Gupta, Rajesh

Rajesh Gupta
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Positions

Assistant Professor, Medicine , College of Medicine and Life Sciences

Contact Info

Rajesh.Gupta@UToledo.edu

https://www.utoledo.edu/med/depts/medicine/research/gupta/

overview

I am a physician-scientist. I work in interventional cardiology and my research includes basic and clinical research. See self-assessment and CV for further details.

selected publications

Article (Faculty180)
- 2020
  
  Comparison of Outcomes of Transcatheter Mitral Valve Repair (MitraClip) in Patients <80 Years Versus ≥80 Years. The American journal of cardiology.
- 2020
  
  IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways. JCI insight. 5.
- 2020
  
  Prognostic Value of Computed Tomography Versus Echocardiography Derived Right to Left Ventricular Diameter Ratio in Acute Pulmonary Embolism. The American journal of the medical sciences.
- 2020
  
  Reappraising Thrombolytic Therapy and Risk Stratification for Acute Pulmonary Embolism: Where Does Hypoxemia Fit In?. The American journal of the medical sciences. 360:107-108.
- 2020
  
  Severe radial artery spasm causing entrapment of the Terumo radial to peripheral destination slender sheath: a case report. European heart journal. Case reports. 4:1-4.
- 2019
  
  Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis. Journal of cardiovascular pharmacology and therapeutics. 24:18-30.
- 2019
  
  Impact of Smoking on Platelet Reactivity and Clinical Outcomes After Percutaneous Coronary Intervention: Findings From the ADAPT-DES Study. Circulation. Cardiovascular interventions. 12:e007982.
- 2019
  
  Long-term mortality after massive, submassive, and low-risk pulmonary embolism. Vascular medicine (London, England). 1358863X19886374.
- 2019
  
  Renal Artery Stenosis and Congestive Heart Failure: What Do We Really Know?. Current cardiology reports. 21:74.
- 2019
  
  Response to Letter to the Editor. The Journal of emergency medicine. 56:718.
- 2018
  
  Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair. Laboratory investigation; a journal of technical methods and pathology. 98:682-691.
- 2018
  
  It's a ST-Elevation Myocardial Infarction (STEMI), or Is It? Massive Pulmonary Embolism Presenting as STEMI. The Journal of emergency medicine. 55:125-127.
- 2018
  
  Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene. Molecular metabolism. 9:98-113.
- 2018
  
  Short- and Long-term Mortality Risk After Acute Pulmonary Embolism. Current cardiology reports. 20:135.
- 2017
  
  Platelet Reactivity and Clinical Outcomes After Coronary Artery Implantation of Drug-Eluting Stents in Subjects With Peripheral Arterial Disease: Analysis From the ADAPT-DES Study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents). Circulation. Cardiovascular interventions. 10.
- 2017
  
  Renal Artery Stenosis: New Findings from the CORAL Trial. Current cardiology reports. 19:75.
- 2016
  
  Differential roles of caveolin-1 in ouabain-induced Na+/K+-ATPase cardiac signaling and contractility. Physiological genomics. 48:739-748.
- 2016
  
  Intravenous Hydration and Contrast-Induced Acute Kidney Injury: Too Much of a Good Thing?. Journal of the American Heart Association. 5.
- 2016
  
  Practical echocardiographic approach for risk stratification of patients with acute pulmonary embolism. Journal of echocardiography. 14:146-155.
- 2014
  
  Coronary artery aneurysms in acute coronary syndrome: case series, review, and proposed management strategy. The Journal of invasive cardiology. 26:283-90.
- 2013
  
  Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. PloS one. 8:e80809.
- 2012
  
  Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. Circulation. 126:418-29.
- 2012
  
  Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction. Circulation research. 111:312-21.
- 2012
  
  The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells. Circulation. 126:2491-501.
- 2011
  
  Cell therapy for critical limb ischemia: moving forward one step at a time. Circulation. Cardiovascular interventions. 4:2-5.
- 2011
  
  Sunitinib, hypertension, and heart failure: a model for kinase inhibitor-mediated cardiotoxicity. Current hypertension reports. 13:430-5.
- 2010
  
  Challenges in the translation of cardiovascular cell therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 51 Suppl 1:122S-127S.
- 2009
  
  Human studies of angiogenic gene therapy. Circulation research. 105:724-36.
- 2007
  
