Lauren Gerard Koch
- Associate Professor, Physiology and Pharmacology , College of Medicine and Life Sciences
Publications
selected publications
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Article (Web of Science)
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2022Age and Intrinsic Fitness Affect the Female Rotator Cuff Tendon Tissue. BIOMEDICINES. 10.Full Text via DOI: 10.3390/biomedicines10020509 PMID: 35203717
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2022The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23.Full Text via DOI: 10.3390/ijms23010079 PMID: 35008516
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2021Influence of Intrinsic Aerobic Exercise Capacity and Sex on Cardiac Injury Following Acute Myocardial Ischemia and Reperfusion. FRONTIERS IN CARDIOVASCULAR MEDICINE. 8.Full Text via DOI: 10.3389/fcvm.2021.751864 PMID: 34901212
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2021Low Intrinsic Aerobic Capacity Limits Recovery Response to Hindlimb Ischemia. FRONTIERS IN CARDIOVASCULAR MEDICINE. 8.Full Text via DOI: 10.3389/fcvm.2021.752955 PMID: 34881306
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2021Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus. BRAIN BEHAVIOR AND IMMUNITY. 97:250-259.Full Text via DOI: 10.1016/j.bbi.2021.06.017 PMID: 34224822
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2021Genetically determined exercise capacity affects systemic glucose response to insulin in rats. PHYSIOLOGICAL GENOMICS. 53:395-405.Full Text via DOI: 10.1152/physiolgenomics.00014.2021 PMID: 34297615
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2021Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young. PHYSIOLOGY & BEHAVIOR. 236.Full Text via DOI: 10.1016/j.physbeh.2021.113417 PMID: 33838202
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2021Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. FRONTIERS IN ENDOCRINOLOGY. 12.Full Text via DOI: 10.3389/fendo.2021.645881 PMID: 34177798
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2021
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2021A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo. PHYSIOLOGICAL REPORTS. 9.Full Text via DOI: 10.14814/phy2.14799 PMID: 34042295
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2021Hydrocephalus Following Experimental Subarachnoid Hemorrhage in Rats with Different Aerobic Capacity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.Full Text via DOI: 10.3390/ijms22094489 PMID: 33925787
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2021Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity. CELL REPORTS. 35.Full Text via DOI: 10.1016/j.celrep.2021.109018 PMID: 33882313
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2021Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats. PHYSIOLOGY & BEHAVIOR. 230.Full Text via DOI: 10.1016/j.physbeh.2020.113280 PMID: 33285179
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2021Low responders to endurance training exhibit impaired hypertrophy and divergent biological process responses in rat skeletal muscle. EXPERIMENTAL PHYSIOLOGY.Full Text via DOI: 10.1113/EP089301 PMID: 33486778
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2021Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety. PHYSIOLOGICAL REPORTS. 9.Full Text via DOI: 10.14814/phy2.14716 PMID: 33619911
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2021Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan. NPJ AGING AND MECHANISMS OF DISEASE. 7.Full Text via DOI: 10.1038/s41514-020-00054-3 PMID: 33398019
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2021Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks. FUNCTION. 2.Full Text via DOI: 10.1093/function/zqaa029 PMID: 33363281
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2021Differential weight loss with intermittent fasting or daily calorie restriction in low‐ and high‐fitness phenotypes. EXPERIMENTAL PHYSIOLOGY. 106:1731-1742.Full Text via DOI: 10.1113/ep089434
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2021Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats. Journal of Alzheimer's Disease Reports. 5:469-475.Full Text via DOI: 10.3233/adr-200289
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2021Low responders to endurance training exhibit impaired hypertrophy and divergent biological process responses in rat skeletal muscle. EXPERIMENTAL PHYSIOLOGY. 106:714-725.Full Text via DOI: 10.1113/ep089301
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2020Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats. FRONTIERS IN ENDOCRINOLOGY. 11.Full Text via DOI: 10.3389/fendo.2020.591476 PMID: 33193103
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2020Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure. PHYSIOLOGY & BEHAVIOR. 225.Full Text via DOI: 10.1016/j.physbeh.2020.113048 PMID: 32628949
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2020Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise. NATURE METABOLISM. 2:902-+.Full Text via DOI: 10.1038/s42255-020-0240-7 PMID: 32694831
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2020Rats genetically selected for low and high aerobic capacity exhibit altered soleus muscle myofilament functions. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 318:C422-C429.Full Text via DOI: 10.1152/ajpcell.00430.2019 PMID: 31875694
