Slama, James T

James T Slama
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Positions

Director of BSPS & Professor, Medicinal and Biological Chemistry , College of Pharmacy and Pharmaceutical Sciences

Contact Info

James.Slama@utoledo.edu

selected publications

Article (Faculty180)
- 2023
  
  Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12. SCIENCE SIGNALING. 16.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  NAADP-binding proteins find their identity. TRENDS IN BIOCHEMICAL SCIENCES. 47:235-249.
- 2022
  
  Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N-2'-O-propargyladenosine and 8-N-2'-O-propargyl-cADPR. Bioorganic & medicinal chemistry. 76:117099.
- 2019
  
  5-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors. Biochimica et biophysica acta. Molecular cell research. 1866:1180-1188.
- 2019
  
  The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells. Cell calcium. 83:102060.
- 2015
  
  Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca²⁺ Release. Journal of medicinal chemistry. 58:3593-610.
- 2012
  
  Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes. Messenger (Los Angeles, Calif. : Print). 1:86-94.
- 2010
  
  Nicotinic acid adenine dinucleotide phosphate analogues containing substituted nicotinic acid: effect of modification on Ca(2+) release. Journal of medicinal chemistry. 53:7599-612.
- 2006
  
  Carbocyclic ribosylamines: synthesis of 5-substituted carbocyclic beta-ribofuranosylamines. The Journal of organic chemistry. 71:7877-80.
- 2005
  
  Cyclic ADP-ribose analogues containing the methylenebisphosphonate linkage: effect of pyrophosphate modifications on Ca2+ release activity. Journal of medicinal chemistry. 48:4177-81.
- 2004
  
  PXR and the regulation of apoA1 and HDL-cholesterol in rodents. Pharmacological research. 50:237-46.
- 1999
  
  Photoaffinity labeling of diphtheria toxin fragment A with 8-azidoadenosyl nicotinamide adenine dinucleotide. Biochemistry. 38:13877-86.
- 1998
  
  Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity. Biochemical pharmacology. 55:1881-92.
- 1998
  
  Syntheses of photoactive analogues of adenosine diphosphate (hydroxymethyl)pyrrolidinediol and photoaffinity labeling of poly(ADP-ribose) glycohydrolase. Biochemistry. 37:7801-12.
- 1995
  
  Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. Journal of medicinal chemistry. 38:4332-6.
- 1995
  
  Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. Journal of medicinal chemistry. 38:389-93.
- 1994
  
  Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives. Carbohydrate research. 259:219-41.
- 1993
  
  Synthesis of [35S]thiophosphoryl adenylic acid, utilizing a general procedure for [35S]thiophosphoryl chloride production. Analytical biochemistry. 209:143-9.
- 1991
  
  A new method for measuring auricular inflammation in the mouse. Journal of pharmacological methods. 26:73-7.
- 1991
  
  Synthesis and properties of photoaffinity labels for the pyridine dinucleotide binding site of NAD glycohydrolase. Biochemistry. 30:2527-34.
- 1991
  
  Synthesis of a new inhibitor of the UDP-GalNAc:polypeptide galactosaminyl transferase. Biochemical and biophysical research communications. 175:668-72.
- 1990
  
  An approach to trapping gamma-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: alpha,beta-methyleneglutamic acid. Journal of medicinal chemistry. 33:824-32.
- 1989
  
  Inhibition of NAD glycohydrolase and ADP-ribosyl transferases by carbocyclic analogues of oxidized nicotinamide adenine dinucleotide. Biochemistry. 28:7688-94.
- 1988
  
  Carbanicotinamide adenine dinucleotide: synthesis and enzymological properties of a carbocyclic analogue of oxidized nicotinamide adenine dinucleotide. Biochemistry. 27:183-93.
Article (Web of Science)
- 2021
  
  Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling. SCIENCE SIGNALING. 14.
  Full Text via DOI: 10.1126/scisignal.abd5605 PMID: 33758061
- 2021
  
  Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs. BIOORGANIC & MEDICINAL CHEMISTRY. 30.
  Full Text via DOI: 10.1016/j.bmc.2020.115901 PMID: 33321420
- 2019
  
  The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells. CELL CALCIUM. 83.
  Full Text via DOI: 10.1016/j.ceca.2019.102060 PMID: 31442840
- 2019
  
  5-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1866:1180-1188.
  Full Text via DOI: 10.1016/j.bbamcr.2018.11.017 PMID: 30521871
- 2018
  
  A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.
  Full Text via DOI: 10.1021/acs.jnatprod.7b00892
- 2016
  
  Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.
  Full Text via DOI: 10.1074/jbc.M115.681833
- 2016
  
  Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.
  Full Text via DOI: 10.1074/jbc.m115.681833
- 2015
  
  Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on Receptor Mediated Ca2+ Release. JOURNAL OF MEDICINAL CHEMISTRY. 58:3593-3610.
  Full Text via DOI: 10.1021/acs.jmedchem.5b00279
- 2014
  