  Statin use and sepsis events [corrected] in patients with chronic kidney disease. JAMA. 297:1455-64.
- Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension. Cardiology. 143:124-133.
- Rotary mechanical circulatory support systems. Journal of rehabilitation and assistive technologies engineering. 4:2055668317725994.
Article (Web of Science)
- 2021
  
  The ketone body beta-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults. KIDNEY INTERNATIONAL. 100:1037-1053.
  Full Text via DOI: 10.1016/j.kint.2021.06.031 PMID: 34246657
- 2021
  
  Prognostic Value of Computed Tomography Versus Echocardiography Derived Right to Left Ventricular Diameter Ratio in Acute Pulmonary Embolism. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 361:445-450.
  Full Text via DOI: 10.1016/j.amjms.2020.07.008. PMID: 32753280
- 2021
  
  Association of Hospital Procedural Volume With Outcomes of Percutaneous Left Atrial Appendage Occlusion. JACC-CARDIOVASCULAR INTERVENTIONS. 14:554-561.
  Full Text via DOI: 10.1016/j.jcin.2020.11.029 PMID: 33663783
- 2021
  
  Right Ventricular Dysfunction and Short‐Term Outcomes Following Left‐Sided Valvular Surgery: An Echocardiographic Study. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 10.
  Full Text via DOI: 10.1161/jaha.120.016283
- 2020
  
  Left atrial appendage perforation with Watchman device implantation: Strategies for surgical repair. JOURNAL OF CARDIAC SURGERY.
  Full Text via DOI: 10.1111/jocs.15145 PMID: 33259077
- 2020
  
  Predictors of reduced cardiac index in patients with acute submassive pulmonary embolism. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS.
  Full Text via DOI: 10.1002/ccd.29269 PMID: 32975377
- 2020
  
  Comparison of Outcomes of Transcatheter Mitral Valve Repair (MitraClip) in Patients < 80 Years Versus >= 80 Years. AMERICAN JOURNAL OF CARDIOLOGY. 131:91-98.
  Full Text via DOI: 10.1016/j.amjcard.2020.06.050 PMID: 32718547
- 2020
  
  IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways. JCI INSIGHT. 5.
  Full Text via DOI: 10.1172/jci.insight.133050 PMID: 32879134
- 2020
  
  Severe radial artery spasmcausing entrapment of the Terumo radial to peripheral destination slender sheath: a case report. EUROPEAN HEART JOURNAL-CASE REPORTS. 4.
  Full Text via DOI: 10.1093/ehjcr/ytaa038 PMID: 32352072
- 2020
  
  Long-term mortality after massive, submassive, and low-risk pulmonary embolism. VASCULAR MEDICINE. 25:141-149.
  Full Text via DOI: 10.1177/1358863x19886374
- 2019
  
  Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension. CARDIOLOGY. 143:124-133.
  Full Text via DOI: 10.1159/000501100 PMID: 31514181
- 2019
  
  Impact of Smoking on Platelet Reactivity and Clinical Outcomes After Percutaneous Coronary Intervention. CIRCULATION-CARDIOVASCULAR INTERVENTIONS. 12.
  Full Text via DOI: 10.1161/circinterventions.119.007982
- 2018
  
  Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair. LABORATORY INVESTIGATION. 98:682-691.
  Full Text via DOI: 10.1038/s41374-018-0028-5
- 2018
  
  Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene. MOLECULAR METABOLISM. 9:98-113.
  Full Text via DOI: 10.1016/j.molmet.2018.01.009
- 2017
  
  Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease. SCIENTIFIC REPORTS. 7.
  Full Text via DOI: 10.1038/s41598-017-08426-8
- 2017
  
  Platelet Reactivity and Clinical Outcomes After Coronary Artery Implantation of Drug-Eluting Stents in Subjects With Peripheral Arterial Disease Analysis From the ADAPT- DES Study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents). CIRCULATION-CARDIOVASCULAR INTERVENTIONS. 10.
  Full Text via DOI: 10.1161/CIRCINTERVENTIONS.116.004904
- 2017
  
  Platelet Reactivity and Clinical Outcomes After Coronary Artery Implantation of Drug-Eluting Stents in Subjects With Peripheral Arterial Disease. CIRCULATION-CARDIOVASCULAR INTERVENTIONS. 10.
  Full Text via DOI: 10.1161/circinterventions.116.004904
- 2016
  