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2020Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training. PHYSIOLOGICAL GENOMICS. 52:35-46.Full Text via DOI: 10.1152/physiolgenomics.00103.2019 PMID: 31790338
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2020Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. PHYSIOLOGICAL GENOMICS. 52:1-14.Full Text via DOI: 10.1152/physiolgenomics.00089.2019 PMID: 31762410
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2019Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training. DATA IN BRIEF. 27.Full Text via DOI: 10.1016/j.dib.2019.104570 PMID: 31687430
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2019Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. EXPERIMENTAL GERONTOLOGY. 125.Full Text via DOI: 10.1016/j.exger.2019.110657 PMID: 31306740
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2019Precision exercise medicine: understanding exercise response variability. BRITISH JOURNAL OF SPORTS MEDICINE. 53:1141-1153.Full Text via DOI: 10.1136/bjsports-2018-100328 PMID: 30862704
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2019Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance. ENDOCRINOLOGY. 160:1179-1192.Full Text via DOI: 10.1210/en.2019-00118 PMID: 31144719
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2018Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-35728-2
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2018
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2018Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. EXPERIMENTAL PHYSIOLOGY. 103:1513-1523.Full Text via DOI: 10.1113/EP087144
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2018Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors. OBESITY. 26:885-894.Full Text via DOI: 10.1002/oby.22166
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2018Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats. NEUROSCIENCE LETTERS. 674:49-53.Full Text via DOI: 10.1016/j.neulet.2018.03.009
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2018Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. MOLECULAR METABOLISM. 11:189-196.Full Text via DOI: 10.1016/j.molmet.2018.02.009
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2018Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. EXPERIMENTAL PHYSIOLOGY. 103:1513-1523.Full Text via DOI: 10.1113/ep087144
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2018Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk. Cold Spring Harbor Perspectives in Medicine. 8:a029868.Full Text via DOI: 10.1101/cshperspect.a029868
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2018Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats. Adipocyte. 7:20-34.Full Text via DOI: 10.1080/21623945.2017.1402991
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2017A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 313:E681-E689.Full Text via DOI: 10.1152/ajpendo.00157.2017
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2017Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis. JOURNAL OF PHYSIOLOGY-LONDON. 595:4909-4926.Full Text via DOI: 10.1113/jp274281
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2017DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. CELL METABOLISM. 25:1135-1146.e7.Full Text via DOI: 10.1016/j.cmet.2017.04.008
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2017Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. FRONTIERS IN IMMUNOLOGY. 8.Full Text via DOI: 10.3389/fimmu.2017.01768
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2017Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 313:E335-E343.Full Text via DOI: 10.1152/ajpendo.00043.2017
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2017High Aerobic Capacity Mitigates Changes in the Plasma Metabolomic Profile Associated with Aging. JOURNAL OF PROTEOME RESEARCH. 16:798-805.Full Text via DOI: 10.1021/acs.jproteome.6b00796
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2017Inherent aerobic capacity-dependent differences in breast carcinogenesis. CARCINOGENESIS. 38:920-928.Full Text via DOI: 10.1093/carcin/bgx066
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2017Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings. PHYSIOLOGICAL GENOMICS. 49:733-746.Full Text via DOI: 10.1152/physiolgenomics.00081.2017
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2017Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain. Brain and Behavior. 7:e00780.Full Text via DOI: 10.1002/brb3.780
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2017Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats. SCIENTIFIC REPORTS. 7:9261.Full Text via DOI: 10.1038/s41598-017-08965-0
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2017Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 49:254-264.Full Text via DOI: 10.1249/mss.0000000000001101
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2017mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. Annals of Clinical and Translational Neurology. 4:844-858.Full Text via DOI: 10.1002/acn3.484
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2016Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 311:E749-E760.Full Text via DOI: 10.1152/ajpendo.00178.2016
