capacity Become Promptly Fatigued and Have Slow Metabolic Recovery after Stimulated, Maximal Muscle Contractions. PLOS ONE. 7:e48345.Full Text via DOI: 10.1371/journal.pone.0048345
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2012Region-specific differences in brain melanocortin receptors in rats of the lean phenotype. Neuroreport. 23:596-600.Full Text via DOI: 10.1097/00001756-201207110-00004
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2012Selective breeding for endurance running capacity affects cognitive but not motor learning in rats. PHYSIOLOGY & BEHAVIOR. 106:95-100.Full Text via DOI: 10.1016/j.physbeh.2012.01.011
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2011A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. JOURNAL OF APPLIED PHYSIOLOGY. 110:46-59.Full Text via DOI: 10.1152/japplphysiol.00634.2010
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2011Changes in mRNA levels for brain-derived neurotrophic factor after wheel running in rats selectively bred for high- and low-aerobic capacity. BRAIN RESEARCH. 1425:90-97.Full Text via DOI: 10.1016/j.brainres.2011.09.059
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2011Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R175-R182.Full Text via DOI: 10.1152/ajpregu.00338.2010
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2011Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity. CIRCULATION RESEARCH. 109:1162-1172.Full Text via DOI: 10.1161/circresaha.111.253807
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2011Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R835-R843.Full Text via DOI: 10.1152/ajpregu.00659.2010
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2011Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R544-R553.Full Text via DOI: 10.1152/ajpregu.00250.2010
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2011Osteoblast Response to Ovariectomy Is Enhanced in Intrinsically High Aerobic-Capacity Rats. CALCIFIED TISSUE INTERNATIONAL. 88:325-335.Full Text via DOI: 10.1007/s00223-010-9457-x
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2011Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. PROTEOMICS. 11:3369-3379.Full Text via DOI: 10.1002/pmic.201000593
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2011Risk-assessment and Coping Strategies Segregate with Divergent Intrinsic Aerobic Capacity in Rats. NEUROPSYCHOPHARMACOLOGY. 36:390-401.Full Text via DOI: 10.1038/npp.2010.144
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2011The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. JOURNAL OF CELLULAR PHYSIOLOGY. 226:2235-2243.Full Text via DOI: 10.1002/jcp.22559
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2010Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity. ENDOCRINOLOGY. 151:5157-5164.Full Text via DOI: 10.1210/en.2010-0176
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2010Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controls. Nutrition & Metabolism. 7:53.Full Text via DOI: 10.1186/1743-7075-7-53
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2010Disrupted Sleep and Delayed Recovery from Chronic Peripheral Neuropathy Are Distinct Phenotypes in a Rat Model of Metabolic Syndrome. ANESTHESIOLOGY. 113:1176-1185.Full Text via DOI: 10.1097/aln.0b013e3181f56248
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2010Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB JOURNAL. 24:4565-4574.Full Text via DOI: 10.1096/fj.10-157313
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2010Locus coeruleus galanin expression is enhanced after exercise in rats selectively bred for high capacity for aerobic activity. Peptides. 31:2264-2268.Full Text via DOI: 10.1016/j.peptides.2010.09.005
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2010Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity. Basic Research in Cardiology. 105:357-364.Full Text via DOI: 10.1007/s00395-010-0087-2
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2010Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity. JOURNAL OF APPLIED PHYSIOLOGY. 109:778-785.Full Text via DOI: 10.1152/japplphysiol.01026.2009
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2010Selection for intrinsic endurance modifies endocrine stress responsiveness. BRAIN RESEARCH. 1357:53-61.Full Text via DOI: 10.1016/j.brainres.2010.07.078
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2010Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM. 35:151-162.Full Text via DOI: 10.1139/h09-139
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2010Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Hormones and Behavior. 58:355-367.Full Text via DOI: 10.1016/j.yhbeh.2010.03.013
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2010Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. JOURNAL OF APPLIED PHYSIOLOGY. 108:1487-1496.Full Text via DOI: 10.1152/japplphysiol.01295.2009
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2009Artificial Selection for Whole Animal Low Intrinsic Aerobic Capacity Co-Segregates with Hypoxia-Induced Cardiac Pump Failure. PLOS ONE. 4:e6117.Full Text via DOI: 10.1371/journal.pone.0006117
