Matam Vijay Kumar
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Professor
Director, UT Microbiome Consortium
Professor (Joint Appointment in Medical Microbiology & Immunology), Physiology and Pharmacology , College of Medicine and Life Sciences
Overview
overview
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My official name is Matam Vijay Kumar, though I go by the name ‘Matam Vijay-Kumar’ in all my publications. I earned my Ph.D. in Biochemistry from the Central Food Technological Research Institute, which is a premier federal research institute in India affiliated with the University of Mysore. My thesis work was focused on the influence of oxidized lipids (cholesterol oxidation products), derived from anhydrous milk fat, on lipid metabolism in laboratory animals. Afterwards, I began my post-doctoral fellowship at Georgetown University, Washington DC, where my project was on the influence of malarial parasite lipids on host innate and adaptive immune responses and their link to febrile illness. Following this work, I did ‘Immunology Fellowship’ at Johns Hopkins Medical Institutions in Baltimore; during this training, I was instrumental in establishing a Cytokine Core Laboratory (first in the Nation) and getting Clinical Laboratory Improvement & Amendment (CLIA) approval. My next stop was at Emory University, where I worked as a post-doctoral fellow focusing on gut microbiota and inflammatory bowel disease. While at Emory, I rose to the rank of Instructor in 2008 and Assistant Professor in 2010, while also successfully earning the Crohn’s and Colitis Foundation of America (CCFA) Career Development Award and NIH-K01 Mentored Career Development Award. In 2011, along with my mentor Dr. Andrew Gewirtz, I moved to Georgia State University. After earning my first NIH-R01 in 2013, I took a tenure track position at The Pennsylvania State University. From 2013-2017, I successfully published in high impact publications (Nature Communications, Cell Metabolism) as a senior author. I secured a second NIH-R01 funding in 2017 and was tenured and promoted to Associate Professor within 3.5 years. In January 2018, I moved to the University of Toledo as a tenured Associate Professor and Director of the UT Microbiome Consortium. Within a year of my appointment, I published in high impact journals (Cell, Gut, Mucosal Immunology, Gastroenterology, Hypertension) as senior author. On July 1, 2020, I was promoted to tenured full Professor. In 2023, I have secured my third NIH-R01funding on investigating the role of neutrophil extracellular traps (NETs) in Inflammatory Bowel Disease. During my tenure at UT, I have published total 55 peer-reviewed publications, four editorial commentaries/perspectives and recipient of UT’s Outstanding Faculty and Research Scholar Award (OFRSA) for the year 2023.
Lab Theme: Gut Microbiota: We can’t live without or with it.
Publications
selected publications
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Abstract of Published Item (Web of Science)
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2016Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation. DATA IN BRIEF. 812-816.Full Text via DOI: 10.1016/j.dib.2016.06.047
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Article (Faculty180)
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2023
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2023Combating hypertension beyond genome-wide association studies: Microbiome and artificial intelligence as opportunities for precision medicine. Cambridge Prisms: Precision Medicine. 1:e26.
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2023Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites. Journal of Hypertension. 41:979.
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2023Crosstalk between gut microbiota and host immunity: Impact on inflammation and immunotherapy. Biomedicines. 11:294.
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2023Gut microbiota lends a helping hand to nurse liver regeneration. Journal of Hepatology. 78:681.
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2023Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor--deficient mice. Hepatology Communications. 7.
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2023Psyllium fiber protects against colitis via activation of bile acid sensor farnesoid X receptor. Cellular and Molecular Gastroenterology and Hepatology. 15:1421.
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2023
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2023Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice. Function. 4:zqad040.
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2022Activation of CD81 skin ILC2s by cold-sensing TRPM8 neuron-derived signals maintains cutaneous thermal homeostasis. Science immunology. 7:eabe0584.
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2022Eat more natural dietary fiber and whole grains to minimize liver disease risk. Hepatobiliary surgery and nutrition. 11:601-604.
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2022Enterohepatic Shunt-Driven Cholemia Predisposes to Liver Cancer. Gastroenterology.
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2022Invited Perspective: PFOS-Pick Fiber, Oust Sulfonate. Environmental health perspectives. 130:111301.
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2022Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate. American journal of physiology. Heart and circulatory physiology. 322:H466-H473.
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2022Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis. Hypertension (Dallas, Tex. : 1979). 79:2239-2249.
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2021Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome. Advances in cancer research. 149:171-255.