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2016Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease. DIABETES. 65:3341-3351.Full Text via DOI: 10.2337/db16-0292
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2016Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression. PHYSIOLOGY & BEHAVIOR. 164:383-389.Full Text via DOI: 10.1016/j.physbeh.2016.06.006
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2016Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. EXPERIMENTAL GERONTOLOGY. 79:46-54.Full Text via DOI: 10.1016/j.exger.2016.03.015
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2016Effects of ovariectomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 310:E190-E199.Full Text via DOI: 10.1152/ajpendo.00434.2015
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2016Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 311:G166-G179.Full Text via DOI: 10.1152/ajpgi.00065.2016
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2016Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. OBESITY. 24:1929-1937.Full Text via DOI: 10.1002/oby.21564
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2016Nucleus accumbens cocaine-amphetamine regulated transcript mediates food intake during novelty conflict. PHYSIOLOGY & BEHAVIOR. 158:76-84.Full Text via DOI: 10.1016/j.physbeh.2016.02.035
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2016Ovariectomized Highly Fit Rats Are Protected against Diet-Induced Insulin Resistance. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 48:1259-1269.Full Text via DOI: 10.1249/mss.0000000000000898
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2016Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. JOURNAL OF PHYSIOLOGY-LONDON. 594:1855-1873.Full Text via DOI: 10.1113/jp271552
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2016Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats. Aging. 8:769-776.Full Text via DOI: 10.18632/aging.100929
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2016Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness. PHYSIOLOGICAL GENOMICS. 48:816-825.Full Text via DOI: 10.1152/physiolgenomics.00118.2015
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2016The rate of training response to aerobic exercise affects brain function of rats. NEUROCHEMISTRY INTERNATIONAL. 99:16-23.Full Text via DOI: 10.1016/j.neuint.2016.05.012
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2016Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. FRONTIERS IN PHYSIOLOGY. 7.Full Text via DOI: 10.3389/fphys.2016.00311
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2015Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. NEUROSCIENCE. 310:252-267.Full Text via DOI: 10.1016/j.neuroscience.2015.09.035
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2015Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLOS ONE. 10:e0126906.Full Text via DOI: 10.1371/journal.pone.0126906
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2015Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 308:R530-R542.Full Text via DOI: 10.1152/ajpregu.00401.2014
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2015High intrinsic aerobic capacity and pomegranate juice are protective against macrophage atherogenecity: studies in high- vs. low-capacity runner (HCR vs. LCR) rats. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 26:1015-1021.Full Text via DOI: 10.1016/j.jnutbio.2015.04.001
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2015Iron-Induced Necrotic Brain Cell Death in Rats with Different Aerobic Capacity. TRANSLATIONAL STROKE RESEARCH. 6:215-223.Full Text via DOI: 10.1007/s12975-015-0388-8
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2015Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity. PROTEOMICS. 15:2342-2349.Full Text via DOI: 10.1002/pmic.201400537
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2015Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation. CELL METABOLISM. 21:468-478.Full Text via DOI: 10.1016/j.cmet.2015.02.007
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2015Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 467:779-788.Full Text via DOI: 10.1007/s00424-014-1554-7
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2015Physical Activity Differentially Affects the Cecal Microbiota of Ovariectomized Female Rats Selectively Bred for High and Low Aerobic Capacity. PLOS ONE. 10:e0136150.Full Text via DOI: 10.1371/journal.pone.0136150
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2015Physical activity in adulthood: genes and mortality. SCIENTIFIC REPORTS. 5:18259.Full Text via DOI: 10.1038/srep18259
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2015Physically active rats lose more weight during calorie restriction. PHYSIOLOGY & BEHAVIOR. 139:303-313.Full Text via DOI: 10.1016/j.physbeh.2014.11.044
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2015Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction. JOURNAL OF APPLIED PHYSIOLOGY. 118:849-857.Full Text via DOI: 10.1152/japplphysiol.00797.2014
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2014Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Annals of Clinical and Translational Neurology. 1:589-604.Full Text via DOI: 10.1002/acn3.86
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2014Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity. Journal of Proteomics. 106:230-245.Full Text via DOI: 10.1016/j.jprot.2014.04.015
