Yuan Tang
- Assistant Professor, Bioengineering , College of Engineering
Overview
overview
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Dr. Yuan Tang joined the Bioengineering department as an Assistant Professor in August 2019. Prior to joining UToledo, he was a Research Assistant Professor in the Department of Mechanical Engineering at Temple University. During his Ph.D. study at Florida International University and postdoctoral training at Widener University, Dr. Tang gained substantial expertise in the applications of nanotechnology in designing targeted drug delivery systems for the treatment of breast cancer and heart disease. His current research focuses on the applications of nanotechnology for developing vascularized microfluidics-based biomimetic systems for drug screening as well as studying the role of endothelial cell inflammation in a variety of different pathological conditions. He is also developing targeted drug delivery systems utilizing natural or induced inflammatory responses in human endothelium, which includes the identification and selection of upregulated adhesion molecules in endothelial cells, synthesis and characterization of nano- or micro-sized drug carriers, drug payload internalization and controlled release, and characterization of various drug delivery routes under different disease conditions. The work of Dr. Yuan Tang has applications in the fields of nanotechnology, molecular imaging, drug delivery and radiation oncology.
Publications
selected publications
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Article (Faculty180)
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2023Biomimetic on-chip assay reveals the anti-metastatic potential of a novel thienopyrimidine compound in triple-negative breast cancer cell lines. Frontiers in Bioengineering and Biotechnology.
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2023Editorial: State-of-the-art rational nanodesign: from screening to theranostics and from bench to clinic. Frontiers in Pharmacology. 14.
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2022
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2022
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2021A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation. Journal of visualized experiments : JoVE.
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2021Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. Frontiers in Bioengineering and Biotechnology.
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2021Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. Frontiers in bioengineering and biotechnology. 9:633671.
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2020Neutrophil-endothelial interactions of murine cells is not a good predictor of their interactions in human cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:2691-2702.
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2019Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. Shock (Augusta, Ga.). 51:538-547.
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2019The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation. International journal of molecular sciences. 20.
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2018PKCδ inhibition as a novel medical countermeasure for radiation-induced vascular damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. fj201701099.
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2018Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage. Journal of neuroinflammation. 15:309.
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2017
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2017Targeted multidrug delivery system to overcome chemoresistance in breast cancer. International journal of nanomedicine. 12:671-681.
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2016A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. Journal of leukocyte biology. 100:1027-1035.
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2016Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer. Clinical breast cancer. 16:335-343.
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2015Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene. Anticancer research. 35:2531-8.
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2014Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model. Nanomedicine : nanotechnology, biology, and medicine. 10:1711-8.
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2013Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks. Microvascular research. 89:107-14.
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2013Increasing the rate of heating: a potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 29:145-55.
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2012Comparative study of the optical and heat generation properties of IR820 and indocyanine green. Molecular imaging. 11:99-113.
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2012Nanoplexes for cell imaging and hyperthermia: in vitro studies. Journal of biomedical nanotechnology. 8:686-94.
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2011Comparing cellular uptake and cytotoxicity of targeted drug carriers in cancer cell lines with different drug resistance mechanisms. Nanomedicine : nanotechnology, biology, and medicine. 7:324-32.
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2011Cytotoxicity of Metal Ions Released from Nitinol Alloys on Endothelial Cells. Journal of materials engineering and performance. 20:816-818.
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2010Simultaneous delivery of chemotherapeutic and thermal-optical agents to cancer cells by a polymeric (PLGA) nanocarrier: an in vitro study. Pharmaceutical research. 27:2242-53.
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2009Combined effects of laser-ICG photothermotherapy and doxorubicin chemotherapy on ovarian cancer cells. Journal of photochemistry and photobiology. B, Biology. 97:138-44.
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Article (Web of Science)
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2020Neutrophil‐endothelial interactions of murine cells is not a good predictor of their interactions in human cells. FASEB JOURNAL. 34:2691-2702.Full Text via DOI: 10.1096/fj.201900048r
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2019Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. SHOCK. 51:538-547.Full Text via DOI: 10.1097/shk.0000000000001247
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2019The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20:1498.Full Text via DOI: 10.3390/ijms20061498
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2018PKCδ inhibition as a novel medical countermeasure for radiation‐induced vascular damage. FASEB JOURNAL. 32:6436-6444.Full Text via DOI: 10.1096/fj.201701099
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2018Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage. JOURNAL OF NEUROINFLAMMATION. 15:309.Full Text via DOI: 10.1186/s12974-018-1342-y
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2017A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems. SCIENTIFIC REPORTS. 7:9359.Full Text via DOI: 10.1038/s41598-017-09815-9
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2017Targeted multidrug delivery system to overcome chemoresistance in breast cancer. International Journal of Nanomedicine. Volume 12:671-681.Full Text via DOI: 10.2147/ijn.s124770
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2016A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil–endothelium interaction. JOURNAL OF LEUKOCYTE BIOLOGY. 100:1027-1035.Full Text via DOI: 10.1189/jlb.3ma0216-087r
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2016Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer. Clinical Breast Cancer. 16:335-343.Full Text via DOI: 10.1016/j.clbc.2016.05.012
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2014Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model. Nanomedicine: Nanotechnology, Biology and Medicine. 10:1711-1718.Full Text via DOI: 10.1016/j.nano.2014.06.001
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2013Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks. Microvascular Research. 89:107-114.Full Text via DOI: 10.1016/j.mvr.2013.03.007
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2013Increasing the rate of heating: A potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy. International Journal of Hyperthermia. 29:145-155.Full Text via DOI: 10.3109/02656736.2012.760757
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Chapter (Faculty180)
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2022Application of nanocarriers for paclitaxel delivery and chemotherapy of cancer. Paclitaxel. ELSEVIER. 73-127.
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Conference Poster (Faculty180)
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Patent (Faculty180)
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Presentation (Faculty180)
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Review Article (Web of Science)
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2021Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.Full Text via DOI: 10.3389/fbioe.2021.633671 PMID: 33777909
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Contact
full name
- Yuan Tang