  Activity of nicotinic acid substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs in a human cell line: Difference in specificity between human and sea urchin NAADP receptors. CELL CALCIUM. 55:93-103.
  Full Text via DOI: 10.1016/j.ceca.2013.12.004
- 2012
  
  Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2308-2315.
  Full Text via DOI: 10.1074/jbc.M111.306563
- 2012
  
  Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2296-2307.
  Full Text via DOI: 10.1074/jbc.M111.305813
- 2012
  
  Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2308-2315.
  Full Text via DOI: 10.1074/jbc.m111.306563
- 2012
  
  Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells*. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:2296-2307.
  Full Text via DOI: 10.1074/jbc.m111.305813
- 2010
  
  Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Containing Substituted Nicotinic Acid: Effect of Modification on Ca2+ Release. JOURNAL OF MEDICINAL CHEMISTRY. 53:7599-7612.
  Full Text via DOI: 10.1021/jm1007209
- 2008
  
  Radioprotectant and radiosensitizer effects on sterility of gamma-irradiated bone. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 466:1796-1803.
  Full Text via DOI: 10.1007/s11999-008-0283-7
- 2007
  
  Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. MOLECULAR CELL. 25:463-472.
  Full Text via DOI: 10.1016/j.molcel.2006.12.022
- 2006
  
  Carbocyclic ribosylamines: Synthesis of 5-substituted carbocyclic beta-ribofuranosylamines. JOURNAL OF ORGANIC CHEMISTRY. 71:7877-7880.
  Full Text via DOI: 10.1021/jo060920l
- 2005
  
  Cyclic ADP-Ribose Analogues Containing the Methylenebisphosphonate Linkage: Effect of Pyrophosphate Modifications on Ca2+ Release Activity. JOURNAL OF MEDICINAL CHEMISTRY. 48:4177-4181.
  Full Text via DOI: 10.1021/jm049469l
- 2004
  
  PXR and the regulation of apoA1 and HDL-cholesterol in rodents. PHARMACOLOGICAL RESEARCH. 50:237-246.
  Full Text via DOI: 10.1016/j.phrs.2004.03.005
- 2004
  
  Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases. BIOCHEMISTRY. 43:9877-9887.
  Full Text via DOI: 10.1021/bi049592e
- 2003
  
  Identification of an Inhibitor Binding Site of Poly(ADP-ribose) Glycohydrolase. BIOCHEMISTRY. 42:4855-4863.
  Full Text via DOI: 10.1021/bi0272048
- 2003
  
  SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase. JOURNAL OF MEDICINAL CHEMISTRY. 46:4322-4332.
  Full Text via DOI: 10.1021/jm020541u
- 2000
  
  A Sensitive Assay for Phosphoinositide Phosphatases. ANALYTICAL BIOCHEMISTRY. 279:248-250.
  Full Text via DOI: 10.1006/abio.2000.4497
- 2000
  
  Role of NAD+ in the Deacetylase Activity of the SIR2-like Proteins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 278:685-690.
  Full Text via DOI: 10.1006/bbrc.2000.3854
- 1999
  
  Photoaffinity Labeling of Diphtheria Toxin Fragment A with 8-Azidoadenosyl Nicotinamide Adenine Dinucleotide. BIOCHEMISTRY. 38:13877-13886.
  Full Text via DOI: 10.1021/bi991528n
- 1998
  
  Influence of Some Novel N-Substituted Azoles and Pyridines on Rat Hepatic CYP3A Activity. BIOCHEMICAL PHARMACOLOGY. 55:1881-1892.
  Full Text via DOI: 10.1016/s0006-2952(98)00096-3
- 1998
  
  Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues. BIOCHEMICAL JOURNAL. 335:631-636.
  Full Text via DOI: 10.1042/bj3350631
- 1998
  
  Syntheses of Photoactive Analogues of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol and Photoaffinity Labeling of Poly(ADP-ribose) Glycohydrolase. BIOCHEMISTRY. 37:7801-7812.
  Full Text via DOI: 10.1021/bi9730386
- 1996
  
  Photodependent Inhibition of Bovine Spleen NAD+Glycohydrolase by 8-Azido Carbocyclic Analogs of NAD+. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 228:128-133.
  Full Text via DOI: 10.1006/bbrc.1996.1627
- 1994
  
  Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives. CARBOHYDRATE RESEARCH. 259:219-241.
  Full Text via DOI: 10.1016/0008-6215(94)84059-8
- 1993
  
  Synthesis of [35S]Thiophosphoryl Adenylic Acid, Utilizing a General Procedure for [35S]Thiophosphoryl Chloride Production. ANALYTICAL BIOCHEMISTRY. 209:143-149.
  Full Text via DOI: 10.1006/abio.1993.1094
- 1992
  
  Application of an N-(4-azido-2,3,5,6-tetrafluorobenzoyl)tyrosine-substituted peptide as a heterobifunctional cross-linking agent in a study of protein O-glycosylation in yeast. BIOCONJUGATE CHEMISTRY. 3:69-73.
  Full Text via DOI: 10.1021/bc00013a011
- 1991
  