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2014Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. BRAIN RESEARCH BULLETIN. 107:54-60.Full Text via DOI: 10.1016/j.brainresbull.2014.07.003
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2014Eszopiclone and Dexmedetomidine Depress Ventilation in Obese Rats with Features of Metabolic Syndrome. SLEEP. 37:871-880.Full Text via DOI: 10.5665/sleep.3650
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2014Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity. PLOS ONE. 9:e114075.Full Text via DOI: 10.1371/journal.pone.0114075
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2014Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 307:E355-E364.Full Text via DOI: 10.1152/ajpendo.00093.2014
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2014Label-free profiling of skeletal muscle using high-definition mass spectrometry. PROTEOMICS. 14:2339-2344.Full Text via DOI: 10.1002/pmic.201400118
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2014Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 306:E635-E647.Full Text via DOI: 10.1152/ajpendo.00555.2013
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2014Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. Acta Physiologica. 210:854-864.Full Text via DOI: 10.1111/apha.12238
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2014Resveratrol Attenuates Exercise-Induced Adaptive Responses in Rats Selectively Bred for Low Running Performance. Dose-Response. 12:dose-response.1.Full Text via DOI: 10.2203/dose-response.13-010.radak
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2014Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity. BRAIN RESEARCH. 1572:11-17.Full Text via DOI: 10.1016/j.brainres.2014.05.014
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2013(–)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. CLINICAL SCIENCE. 124:663-674.Full Text via DOI: 10.1042/cs20120469
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2013Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair. NEUROSCIENCE. 252:326-336.Full Text via DOI: 10.1016/j.neuroscience.2013.08.020
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2013Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE. 8:e76568.Full Text via DOI: 10.1371/journal.pone.0076568
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2013Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity. PHYSIOLOGICAL GENOMICS. 45:17-25.Full Text via DOI: 10.1152/physiolgenomics.00111.2012
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2013Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 305:E429-E438.Full Text via DOI: 10.1152/ajpendo.00544.2012
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2013Genetic Analysis of a Rat Model of Aerobic Capacity and Metabolic Fitness. PLOS ONE. 8:e77588.Full Text via DOI: 10.1371/journal.pone.0077588
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2013High inborn aerobic capacity does not protect the heart following myocardial infarction. JOURNAL OF APPLIED PHYSIOLOGY. 115:1788-1795.Full Text via DOI: 10.1152/japplphysiol.00312.2013
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2013Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 304:H729-H739.Full Text via DOI: 10.1152/ajpheart.00638.2012
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2013Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 305:H403-H409.Full Text via DOI: 10.1152/ajpheart.00317.2013
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2013Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks. DIABETES. 62:2717-2727.Full Text via DOI: 10.2337/db13-0062
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2013Resveratrol enhances exercise training responses in rats selectively bred for high running performance. FOOD AND CHEMICAL TOXICOLOGY. 61:53-59.Full Text via DOI: 10.1016/j.fct.2013.01.051
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2013Selectively bred rat model system for low and high response to exercise training. PHYSIOLOGICAL GENOMICS. 45:606-614.Full Text via DOI: 10.1152/physiolgenomics.00021.2013
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2013Susceptibility to intracerebral hemorrhage-induced brain injury segregates with low aerobic capacity in rats. NEUROBIOLOGY OF DISEASE. 49:22-28.Full Text via DOI: 10.1016/j.nbd.2012.08.014
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2013Uphill running does not exacerbate collagenase-induced pathological changes in the Achilles tendon of rats selectively bred for high-capacity running. Connective Tissue Research. 54:386-393.Full Text via DOI: 10.3109/03008207.2013.848201
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2013Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon. BMC Musculoskeletal Disorders. 14:90.Full Text via DOI: 10.1186/1471-2474-14-90
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2013Vascularity of myocardium and gastrocnemius muscle in rats selectively bred for endurance running capacity. PHYSIOLOGICAL GENOMICS. 45:119-125.Full Text via DOI: 10.1152/physiolgenomics.00110.2012
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2012Brain Activation Patterns at Exhaustion in Rats That Differ in Inherent Exercise Capacity. PLOS ONE. 7:e45415.Full Text via DOI: 10.1371/journal.pone.0045415
