Tillekeratne, Liyanaaratchige

Liyanaaratchige Tillekeratne
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Positions

Professor, Medicinal and Biological Chemistry , College of Pharmacy and Pharmaceutical Sciences

Contact Info

liyanaaratchige.tillekeratne@utoledo.edu

selected publications

Article (Faculty180)
- 2022
  
  Bioactive constituents isolated from the Sri Lankan endemic plant Artocarpus nobilis and their potential to use in novel cosmeceuticals. INDUSTRIAL CROPS AND PRODUCTS. 184.
- 2022
  
  First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids. Journal of medicinal chemistry. 65:14764-14791.
- 2022
  
  Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics. Bioorganic chemistry. 122:105700.
- 2022
  
  Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics. BIOORGANIC CHEMISTRY. 122.
- 2022
  
  Photoaffinity labeling and bioorthogonal ligation: Two critical tools for designing "Fish Hooks" to scout for target proteins. Bioorganic & medicinal chemistry. 62:116721.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European journal of medicinal chemistry. 244:114807.
- 2022
  
  Synthesis and Development of a Novel First-in-Class Cofilin Inhibitor for Neuroinflammation in Hemorrhagic Brain Injury. ACS chemical neuroscience. 13:1014-1029.
- 2022
  
  Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis. Journal of medicinal chemistry. 65:11788-11817.
- 2021
  
  . The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents. Bioorg. Med. Chem. Lett. . 47:128205.
- 2021
  
  A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. Bioorganic chemistry. 116:105297.
- 2021
  
  Potential SARS-CoV-2 main protease inhibitors. Drug discovery today. 26:804-816.
- 2021
  
  Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F. The Journal of biological chemistry. 297:101365.
- 2018
  
  Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.
- 2017
  
  Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.
- 2017
  
  Electropolymerized Pyrrole-Based Conductive Polymeric Ionic Liquids and Their Application for Solid-Phase Microextraction. ACS applied materials & interfaces. 9:24955-24963.
- 2017
  
  New cyclic 2,3-sulfite ester derivatives of poststerone-Discriminating diastereomers and probing spatial proximities by NMR and DFT calculations. Magnetic resonance in chemistry : MRC. 55:1102-1107.
- 2016
  
  Conductive polymeric ionic liquids for electroanalysis and solid-phase microextraction. Analytica chimica acta. 910:45-52.
- 2016
  
  Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of medicinal chemistry. 59:10642-10660.
- 2016
  
  Synthesis and in vitro evaluation of the antitumor potential and chemo-sensitizing activity of fluorinated ecdysteroid derivatives. MEDCHEMCOMM. 7:2282-2289.
- 2015
  
  Synthesis and characterization of water soluble choline labeled cadmium selenide/zinc selenide/zinc sulfide luminescent quantum dots. INORGANIC CHEMISTRY COMMUNICATIONS. 60:87-90.
- 2014
  
  Epigenetic regulation of IL-6 by pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts: role of HDAC inhibitors. FASEB JOURNAL. 28.
- 2014
  
  Ion-Tagged Phosphines as Ligands for Suzuki Coupling of Aryl Halides in a Phosphonium Ionic Liquid. SYNLETT. 25:977-982.
- 2014
  
  Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. European journal of medicinal chemistry. 86:528-41.
- 2013
  
  Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. Toxicology and applied pharmacology. 270:87-96.
- 2013
  
  Largazole, a class I histone deacetylase inhibitor, synergizes with TNF-α to induce ICAM-1 and VCAM-1 expression in Rheumatoid Arthritis Synovial Fibroblasts. Toxicol. Appl. Pharmacol. 270:87-96.
- 2013
  
  Natural products inspired synthesis of neuroprotective agents against H₂O₂-induced cell death. Bioorganic & medicinal chemistry letters. 23:1232-7.
- 2012
  
  Synthesis and characterization of luminescent cadmium selenide/zinc selenide/zinc sulfide cholinomimetic quantum dots. Nanoscale. 4:4719-25.
- 2011
  
  In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications. ELECTROANALYSIS. 23:2275-2279.
- 2011
  
  Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. Journal of medicinal chemistry. 54:7453-63.
- 2010
  
  Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL. Bioorganic & medicinal chemistry. 18:849-54.
- 2008
  
  Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone. ELECTROANALYSIS. 20:2177-2184.
- 2008
  
  Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport. Analytical and bioanalytical chemistry. 392:651-62.
- 2008
  