  A new method for measuring auricular inflammation in the mouse. Journal of Pharmacological Methods. 26:73-77.
  Full Text via DOI: 10.1016/0160-5402(91)90056-b
- 1991
  
  Synthesis and properties of photoaffinity labels for the pyridine dinucleotide binding site of NAD glycohydrolase. BIOCHEMISTRY. 30:2527-2534.
  Full Text via DOI: 10.1021/bi00223a033
- 1991
  
  Synthesis of a new inhibitor of the UDP-GalNAc: Polypeptide galactosaminyl transferase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 175:668-672.
  Full Text via DOI: 10.1016/0006-291x(91)91617-l
- 1990
  
  An approach to trapping .gamma.-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: .alpha.,.beta.-methyleneglutamic acid. JOURNAL OF MEDICINAL CHEMISTRY. 33:824-832.
  Full Text via DOI: 10.1021/jm00164a056
- 1989
  
  Inhibition of NAD glycohydrolase and ADP-ribosyl transferases by carbocyclic analogs of oxidized nicotinamide adenine dinucleotide. BIOCHEMISTRY. 28:7688-7694.
  Full Text via DOI: 10.1021/bi00445a025
- 1988
  
  Carbanicotinamide adenine dinucleotide: synthesis and enzymological properties of a carbocyclic analog of oxidized nicotinamide adenine dinucleotide. BIOCHEMISTRY. 27:183-193.
  Full Text via DOI: 10.1021/bi00401a028
- 1987
  
  Inhibition of thiaminase I from Bacillus thiaminolyticus. Evidence supporting a covalent 1,6-dihydropyrimidinyl-enzyme intermediate. BIOCHEMISTRY. 26:1969-1973.
  Full Text via DOI: 10.1021/bi00381a028
- 1984
  
  Semisynthetic enzymes: characterization of isomeric flavopapains with widely different catalytic efficiencies. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 106:6778-6785.
  Full Text via DOI: 10.1021/ja00334a053
- 1981
  
  The synthesis of glycolipids containing a hydrophilic spacer-group. CARBOHYDRATE RESEARCH. 88:213-221.
  Full Text via DOI: 10.1016/s0008-6215(00)85535-4
- 1980
  
  Functional incorporation of synthetic glycolipids into cells.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 77:2510-2513.
  Full Text via DOI: 10.1073/pnas.77.5.2510
Conference Poster (Faculty180)
- 2023
  
  Understanding the involvement of sphingosine kinase-1 and two-pore channels in calcium signaling in T cells. J Immunol 1 May 2023; 210 (1_Supplement): 154.28.
Dissertation (Faculty180)
- 2023
  
  Synthesis of Diazirine All-In-One-Click NAADP for Isolation and Purification of the
  NAADP Receptor in Sea Urchin Egg Homogenates
Meeting Abstract (Web of Science)
- 2018
  
  NAADP-BODIPY dye conjugates for characterizing NAADP binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2018
  
  Modular biotinylated and photoactive NAADP analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2017
  
  Affinity ligand purification for pyridine dinucleotide binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2017
  
  Chemo-enzymatic synthesis of an effective bifunctional NAADP analog for isolation and purification of the NAADP receptor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2016
  
  Nicotinic acid adenine dinucleotide (NAADP) analogs substituted on the nicotinic acid and adenine. Clickable photoaffinity probes for NAADP binding proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2016
  
  Differences in NAADP-mediated calcium signaling between natural regulatory T cells and naive or effector T cells. JOURNAL OF IMMUNOLOGY.
- 2015
  
  Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104A-104A.
- 2015
  
  Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104a.
  Full Text via DOI: 10.1016/j.bpj.2014.11.594
- 2014
  
  NAADP mediated calcium release from acidic stores plays a critical role in downstream physiological responses of naive CD4 and CD8 T cells. JOURNAL OF IMMUNOLOGY.
- 2014
  
  NAADP evokes calcium signals and plays a critical role in downstream physiological responses in naive T cells. FASEB JOURNAL.
- 2014
  
  Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530A-530A.
- 2014
  
  Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530a.
  Full Text via DOI: 10.1016/j.bpj.2013.11.2958
Note (Web of Science)
- 1995
  
  Mechanism of Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol. JOURNAL OF MEDICINAL CHEMISTRY. 4332-4336.
  Full Text via DOI: 10.1021/jm00021a023
- 1995
  
  Specific Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol. JOURNAL OF MEDICINAL CHEMISTRY. 389-393.
  Full Text via DOI: 10.1021/jm00002a021
- 1981
  
  Semisynthetic enzymes: synthesis of a new flavopapain with high catalytic efficiency. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 6211-6213.
  Full Text via DOI: 10.1021/ja00410a040
Review Article (Web of Science)
- 2001
  
  PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench. CURRENT OPINION IN CELL BIOLOGY. 172-181.
  Full Text via DOI: 10.1016/s0955-0674(00)00195-2

full name

James T Slama

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