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2012Determination of Minimum Alveolar Concentration for Isoflurane and Sevoflurane in a Rodent Model of Human Metabolic Syndrome. ANESTHESIA AND ANALGESIA. 114:297-302.Full Text via DOI: 10.1213/ane.0b013e31823ede22
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2012Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?. JOURNAL OF APPLIED PHYSIOLOGY. 113:1403-1412.Full Text via DOI: 10.1152/japplphysiol.00788.2012
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2012Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome. Molecular Medicine. 18:1481-1490.Full Text via DOI: 10.2119/molmed.2012.00351
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2012Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2emission capacities without major shifts in myosin heavy chain isoform. JOURNAL OF APPLIED PHYSIOLOGY. 113:1624-1634.Full Text via DOI: 10.1152/japplphysiol.01475.2011
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2012Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 302:H1667-H1682.Full Text via DOI: 10.1152/ajpheart.01027.2011
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2012
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2012Region-specific differences in brain melanocortin receptors in rats of the lean phenotype. Neuroreport. 23:596-600.Full Text via DOI: 10.1097/00001756-201207110-00004
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2012Selective breeding for endurance running capacity affects cognitive but not motor learning in rats. PHYSIOLOGY & BEHAVIOR. 106:95-100.Full Text via DOI: 10.1016/j.physbeh.2012.01.011
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2011A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. JOURNAL OF APPLIED PHYSIOLOGY. 110:46-59.Full Text via DOI: 10.1152/japplphysiol.00634.2010
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2011Changes in mRNA levels for brain-derived neurotrophic factor after wheel running in rats selectively bred for high- and low-aerobic capacity. BRAIN RESEARCH. 1425:90-97.Full Text via DOI: 10.1016/j.brainres.2011.09.059
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2011Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R175-R182.Full Text via DOI: 10.1152/ajpregu.00338.2010
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2011Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity. CIRCULATION RESEARCH. 109:1162-1172.Full Text via DOI: 10.1161/circresaha.111.253807
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2011Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R835-R843.Full Text via DOI: 10.1152/ajpregu.00659.2010
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2011Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 300:R544-R553.Full Text via DOI: 10.1152/ajpregu.00250.2010
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2011Osteoblast Response to Ovariectomy Is Enhanced in Intrinsically High Aerobic-Capacity Rats. CALCIFIED TISSUE INTERNATIONAL. 88:325-335.Full Text via DOI: 10.1007/s00223-010-9457-x
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2011Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity. PROTEOMICS. 11:3369-3379.Full Text via DOI: 10.1002/pmic.201000593
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2011Risk-assessment and Coping Strategies Segregate with Divergent Intrinsic Aerobic Capacity in Rats. NEUROPSYCHOPHARMACOLOGY. 36:390-401.Full Text via DOI: 10.1038/npp.2010.144
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2011The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. JOURNAL OF CELLULAR PHYSIOLOGY. 226:2235-2243.Full Text via DOI: 10.1002/jcp.22559
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2010Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity. ENDOCRINOLOGY. 151:5157-5164.Full Text via DOI: 10.1210/en.2010-0176
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2010Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controls. Nutrition & Metabolism. 7:53.Full Text via DOI: 10.1186/1743-7075-7-53
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2010Disrupted Sleep and Delayed Recovery from Chronic Peripheral Neuropathy Are Distinct Phenotypes in a Rat Model of Metabolic Syndrome. ANESTHESIOLOGY. 113:1176-1185.Full Text via DOI: 10.1097/aln.0b013e3181f56248
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2010Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB JOURNAL. 24:4565-4574.Full Text via DOI: 10.1096/fj.10-157313
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2010Locus coeruleus galanin expression is enhanced after exercise in rats selectively bred for high capacity for aerobic activity. Peptides. 31:2264-2268.Full Text via DOI: 10.1016/j.peptides.2010.09.005
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2010Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity. Basic Research in Cardiology. 105:357-364.Full Text via DOI: 10.1007/s00395-010-0087-2
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2010Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity. JOURNAL OF APPLIED PHYSIOLOGY. 109:778-785.Full Text via DOI: 10.1152/japplphysiol.01026.2009
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2010Selection for intrinsic endurance modifies endocrine stress responsiveness. BRAIN RESEARCH. 1357:53-61.Full Text via DOI: 10.1016/j.brainres.2010.07.078