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2021Bacterial Swarmers Enriched During Intestinal Stress Ameliorate Damage. Gastroenterology. 161:211-224.
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2021Critical Role of Innate Immunity to Flagellin in the Absence of Adaptive Immunity. The Journal of infectious diseases. 223:1478-1487.
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2021IL-10 Receptor Neutralization-Induced Colitis in Mice: A Comprehensive Guide. Current protocols. 1:e227.
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2021Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis. Microorganisms. 9.
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2021Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. Current hypertension reports. 23:28.
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2021Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs). Comprehensive Physiology. 11:1575-1589.
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2021Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator. JCI insight. 6.
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2021Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content. Physiological genomics. 53:518-533.
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2020"Western Diet"-Induced Adipose Inflammation Requires a Complex Gut Microbiota. Cellular and molecular gastroenterology and hepatology. 9:313-333.
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2020Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota. The Journal of nutritional biochemistry. 80:108360.
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2020
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2020Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains. Physiological reports. 8:e14441.
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2020Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage. Hypertension (Dallas, Tex. : 1979). 76:59-72.
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2020
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2020Exposure to Amoxicillin in Early Life Is Associated With Changes in Gut Microbiota and Reduction in Blood Pressure: Findings From a Study on Rat Dams and Offspring. Journal of the American Heart Association. 9:e014373.
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2020
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2020Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice. American journal of physiology. Gastrointestinal and liver physiology. 318:G955-G965.
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2020Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of , the Receptor for SARS-CoV-2 Infectivity. Hypertension (Dallas, Tex. : 1979). 76:e1-e3.
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2020Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease. Physiological genomics. 52:217-221.
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2020Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice. Physiological genomics. 52:314-321.
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2020Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award. Hypertension (Dallas, Tex. : 1979). 75:1386-1396.
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2020Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice. Vascular pharmacology. 125-126:106633.
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2020Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota. Gut microbes. 11:1077-1091.
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2020Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. Physiological genomics. 52:1-14.
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2019Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses. Frontiers in cellular and infection microbiology. 9.
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2019Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses. Frontiers in cellular and infection microbiology. 9:29.
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2019Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nature communications. 10:89.
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2019Enterobactin, an iron chelating bacterial siderophore, arrests cancer cell proliferation.. Biochemical Pharmacology. 168:71-81.
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2019Functional MAIT Cells Are Associated With Reduced Simian-Human Immunodeficiency Virus Infection. Frontiers in immunology. 10:3053.
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2019Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. Science signaling. 12.
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2019
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2019PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium. Mucosal immunology. 12:761-771.
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2019PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium. Mucosal immunology. 12:761-771.
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2019Salt-Responsive Metabolite, beta-Hydroxybutyrate, Attenuates Hypertension. The FASEB Journal. 33:866.
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2018
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2018Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort. JNCI cancer spectrum. 2:pky083.
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2018Disparate effects of antibiotics on hypertension. Physiological genomics. 50:837.
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2018
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2018Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects. The Journal of nutritional biochemistry. 62:28.
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2018Salt-responsive metabolite, $beta$-hydroxybutyrate, attenuates hypertension. Cell reports. 25:677.
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2017Bacterial siderophores hijack neutrophil functions. The Journal of Immunology. 198:4293.
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2017Ectopic expression of innate immune protein, Lipocalin-2, in Lactococcus lactis protects against gut and environmental stressors. Inflammatory bowel diseases. 23:1120.
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2017How diet can impact gut microbiota to promote or endanger health.. Current opinion in gastroenterology. 33:417.
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2017Microbiotal-host interactions and hypertension. Physiology. 32:224.
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2017Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice. The Journal of nutritional biochemistry. 41:25.
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2017Pigs, unlike mice, have two distinct colonic stem cell populations similar to humans that respond to high-calorie diet prior to insulin resistance. Cancer Prevention Research. 10:442.
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2017Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis. Inflammatory Bowel Disease. 23:1133-1143.
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2017
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2016(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss. Molecular nutrition & food research. 60:2267.
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2016Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation. Data in brief. 8:812.
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2016Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation. The American journal of pathology. 186:912.
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2016
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2016Hepatocyte toll-like receptor 5 promotes bacterial clearance and protects mice against high-fat diet--induced liver disease. Cellular and molecular gastroenterology and hepatology. 2:584.
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2016Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in apolipoprotein E deficient mice. Inflammatory bowel diseases. 22:841.
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2016Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice. Cellular and molecular gastroenterology and hepatology. 2:328.
