James T Slama
- Director of BSPS & Professor, Medicinal and Biological Chemistry , College of Pharmacy and Pharmaceutical Sciences
Contact Info
Publications
selected publications
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Article (Faculty180)
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2023Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12. SCIENCE SIGNALING. 16.
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2022Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
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2022NAADP-binding proteins find their identity. TRENDS IN BIOCHEMICAL SCIENCES. 47:235-249.
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20195-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors. Biochimica et biophysica acta. Molecular cell research. 1866:1180-1188.
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2019The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells. Cell calcium. 83:102060.
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2015Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca²⁺ Release. Journal of medicinal chemistry. 58:3593-610.
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2012Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes. Messenger (Los Angeles, Calif. : Print). 1:86-94.
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2010Nicotinic acid adenine dinucleotide phosphate analogues containing substituted nicotinic acid: effect of modification on Ca(2+) release. Journal of medicinal chemistry. 53:7599-612.
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2006Carbocyclic ribosylamines: synthesis of 5-substituted carbocyclic beta-ribofuranosylamines. The Journal of organic chemistry. 71:7877-80.
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2005Cyclic ADP-ribose analogues containing the methylenebisphosphonate linkage: effect of pyrophosphate modifications on Ca2+ release activity. Journal of medicinal chemistry. 48:4177-81.
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2004PXR and the regulation of apoA1 and HDL-cholesterol in rodents. Pharmacological research. 50:237-46.
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1999Photoaffinity labeling of diphtheria toxin fragment A with 8-azidoadenosyl nicotinamide adenine dinucleotide. Biochemistry. 38:13877-86.
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1998Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity. Biochemical pharmacology. 55:1881-92.
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1995Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. Journal of medicinal chemistry. 38:4332-6.
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1995Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. Journal of medicinal chemistry. 38:389-93.
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1994Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives. Carbohydrate research. 259:219-41.
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1993Synthesis of [35S]thiophosphoryl adenylic acid, utilizing a general procedure for [35S]thiophosphoryl chloride production. Analytical biochemistry. 209:143-9.
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1991A new method for measuring auricular inflammation in the mouse. Journal of pharmacological methods. 26:73-7.
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1991
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1991Synthesis of a new inhibitor of the UDP-GalNAc:polypeptide galactosaminyl transferase. Biochemical and biophysical research communications. 175:668-72.
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1990An approach to trapping gamma-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: alpha,beta-methyleneglutamic acid. Journal of medicinal chemistry. 33:824-32.
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Article (Web of Science)
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2021Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling. SCIENCE SIGNALING. 14.Full Text via DOI: 10.1126/scisignal.abd5605 PMID: 33758061
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2021Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs. BIOORGANIC & MEDICINAL CHEMISTRY. 30.Full Text via DOI: 10.1016/j.bmc.2020.115901 PMID: 33321420
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2019The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells. CELL CALCIUM. 83.Full Text via DOI: 10.1016/j.ceca.2019.102060 PMID: 31442840
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20195-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1866:1180-1188.Full Text via DOI: 10.1016/j.bbamcr.2018.11.017 PMID: 30521871
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2018A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.Full Text via DOI: 10.1021/acs.jnatprod.7b00892
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2016Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.Full Text via DOI: 10.1074/jbc.M115.681833
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2016Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.Full Text via DOI: 10.1074/jbc.m115.681833