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2009Continued artificial selection for running endurance in rats is associated with improved lung function. JOURNAL OF APPLIED PHYSIOLOGY. 106:1810-1818.Full Text via DOI: 10.1152/japplphysiol.90419.2008
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2009High-Fat Diet Induces IKKβ and Reduces Insulin Sensitivity in Rats with Low Running Capacity. INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 30:631-635.Full Text via DOI: 10.1055/s-0029-1224174
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2009Impaired Skeletal Muscle β-Adrenergic Activation and Lipolysis Are Associated with Whole-Body Insulin Resistance in Rats Bred for Low Intrinsic Exercise Capacity. ENDOCRINOLOGY. 150:4883-4891.Full Text via DOI: 10.1210/en.2009-0158
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2009Low Aerobic Capacity and High-Fat Diet Contribute to Oxidative Stress and IRS-1 Degradation in the Kidney. AMERICAN JOURNAL OF NEPHROLOGY. 30:112-119.Full Text via DOI: 10.1159/000204362
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2009Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity. JOURNAL OF APPLIED PHYSIOLOGY. 106:1819-1825.Full Text via DOI: 10.1152/japplphysiol.00914.2007
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2009Rat Strains Bred for Low and High Aerobic Running Capacity Do Not Differ in Their Survival Time to Hemorrhage. Experimental Biology and Medicine. 234:1503-1510.Full Text via DOI: 10.3181/0812-rm-355
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2009Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. JOURNAL OF PHYSIOLOGY-LONDON. 587:1805-1816.Full Text via DOI: 10.1113/jphysiol.2009.169060
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2008Aerobic capacity-dependent differences in cardiac gene expression. PHYSIOLOGICAL GENOMICS. 33:100-109.Full Text via DOI: 10.1152/physiolgenomics.00269.2007 PMID: 18171719
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2008Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. CARDIOVASCULAR RESEARCH. 81:723-732.Full Text via DOI: 10.1093/cvr/cvn332
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2008Body Mass Index Measures in Children with Cerebral Palsy Related to Gross Motor Function Classification. American Journal of Physical Medicine & Rehabilitation. 87:395-403.Full Text via DOI: 10.1097/phm.0b013e3181617736
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2008Development of Animal Models to Test the Fundamental Basis of Gene-Environment Interactions. OBESITY. 16:S28-S32.Full Text via DOI: 10.1038/oby.2008.513
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2008Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. PHYSIOLOGICAL GENOMICS. 35:213-221.Full Text via DOI: 10.1152/physiolgenomics.90282.2008
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2008Initial signaling response to acute exercise bout is similar in hearts of rats bred for divergent exercise capacities. FRONTIERS IN BIOSCIENCE-LANDMARK. 13:347.Full Text via DOI: 10.2741/2684
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2008Nociception before and after exercise in rats bred for high and low aerobic capacity. NEUROSCIENCE LETTERS. 443:37-40.Full Text via DOI: 10.1016/j.neulet.2008.07.040
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2008Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity. PHYSIOLOGY & BEHAVIOR. 93:1044-1054.Full Text via DOI: 10.1016/j.physbeh.2008.01.013
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2007Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes. PHYSIOLOGICAL GENOMICS. 29:91-97.Full Text via DOI: 10.1152/physiolgenomics.00027.2006
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2007Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 293:E31-E41.Full Text via DOI: 10.1152/ajpendo.00500.2006
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2007Evolution, atmospheric oxygen, and complex disease. PHYSIOLOGICAL GENOMICS. 30:205-208.Full Text via DOI: 10.1152/physiolgenomics.00043.2007
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2007Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention & Rehabilitation. 14:319-325.Full Text via DOI: 10.1097/01.hjr.0b013e3280128bef
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2007Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome. NEUROSCIENCE LETTERS. 419:178-183.Full Text via DOI: 10.1016/j.neulet.2007.04.042
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2006Continued divergence in V̇
o 2 maxof rats artificially selected for running endurance is mediated by greater convective blood O2delivery. JOURNAL OF APPLIED PHYSIOLOGY. 101:1288-1296.Full Text via DOI: 10.1152/japplphysiol.01527.2005 -
2006Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: Implications for central fatigue. BEHAVIOURAL BRAIN RESEARCH. 174:132-142.Full Text via DOI: 10.1016/j.bbr.2006.07.018