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2010Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM. 35:151-162.Full Text via DOI: 10.1139/h09-139
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2010Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Hormones and Behavior. 58:355-367.Full Text via DOI: 10.1016/j.yhbeh.2010.03.013
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2010Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. JOURNAL OF APPLIED PHYSIOLOGY. 108:1487-1496.Full Text via DOI: 10.1152/japplphysiol.01295.2009
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2009Artificial Selection for Whole Animal Low Intrinsic Aerobic Capacity Co-Segregates with Hypoxia-Induced Cardiac Pump Failure. PLOS ONE. 4:e6117.Full Text via DOI: 10.1371/journal.pone.0006117
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2009Continued artificial selection for running endurance in rats is associated with improved lung function. JOURNAL OF APPLIED PHYSIOLOGY. 106:1810-1818.Full Text via DOI: 10.1152/japplphysiol.90419.2008
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2009High-Fat Diet Induces IKKβ and Reduces Insulin Sensitivity in Rats with Low Running Capacity. INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 30:631-635.Full Text via DOI: 10.1055/s-0029-1224174
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2009Impaired Skeletal Muscle β-Adrenergic Activation and Lipolysis Are Associated with Whole-Body Insulin Resistance in Rats Bred for Low Intrinsic Exercise Capacity. ENDOCRINOLOGY. 150:4883-4891.Full Text via DOI: 10.1210/en.2009-0158
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2009Low Aerobic Capacity and High-Fat Diet Contribute to Oxidative Stress and IRS-1 Degradation in the Kidney. AMERICAN JOURNAL OF NEPHROLOGY. 30:112-119.Full Text via DOI: 10.1159/000204362
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2009Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity. JOURNAL OF APPLIED PHYSIOLOGY. 106:1819-1825.Full Text via DOI: 10.1152/japplphysiol.00914.2007
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2009Rat Strains Bred for Low and High Aerobic Running Capacity Do Not Differ in Their Survival Time to Hemorrhage. Experimental Biology and Medicine. 234:1503-1510.Full Text via DOI: 10.3181/0812-rm-355
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2009Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. JOURNAL OF PHYSIOLOGY-LONDON. 587:1805-1816.Full Text via DOI: 10.1113/jphysiol.2009.169060
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2008Aerobic capacity-dependent differences in cardiac gene expression. PHYSIOLOGICAL GENOMICS. 33:100-109.Full Text via DOI: 10.1152/physiolgenomics.00269.2007 PMID: 18171719
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2008Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. CARDIOVASCULAR RESEARCH. 81:723-732.Full Text via DOI: 10.1093/cvr/cvn332
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2008Body Mass Index Measures in Children with Cerebral Palsy Related to Gross Motor Function Classification. American Journal of Physical Medicine & Rehabilitation. 87:395-403.Full Text via DOI: 10.1097/phm.0b013e3181617736
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2008Development of Animal Models to Test the Fundamental Basis of Gene-Environment Interactions. OBESITY. 16:S28-S32.Full Text via DOI: 10.1038/oby.2008.513
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2008Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. PHYSIOLOGICAL GENOMICS. 35:213-221.Full Text via DOI: 10.1152/physiolgenomics.90282.2008
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2008Initial signaling response to acute exercise bout is similar in hearts of rats bred for divergent exercise capacities. FRONTIERS IN BIOSCIENCE-LANDMARK. 13:347.Full Text via DOI: 10.2741/2684
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2008Nociception before and after exercise in rats bred for high and low aerobic capacity. NEUROSCIENCE LETTERS. 443:37-40.Full Text via DOI: 10.1016/j.neulet.2008.07.040
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2008Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity. PHYSIOLOGY & BEHAVIOR. 93:1044-1054.Full Text via DOI: 10.1016/j.physbeh.2008.01.013
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2007Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes. PHYSIOLOGICAL GENOMICS. 29:91-97.Full Text via DOI: 10.1152/physiolgenomics.00027.2006
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2007Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 293:E31-E41.Full Text via DOI: 10.1152/ajpendo.00500.2006
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2007Evolution, atmospheric oxygen, and complex disease. PHYSIOLOGICAL GENOMICS. 30:205-208.Full Text via DOI: 10.1152/physiolgenomics.00043.2007
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2007Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. European Journal of Cardiovascular Prevention & Rehabilitation. 14:319-325.Full Text via DOI: 10.1097/01.hjr.0b013e3280128bef
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2007Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome. NEUROSCIENCE LETTERS. 419:178-183.Full Text via DOI: 10.1016/j.neulet.2007.04.042
