Novel inhibitors of HIV-reverse transcriptase catalyzed DNA strand transfer: can we alter the infidelity of the enzyme? Article (Faculty180)

cited authors

  • Suleman, A S; Tillekeratne, L M; Hudson, R A


  • Reverse transcription of viral RNA by the enzyme HIV1-reverse transcriptase (HIV1-RT) involves two DNA-strand transfers (DNA-ST). We report here a time-dependent inactivation of DNA-strand transfer by specific DNA-strand transfer inhibitors that do not affect the polymerase activity of the enzyme. Irreversible inhibitors of this type may be useful in characterizing the sites on the enzyme responsible for DNA-strand transfer.

publication date

  • 2001

start page

  • 896

end page

  • 9


  • 283