  Differential roles of caveolin-1 in ouabain-induced Na+/K+-ATPase cardiac signaling and contractility. PHYSIOLOGICAL GENOMICS. 48:739-748.
  Full Text via DOI: 10.1152/physiolgenomics.00042.2016
- 2013
  
  Loss of the Cytoskeletal Protein Pdlim7 Predisposes Mice to Heart Defects and Hemostatic Dysfunction. PLOS ONE. 8:e80809.
  Full Text via DOI: 10.1371/journal.pone.0080809
- 2012
  
  Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB. CIRCULATION. 126:418-429.
  Full Text via DOI: 10.1161/circulationaha.112.112185
- 2012
  
  Sonic Hedgehog–Modified Human CD34+ Cells Preserve Cardiac Function After Acute Myocardial Infarction. CIRCULATION RESEARCH. 111:312-321.
  Full Text via DOI: 10.1161/circresaha.112.266015
- 2012
  
  The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells. CIRCULATION. 126:2491-2501.
  Full Text via DOI: 10.1161/circulationaha.111.076950
- 2011
  
  Sunitinib, Hypertension, and Heart Failure: A Model for Kinase Inhibitor-Mediated Cardiotoxicity. CURRENT HYPERTENSION REPORTS. 13:430-435.
  Full Text via DOI: 10.1007/s11906-011-0229-4
- 2010
  
  Challenges in the Translation of Cardiovascular Cell Therapy. JOURNAL OF NUCLEAR MEDICINE. 51:122S-127S.
  Full Text via DOI: 10.2967/jnumed.109.068304
Book Chapter (Web of Science)
- 2011
  
  Therapeutic Lifestyle Change for the Prevention and Treatment of Hyperlipidemia and Coronary Artery Disease. Hyperlipidemia in Primary Care. 105-120.
  Full Text via DOI: 10.1007/978-1-60327-502-6_6
Chapter (Faculty180)
- 2011
  
  Therapeutic Lifestyle Change for the Prevention and Treatment of Hyperlipidemia and Coronary Artery Disease. Hyperlipidemia in Primary Care. Humana Press. 105-120.
Correction (Web of Science)
- 2008
  
  Correction: Inaccurate Classification and Information Reported in a Study of Statin Use and Sepsis in Patients With Chronic Kidney Disease. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 765.
  Full Text via DOI: 10.1001/jama.299.7.765-b
Editorial Material (Web of Science)
- 2021
  
  Association of Peri-Procedural Major Bleeding With Outcomes in Patients Undergoing Transcatheter Mitral Edge-To-Edge Repair. AMERICAN JOURNAL OF CARDIOLOGY. 172-174.
  Full Text via DOI: 10.1016/j.amjcard.2021.04.025 PMID: 34092365
- 2018
  
  IT'S A ST-ELEVATION MYOCARDIAL INFARCTION (STEMI), OR IS IT? MASSIVE PULMONARY EMBOLISM PRESENTING AS STEMI. JOURNAL OF EMERGENCY MEDICINE. 125-127.
  Full Text via DOI: 10.1016/j.jemermed.2018.04.002
- 2016
  
  Intravenous Hydration and Contrast-Induced Acute Kidney Injury: Too Much of a Good Thing?. JOURNAL OF THE AMERICAN HEART ASSOCIATION.
  Full Text via DOI: 10.1161/JAHA.116.003777
- 2016
  
  Intravenous Hydration and Contrast‐Induced Acute Kidney Injury: Too Much of a Good Thing?. JOURNAL OF THE AMERICAN HEART ASSOCIATION.
  Full Text via DOI: 10.1161/jaha.116.003777
- 2011
  
  Cell Therapy for Critical Limb Ischemia. CIRCULATION-CARDIOVASCULAR INTERVENTIONS. 2-5.
  Full Text via DOI: 10.1161/circinterventions.110.960716
Letter (Web of Science)
- 2020
  
  Meta-Analysis of the Efficacy and Safety of Genotype-Guided Strategy for Selection of P2Y12 Inhibitors in Coronary Artery Disease. AMERICAN JOURNAL OF CARDIOLOGY. 168-170.
  Full Text via DOI: 10.1016/j.amjcard.2020.09.023 PMID: 32961111
- 2020
  
  Meta-Analysis Comparing Angiography-Guided Versus FFR-Guided Coronary Artery Bypass Grafting. AMERICAN JOURNAL OF CARDIOLOGY. 184-185.
  Full Text via DOI: 10.1016/j.amjcard.2020.09.002 PMID: 32916146
- 2019
  
