Liyanaaratchige Tillekeratne
Contact Info
Publications
selected publications
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Article (Faculty180)
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2024CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes. Journal of medicinal chemistry.
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2024Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related-Neuroinflammation. Pharmaceuticals (Basel, Switzerland). 17.
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2024Mutant p53 reactivators protect breast cancer cells from ferroptosis. Cell biochemistry and function. 42:e4036.
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2022Bioactive constituents isolated from the Sri Lankan endemic plant Artocarpus nobilis and their potential to use in novel cosmeceuticals. INDUSTRIAL CROPS AND PRODUCTS. 184.
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2022First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids. Journal of medicinal chemistry. 65:14764-14791.
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2022Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics. Bioorganic chemistry. 122:105700.
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2022Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics. BIOORGANIC CHEMISTRY. 122.
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2022Photoaffinity labeling and bioorthogonal ligation: Two critical tools for designing "Fish Hooks" to scout for target proteins. Bioorganic & medicinal chemistry. 62:116721.
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2022Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European journal of medicinal chemistry. 244:114807.
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2022Synthesis and Development of a Novel First-in-Class Cofilin Inhibitor for Neuroinflammation in Hemorrhagic Brain Injury. ACS chemical neuroscience. 13:1014-1029.
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2022Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis. Journal of medicinal chemistry. 65:11788-11817.
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2021. The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents. Bioorg. Med. Chem. Lett. . 47:128205.
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2021A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. Bioorganic chemistry. 116:105297.
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2021Potential SARS-CoV-2 main protease inhibitors. Drug discovery today. 26:804-816.
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2021Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F. The Journal of biological chemistry. 297:101365.
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2018Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.
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2017Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.
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2017Electropolymerized Pyrrole-Based Conductive Polymeric Ionic Liquids and Their Application for Solid-Phase Microextraction. ACS applied materials & interfaces. 9:24955-24963.
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2017New cyclic 2,3-sulfite ester derivatives of poststerone-Discriminating diastereomers and probing spatial proximities by NMR and DFT calculations. Magnetic resonance in chemistry : MRC. 55:1102-1107.
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2016Conductive polymeric ionic liquids for electroanalysis and solid-phase microextraction. Analytica chimica acta. 910:45-52.
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2016Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of medicinal chemistry. 59:10642-10660.
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2015Synthesis and characterization of water soluble choline labeled cadmium selenide/zinc selenide/zinc sulfide luminescent quantum dots. INORGANIC CHEMISTRY COMMUNICATIONS. 60:87-90.
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2014
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2014Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. European journal of medicinal chemistry. 86:528-41.
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2013Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. Toxicology and applied pharmacology. 270:87-96.
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2013
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2013Natural products inspired synthesis of neuroprotective agents against H₂O₂-induced cell death. Bioorganic & medicinal chemistry letters. 23:1232-7.
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2011In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications. ELECTROANALYSIS. 23:2275-2279.
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2011Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. Journal of medicinal chemistry. 54:7453-63.
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2010Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL. Bioorganic & medicinal chemistry. 18:849-54.
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2008Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone. ELECTROANALYSIS. 20:2177-2184.
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2008Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport. Analytical and bioanalytical chemistry. 392:651-62.
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2008Total synthesis and selective activity of a new class of conformationally restrained epothilones. Chemistry (Weinheim an der Bergstrasse, Germany). 14:570-81.
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2007First total synthesis and absolute configuration of the styryl lactone gonioheptolide A. SYNTHESIS-STUTTGART. 3512-3518.
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2007Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. Bioorganic & medicinal chemistry. 15:7042-7.
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2006Design, total synthesis, and evaluation of novel open-chain epothilone analogues. Organic letters. 8:685-8.
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2005Reductive monoalkylation of aromatic and aliphatic nitro compounds and the corresponding amines with nitriles. ORGANIC LETTERS. 7:471-474.
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2005
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2004Chiral separation of highly negatively charged enantiomers by capillary electrophoresis. Journal of chromatography. A. 1033:349-56.
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2004Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation. Biochemical and biophysical research communications. 318:1-3.
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2004Synthesis of imidazolo analogues of the oxidation-reduction cofactor pyrroloquinoline quinone (PQQ). The Journal of organic chemistry. 69:2626-9.
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2002Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters. 12:525-8.
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2002New tropane alkaloids from Erythroxylum moonii. Journal of natural products. 65:929-31.
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2001Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry. 56:857-61.
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2001Desilylation of TBDMS ethers of phenols susceptible to polymerization. SYNTHETIC COMMUNICATIONS. 31:3303-3308.
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2001Human sperm motility stimulating activity of a sulfono glycolipid isolated from Sri Lankan marine red alga Gelidiella acerosa. Asian journal of andrology. 3:27-31.
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2001Novel inhibitors of HIV-reverse transcriptase catalyzed DNA strand transfer: can we alter the infidelity of the enzyme?. Biochemical and biophysical research communications. 283:896-9.