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2006Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity. JOURNAL OF APPLIED PHYSIOLOGY. 100:1765-1769.Full Text via DOI: 10.1152/japplphysiol.01533.2005
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2006Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 291:H2933-H2941.Full Text via DOI: 10.1152/ajpheart.00514.2006
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2006Systemic oxygen transport in rats artificially selected for running endurance. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 151:141-150.Full Text via DOI: 10.1016/j.resp.2005.09.012
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2005Cardiac Rehabilitation After Heart Transplantation in a Patient With Becker’s Muscular Dystrophy: A Case Report. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 86:2059-2061.Full Text via DOI: 10.1016/j.apmr.2005.03.036
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2005Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity. SCIENCE. 307:418-420.Full Text via DOI: 10.1126/science.1108177
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2005Divergent Selection for Aerobic Capacity in Rats as a Model for Complex Disease. INTEGRATIVE AND COMPARATIVE BIOLOGY. 45:405-415.Full Text via DOI: 10.1093/icb/45.3.405
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2005Test of the principle of initial value in rat genetic models of exercise capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 288:R466-R472.Full Text via DOI: 10.1152/ajpregu.00621.2004
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2003Genetic component of sensorimotor capacity in rats. PHYSIOLOGICAL GENOMICS. 13:241-247.Full Text via DOI: 10.1152/physiolgenomics.00137.2002
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2003Selected Contribution: Skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. JOURNAL OF APPLIED PHYSIOLOGY. 94:1682-1688.Full Text via DOI: 10.1152/japplphysiol.00556.2002
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2003Selected Contribution: Variation and heritability for the adaptational response to exercise in genetically heterogeneous rats. JOURNAL OF APPLIED PHYSIOLOGY. 94:1674-1681.Full Text via DOI: 10.1152/japplphysiol.00851.2002
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2002A Genome Scan for Loci Associated with Aerobic Running Capacity in Rats. GENOMICS. 80:13-20.Full Text via DOI: 10.1006/geno.2002.6797
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2002Cardiac adenosine production in rat genetic models of low and high exercise capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 283:R168-R173.Full Text via DOI: 10.1152/ajpregu.00621.2001
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2002Determinants of maximal O2 uptake in rats selectively bred for endurance running capacity. JOURNAL OF APPLIED PHYSIOLOGY. 93:1265-1274.Full Text via DOI: 10.1152/japplphysiol.00809.2001
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2002Myocardial function in rat genetic models of low and high aerobic running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 282:R721-R726.Full Text via DOI: 10.1152/ajpregu.00367.2001
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2001Artificial selection for intrinsic aerobic endurance running capacity in rats. PHYSIOLOGICAL GENOMICS. 5:45-52.Full Text via DOI: 10.1152/physiolgenomics.2001.5.1.45
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2001Cardiac function in rats selectively bred for low- and high-capacity running. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 281:R1787-R1791.Full Text via DOI: 10.1152/ajpregu.2001.281.6.r1787
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2001Cardiac performance in inbred rat genetic models of low and high running capacity. JOURNAL OF PHYSIOLOGY-LONDON. 535:611-617.Full Text via DOI: 10.1111/j.1469-7793.2001.00611.x
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2000State-Dependent Expression of Pressure Diuresis in Conscious Rats. Proceedings of the Society for Experimental Biology and Medicine. 224:109-115.Full Text via DOI: 10.1046/j.1525-1373.2000.22408.x
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1999A Gravimetric Method for the Measurement of Total Spontaneous Activity in Rats. Proceedings of the Society for Experimental Biology and Medicine. 222:65-69.Full Text via DOI: 10.1111/j.1525-1373.1999.09996.x
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1999Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. PHYSIOLOGICAL GENOMICS. 1:63-69.Full Text via DOI: 10.1152/physiolgenomics.1999.1.2.63
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1999Phenotypic variation in sensorimotor performance among eleven inbred rat strains. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 276:R1383-R1389.Full Text via DOI: 10.1152/ajpregu.1999.276.5.r1383
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1998Heritability of treadmill running endurance in rats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 275:R1455-R1460.Full Text via DOI: 10.1152/ajpregu.1998.275.5.r1455