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2016Microbiota-inducible innate immune siderophore binding protein lipocalin 2 is critical for intestinal homeostasis. Cellular and molecular gastroenterology and hepatology. 2:482.
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2015Evidence for a link between gut microbiota and hypertension in the Dahl rat. Physiological genomics. 47:187.
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2015Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. Nature communications. 6:7113.
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2015Lack of soluble fiber drives diet-induced adiposity in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology. 309:G528.
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2015Proneness of TLR5 deficient mice to develop colitis is microbiota dependent. Gut Microbes. 6:279.
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2014The microbiome and obesity—an established risk for certain types of cancer. The Cancer Journal. 20:176.
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2013Differential Role of Lipocalin 2 During Immune Complex--Mediated Acute and Chronic Inflammation in Mice. Arthritis & Rheumatism. 65:1064.
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2013Harnessing the beneficial properties of adipogenic microbes for improving human health. Obesity Reviews. 14:721.
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2013Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell host & microbe. 14:571.
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2012Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. Mucosal immunology. 288.
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2012
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2012Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology. 143:1006.
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2012Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. The Journal of Immunology. 189:1911.
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2012Toll-like receptor--gut microbiota interactions: perturb at your own risk!. Annual review of physiology. 74:177.
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2012Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host & Microbe. 12:139.
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2011Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proceedings of the National Academy of Sciences. 108:8803.
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2011
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2010A comprehensive study on the serum lipid profile and risk factor analysis for cardiovascular disease in a cross-sectional Indian Population. Journal of Indian Medical Association. 108:158-160.
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2010Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. The Journal of clinical investigation. 120:3878.
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2010Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components. Mucosal immunology. 3:622.
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2010Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (1500 citations as of Dec 2022). 328:228.
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2010TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. European journal of immunology. 40:3528.
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2009Flagellin: key target of mucosal innate immunity. Mucosal immunology. 2:197.
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2009Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G175.
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2009Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology. 137:199.
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2008A2B adenosine receptor gene deletion attenuates murine colitis. Gastroenterology. 135:861.
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2008Blockade of adenosine A2B receptors ameliorates murine colitis. British journal of pharmacology. 155:127.
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2008Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. The Journal of Immunology. 180:8280.
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2008Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine. Gastroenterology. 135:351.
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2008Role of flagellin in Crohn's disease: emblematic of the progress and enigmas in understanding inflammatory bowel disease. Inflammatory bowel diseases. 15:789.
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2008Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. PLoS One. 3:e3304.
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2008
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2007Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflammatory Bowel Diseases. 13:856.
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2007Deletion of TLR5 results in spontaneous colitis in mice. The Journal of Clinical Investigation. 117:3909.
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2006Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G1157.
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2006Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. The American journal of pathology. 169:1686.
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2006Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. The Journal of Immunology. 177:4103.
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2005Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. The Journal of Immunology. 174:6322.
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2005
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2004STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-$alpha$-induced epithelial gene expression. Journal of Biological Chemistry. 279:35210.
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2000Hypocholesterolemic effect of anhydrous milk fat ghee is mediated by increasing the secretion of biliary lipids.. Journal of Nutritional biochemistry. 11:69-75.
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1999Effect of dietary ghee--the anhydrous milk fat, on blood and liver lipids in rats. Journal of Nutritional biochemistry. 10:96-104.
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1999The anhydrous milk fat, ghee, lowers serum prostaglandins and secretion of leukotrienes by rat peritoneal macrophages.. Prostaglandins Leukotrienes & Essential Fatty Acids. 61:249-254.
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1998Inhibitory effect of Garcinia kola on lipid peroxidation in rat liver homogenate. . Indian Journal of Experimental Biology. 36:907-910.