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2006Continued divergence in V̇
o 2 maxof rats artificially selected for running endurance is mediated by greater convective blood O2delivery. JOURNAL OF APPLIED PHYSIOLOGY. 101:1288-1296.Full Text via DOI: 10.1152/japplphysiol.01527.2005 -
2006Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: Implications for central fatigue. BEHAVIOURAL BRAIN RESEARCH. 174:132-142.Full Text via DOI: 10.1016/j.bbr.2006.07.018
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2006Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity. JOURNAL OF APPLIED PHYSIOLOGY. 100:1765-1769.Full Text via DOI: 10.1152/japplphysiol.01533.2005
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2006Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 291:H2933-H2941.Full Text via DOI: 10.1152/ajpheart.00514.2006
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2006Systemic oxygen transport in rats artificially selected for running endurance. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 151:141-150.Full Text via DOI: 10.1016/j.resp.2005.09.012
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2005Cardiac Rehabilitation After Heart Transplantation in a Patient With Becker’s Muscular Dystrophy: A Case Report. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 86:2059-2061.Full Text via DOI: 10.1016/j.apmr.2005.03.036
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2005Cardiovascular Risk Factors Emerge After Artificial Selection for Low Aerobic Capacity. SCIENCE. 307:418-420.Full Text via DOI: 10.1126/science.1108177
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2005Divergent Selection for Aerobic Capacity in Rats as a Model for Complex Disease. INTEGRATIVE AND COMPARATIVE BIOLOGY. 45:405-415.Full Text via DOI: 10.1093/icb/45.3.405
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2005Test of the principle of initial value in rat genetic models of exercise capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 288:R466-R472.Full Text via DOI: 10.1152/ajpregu.00621.2004
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2003Genetic component of sensorimotor capacity in rats. PHYSIOLOGICAL GENOMICS. 13:241-247.Full Text via DOI: 10.1152/physiolgenomics.00137.2002
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2003Selected Contribution: Skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. JOURNAL OF APPLIED PHYSIOLOGY. 94:1682-1688.Full Text via DOI: 10.1152/japplphysiol.00556.2002
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2003Selected Contribution: Variation and heritability for the adaptational response to exercise in genetically heterogeneous rats. JOURNAL OF APPLIED PHYSIOLOGY. 94:1674-1681.Full Text via DOI: 10.1152/japplphysiol.00851.2002
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2002A Genome Scan for Loci Associated with Aerobic Running Capacity in Rats. GENOMICS. 80:13-20.Full Text via DOI: 10.1006/geno.2002.6797
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2002Cardiac adenosine production in rat genetic models of low and high exercise capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 283:R168-R173.Full Text via DOI: 10.1152/ajpregu.00621.2001
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2002Determinants of maximal O2 uptake in rats selectively bred for endurance running capacity. JOURNAL OF APPLIED PHYSIOLOGY. 93:1265-1274.Full Text via DOI: 10.1152/japplphysiol.00809.2001
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2002Myocardial function in rat genetic models of low and high aerobic running capacity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 282:R721-R726.Full Text via DOI: 10.1152/ajpregu.00367.2001
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2001Artificial selection for intrinsic aerobic endurance running capacity in rats. PHYSIOLOGICAL GENOMICS. 5:45-52.Full Text via DOI: 10.1152/physiolgenomics.2001.5.1.45
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2001Cardiac function in rats selectively bred for low- and high-capacity running. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 281:R1787-R1791.Full Text via DOI: 10.1152/ajpregu.2001.281.6.r1787
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2001Cardiac performance in inbred rat genetic models of low and high running capacity. JOURNAL OF PHYSIOLOGY-LONDON. 535:611-617.Full Text via DOI: 10.1111/j.1469-7793.2001.00611.x
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2000State-Dependent Expression of Pressure Diuresis in Conscious Rats. Proceedings of the Society for Experimental Biology and Medicine. 224:109-115.Full Text via DOI: 10.1046/j.1525-1373.2000.22408.x
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1999A Gravimetric Method for the Measurement of Total Spontaneous Activity in Rats. Proceedings of the Society for Experimental Biology and Medicine. 222:65-69.Full Text via DOI: 10.1111/j.1525-1373.1999.09996.x
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1999Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. PHYSIOLOGICAL GENOMICS. 1:63-69.Full Text via DOI: 10.1152/physiolgenomics.1999.1.2.63
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1999Phenotypic variation in sensorimotor performance among eleven inbred rat strains. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 276:R1383-R1389.Full Text via DOI: 10.1152/ajpregu.1999.276.5.r1383
