Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats

Article (Faculty180)

cited authors

  • Yang, Tao; Magee, Kacy L; Colon-Perez, Luis M; Larkin, Riley; Liao, Yan-Shi S; Balazic, Eliza; Cowart, Jonathan R; Arocha, Rebeca; Redler, Ty; Febo, Marcelo; Vickroy, Thomas; Martyniuk, Christopher J; Reznikov, Leah R; Zubcevic, Jasenka

description

  • <p>Butyrate is a major gut microbiota-derived metabolite. Reduced butyrate-producing bacteria has been reported in the spontaneously hypertensive rat (SHR), a model of hypertension characterized by dysfunctional autonomic nervous system and gut dysbiosis. Here, we demonstrate a potential mechanism for butyrate in blood pressure regulation.</p>

authors

publication date

  • 2019

published in

start page

  • e13256

volume

  • 226