Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia-induced pulmonary hypertension

Article (Faculty180)

cited authors

  • Oliveira, Aline C; Yang, Tao; Li, Jing; Sharma, Ravindra K; Karas, Marianthi K; Bryant, Andrew J; de Kloet, Annette D; Krause, Eric G; Joe, Bina; Richards, Elaine M; Raizada, Mohan K

description

  • <p>Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.</p>

authors

publication date

  • 2022

published in

start page

  • e12015

volume

  • 12