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Article (Web of Science)
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2022Dynamics of antimicrobial protein secretion in mouse milk. JOURNAL OF IMMUNOLOGY. 208:51.12-51.12.Full Text via DOI: 10.4049/jimmunol.208.supp.51.12
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2022Sterile neutrophilia induced via CXCR4 antagonism ameliorates colonic inflammation by increasing immunosuppressive regulatory T cells. JOURNAL OF IMMUNOLOGY. 208:54.11-54.11.Full Text via DOI: 10.4049/jimmunol.208.supp.54.11
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2021Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content. PHYSIOLOGICAL GENOMICS. 53:518-533.Full Text via DOI: 10.1152/physiolgenomics.00017.2021 PMID: 34714176
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2021Ketone body beta-hydroxybutyrate is an autophagy-dependent vasodilator. JCI INSIGHT. 6.Full Text via DOI: 10.1172/jci.insight.149037 PMID: 34499623
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2021Bacterial Swarmers Enriched During Intestinal Stress Ameliorate Damage. GASTROENTEROLOGY. 161:211-224.Full Text via DOI: 10.1053/j.gastro.2021.03.017 PMID: 33741315
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2021Critical Role of Innate Immunity to Flagellin in the Absence of Adaptive Immunity. JOURNAL OF INFECTIOUS DISEASES. 223:1478-1487.Full Text via DOI: 10.1093/infdis/jiaa521 PMID: 32830227
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2021Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracelluar Traps (NETs). COMPREHENSIVE PHYSIOLOGY. 11:1575-1589.Full Text via DOI: 10.1002/cphy.c200020 PMID: 33577121
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2021Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks. FUNCTION. 2.Full Text via DOI: 10.1093/function/zqaa029 PMID: 33363281
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2021I ncreased Host Energy Metabolism in the Proximal Colon‐Microbiota Interface Elevates Blood Pressure. FASEB JOURNAL. 35:fasebj.2021.35.S1.01714.Full Text via DOI: 10.1096/fasebj.2021.35.s1.01714
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2021FPR-1 (Formyl Peptide Receptor-1) Activation Promotes Spontaneous, Premature Hypertension in Dahl Salt-Sensitive Rats. HYPERTENSION. 77:1191-1202.Full Text via DOI: 10.1161/hypertensionaha.120.16237
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2021Metabolomics reveal dynamic host responses in lipid, amino acid, and energy metabolism after acute exposure of gut microbiota in germ‐free rats. FASEB JOURNAL. 35:fasebj.2021.35.S1.04820.Full Text via DOI: 10.1096/fasebj.2021.35.s1.04820
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2020Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron. GUT MICROBES. 12.Full Text via DOI: 10.1080/19490976.2020.1841548 PMID: 33171063
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2020Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice. PHYSIOLOGICAL GENOMICS. 52:314-321.Full Text via DOI: 10.1152/physiolgenomics.00118.2019 PMID: 32628083
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2020Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer. PLOS ONE. 15.Full Text via DOI: 10.1371/journal.pone.0234726 PMID: 32559205
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2020Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains. PHYSIOLOGICAL REPORTS. 8.Full Text via DOI: 10.14814/phy2.14441 PMID: 32385968
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2020Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 318:G955-G965.Full Text via DOI: 10.1152/ajpgi.00349.2019 PMID: 32200644
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2020Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota. GUT MICROBES.Full Text via DOI: 10.1080/19490976.2020.1743492 PMID: 32223398
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2020Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice. VASCULAR PHARMACOLOGY. 125.Full Text via DOI: 10.1016/j.vph.2019.106633 PMID: 31843471
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2020Functional MAIT Cells Are Associated With Reduced Simian-Human Immunodeficiency Virus Infection. FRONTIERS IN IMMUNOLOGY. 10.Full Text via DOI: 10.3389/fimmu.2019.03053 PMID: 32010135
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2020"Western Diet"-Induced Adipose Inflammation Requires a Complex Gut Microbiota. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 9:313-333.Full Text via DOI: 10.1016/j.jcmgh.2019.09.009 PMID: 31593782
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2020Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. PHYSIOLOGICAL GENOMICS. 52:1-14.Full Text via DOI: 10.1152/physiolgenomics.00089.2019 PMID: 31762410
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2020Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage. HYPERTENSION. 76:59-72.Full Text via DOI: 10.1161/hypertensionaha.120.14830
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2020Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure. HYPERTENSION. 76:1847-1855.Full Text via DOI: 10.1161/hypertensionaha.120.15939
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2019Enterobactin, an iron chelating bacterial siderophore, arrests cancer cell proliferation. BIOCHEMICAL PHARMACOLOGY. 168:71-81.Full Text via DOI: 10.1016/j.bcp.2019.06.017 PMID: 31228465
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2019Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. GUT. 68:1801-1812.Full Text via DOI: 10.1136/gutjnl-2018-316250 PMID: 30670576
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2019Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. SCIENCE SIGNALING. 12.Full Text via DOI: 10.1126/scisignal.aap7336 PMID: 31506384
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2019PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium. MUCOSAL IMMUNOLOGY. 12:761-771.Full Text via DOI: 10.1038/s41385-019-0139-3 PMID: 30710097
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2019Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 9.Full Text via DOI: 10.3389/fcimb.2019.00029
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2019Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. NATURE COMMUNICATIONS. 10.Full Text via DOI: 10.1038/s41467-018-07859-7
