Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation Article (Faculty180)

cited authors

  • Soroush, Fariborz; Tang, Yuan; Guglielmo, Kimberly; Engelmann, Alex; Liverani, Elisabetta; Patel, Akruti; Langston, Jordan; Sun, Shuang; Kunapuli, Satya; Kiani, Mohammad F; Kilpatrick, Lauri E


  • Neutrophil dysfunction plays an important role in inflammation-induced tissue injury. Previously, we identified protein kinase C-δ (PKCδ) as a critical controller of neutrophil activation and trafficking but how PKCδ is regulated in inflammation has not been delineated. PKCδ activity is regulated by tyrosine phosphorylation on multiple sites. Tyrosine155 is a key regulator of apoptosis and gene expression, but its role in proinflammatory signaling is not known.


publication date

  • 2019

published in

start page

  • 538

end page

  • 547


  • 51