Nagalakshmi Nadiminty
- Assistant Professor, Urology , College of Medicine and Life Sciences
Contact Info
Overview
overview
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I have extensive background in urologic cancer research with particular emphasis on experimental therapeutics and combinatorial strategies. My lab works on projects elucidating cell signaling pathways and therapy resistance mechanisms in urologic cancers. Other research interests include the identification and characterization of: 1) the role of androgen receptor signaling in castration and therapy resistance in prostate cancer, 2) the identification and characterization of novel targets and therapeutics in castration-resistant prostate cancer (CRPC), 3) the role of microRNAs in CRPC, and 4) the identification of novel therapeutic targets in bladder cancer. I have current funding from the Department of Defense Prostate Cancer Research Program (DoD-PCRP) and previous funding from the Department of Defense, the American Cancer Society, and the NCI. As an early career researcher, I laid the groundwork for an independent career by developing the technical expertise and collaborations required. In addition, I successfully administered the projects (e.g. staffing, research protections, budget), collaborated with other researchers, and produced peer-reviewed publications from each project.
Publications
selected publications
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Article (Faculty180)
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2022False Positive Pregnancy Test Before Kidney Transplant: Case Report and Review of Literature. Transplantation proceedings. S0041-1345(22)00400-6.
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2022Serum bilirubin as a predictor of graft outcomes after renal transplant. American journal of clinical and experimental urology. 10:37-43.
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2022Sperm centriole assessment identifies male factor infertility in couples with unexplained infertility - a pilot study. European Journal of Cell Biology. 101:151243.
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2021Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality. Frontiers in cell and developmental biology. 9:658891.
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2021The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma. Frontiers in oncology. 11:681441.
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2020Sterility, an overlooked health condition. Women. 1:29-45.
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2017Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. Molecular cancer therapeutics. 16:1521-1530.
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2017Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells. Molecular cancer therapeutics. 16:2770-2779.
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2016Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation. The Prostate. 76:445-55.
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2015Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer. Cancer research. 75:1413-22.
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2015NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer. Molecular cancer therapeutics. 14:1884-95.
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2014
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2014Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 20:3198-3210.
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2014Upregulation of glucose metabolism by NF-κB2/p52 mediates enzalutamide resistance in castration-resistant prostate cancer cells. Endocrine-related cancer. 21:435-42.
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2013Functional p53 determines docetaxel sensitivity in prostate cancer cells. The Prostate. 73:418-27.
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2013Inhibition of ABCB1 expression overcomes acquired docetaxel resistance in prostate cancer. Molecular cancer therapeutics. 12:1829-36.
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2013Lin28 promotes growth of prostate cancer cells and activates the androgen receptor. The American journal of pathology. 183:288-95.
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2013NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants. Molecular cancer therapeutics. 12:1629-37.
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2013RhoGDIα downregulates androgen receptor signaling in prostate cancer cells. The Prostate. 73:1614-22.
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2012
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2012Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives. World journal of urology. 30:287-95.
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2012
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2012MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. The Journal of biological chemistry. 287:1527-37.
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2012RhoGDIα suppresses growth and survival of prostate cancer cells. The Prostate. 72:392-8.
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2011Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes & cancer. 2:151-9.
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2010ABERRANT ACTIVATION OF THE ANDROGEN RECEPTOR BY NF-KAPPAB2/P52. JOURNAL OF UROLOGY. 183:E498.
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2010Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer research. 70:3309-19.
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2010
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2010Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells. The Prostate. 70:276-87.
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2010Sanguinarine suppresses prostate tumor growth and inhibits survivin expression. Genes & cancer. 1:283-92.
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2010The N-terminal kinase suppressor of Ras complex has a weak nucleoside diphosphate kinase activity. Thoracic cancer. 1:109-115.
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2009Interleukin-4 activates androgen receptor through CBP/p300. The Prostate. 69:126-32.
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2009Interleukin-6 regulates androgen synthesis in prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 15:4815-22.
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2008Mechanisms of selenium chemoprevention and therapy in prostate cancer. Molecular nutrition & food research. 52:1247-60.
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2008Transcriptional regulation of human RANK ligand gene expression by E2F1. Biochemical and biophysical research communications. 370:440-4.
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2007Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line. The Prostate. 67:1293-300.
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2007LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochemical and biophysical research communications. 359:379-84.
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2006Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer. Molecular cancer therapeutics. 5:913-8.
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2006Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. Clinical cancer research : an official journal of the American Association for Cancer Research. 12:1420-30.
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2006Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proceedings of the National Academy of Sciences of the United States of America. 103:7264-9.
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2005Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity. The Journal of biological chemistry. 280:5812-9.
