Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity Article (Faculty180)

cited authors

  • Høydal, M A; Stølen, T O; Johnsen, A B; Alvez, M; Catalucci, D; Condorelli, G; Koch, L G; Britton, S L; Smith, G L; Wisløff, U


  • Rats selectively bred for inborn low capacity of running (LCR) display a series of poor health indices, whereas rats selected for high capacity of running (HCR) display a healthy profile. We hypothesized that selection of low aerobic capacity over generations leads to a phenotype with increased diastolic Ca(2+) leak that trigger arrhythmia.

publication date

  • 2014

published in

start page

  • 854

end page

  • 64


  • 210