  Total synthesis and selective activity of a new class of conformationally restrained epothilones. Chemistry (Weinheim an der Bergstrasse, Germany). 14:570-81.
- 2007
  
  First total synthesis and absolute configuration of the styryl lactone gonioheptolide A. SYNTHESIS-STUTTGART. 3512-3518.
- 2007
  
  Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. Bioorganic & medicinal chemistry. 15:7042-7.
- 2006
  
  Design, total synthesis, and evaluation of novel open-chain epothilone analogues. Organic letters. 8:685-8.
- 2005
  
  An efficient one-pot synthesis of aminobenzimidazoles avoiding a troublesome actonitrile-mediated reductive ethylation reaction. Synthesis,. 17-18.
- 2005
  
  Evaluation of chiral discrimination of highly negatively charged enantiomers by quaternary ammonium beta-cyclodextrin using 1H NMR. Chirality. 17:570-6.
- 2005
  
  Reductive monoalkylation of aromatic and aliphatic nitro compounds and the corresponding amines with nitriles. ORGANIC LETTERS. 7:471-474.
- 2005
  
  Reductive monoalkylation of aromatic and aliphatic nitro compounds and the corresponding amines with nitriles. Organic letters. 7:471-4.
- 2004
  
  Chiral separation of highly negatively charged enantiomers by capillary electrophoresis. Journal of chromatography. A. 1033:349-56.
- 2004
  
  Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation. Biochemical and biophysical research communications. 318:1-3.
- 2004
  
  Synthesis of imidazolo analogues of the oxidation-reduction cofactor pyrroloquinoline quinone (PQQ). The Journal of organic chemistry. 69:2626-9.
- 2002
  
  Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters. 12:525-8.
- 2002
  
  New tropane alkaloids from Erythroxylum moonii. Journal of natural products. 65:929-31.
- 2001
  
  Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum. Phytochemistry. 56:857-61.
- 2001
  
  Desilylation of TBDMS ethers of phenols susceptible to polymerization. SYNTHETIC COMMUNICATIONS. 31:3303-3308.
- 2001
  
  Human sperm motility stimulating activity of a sulfono glycolipid isolated from Sri Lankan marine red alga Gelidiella acerosa. Asian journal of andrology. 3:27-31.
- 2001
  
  Novel inhibitors of HIV-reverse transcriptase catalyzed DNA strand transfer: can we alter the infidelity of the enzyme?. Biochemical and biophysical research communications. 283:896-9.
- 2001
  
  Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters. 11:2763-7.
- 2000
  
  Separation of the enzyme cofactor pyrroloquinoline quinone and three isomeric analogues by capillary electrophoresis with ion-pairing media. Journal of chromatography. A. 876:193-9.
- 1999
  
  Separation of negatively charged isomeric quinones in acidic solution by capillary electrophoresis with reductive electrochemical detection. ANALYTICAL COMMUNICATIONS. 36:371-374.
- 1999
  
  Studies on the post-coital contraceptive mechanisms of a crude extract of Sri Lankan soft coral, Sinularia crispa. MEDICAL SCIENCE RESEARCH. 27:331-334.
Article (Web of Science)
- 2021
  
  The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 47.
  Full Text via DOI: 10.1016/j.bmcl.2021.128205 PMID: 34139326
- 2019
  
  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-42251-5 PMID: 30976078
- 2018
  
  A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.
  Full Text via DOI: 10.1021/acs.jnatprod.7b00892
- 2018
  
  Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.
  Full Text via DOI: 10.1039/c7ob03086j
- 2017
  
  Electropolymerized Pyrrole-Based Conductive Polymeric Ionic Liquids and Their Application for Solid-Phase Microextraction. ACS APPLIED MATERIALS & INTERFACES. 9:24955-24963.
  Full Text via DOI: 10.1021/acsami.7b05793
- 2017
  
  Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.
  Full Text via DOI: 10.1016/j.indcrop.2016.12.011
- 2016
  
  Conductive polymeric ionic liquids for electroanalysis and solid-phase microextraction. ANALYTICA CHIMICA ACTA. 910:45-52.
  Full Text via DOI: 10.1016/j.aca.2016.01.017
- 2016
  
  Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. JOURNAL OF MEDICINAL CHEMISTRY. 59:10642-10660.
  Full Text via DOI: 10.1021/acs.jmedchem.6b01271
- 2016
  