  UNRAVELING THE RIDDLE OF ISCHEMIC FINDINGS IN PULMONARY EMBOLISM Reply. JOURNAL OF EMERGENCY MEDICINE. 718-718.
  Full Text via DOI: 10.1016/j.jemermed.2019.02.001 PMID: 31229260
Meeting Abstract (Web of Science)
- 2018
  
  Clinical Characteristics and Long-Term Outcomes of Patients with Combined Post and Precapillary Hypertension in HFpEF. JOURNAL OF CARDIAC FAILURE. S97-S97.
- 2018
  
  ENDOTHELIN 1 GRADIENT-A MARKER FOR PULMONARY HYPERTENSION AND ADVERSE ONE YEAR OUTCOMES IN HFPEF. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 769-769.
  Full Text via DOI: 10.1016/S0735-1097(18)31310-X
- 2018
  
  IS CT ANGIOGRAPHY-DERIVED RIGHT TO LEFT VENTRICULAR DIAMETER RATIO ADEQUATE FOR PULMONARY EMBOLISM RISK STRATIFICATION?. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 1929-1929.
  Full Text via DOI: 10.1016/S0735-1097(18)32470-7
- 2018
  
  Clinical Characteristics and Long-Term Outcomes of Patients with Combined Post and Precapillary Hypertension in HFpEF. JOURNAL OF CARDIAC FAILURE. S97.
  Full Text via DOI: 10.1016/j.cardfail.2018.07.373
- 2018
  
  ENDOTHELIN 1 GRADIENT- A MARKER FOR PULMONARY HYPERTENSION AND ADVERSE ONE YEAR OUTCOMES IN HFPEF. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. A769.
  Full Text via DOI: 10.1016/s0735-1097(18)31310-x
- 2018
  
  IS CT ANGIOGRAPHY-DERIVED RIGHT TO LEFT VENTRICULAR DIAMETER RATIO ADEQUATE FOR PULMONARY EMBOLISM RISK STRATIFICATION?. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. A1929.
  Full Text via DOI: 10.1016/s0735-1097(18)32470-7
- 2017
  
  Congestive Heart Failure Does Not Affect Fractional Flow Reserve Measurement in Intermediate Coronary Lesions. JOURNAL OF CARDIAC FAILURE. S40-S40.
- 2017
  
  Congestive Heart Failure Does Not Affect Fractional Flow Reserve Measurement in Intermediate Coronary Lesions. JOURNAL OF CARDIAC FAILURE. S40.
  Full Text via DOI: 10.1016/j.cardfail.2017.07.111
- 2014
  
  PLATELET REACTIVITY AND CLINICAL OUTCOMES AFTER CORONARY ARTERY IMPLANTATION OF DRUG-ELUTING STENTS IN SUBJECTS WITH PERIPHERAL ARTERIAL DISEASE: ANALYSIS FROM THE ADAPT-DES STUDY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. A1862.
  Full Text via DOI: 10.1016/s0735-1097(14)61865-9
Review Article (Web of Science)
- 2021
  
  Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall. BIOMEDICINES.
  Full Text via DOI: 10.3390/biomedicines9040404 PMID: 33917965
- 2019
  
  Renal Artery Stenosis and Congestive Heart Failure: What Do We Really Know?. CURRENT CARDIOLOGY REPORTS.
  Full Text via DOI: 10.1007/s11886-019-1169-x PMID: 31236719
- 2019
  
  Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS. 18-30.
  Full Text via DOI: 10.1177/1074248418788575
- 2018
  
  Short- and Long-term Mortality Risk After Acute Pulmonary Embolism. CURRENT CARDIOLOGY REPORTS.
  Full Text via DOI: 10.1007/s11886-018-1084-6
- 2017
  
  Renal Artery Stenosis: New Findings from the CORAL Trial. CURRENT CARDIOLOGY REPORTS.
  Full Text via DOI: 10.1007/s11886-017-0894-2
- 2016
  
  Practical echocardiographic approach for risk stratification of patients with acute pulmonary embolism. JOURNAL OF ECHOCARDIOGRAPHY. 146-155.
  Full Text via DOI: 10.1007/s12574-016-0306-4
- 2009
  
  Human Studies of Angiogenic Gene Therapy. CIRCULATION RESEARCH. 724-736.
  Full Text via DOI: 10.1161/circresaha.109.200386

full name

Rajesh Gupta

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