The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells

cited authors

  • Albrecht-Schgoer, Karin; Schgoer, Wilfried; Holfeld, Johannes; Theurl, Markus; Wiedemann, Dominik; Steger, Christina; Gupta, Rajesh; Semsroth, Severin; Fischer-Colbrie, Reiner; Beer, Arno G; Stanzl, Ursula; Huber, Eva; Misener, Sol; Dejaco, Daniel; Kishore, Raj; Pachinger, Otmar; Grimm, Michael; Bonaros, Nikolaos; Kirchmair, Rudolf

description

  • Secretoneurin is a neuropeptide located in nerve fibers along blood vessels, is upregulated by hypoxia, and induces angiogenesis. We tested the hypothesis that secretoneurin gene therapy exerts beneficial effects in a rat model of myocardial infarction and evaluated the mechanism of action on coronary endothelial cells.

authors

publication date

  • 2012

published in

start page

  • 2491

end page

  • 501

volume

  • 126