Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses

Article (Faculty180)

cited authors

  • Cheng, Sam X; Lightfoot, Yaíma L; Yang, Tao; Zadeh, Mojgan; Tang, Lieqi; Sahay, Bikash; Wang, Gary P; Owen, Jennifer L; Mohamadzadeh, Mansour

description

  • <p>The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.</p>

authors

publication date

  • 2014

published in

start page

  • 4158

end page

  • 66

volume

  • 588