  Synthesis and in vitro evaluation of the antitumor potential and chemo-sensitizing activity of fluorinated ecdysteroid derivatives. MEDCHEMCOMM. 7:2282-2289.
  Full Text via DOI: 10.1039/c6md00431h
- 2015
  
  Synthesis and characterization of water soluble choline labeled cadmium selenide/zinc selenide/zinc sulfide luminescent quantum dots. INORGANIC CHEMISTRY COMMUNICATIONS. 60:87-90.
  Full Text via DOI: 10.1016/j.inoche.2015.07.012
- 2014
  
  Ion-Tagged Phosphines as Ligands for Suzuki Coupling of Aryl Halides in a Phosphonium Ionic Liquid. SYNLETT. 25:977-982.
  Full Text via DOI: 10.1055/s-0033-1340846
- 2014
  
  Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 86:528-541.
  Full Text via DOI: 10.1016/j.ejmech.2014.09.009
- 2013
  
  Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 23:1232-1237.
  Full Text via DOI: 10.1016/j.bmcl.2013.01.013
- 2013
  
  Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts. TOXICOLOGY AND APPLIED PHARMACOLOGY. 270:87-96.
  Full Text via DOI: 10.1016/j.taap.2013.04.014
- 2012
  
  Synthesis and characterization of luminescent cadmium selenide/zinc selenide/zinc sulfide cholinomimetic quantum dots. NANOSCALE. 4:4719-4725.
  Full Text via DOI: 10.1039/c2nr30713h
- 2011
  
  In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications. ELECTROANALYSIS. 23:2275-2279.
  Full Text via DOI: 10.1002/elan.201100276
- 2011
  
  Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY. 54:7453-7463.
  Full Text via DOI: 10.1021/jm200432a
- 2010
  
  Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL. BIOORGANIC & MEDICINAL CHEMISTRY. 18:849-854.
  Full Text via DOI: 10.1016/j.bmc.2009.11.045
- 2008
  
  Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone. ELECTROANALYSIS. 20:2177-2184.
  Full Text via DOI: 10.1002/elan.200804315
- 2008
  
  Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part I: Compositional effects. POLYMER. 49:3737-3743.
  Full Text via DOI: 10.1016/j.polymer.2008.06.037
- 2008
  
  Equilibrium swelling behavior of thermally responsive metal affinity hydrogels, Part II: Solution effects. POLYMER. 49:3744-3750.
  Full Text via DOI: 10.1016/j.polymer.2008.06.036
- 2008
  
  Total Synthesis and Selective Activity of a New Class of Conformationally Restrained Epothilones. CHEMISTRY-A EUROPEAN JOURNAL. 14:570-581.
  Full Text via DOI: 10.1002/chem.200701143
- 2007
  
  Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. BIOORGANIC & MEDICINAL CHEMISTRY. 15:7042-7047.
  Full Text via DOI: 10.1016/j.bmc.2007.07.041
- 2007
  
  Controlling phase transition behavior of thermally responsive metal affinity hydrogels: A molecular design approach. MACROMOLECULES. 40:5850-5857.
  Full Text via DOI: 10.1021/ma0706881
- 2007
  
  First Total Synthesis and Absolute Configuration of the Styryl Lactone Gonioheptolide A. SYNTHESIS-STUTTGART. 2007:3512-3518.
  Full Text via DOI: 10.1055/s-2007-990862
- 2006
  
  Design, Total Synthesis, and Evaluation of Novel Open-Chain Epothilone Analogues. ORGANIC LETTERS. 8:685-688.
  Full Text via DOI: 10.1021/ol0528787
- 2005
  
  Evaluation of chiral discrimination of highly negatively charged enantiomers by quaternary ammonium β-cyclodextrin using1H NMR. Chirality. 17:570-576.
  Full Text via DOI: 10.1002/chir.20209
- 2005
  
  Reductive Monoalkylation of Aromatic and Aliphatic Nitro Compounds and the Corresponding Amines with Nitriles. ORGANIC LETTERS. 7:471-474.
  Full Text via DOI: 10.1021/ol047580f
- 2004
  
  An Efficient One-Pot Synthesis of Aminobenzimidazoles. SYNTHESIS-STUTTGART. 2005:17-18.
  Full Text via DOI: 10.1055/s-2004-834925
- 2004
  
  Chiral separation of highly negatively charged enantiomers by capillary electrophoresis. JOURNAL OF CHROMATOGRAPHY A. 1033:349-356.
  Full Text via DOI: 10.1016/j.chroma.2004.01.023
- 2004
  