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2019The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages. GUT MICROBES. 10:412-423.Full Text via DOI: 10.1080/19490976.2018.1546519 PMID: 30449241
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2018Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 62:28-34.Full Text via DOI: 10.1016/j.jnutbio.2018.08.003
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2018Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. HYPERTENSION. 72:1125-1132.Full Text via DOI: 10.1161/HYPERTENSIONAHA.118.11175
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2018Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. CELL. 175:679-+.Full Text via DOI: 10.1016/j.cell.2018.09.004
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2018Salt-Responsive Metabolite, beta-Hydroxybutyrate, Attenuates Hypertension. CELL REPORTS. 25:677-+.Full Text via DOI: 10.1016/j.celrep.2018.09.058
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2018Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort. JNCI CANCER SPECTRUM. 2.Full Text via DOI: 10.1093/jncics/pky083 PMID: 30815627
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2018Disparate effects of antibiotics on hypertension. PHYSIOLOGICAL GENOMICS. 50:837-845.Full Text via DOI: 10.1152/physiolgenomics.00073.2018
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2018Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. HYPERTENSION. 72:1125-1132.Full Text via DOI: 10.1161/hypertensionaha.118.11175
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2018Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health. CELL HOST & MICROBE. 23:41-53.e4.Full Text via DOI: 10.1016/j.chom.2017.11.003
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2017Bacterial Siderophores Hijack Neutrophil Functions. JOURNAL OF IMMUNOLOGY. 198:4293-4303.Full Text via DOI: 10.4049/jimmunol.1700261
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2017Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background. DATA IN BRIEF. 11:588-592.Full Text via DOI: 10.1016/j.dib.2017.03.002
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2017Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors. Inflammatory bowel diseases. 23:1120-1132.Full Text via DOI: 10.1097/mib.0000000000001134
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2017Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 41:25-33.Full Text via DOI: 10.1016/j.jnutbio.2016.11.014
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2017Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance. Cancer Prevention Research. 10:442-450.Full Text via DOI: 10.1158/1940-6207.capr-17-0010
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2017Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis. Inflammatory bowel diseases. 23:1133-1143.Full Text via DOI: 10.1097/mib.0000000000001155
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2017Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling. JOURNAL OF PHYSIOLOGY-LONDON. 595:1831-1846.Full Text via DOI: 10.1113/jp273269
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2016Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 311:G713-G723.Full Text via DOI: 10.1152/ajpgi.00174.2016
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2016Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation. AMERICAN JOURNAL OF PATHOLOGY. 186:912-926.Full Text via DOI: 10.1016/j.ajpath.2015.12.004
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2016(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss. MOLECULAR NUTRITION & FOOD RESEARCH. 60:2267-2274.Full Text via DOI: 10.1002/mnfr.201501042
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2016An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis. ONCOGENESIS. 5:e238-e238.Full Text via DOI: 10.1038/oncsis.2016.38
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2016Feed your gut with caution!. TRANSLATIONAL CANCER RESEARCH. 5:S507-S513.Full Text via DOI: 10.21037/tcr.2016.09.13
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2016Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases. PLOS ONE. 11:e0156811.Full Text via DOI: 10.1371/journal.pone.0156811
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2016Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet–Induced Liver Disease. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2:584-604.Full Text via DOI: 10.1016/j.jcmgh.2016.04.007
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2016Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice. Inflammatory bowel diseases. 22:841-852.Full Text via DOI: 10.1097/mib.0000000000000699
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2016Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2:328-339.Full Text via DOI: 10.1016/j.jcmgh.2015.12.008
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2016Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation. BioMetals. 29:451-465.Full Text via DOI: 10.1007/s10534-016-9925-5
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2016Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2:482-498.e6.Full Text via DOI: 10.1016/j.jcmgh.2016.03.007
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2015Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. CELL METABOLISM. 22:983-996.Full Text via DOI: 10.1016/j.cmet.2015.09.028
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2015Evidence for a link between gut microbiota and hypertension in the Dahl rat. PHYSIOLOGICAL GENOMICS. 47:187-197.Full Text via DOI: 10.1152/physiolgenomics.00136.2014
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2015Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. NATURE COMMUNICATIONS. 6.Full Text via DOI: 10.1038/ncomms8113
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2015Lack of soluble fiber drives diet-induced adiposity in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 309:G528-G541.Full Text via DOI: 10.1152/ajpgi.00172.2015
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2015Proneness of TLR5 deficient mice to develop colitis is microbiota dependent. GUT MICROBES. 6:279-283.Full Text via DOI: 10.1080/19490976.2015.1060390