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2001Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters. 11:2763-7.
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2000Separation of the enzyme cofactor pyrroloquinoline quinone and three isomeric analogues by capillary electrophoresis with ion-pairing media. Journal of chromatography. A. 876:193-9.
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1999Separation of negatively charged isomeric quinones in acidic solution by capillary electrophoresis with reductive electrochemical detection. ANALYTICAL COMMUNICATIONS. 36:371-374.
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1999Studies on the post-coital contraceptive mechanisms of a crude extract of Sri Lankan soft coral, Sinularia crispa. MEDICAL SCIENCE RESEARCH. 27:331-334.
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Article (Web of Science)
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2021The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 47.Full Text via DOI: 10.1016/j.bmcl.2021.128205 PMID: 34139326
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2019Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-42251-5 PMID: 30976078
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2018A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.Full Text via DOI: 10.1021/acs.jnatprod.7b00892
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2018Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.Full Text via DOI: 10.1039/c7ob03086j
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2017Electropolymerized Pyrrole-Based Conductive Polymeric Ionic Liquids and Their Application for Solid-Phase Microextraction. ACS APPLIED MATERIALS & INTERFACES. 9:24955-24963.Full Text via DOI: 10.1021/acsami.7b05793
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2017Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.Full Text via DOI: 10.1016/j.indcrop.2016.12.011
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2016Conductive polymeric ionic liquids for electroanalysis and solid-phase microextraction. ANALYTICA CHIMICA ACTA. 910:45-52.Full Text via DOI: 10.1016/j.aca.2016.01.017
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2016Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. JOURNAL OF MEDICINAL CHEMISTRY. 59:10642-10660.Full Text via DOI: 10.1021/acs.jmedchem.6b01271
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2016Synthesis and in vitro evaluation of the antitumor potential and chemo-sensitizing activity of fluorinated ecdysteroid derivatives. MEDCHEMCOMM. 7:2282-2289.Full Text via DOI: 10.1039/c6md00431h
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2015Synthesis and characterization of water soluble choline labeled cadmium selenide/zinc selenide/zinc sulfide luminescent quantum dots. INORGANIC CHEMISTRY COMMUNICATIONS. 60:87-90.Full Text via DOI: 10.1016/j.inoche.2015.07.012
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2014Ion-Tagged Phosphines as Ligands for Suzuki Coupling of Aryl Halides in a Phosphonium Ionic Liquid. SYNLETT. 25:977-982.Full Text via DOI: 10.1055/s-0033-1340846
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2014Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 86:528-541.Full Text via DOI: 10.1016/j.ejmech.2014.09.009
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2013Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 23:1232-1237.Full Text via DOI: 10.1016/j.bmcl.2013.01.013
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2013Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. TOXICOLOGY AND APPLIED PHARMACOLOGY. 270:87-96.Full Text via DOI: 10.1016/j.taap.2013.04.014
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2012Synthesis and characterization of luminescent cadmium selenide/zinc selenide/zinc sulfide cholinomimetic quantum dots. NANOSCALE. 4:4719-4725.Full Text via DOI: 10.1039/c2nr30713h
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2011In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications. ELECTROANALYSIS. 23:2275-2279.Full Text via DOI: 10.1002/elan.201100276
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2011Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY. 54:7453-7463.Full Text via DOI: 10.1021/jm200432a
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2010Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL. BIOORGANIC & MEDICINAL CHEMISTRY. 18:849-854.Full Text via DOI: 10.1016/j.bmc.2009.11.045
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2008Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone. ELECTROANALYSIS. 20:2177-2184.Full Text via DOI: 10.1002/elan.200804315
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2008Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part I: Compositional effects. POLYMER. 49:3737-3743.Full Text via DOI: 10.1016/j.polymer.2008.06.037
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2008Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part II: Solution effects. POLYMER. 49:3744-3750.Full Text via DOI: 10.1016/j.polymer.2008.06.036
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2008Total Synthesis and Selective Activity of a New Class of Conformationally Restrained Epothilones. CHEMISTRY-A EUROPEAN JOURNAL. 14:570-581.Full Text via DOI: 10.1002/chem.200701143
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2007Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. BIOORGANIC & MEDICINAL CHEMISTRY. 15:7042-7047.Full Text via DOI: 10.1016/j.bmc.2007.07.041
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2007Controlling phase transition behavior of thermally responsive metal affinity hydrogels: A molecular design approach. MACROMOLECULES. 40:5850-5857.Full Text via DOI: 10.1021/ma0706881
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2007First Total Synthesis and Absolute Configuration of the Styryl Lactone Gonioheptolide A. SYNTHESIS-STUTTGART. 2007:3512-3518.Full Text via DOI: 10.1055/s-2007-990862