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1998Spectrum of aerobic endurance running performance in eleven inbred strains of rats. JOURNAL OF APPLIED PHYSIOLOGY. 85:530-536.Full Text via DOI: 10.1152/jappl.1998.85.2.530
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1991Reflex versus autoregulatory control of hindlimb blood flow during treadmill exercise in dogs. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 260:H436-H444.Full Text via DOI: 10.1152/ajpheart.1991.260.2.h436
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1990Adenosine is not essential for exercise hyperaemia in the hindlimb in conscious dogs.. JOURNAL OF PHYSIOLOGY-LONDON. 429:63-75.Full Text via DOI: 10.1113/jphysiol.1990.sp018244
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Early Access (Web of Science)
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2020Aerobics - decades of data for future hypothesis-testing research. NATURE REVIEWS ENDOCRINOLOGY.Full Text via DOI: 10.1038/s41574-020-00415-8 PMID: 32895502
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Letter (Web of Science)
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2015Blunted Cardiomyocyte Remodeling Response in Exercise-Resistant Rats. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 1378-1380.Full Text via DOI: 10.1016/j.jacc.2015.01.041
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Meeting Abstract (Web of Science)
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2018High Intrinsic Aerobic Endurance Capacity Preserves Cardiomyocyte Quality Control, Mitochondrial Fitness and Lifespan. BIOPHYSICAL JOURNAL. 662a.Full Text via DOI: 10.1016/j.bpj.2017.11.3572
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2016Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. FREE RADICAL BIOLOGY AND MEDICINE. S34-S35.Full Text via DOI: 10.1016/j.freeradbiomed.2016.04.069
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2016Effects Of Intrinsic Aerobic Capacity And Ovariectomy on Voluntary Wheel Running and Mid-brain Dopamine Signaling. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 823.Full Text via DOI: 10.1249/01.mss.0000487470.04975.2a
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2010Influence of Intrinsic Aerobic Exercise Capacity on Skeletal Health. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 821.Full Text via DOI: 10.1249/01.mss.0000386535.36330.dd
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2006Tu-P7:77 Endurance training reduces disease risk factors in rats artificially selected for low aerobic capacity. Atherosclerosis Supplements. 202.Full Text via DOI: 10.1016/s1567-5688(06)80785-3
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2005Genetically Selected High Capacity Runners Have Altered Serotonergic and Dopaminergic Receptor mRNA in the Brain. MEDICINE & SCIENCE IN SPORTS & EXERCISE. S133.Full Text via DOI: 10.1097/00005768-200505001-00698
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2005IN VITRO TNF-α PRODUCTION IS INCREASED IN ENDO- TOXIN-STIMULATED AVEOLAR MACROPHAGES FROM HIGH VERSUS LOW AEROBIC CAPACITY RATS.. CRITICAL CARE MEDICINE. A149.Full Text via DOI: 10.1097/00003246-200512002-00526
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Proceedings Paper (Web of Science)
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2016Effect of Gender on Iron-induced Brain Injury in Low Aerobic Capacity Rats. Acta Neurochirurgica Supplement. 367-371.Full Text via DOI: 10.1007/978-3-319-18497-5_63
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2016Effects of Aerobic Capacity on Thrombin-Induced Hydrocephalus and White Matter Injury. Acta Neurochirurgica Supplement. 379-384.Full Text via DOI: 10.1007/978-3-319-18497-5_65
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Review Article (Web of Science)
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2021SARS-CoV-2, ACE2 expression, and systemic organ invasion. PHYSIOLOGICAL GENOMICS. 51-60.Full Text via DOI: 10.1152/physiolgenomics.00087.2020 PMID: 33275540
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2018Are There Limitations to Exercise Benefits in Peripheral Arterial Disease?. FRONTIERS IN CARDIOVASCULAR MEDICINE.Full Text via DOI: 10.3389/fcvm.2018.00173 PMID: 30538994
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2016Rodent models for resolving extremes of exercise and health. PHYSIOLOGICAL GENOMICS. 82-92.Full Text via DOI: 10.1152/physiolgenomics.00077.2015
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2008Aerobic metabolism underlies complexity and capacity. JOURNAL OF PHYSIOLOGY-LONDON. 83-95.Full Text via DOI: 10.1113/jphysiol.2007.144709
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2006Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease—A new take on an old hypothesis. Pharmacology & Therapeutics. 71-82.Full Text via DOI: 10.1016/j.pharmthera.2005.09.006
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2005Animal models of complex diseases: An initial strategy. IUBMB LIFE. 631-638.Full Text via DOI: 10.1080/15216540500251684
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