Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation Article (Faculty180)

cited authors

  • Singh, Vishal; Yeoh, Beng S; Walker, Rach E; Xiao, Xia; Saha, Piu; Golonka, Rachel M; Cai, Jingwei; Bretin, Alexis Charles Andre; Cheng, Xi; Liu, Qing; Flythe, Michael D; Chassaing, Benoit; Shearer, Gregory C; Patterson, An D; Gewirtz, Andrew T; Vijay-Kumar, Matam


  • Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fermentable fibre-rich foods. Intervention studies with dietary fibres in murine models of colonic inflammation have yielded conflicting results on whether fibres ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, with the fermentable fibres, inulin or pectin, impacted murine colitis resulting from immune dysregulation via inhibition of interleukin (IL)-10 signalling and/or innate immune deficiency (KO).

publication date

  • 2019

published in

  • Gut  Journal

start page

  • 1801

end page

  • 1812


  • 68