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2005
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2005
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Article (Web of Science)
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2022PARP inhibitors chemopotentiate and synergize with cisplatin to inhibit bladder cancer cell survival and tumor growth. BMC CANCER. 22.Full Text via DOI: 10.1186/s12885-022-09376-9 PMID: 35321693
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2021The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma. FRONTIERS IN ONCOLOGY. 11.Full Text via DOI: 10.3389/fonc.2021.681441 PMID: 34307148
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2021Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 9.Full Text via DOI: 10.3389/fcell.2021.658891 PMID: 33968935
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2017Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells. MOLECULAR CANCER THERAPEUTICS. 16:2770-2779.Full Text via DOI: 10.1158/1535-7163.MCT-17-0030
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2017Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. MOLECULAR CANCER THERAPEUTICS. 16:1521-1530.Full Text via DOI: 10.1158/1535-7163.mct-16-0912
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2017Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells. MOLECULAR CANCER THERAPEUTICS. 16:2770-2779.Full Text via DOI: 10.1158/1535-7163.mct-17-0030
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2016Lin28 induces resistance to anti‐androgens via promotion of AR splice variant generation. PROSTATE. 76:445-455.Full Text via DOI: 10.1002/pros.23134
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2015Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer. CANCER RESEARCH. 75:1413-1422.Full Text via DOI: 10.1158/0008-5472.can-14-3080
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2015NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer. MOLECULAR CANCER THERAPEUTICS. 14:1884-1895.Full Text via DOI: 10.1158/1535-7163.mct-14-1057
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2014Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST). PROSTATE. 74:1086-1094.Full Text via DOI: 10.1002/pros.22819
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2014Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer. CLINICAL CANCER RESEARCH. 20:3198-3210.Full Text via DOI: 10.1158/1078-0432.ccr-13-3296
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2014Upregulation of glucose metabolism by NF-κB2/p52 mediates enzalutamide resistance in castration-resistant prostate cancer cells. Endocrine-Related Cancer. 21:435-442.Full Text via DOI: 10.1530/erc-14-0107
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2013Functional p53 determines docetaxel sensitivity in prostate cancer cells. PROSTATE. 73:418-427.Full Text via DOI: 10.1002/pros.22583
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2013Inhibition of ABCB1 Expression Overcomes Acquired Docetaxel Resistance in Prostate Cancer. MOLECULAR CANCER THERAPEUTICS. 12:1829-1836.Full Text via DOI: 10.1158/1535-7163.mct-13-0208
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2013Lin28 Promotes Growth of Prostate Cancer Cells and Activates the Androgen Receptor. AMERICAN JOURNAL OF PATHOLOGY. 183:288-295.Full Text via DOI: 10.1016/j.ajpath.2013.03.011
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2013NF-κB2/p52 Induces Resistance to Enzalutamide in Prostate Cancer: Role of Androgen Receptor and Its Variants. MOLECULAR CANCER THERAPEUTICS. 12:1629-1637.Full Text via DOI: 10.1158/1535-7163.mct-13-0027
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2013RhoGDIα downregulates androgen receptor signaling in prostate cancer cells. PROSTATE. 73:1614-1622.Full Text via DOI: 10.1002/pros.22615
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2012Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. PROSTATE. 72:82-89.Full Text via DOI: 10.1002/pros.21409
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2012Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives. WORLD JOURNAL OF UROLOGY. 30:287-295.Full Text via DOI: 10.1007/s00345-011-0771-3
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2012MicroRNA let-7c Is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth. PLOS ONE. 7:e32832.Full Text via DOI: 10.1371/journal.pone.0032832
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2012MicroRNA let-7c Suppresses Androgen Receptor Expression and Activity via Regulation of Myc Expression in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:1527-1537.Full Text via DOI: 10.1074/jbc.m111.278705
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2012RhoGDIα suppresses growth and survival of prostate cancer cells. PROSTATE. 72:392-398.Full Text via DOI: 10.1002/pros.21441
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2010Aberrant Activation of the Androgen Receptor by NF-κB2/p52 in Prostate Cancer Cells. CANCER RESEARCH. 70:3309-3319.Full Text via DOI: 10.1158/0008-5472.can-09-3703
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2010Microarray analysis reveals potential target genes of NF-κB2/p52 in LNCaP prostate cancer cells. PROSTATE. 70:276-287.Full Text via DOI: 10.1002/pros.21062
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2010The N-terminal kinase suppressor of Ras complex has a weak nucleoside diphosphate kinase activity. Thoracic Cancer. 1:109-115.Full Text via DOI: 10.1111/j.1759-7714.2010.00020.x
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2009Interleukin-4 activates androgen receptor through CBP/p300. PROSTATE. 69:126-132.Full Text via DOI: 10.1002/pros.20865
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2009Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells. CLINICAL CANCER RESEARCH. 15:4815-4822.Full Text via DOI: 10.1158/1078-0432.ccr-09-0640
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2008NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. PROSTATE. 68:1725-1733.Full Text via DOI: 10.1002/pros.20839
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2008Transcriptional regulation of human RANK ligand gene expression by E2F1. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 370:440-444.Full Text via DOI: 10.1016/j.bbrc.2008.03.106
