Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity Article (Faculty180)

cited authors

  • Høydal, Morten A; Wisløff, Ulrik; Kemi, Ole J; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Ellingsen


  • The neuronal isoform of nitric oxide synthase (NOS-1) may be an important regulator of cardiac contractility by modifying calcium release and uptake from sarcoplasmic reticulum. Our working hypothesis was that NOS-1 modulates cardiomyocyte contractility more markedly in rat lines with low versus high congenital aerobic fitness.

publication date

  • 2007

start page

  • 319

end page

  • 25


  • 14