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2015Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on Receptor Mediated Ca2+ Release. JOURNAL OF MEDICINAL CHEMISTRY. 58:3593-3610.Full Text via DOI: 10.1021/acs.jmedchem.5b00279
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2012Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2308-2315.Full Text via DOI: 10.1074/jbc.M111.306563
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2012Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2296-2307.Full Text via DOI: 10.1074/jbc.M111.305813
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2012Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2308-2315.Full Text via DOI: 10.1074/jbc.m111.306563
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2012Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells*. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2296-2307.Full Text via DOI: 10.1074/jbc.m111.305813
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2010Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Containing Substituted Nicotinic Acid: Effect of Modification on Ca2+ Release. JOURNAL OF MEDICINAL CHEMISTRY. 53:7599-7612.Full Text via DOI: 10.1021/jm1007209
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2008Radioprotectant and radiosensitizer effects on sterility of gamma-irradiated bone. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 466:1796-1803.Full Text via DOI: 10.1007/s11999-008-0283-7
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2007Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. MOLECULAR CELL. 25:463-472.Full Text via DOI: 10.1016/j.molcel.2006.12.022
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2006Carbocyclic ribosylamines: Synthesis of 5-substituted carbocyclic beta-ribofuranosylamines. JOURNAL OF ORGANIC CHEMISTRY. 71:7877-7880.Full Text via DOI: 10.1021/jo060920l
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2005Cyclic ADP-Ribose Analogues Containing the Methylenebisphosphonate Linkage: Effect of Pyrophosphate Modifications on Ca2+ Release Activity. JOURNAL OF MEDICINAL CHEMISTRY. 48:4177-4181.Full Text via DOI: 10.1021/jm049469l
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2004PXR and the regulation of apoA1 and HDL-cholesterol in rodents. PHARMACOLOGICAL RESEARCH. 50:237-246.Full Text via DOI: 10.1016/j.phrs.2004.03.005
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2004Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases. BIOCHEMISTRY. 43:9877-9887.Full Text via DOI: 10.1021/bi049592e
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2003Identification of an Inhibitor Binding Site of Poly(ADP-ribose) Glycohydrolase. BIOCHEMISTRY. 42:4855-4863.Full Text via DOI: 10.1021/bi0272048
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2003SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase. JOURNAL OF MEDICINAL CHEMISTRY. 46:4322-4332.Full Text via DOI: 10.1021/jm020541u
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2000A Sensitive Assay for Phosphoinositide Phosphatases. ANALYTICAL BIOCHEMISTRY. 279:248-250.Full Text via DOI: 10.1006/abio.2000.4497
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2000Role of NAD+ in the Deacetylase Activity of the SIR2-like Proteins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 278:685-690.Full Text via DOI: 10.1006/bbrc.2000.3854
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1999Photoaffinity Labeling of Diphtheria Toxin Fragment A with 8-Azidoadenosyl Nicotinamide Adenine Dinucleotide. BIOCHEMISTRY. 38:13877-13886.Full Text via DOI: 10.1021/bi991528n
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1998Influence of Some Novel N-Substituted Azoles and Pyridines on Rat Hepatic CYP3A Activity. BIOCHEMICAL PHARMACOLOGY. 55:1881-1892.Full Text via DOI: 10.1016/s0006-2952(98)00096-3
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1998Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues. BIOCHEMICAL JOURNAL. 335:631-636.Full Text via DOI: 10.1042/bj3350631
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1998Syntheses of Photoactive Analogues of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol and Photoaffinity Labeling of Poly(ADP-ribose) Glycohydrolase. BIOCHEMISTRY. 37:7801-7812.Full Text via DOI: 10.1021/bi9730386
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1996Photodependent Inhibition of Bovine Spleen NAD+Glycohydrolase by 8-Azido Carbocyclic Analogs of NAD+. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 228:128-133.Full Text via DOI: 10.1006/bbrc.1996.1627
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1994Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives. CARBOHYDRATE RESEARCH. 259:219-241.Full Text via DOI: 10.1016/0008-6215(94)84059-8
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1993Synthesis of [35S]Thiophosphoryl Adenylic Acid, Utilizing a General Procedure for [35S]Thiophosphoryl Chloride Production. ANALYTICAL BIOCHEMISTRY. 209:143-149.Full Text via DOI: 10.1006/abio.1993.1094
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1992Application of an N-(4-azido-2,3,5,6-tetrafluorobenzoyl)tyrosine-substituted peptide as a heterobifunctional cross-linking agent in a study of protein O-glycosylation in yeast. BIOCONJUGATE CHEMISTRY. 3:69-73.Full Text via DOI: 10.1021/bc00013a011