  Potent isothiocyanate inhibitors of carbonic anhydrase: synthesis and evaluation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 318:1-3.
  Full Text via DOI: 10.1016/j.bbrc.2004.03.181
- 2004
  
  Synthesis of Imidazolo Analogues of the Oxidation−Reduction Cofactor Pyrroloquinoline Quinone (PQQ). JOURNAL OF ORGANIC CHEMISTRY. 69:2626-2629.
  Full Text via DOI: 10.1021/jo035390x
- 2002
  
  Differential Inhibition of polymerase and Strand-Transfer Activities of HIV-1 Reverse Transcriptase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 12:525-528.
  Full Text via DOI: 10.1016/s0960-894x(01)00827-7
- 2001
  
  DESILYLATION OF TBDMS ETHERS OF PHENOLS SUSCEPTIBLE TO POLYMERIZATION. SYNTHETIC COMMUNICATIONS. 31:3303-3308.
  Full Text via DOI: 10.1081/scc-100106040
- 2001
  
  Novel Inhibitors of HIV-Reverse Transcriptase Catalyzed DNA Strand Transfer: Can We Alter the Infidelity of the Enzyme?. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 283:896-899.
  Full Text via DOI: 10.1006/bbrc.2001.4875
- 2001
  
  Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 11:2763-2767.
  Full Text via DOI: 10.1016/s0960-894x(01)00577-7
- 2000
  
  Separation of the enzyme cofactor pyrroloquinoline quinone and three isomeric analogues by capillary electrophoresis with ion-pairing media. JOURNAL OF CHROMATOGRAPHY A. 876:193-199.
  Full Text via DOI: 10.1016/s0021-9673(00)00099-6
- 1999
  
  Separation of negatively charged isomeric quinones in acidic solution by capillary electrophoresis with reductive electrochemical detection. Analytical Communications. 36:371.
  Full Text via DOI: 10.1039/a906790f
- 1998
  
  An unusual product in a Doebner-von Miller quinoline synthesis. TETRAHEDRON LETTERS. 39:5133-5134.
  Full Text via DOI: 10.1016/s0040-4039(98)01008-9
- 1996
  
  6-Hydroxycatecholine, a Choline-Mimicking Analogue of the Selective Neurotoxin, 6-Hydroxydopamine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 228:187-192.
  Full Text via DOI: 10.1006/bbrc.1996.1637
- 1995
  
  High-Performance Liquid Chromatographic Separation and pH-Dependent Electrochemical Properties of Pyrroloquinoline Quinone and Three Closely Related Isomeric Analogues. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 212:41-47.
  Full Text via DOI: 10.1006/bbrc.1995.1933
- 1989
  
  Xanthyletin and Xanthoxyletin from a Gorgonian, Echinogorgia sp.. JOURNAL OF NATURAL PRODUCTS. 52:1303-1304.
  Full Text via DOI: 10.1021/np50066a017
- 1985
  
  Marine Natural Products: Pyrrololactams from Several Sponges. JOURNAL OF NATURAL PRODUCTS. 48:47-53.
  Full Text via DOI: 10.1021/np50037a008
Letter (Web of Science)
- 2017
  
  New cyclic 2,3-sulfite ester derivatives of poststeroneDiscriminating diastereomers and probing spatial proximities by NMR and DFT calculations. MAGNETIC RESONANCE IN CHEMISTRY. 1102-1107.
  Full Text via DOI: 10.1002/mrc.4641 PMID: 28778115
Note (Web of Science)
- 1989
  
  A New Spermatostatic Glycoside from the Soft Coral Sinularia crispa. JOURNAL OF NATURAL PRODUCTS. 1143-1145.
  Full Text via DOI: 10.1021/np50065a038
- 1984
  
  4,9-diacetoxyudoteal: A linear diterpene aldehyde from the green alga Halimeda opuntia. Phytochemistry. 1331-1333.
  Full Text via DOI: 10.1016/s0031-9422(00)80455-0
Patent (Faculty180)
Review Article (Web of Science)
- 2021
  
  Potential SARS-CoV-2 main protease inhibitors. DRUG DISCOVERY TODAY. 804-816.
  Full Text via DOI: 10.1016/j.drudis.2020.12.005 PMID: 33309533
- 2008
  
  Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 651-662.
  Full Text via DOI: 10.1007/s00216-008-2307-2

full name

Liyanaaratchige Tillekeratne

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