Tao Yang
Overview
overview
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My name is Tao Yang, an Assistant Professor at the University of Toledo. I lead a multidisciplinary research program focused on the interplay between the gut microbiome, host metabolism, and blood pressure regulation. My work bridges physiology, microbiology, and translational medicine, with particular interest in the mechanisms by which diet, sex, and microbial metabolites influence cardiovascular health.
I have authored over 50 peer-reviewed publications in pretigious journals, such as including Nature Review Nephrology, Circulation Research, Hypertension, etc. and serves on editorial boards for Hypertension and Physiological Genomics. My research has been supported by the Biocodex Microbiota Foundation, American Heart Association and NIH, and my lab has made pioneering discoveries on the sex-specific roles of gut bacteria in hypertension.
I am also committed to academic service, mentoring trainees, and serving on selective professional committees. I am a Fellow of American Heart Association. My trainees have secured early career awards from the American Heart Association for 3 consecutive years. Through both research and service, I have contributed to advancing precision medicine approaches for cardiovascular disease.
Publications
selected publications
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Article (Faculty180)
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2025
Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat
. Hypertension (Dallas, Tex. : 1979). -
2025
Hypertension and the Gut Microbiome: A Science Advisory From the American Heart Association
. Hypertension (Dallas, Tex. : 1979). -
2025
Microbiota and kidney disease: the road ahead
. Nature reviews. Nephrology. -
2025
Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway
. Hypertension (Dallas, Tex. : 1979). -
2025
Sex differences in gut microbiota, hypertension, and cardiovascular risk
. European journal of pharmacology. 987:177183. -
2024
Prospects for Leveraging the Microbiota as Medicine for Hypertension
. Hypertension (Dallas, Tex. : 1979). 81:951-963. -
2024
Salt-Responsive Gut Microbiota Induces Sex-Specific Blood Pressure Changes.
. Circulation research. 135:1122-1137. -
2024
Untapped potential of gut microbiome for hypertension management
. Gut microbes. 16:2356278. -
2023
Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites
. Journal of hypertension. 41:979-994. -
2023
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2023
Host-Microbiota Communication in Spontaneously Hypertensive Rats Generates Unique IgA-Coated Gut Microbes
. Journal of the American Heart Association. 12:e027918. -
2023
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2023
Sexual Dimorphic Interplays Between Gut Microbiota and Antihypertensive Drugs
. Current hypertension reports. 25:163-172. -
2022
Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities
. Physiological genomics. 54:242-250. -
2022
Depletion of the gut microbiota enhances the blood pressure-lowering effect of captopril: implication of the gut microbiota in resistant hypertension
. Hypertension research : official journal of the Japanese Society of Hypertension. 45:1505-1510. -
2022
Feacalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis
. Circulation research. 131:e120-e134. -
2022
Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia-induced pulmonary hypertension
. Pulmonary circulation. 12:e12015. -
2022
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning
. Physiological genomics. 54:177-185. -
2022
Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors
. Hypertension (Dallas, Tex. : 1979). 79:1591-1601. -
2022
Repurposing a Drug Targeting Inflammatory Bowel Disease for Lowering Hypertension
. Journal of the American Heart Association. 11:e027893. -
2022
Resistance to Antihypertensive Drugs: Is Gut Microbiota the Missing Link?
. Hypertension (Dallas, Tex. : 1979). 79:2138-2147. -
2021
Komagataella pastoris: A new yeast probiotic for depression?
. Pharmacological research. 171:105762. -
2021
Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation
. Comprehensive Physiology. 11:1731-1757. -
2020
Gastrointestinal dysbiosis following diethylhexyl phthalate exposure in zebrafish (Danio rerio): Altered microbial diversity, functionality, and network connectivity
. Environmental pollution (Barking, Essex : 1987). 265:114496. -
2020
Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of , the Receptor for SARS-CoV-2 Infectivity
. Hypertension (Dallas, Tex. : 1979). 76:e1-e3. -
2020
Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension
. Hypertension (Dallas, Tex. : 1979). 76:206-216. -
2020
Maternal Treatment With Captopril Persistently Alters Gut-Brain Communication and Attenuates Hypertension of Male Offspring
. Hypertension (Dallas, Tex. : 1979). 75:1315-1324. -
2020
Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award
. Hypertension (Dallas, Tex. : 1979). 75:1386-1396. -
2020
Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure
. Hypertension (Dallas, Tex. : 1979). 76:1847-1855. -
2020
Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats
. Antioxidants (Basel, Switzerland). 9. -
2020
Probiotic Bifidobacterium breve prevents DOCA-salt hypertension
. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:13626-13640. -
2020
Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids
. Molecular nutrition & food research. 64:e1900616. -
2020
Pulmonary arterial hypertension-associated changes in gut pathology and microbiota
. ERJ open research. 6. -
2020
Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats
. Physiological genomics. 52:121-132. -
2019
Critical Role of the Interaction Gut Microbiota - Sympathetic Nervous System in the Regulation of Blood Pressure
. Frontiers in physiology. 10:231. -
2019
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension
. Circulation research. 125:104-116. -
2019
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats
. Acta physiologica (Oxford, England). 226:e13256. -
2019
Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension
. Circulation research. 124:727-736. -
2019
Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat
. Journal of the American Heart Association. 8:e010721. -
2018
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2018
The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease
. Nature reviews. Nephrology. 14:442-456. -
2017
Gut-Brain Axis in Regulation of Blood Pressure
. Frontiers in physiology. 8:845. -
2017
Hypertension-Linked Pathophysiological Alterations in the Gut
. Circulation research. 120:312-323. -
2015
Gut dysbiosis is linked to hypertension
. Hypertension (Dallas, Tex. : 1979). 65:1331-40. -
2015
New insights into gastrointestinal anthrax infection
. Trends in molecular medicine. 21:154-63. -
2015
SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis
. The EMBO journal. 34:881-95. -
2014
Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses
. FEBS letters. 588:4158-66. -
2014
Impaired colonic B-cell responses by gastrointestinal Bacillus anthracis infection
. The Journal of infectious diseases. 210:1499-507. -
2013
Activation of B cells by a dendritic cell-targeted oral vaccine
. Current pharmaceutical biotechnology. 14:867-77. -
2013
Microbiota impact on the epigenetic regulation of colorectal cancer
. Trends in molecular medicine. 19:714-25. -
2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity
. The Journal of biological chemistry. 287:40279-91.
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Workshop (Faculty180)
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2024
Targeting a Microbial Pathway for Management of Kidney Disease
. https://www.niddk.nih.gov/news/meetings-workshops/2024/gut-microbiota-and-kidney-disease-2024?agenda.
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Contact
full name
- Tao Yang