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1991A new method for measuring auricular inflammation in the mouse. Journal of Pharmacological Methods. 26:73-77.Full Text via DOI: 10.1016/0160-5402(91)90056-b
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1991Synthesis and properties of photoaffinity labels for the pyridine dinucleotide binding site of NAD glycohydrolase. BIOCHEMISTRY. 30:2527-2534.Full Text via DOI: 10.1021/bi00223a033
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1991Synthesis of a new inhibitor of the UDP-GalNAc: Polypeptide galactosaminyl transferase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 175:668-672.Full Text via DOI: 10.1016/0006-291x(91)91617-l
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1990An approach to trapping .gamma.-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: .alpha.,.beta.-methyleneglutamic acid. JOURNAL OF MEDICINAL CHEMISTRY. 33:824-832.Full Text via DOI: 10.1021/jm00164a056
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1989Inhibition of NAD glycohydrolase and ADP-ribosyl transferases by carbocyclic analogs of oxidized nicotinamide adenine dinucleotide. BIOCHEMISTRY. 28:7688-7694.Full Text via DOI: 10.1021/bi00445a025
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1988Carbanicotinamide adenine dinucleotide: synthesis and enzymological properties of a carbocyclic analog of oxidized nicotinamide adenine dinucleotide. BIOCHEMISTRY. 27:183-193.Full Text via DOI: 10.1021/bi00401a028
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1987Inhibition of thiaminase I from Bacillus thiaminolyticus. Evidence supporting a covalent 1,6-dihydropyrimidinyl-enzyme intermediate. BIOCHEMISTRY. 26:1969-1973.Full Text via DOI: 10.1021/bi00381a028
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1984Semisynthetic enzymes: characterization of isomeric flavopapains with widely different catalytic efficiencies. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 106:6778-6785.Full Text via DOI: 10.1021/ja00334a053
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1981The synthesis of glycolipids containing a hydrophilic spacer-group. CARBOHYDRATE RESEARCH. 88:213-221.Full Text via DOI: 10.1016/s0008-6215(00)85535-4
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1980Functional incorporation of synthetic glycolipids into cells.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 77:2510-2513.Full Text via DOI: 10.1073/pnas.77.5.2510
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Meeting Abstract (Web of Science)
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2018NAADP-BODIPY dye conjugates for characterizing NAADP binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2018Modular biotinylated and photoactive NAADP analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2017Affinity ligand purification for pyridine dinucleotide binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2017Chemo-enzymatic synthesis of an effective bifunctional NAADP analog for isolation and purification of the NAADP receptor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2016Nicotinic acid adenine dinucleotide (NAADP) analogs substituted on the nicotinic acid and adenine. Clickable photoaffinity probes for NAADP binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2016
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2015Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104A-104A.
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2015Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104a.Full Text via DOI: 10.1016/j.bpj.2014.11.594
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2014Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530A-530A.
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2014Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530a.Full Text via DOI: 10.1016/j.bpj.2013.11.2958
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Note (Web of Science)
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1995Mechanism of Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol. JOURNAL OF MEDICINAL CHEMISTRY. 4332-4336.Full Text via DOI: 10.1021/jm00021a023
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1995Specific Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol. JOURNAL OF MEDICINAL CHEMISTRY. 389-393.Full Text via DOI: 10.1021/jm00002a021
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1981Semisynthetic enzymes: synthesis of a new flavopapain with high catalytic efficiency. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 6211-6213.Full Text via DOI: 10.1021/ja00410a040
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Review Article (Web of Science)
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2001PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench. CURRENT OPINION IN CELL BIOLOGY. 172-181.Full Text via DOI: 10.1016/s0955-0674(00)00195-2
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Contact
full name
- James T Slama
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Cumulative publications in Scholars@UToledo