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1998Heritability of treadmill running endurance in rats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 275:R1455-R1460.Full Text via DOI: 10.1152/ajpregu.1998.275.5.r1455
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1998Spectrum of aerobic endurance running performance in eleven inbred strains of rats. JOURNAL OF APPLIED PHYSIOLOGY. 85:530-536.Full Text via DOI: 10.1152/jappl.1998.85.2.530
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1991Reflex versus autoregulatory control of hindlimb blood flow during treadmill exercise in dogs. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 260:H436-H444.Full Text via DOI: 10.1152/ajpheart.1991.260.2.h436
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1990Adenosine is not essential for exercise hyperaemia in the hindlimb in conscious dogs.. JOURNAL OF PHYSIOLOGY-LONDON. 429:63-75.Full Text via DOI: 10.1113/jphysiol.1990.sp018244
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Early Access (Web of Science)
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2020Aerobics - decades of data for future hypothesis-testing research. NATURE REVIEWS ENDOCRINOLOGY.Full Text via DOI: 10.1038/s41574-020-00415-8 PMID: 32895502
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Letter (Web of Science)
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2015Blunted Cardiomyocyte Remodeling Response in Exercise-Resistant Rats. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 1378-1380.Full Text via DOI: 10.1016/j.jacc.2015.01.041
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Meeting Abstract (Web of Science)
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2018High Intrinsic Aerobic Endurance Capacity Preserves Cardiomyocyte Quality Control, Mitochondrial Fitness and Lifespan. BIOPHYSICAL JOURNAL. 662a.Full Text via DOI: 10.1016/j.bpj.2017.11.3572
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2016Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. FREE RADICAL BIOLOGY AND MEDICINE. S34-S35.Full Text via DOI: 10.1016/j.freeradbiomed.2016.04.069
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2016Effects Of Intrinsic Aerobic Capacity And Ovariectomy on Voluntary Wheel Running and Mid-brain Dopamine Signaling. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 823.Full Text via DOI: 10.1249/01.mss.0000487470.04975.2a
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2010Influence of Intrinsic Aerobic Exercise Capacity on Skeletal Health. MEDICINE & SCIENCE IN SPORTS & EXERCISE. 821.Full Text via DOI: 10.1249/01.mss.0000386535.36330.dd
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2006Tu-P7:77 Endurance training reduces disease risk factors in rats artificially selected for low aerobic capacity. Atherosclerosis Supplements. 202.Full Text via DOI: 10.1016/s1567-5688(06)80785-3
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2005Genetically Selected High Capacity Runners Have Altered Serotonergic and Dopaminergic Receptor mRNA in the Brain. MEDICINE & SCIENCE IN SPORTS & EXERCISE. S133.Full Text via DOI: 10.1097/00005768-200505001-00698
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2005IN VITRO TNF-α PRODUCTION IS INCREASED IN ENDO- TOXIN-STIMULATED AVEOLAR MACROPHAGES FROM HIGH VERSUS LOW AEROBIC CAPACITY RATS.. CRITICAL CARE MEDICINE. A149.Full Text via DOI: 10.1097/00003246-200512002-00526
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Proceedings Paper (Web of Science)
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2016Effect of Gender on Iron-induced Brain Injury in Low Aerobic Capacity Rats. Acta Neurochirurgica Supplement. 367-371.Full Text via DOI: 10.1007/978-3-319-18497-5_63
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2016Effects of Aerobic Capacity on Thrombin-Induced Hydrocephalus and White Matter Injury. Acta Neurochirurgica Supplement. 379-384.Full Text via DOI: 10.1007/978-3-319-18497-5_65
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Review Article (Web of Science)
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2021SARS-CoV-2, ACE2 expression, and systemic organ invasion. PHYSIOLOGICAL GENOMICS. 51-60.Full Text via DOI: 10.1152/physiolgenomics.00087.2020 PMID: 33275540
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2018Are There Limitations to Exercise Benefits in Peripheral Arterial Disease?. FRONTIERS IN CARDIOVASCULAR MEDICINE.Full Text via DOI: 10.3389/fcvm.2018.00173 PMID: 30538994
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2016Rodent models for resolving extremes of exercise and health. PHYSIOLOGICAL GENOMICS. 82-92.Full Text via DOI: 10.1152/physiolgenomics.00077.2015
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2008Aerobic metabolism underlies complexity and capacity. JOURNAL OF PHYSIOLOGY-LONDON. 83-95.Full Text via DOI: 10.1113/jphysiol.2007.144709
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2006Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease—A new take on an old hypothesis. Pharmacology & Therapeutics. 71-82.Full Text via DOI: 10.1016/j.pharmthera.2005.09.006
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2005Animal models of complex diseases: An initial strategy. IUBMB LIFE. 631-638.Full Text via DOI: 10.1080/15216540500251684
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