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2014Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18. SCIENCE. 346:861-865.Full Text via DOI: 10.1126/science.1256999
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2013Differential Role of Lipocalin 2 During Immune Complex-Mediated Acute and Chronic Inflammation in Mice. ARTHRITIS AND RHEUMATISM. 65:1064-1073.Full Text via DOI: 10.1002/art.37840
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2013Harnessing the beneficial properties of adipogenic microbes for improving human health. Obesity Reviews. 14:721-735.Full Text via DOI: 10.1111/obr.12045
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2013Innate and Adaptive Immunity Interact to Quench Microbiome Flagellar Motility in the Gut. CELL HOST & MICROBE. 14:571-581.Full Text via DOI: 10.1016/j.chom.2013.10.009
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2012Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. MUCOSAL IMMUNOLOGY. 5:288-298.Full Text via DOI: 10.1038/mi.2012.8
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2012Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation. PLOS ONE. 7:e44328.Full Text via DOI: 10.1371/journal.pone.0044328
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2012Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling. GASTROENTEROLOGY. 143:1006-1016.e4.Full Text via DOI: 10.1053/j.gastro.2012.06.034
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2012Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis. JOURNAL OF IMMUNOLOGY. 189:1911-1919.Full Text via DOI: 10.4049/jimmunol.1200892
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2012Rotavirus-induced IFN-β promotes anti-viral signaling and apoptosis that modulate viral replication in intestinal epithelial cells. Innate Immunity. 18:294-306.Full Text via DOI: 10.1177/1753425911401930
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2012Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. CELL HOST & MICROBE. 12:139-152.Full Text via DOI: 10.1016/j.chom.2012.07.004
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2011Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:8803-8808.Full Text via DOI: 10.1073/pnas.1010042108
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2011Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. GUT. 60:648-657.Full Text via DOI: 10.1136/gut.2010.223891
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2011TLR5 activation induces secretory interleukin-1 receptor antagonist (sIL-1Ra) and reduces inflammasome-associated tissue damage. MUCOSAL IMMUNOLOGY. 4:102-111.Full Text via DOI: 10.1038/mi.2010.57
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2010Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. JOURNAL OF CLINICAL INVESTIGATION. 120:3878-3890.Full Text via DOI: 10.1172/jci43271
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2010Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components. MUCOSAL IMMUNOLOGY. 3:622-632.Full Text via DOI: 10.1038/mi.2010.39
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2010Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5. SCIENCE. 328:228-231.Full Text via DOI: 10.1126/science.1179721
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2010TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. EUROPEAN JOURNAL OF IMMUNOLOGY. 40:3528-3534.Full Text via DOI: 10.1002/eji.201040421
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2009Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 296:G175-G184.Full Text via DOI: 10.1152/ajpgi.90454.2008
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2009Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice. GASTROENTEROLOGY. 137:199-208.e6.Full Text via DOI: 10.1053/j.gastro.2009.03.033
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2008A2B Adenosine Receptor Gene Deletion Attenuates Murine Colitis. GASTROENTEROLOGY. 135:861-870.Full Text via DOI: 10.1053/j.gastro.2008.05.049
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2008Blockade of adenosine A2B receptors ameliorates murine colitis. British Journal of Pharmacology. 155:127-137.Full Text via DOI: 10.1038/bjp.2008.227
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2008Flagellin Treatment Protects against Chemicals, Bacteria, Viruses, and Radiation. JOURNAL OF IMMUNOLOGY. 180:8280-8285.Full Text via DOI: 10.4049/jimmunol.180.12.8280
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2008Targeted Deletion of Neuropeptide Y (NPY) Modulates Experimental Colitis. PLOS ONE. 3:e3304.Full Text via DOI: 10.1371/journal.pone.0003304
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2008Toll-Like Receptor 5-Deficient Mice Have Dysregulated Intestinal Gene Expression and Nonspecific Resistance to Salmonella -Induced Typhoid-Like Disease. INFECTION AND IMMUNITY. 76:1276-1281.Full Text via DOI: 10.1128/iai.01491-07
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Book Chapter (Web of Science)
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2021Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome. MECHANISMS AND THERAPY OF LIVER CANCER. 171-255.Full Text via DOI: 10.1016/bs.acr.2020.10.004 PMID: 33579424
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2018Altered Microbiota and Their Metabolism in Host Metabolic Diseases. Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. 129-165.Full Text via DOI: 10.1007/978-1-4939-7534-1_7
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2017The Relationship Between Probiotics and Dietary Fiber Consumption and Cardiovascular Health. 73-90.Full Text via DOI: 10.1016/b978-0-12-805130-6.00005-7
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2005Role of Epithelium in Mucosal Immunity. 423-434.Full Text via DOI: 10.1016/b978-012491543-5/50028-0
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Microbial molecular patterns and host defense. 99-130.Full Text via DOI: 10.1017/cbo9780511541537.004
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Chapter (Faculty180)
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2018Altered Microbiota and Their Metabolism in Host Metabolic Diseases. Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. Springer, Boston, MA. 129.