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2007Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line. PROSTATE. 67:1293-1300.Full Text via DOI: 10.1002/pros.20621
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2007LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 359:379-384.Full Text via DOI: 10.1016/j.bbrc.2007.05.119
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2006Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer. MOLECULAR CANCER THERAPEUTICS. 5:913-918.Full Text via DOI: 10.1158/1535-7163.mct-05-0389
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2006Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). PROSTATE. 66:1070-1075.Full Text via DOI: 10.1002/pros.20329
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2006Prostate-Specific Antigen Modulates Genes Involved in Bone Remodeling and Induces Osteoblast Differentiation of Human Osteosarcoma Cell Line SaOS-2. CLINICAL CANCER RESEARCH. 12:1420-1430.Full Text via DOI: 10.1158/1078-0432.ccr-05-1849
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2006Stat3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103:7264-7269.Full Text via DOI: 10.1073/pnas.0509808103
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2005Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 280:5812-5819.Full Text via DOI: 10.1074/jbc.m411429200
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2005Requirement for NF-κB in interleukin-4-induced androgen receptor activation in prostate cancer cells. PROSTATE. 64:160-167.Full Text via DOI: 10.1002/pros.20218
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2005Selenium Disrupts Estrogen Signaling by Altering Estrogen Receptor Expression and Ligand Binding in Human Breast Cancer Cells. CANCER RESEARCH. 65:3487-3492.Full Text via DOI: 10.1158/0008-5472.can-04-3267
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Book Chapter (Web of Science)
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2009Selenium and Androgen Receptor in Prostate Cancer. Androgen Action in Prostate Cancer. 755-780.Full Text via DOI: 10.1007/978-0-387-69179-4_33
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Conference Poster (Faculty180)
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Correction (Web of Science)
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2017Correction: Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer. CLINICAL CANCER RESEARCH. 323-323.Full Text via DOI: 10.1158/1078-0432.ccr-16-2585
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Meeting Abstract (Web of Science)
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2015MP46-02 UP-REGULATION OF GLUCOSE METABOLISM BY NF-κB2/P52 MEDIATES ENZALUTAMIDE RESISTANCE IN PROSTATE CANCER CELLS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2015.02.1565
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2014MP24-07 NF-KAPPAB2/P52 INDUCES RESISTANCE TO ENZALUTAMIDE IN PROSTATE CANCER: ROLE OF ANDROGEN RECEPTOR AND ITS VARIANTS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2014.02.288
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20131322 LIN28 PROMOTES GROWTH OF PROSTATE CANCER CELLS AND ACTIVATES THE ANDROGEN RECEPTOR. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2013.02.2676
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20131327 NF-κB2/P52 INDUCES RESISTANCE TO ENZALUTAMIDE POSSIBLY BY UPREGULATION OF AR-V7. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2013.02.2681
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2013975 MIR-LET-7C AXIS REGULATES ANDROGEN SIGNALING AND THE GROWTH OF PROSTATE CANCER CELLS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2013.02.557
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2012483 RHOGDIÁ SUPPRESSES GROWTH AND SURVIVAL OF PROSTATE CANCER CELLS BY REGULATING ANDROGEN RECEPTOR (AR) SIGNALING PATHWAY. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2012.02.552
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2012782 SANGUINARINE INHIBITS STAT3 ACTIVATION AND TUMOR GROWTH IN PROSTATE CANCER CELLS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2012.02.870
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20111453 REGULATION OF INTRACRINE ANDROGEN SYNTHESIS BY NF-KAPPAB2/P52. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2011.02.1366
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20111619 ANDROGRAPHOLIDE IS A NOVEL INHIBITOR OF INTERLEUKIN-6 AND SUPPRESSES PROSTATE TUMOR GROWTH. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2011.02.1727
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20111622 LIN28/MIR-LET-7C AXIS CONTROLS THE GROWTH AND TUMORIGENICITY OF PROSTATE CANCER CELLS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2011.02.1730
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2011415 ANDROGRAPHOLIDE TARGETS AR PATHWAY IN CASTRATION-RESISTANT PROSTATE CANCER. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2011.02.504
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20101195 PSA-INDUCED OSTEOBLASTIC DIFFERENTIATION IN SAOS-2 CELLS: ROLE OF WIF-1 AND TGF-BETA. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2010.02.696
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20101286 ABERRANT ACTIVATION OF THE ANDROGEN RECEPTOR BY NF-KAPPAB2/P52. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2010.02.870
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20101291 INTERLEUKIN-6 REGULATES INTRACRINE ANDROGEN SYNTHESIS IN PROSTATE CANCER CELLS. JOURNAL OF UROLOGY.Full Text via DOI: 10.1016/j.juro.2010.02.875
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2010Abstract 1709: Activation of androgen signaling axis by NF-kappaB2/p52Full Text via DOI: 10.1158/1538-7445.am10-1709
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Proceedings (Faculty180)
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2011
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Review Article (Web of Science)
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2008Mechanisms of selenium chemoprevention and therapy in prostate cancer. MOLECULAR NUTRITION & FOOD RESEARCH. 1247-1260.Full Text via DOI: 10.1002/mnfr.200700369
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Contact
full name
- Nagalakshmi Nadiminty