Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene
Article (Faculty180)
Tang, Yuan; Wang, Yue; Deosarkar, Sudhir; Soroush, Fariborz; Kiani, Mohammad F; Wang, Bin
description
Patients with P-glycoprotein and HER2/neu (HER2) receptor-overexpressing breast cancer usually have poor clinical outcomes. However, there exist no commercially available breast cancer cell lines that are HER2/P-glycoprotein double-positive, which limits research in this field.