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2018Altered Microbiota and their Metabolism in Host Metabolic Diseases. Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. Springer. 129-165.
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2017The relationship between probiotics and dietary fiber consumption and cardiovascular health. Dietary Fiber for the Prevention of Cardiovascular Disease .
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2015Influence of Gut Microbiota on Hepatic Lipogenesis and Disease Pathogenesis. Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer. Chapter 9.
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2014Dextran sulfate sodium (DSS)-induced colitis in mice. Current Protocols in Immunology (1272 citations as of Nov 2022). 15.
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2012Gut microbiota drives metabolic disease in immunologically altered mice. Advances in immunology. Academic Press. 93.
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2006Microbial Molecular Patterns and Host Defense. Bacterial Epithelial Cell Cross Talk: Molecular Mechanisms in Pathogenesis. Cambridge University Press. 99-130.
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2005Role of epithelium in mucosal immunity. Mucosal Immunology, Two-Volume Set. Elsevier Inc.. 423.
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Early Access (Web of Science)
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2022Eat more natural dietary fiber and whole grains to minimize liver disease risk. HEPATOBILIARY SURGERY AND NUTRITION.Full Text via DOI: 10.21037/hbsn-22-155
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Editorial Material (Web of Science)
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2020Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease. PHYSIOLOGICAL GENOMICS. 217-221.Full Text via DOI: 10.1152/physiolgenomics.00033.2020 PMID: 32275178
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2019Pressure From the Bugs Within. HYPERTENSION. 977-979.Full Text via DOI: 10.1161/hypertensionaha.119.12685
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2015Debugging the host browns the fat. Nature Medicine. 1390-1391.Full Text via DOI: 10.1038/nm.3999
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2012Is Predisposition to NAFLD and Obesity Communicable?. CELL METABOLISM. 419-420.Full Text via DOI: 10.1016/j.cmet.2012.03.013
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2008Guardians of the Gut: Newly Appreciated Role of Epithelial Toll-Like Receptors in Protecting the Intestine. GASTROENTEROLOGY. 351-354.Full Text via DOI: 10.1053/j.gastro.2008.06.064
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Letter (Web of Science)
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2020Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2 , the Receptor for SARS-CoV-2 Infectivity. HYPERTENSION.Full Text via DOI: 10.1161/hypertensionaha.120.15360
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Meeting Abstract (Web of Science)
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2020Formyl Peptide Receptor-1 Activation Is Crucial For The Cause Of Spontaneous Hypertension In Dahl Salt Sensitive Rats.. HYPERTENSION.Full Text via DOI: 10.1161/hyp.76.suppl_1.22
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2020Commensal microbiota are essential for vascular contractility mediated by actin polymerization. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.06343
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2020Concerted diurnal rhythms of gut microbiota with salt-sensitive hypertension and renal inflammation. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.06693
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2020Reshaping commensal gut microbiota in early life lowers blood pressure potentially via a succinate mediated mechanism. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.06799
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2020Abstract P149: Germ-free Rats Reveal An Obligatory Role Of Microbiota In Blood Pressure. HYPERTENSION.Full Text via DOI: 10.1161/hyp.76.suppl_1.p149
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2020Abstract P150: Concerted Diurnal Rhythms Of Gut Microbiota With Salt-sensitive Hypertension And Renal Damage. HYPERTENSION.Full Text via DOI: 10.1161/hyp.76.suppl_1.p150
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2020Abstract P238: Bile Acid Metabolites Modulate Hypertension. HYPERTENSION.Full Text via DOI: 10.1161/hyp.76.suppl_1.p238
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2018Anti-Flagellin antibodies dampen TLR5 and NLRC4 innate immune responses to flagellin. JOURNAL OF IMMUNOLOGY.
