Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2 Article (Faculty180)

cited authors

  • Nadiminty, Nagalakshmi; Lou, Wei; Lee, Soo Ok; Mehraein-Ghomi, Farideh; Kirk, Jason S; Conroy, Jeffrey M; Zhang, Haitao; Gao, Allen C


  • The high prevalence of osteoblastic bone metastases in prostate cancer involves the production of osteoblast-stimulating factors by prostate cancer cells. Prostate-specific antigen (PSA) is a serine protease uniquely produced by prostate cancer cells and is an important serologic marker for prostate cancer. In this study, we examined the role of PSA in the induction of osteoblast differentiation.

publication date

  • 2006

start page

  • 1420

end page

  • 30


  • 12