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2006Design, Total Synthesis, and Evaluation of Novel Open-Chain Epothilone Analogues. ORGANIC LETTERS. 8:685-688.Full Text via DOI: 10.1021/ol0528787
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2005Evaluation of chiral discrimination of highly negatively charged enantiomers by quaternary ammonium β-cyclodextrin using1H NMR. Chirality. 17:570-576.Full Text via DOI: 10.1002/chir.20209
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2005Reductive Monoalkylation of Aromatic and Aliphatic Nitro Compounds and the Corresponding Amines with Nitriles. ORGANIC LETTERS. 7:471-474.Full Text via DOI: 10.1021/ol047580f
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2004An Efficient One-Pot Synthesis of Aminobenzimidazoles. SYNTHESIS-STUTTGART. 2005:17-18.Full Text via DOI: 10.1055/s-2004-834925
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2004Chiral separation of highly negatively charged enantiomers by capillary electrophoresis. JOURNAL OF CHROMATOGRAPHY A. 1033:349-356.Full Text via DOI: 10.1016/j.chroma.2004.01.023
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2004Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 318:1-3.Full Text via DOI: 10.1016/j.bbrc.2004.03.181
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2004Synthesis of Imidazolo Analogues of the Oxidation−Reduction Cofactor Pyrroloquinoline Quinone (PQQ). JOURNAL OF ORGANIC CHEMISTRY. 69:2626-2629.Full Text via DOI: 10.1021/jo035390x
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2002Differential Inhibition of polymerase and Strand-Transfer Activities of HIV-1 Reverse Transcriptase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 12:525-528.Full Text via DOI: 10.1016/s0960-894x(01)00827-7
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2001DESILYLATION OF TBDMS ETHERS OF PHENOLS SUSCEPTIBLE TO POLYMERIZATION. SYNTHETIC COMMUNICATIONS. 31:3303-3308.Full Text via DOI: 10.1081/scc-100106040
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2001Novel Inhibitors of HIV-Reverse Transcriptase Catalyzed DNA Strand Transfer: Can We Alter the Infidelity of the Enzyme?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 283:896-899.Full Text via DOI: 10.1006/bbrc.2001.4875
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2001Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 11:2763-2767.Full Text via DOI: 10.1016/s0960-894x(01)00577-7
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2000Separation of the enzyme cofactor pyrroloquinoline quinone and three isomeric analogues by capillary electrophoresis with ion-pairing media. JOURNAL OF CHROMATOGRAPHY A. 876:193-199.Full Text via DOI: 10.1016/s0021-9673(00)00099-6
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1999Separation of negatively charged isomeric quinones in acidic solution by capillary electrophoresis with reductive electrochemical detection. Analytical Communications. 36:371.Full Text via DOI: 10.1039/a906790f
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1998An unusual product in a Doebner-von Miller quinoline synthesis. TETRAHEDRON LETTERS. 39:5133-5134.Full Text via DOI: 10.1016/s0040-4039(98)01008-9
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19966-Hydroxycatecholine, a Choline-Mimicking Analogue of the Selective Neurotoxin, 6-Hydroxydopamine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 228:187-192.Full Text via DOI: 10.1006/bbrc.1996.1637
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1995High-Performance Liquid Chromatographic Separation and pH-Dependent Electrochemical Properties of Pyrroloquinoline Quinone and Three Closely Related Isomeric Analogues. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 212:41-47.Full Text via DOI: 10.1006/bbrc.1995.1933
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1989Xanthyletin and Xanthoxyletin from a Gorgonian, Echinogorgia sp.. JOURNAL OF NATURAL PRODUCTS. 52:1303-1304.Full Text via DOI: 10.1021/np50066a017
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1985Marine Natural Products: Pyrrololactams from Several Sponges. JOURNAL OF NATURAL PRODUCTS. 48:47-53.Full Text via DOI: 10.1021/np50037a008
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Letter (Web of Science)
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2017New cyclic 2,3-sulfite ester derivatives of poststeroneDiscriminating diastereomers and probing spatial proximities by NMR and DFT calculations. MAGNETIC RESONANCE IN CHEMISTRY. 1102-1107.Full Text via DOI: 10.1002/mrc.4641 PMID: 28778115
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Note (Web of Science)
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1989A New Spermatostatic Glycoside from the Soft Coral Sinularia crispa. JOURNAL OF NATURAL PRODUCTS. 1143-1145.Full Text via DOI: 10.1021/np50065a038
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19844,9-diacetoxyudoteal: A linear diterpene aldehyde from the green alga Halimeda opuntia. Phytochemistry. 1331-1333.Full Text via DOI: 10.1016/s0031-9422(00)80455-0
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Patent (Faculty180)
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Review Article (Web of Science)
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2021Potential SARS-CoV-2 main protease inhibitors. DRUG DISCOVERY TODAY. 804-816.Full Text via DOI: 10.1016/j.drudis.2020.12.005 PMID: 33309533
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2008Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 651-662.Full Text via DOI: 10.1007/s00216-008-2307-2
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Contact
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- Liyanaaratchige Tillekeratne
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Cumulative publications in Scholars@UToledo