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2018Deficiency of neutrophil extracellular traps increases susceptibility to colonic inflammation. JOURNAL OF IMMUNOLOGY.
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2018Distinct iron homeostasis in Th1-and Th2-biased mouse strains. JOURNAL OF IMMUNOLOGY.
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2018Myeloperoxidase Deficiency Attenuates Dietary and Systemic Iron-induced Toxicity. JOURNAL OF IMMUNOLOGY.
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2012Defect in TLR5 Expression Enhances Spontaneous Visceral Hypersensitivity. Inflammatory bowel diseases. S108.Full Text via DOI: 10.1097/00054725-201212001-00276
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2012Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker of Gut Inflammation. Inflammatory bowel diseases. S108.Full Text via DOI: 10.1097/00054725-201212001-00277
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2011Lipocalin-2 deficiency excerbates dextran sulfate sodium (DSS) induced murine colitis.. Inflammatory bowel diseases. S18-S18.Full Text via DOI: 10.1093/ibd/17.supplement1.s18a
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Other Scholarly Work (Faculty180)
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2023Invited Seminars. Students and faculty in other institutions.
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2019
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2016Feed Your Gut with Caution!. Translational Cancer Research.
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2015Debugging the host browns the fat. Nature Medicine.
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2012Is predisposition to NAFLD and obesity communicable?. Cell metabolism.
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1999Popular Science articles for general public. Indian Express, National English Daily News paper.
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Press (Faculty180)
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2018Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. Cell Publication Media Coverage.
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2015Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. Nature Communications Publication Coverage.
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Proceedings (Faculty180)
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Review (Faculty180)
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2014Mammalian gut immunity. 246.
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Review Article (Web of Science)
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2021Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis. MICROORGANISMS.Full Text via DOI: 10.3390/microorganisms9102117 PMID: 34683438
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2021Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. CURRENT HYPERTENSION REPORTS.Full Text via DOI: 10.1007/s11906-021-01142-9 PMID: 33961141
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2020Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.Full Text via DOI: 10.1016/j.jnutbio.2020.108360 PMID: 32163821
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2020Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health: health benefits of refined dietary fibers need to be redefined!. GASTROENTEROLOGY REPORT. 85-89.Full Text via DOI: 10.1093/gastro/goz072 PMID: 32280467
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2019The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity. JOURNAL OF INNATE IMMUNITY. 249-262.Full Text via DOI: 10.1159/000494627 PMID: 30605903
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2017Microbiotal-Host Interactions and Hypertension. PHYSIOLOGY. 224-233.Full Text via DOI: 10.1152/physiol.00003.2017
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2017How diet can impact gut microbiota to promote or endanger health. CURRENT OPINION IN GASTROENTEROLOGY. 417-421.Full Text via DOI: 10.1097/mog.0000000000000401
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2017Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation. Annual Review of Nutrition. 103-130.Full Text via DOI: 10.1146/annurev-nutr-071816-064559
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2016Gut microbiome as a novel cardiovascular therapeutic target. CURRENT OPINION IN PHARMACOLOGY. 8-12.Full Text via DOI: 10.1016/j.coph.2016.01.002
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2014The Microbiome and Obesity—An Established Risk for Certain Types of Cancer. The Cancer Journal. 176-180.Full Text via DOI: 10.1097/ppo.0000000000000049
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2012Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice. 93-112.Full Text via DOI: 10.1016/b978-0-12-394300-2.00003-x
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2012Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!. Annual Review of Physiology. 177-198.Full Text via DOI: 10.1146/annurev-physiol-020911-153330
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2009Flagellin: key target of mucosal innate immunity. MUCOSAL IMMUNOLOGY. 197-205.Full Text via DOI: 10.1038/mi.2009.9
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2009Role of flagellin in Crohnʼs disease: Emblematic of the progress and enigmas in understanding inflammatory bowel disease. Inflammatory bowel diseases. 789-795.Full Text via DOI: 10.1002/ibd.20734
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2008Toll like receptor-5: protecting the gut from enteric microbes. SEMINARS IN IMMUNOPATHOLOGY. 11-21.Full Text via DOI: 10.1007/s00281-007-0100-5
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Workshop (Faculty180)
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2015Microbe-Host Interaction Workshop. The Pennsylvania State University.
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2014Microbiome Workshop. The Pennsylvania State University.
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