Singh, Vishal; Yeoh, Beng S; Walker, Rach E; Xiao, Xia; Saha, Piu; Golonka, Rachel M; Cai, Jingwei; Bretin, Alexis Charles Andre; Cheng, Xi; Liu, Qing; Flythe, Michael D; Chassaing, Benoit; Shearer, Gregory C; Patterson, An D; Gewirtz, Andrew T; Vijay-Kumar, Matam
description
Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fermentable fibre-rich foods. Intervention studies with dietary fibres in murine models of colonic inflammation have yielded conflicting results on whether fibres ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, with the fermentable fibres, inulin or pectin, impacted murine colitis resulting from immune dysregulation via inhibition of interleukin (IL)-10 signalling and/or innate immune deficiency (KO).
