Ferreira, Viviana P

Viviana P Ferreira
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Positions

Associate Professor, Medical Microbiology and Immunology , College of Medicine and Life Sciences

Contact Info

Viviana.Ferreira@utoledo.edu

selected publications

Article (Faculty180)
- 2022
  
  Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation. Frontiers in immunology. 13:845953.
- 2021
  
  Hijacking Factor H for Complement Immune Evasion. Frontiers in immunology. 12:602277.
- 2021
  
  Is It Possible to Intervene in the Capacity of to Elicit and Evade the Complement System?. Frontiers in immunology. 12:789145.
- 2021
  
  Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. Cancer immunology research. 9:790-810.
- 2020
  
  Properdin is a key player in lysis of red blood cells and complement activation on endothelial cells in hemolytic anemias caused by complement dysregulation.. Frontiers in Immunology. 11:1460.
- 2020
  
  The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence. Frontiers in immunology. 11:1561.
- 2017
  
  Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. Frontiers in immunology. 8:1586.
- 2016
  
  Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. Journal of immunology (Baltimore, Md. : 1950). 196:4671-4680.
- 2016
  
  RAPAMYCIN INCREASES LENGTH AND MECHANOSENSORY FUNCTION OF PRIMARY CILIA IN RENAL EPITHELIAL AND VASCULAR ENDOTHELIAL CELLS. International education and research journal. 2:91-97.
- 2016
  
  SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. Scientific reports. 6:19300.
- 2014
  
  Delineating the importance of serum opsonins and the bacterial capsule in affecting the uptake and killing of Burkholderia pseudomallei by murine neutrophils and macrophages. PLoS neglected tropical diseases. 8:e2988.
- 2014
  
  Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection. Proceedings of the National Academy of Sciences of the United States of America. 111:5301-6.
- 2014
  
  New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Molecular immunology. 62:235-48.
- 2013
  
  Cyclosporine induces endothelial cell release of complement-activating microparticles. Journal of the American Society of Nephrology : JASN. 24:1849-62.
- 2013
  
  Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. Journal of immunology (Baltimore, Md. : 1950). 190:3560-9.
- 2013
  
  Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O). Journal of immunology (Baltimore, Md. : 1950). 190:6457-67.
- 2012
  
  The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. Journal of immunology (Baltimore, Md. : 1950). 188:661-7.
- 2011
  
  Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney international. 80:165-73.
- 2011
  
  Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infection and immunity. 79:724-31.
- 2011
  
  Trypanosoma cruzi calreticulin: a novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity. Immunobiology. 216:265-73.
- 2010
  
  An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. Journal of immunology (Baltimore, Md. : 1950). 185:507-16.
- 2010
  
  Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin. Molecular immunology. 47:1516-21.
- 2010
  
  Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology. 215:932-40.
- 2010
  
  The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. Journal of immunology (Baltimore, Md. : 1950). 185:3086-94.
- 2009
  
  Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. The Journal of biological chemistry. 284:16939-47.
- 2009
  
  Polyanion-induced self-association of complement factor H. Journal of immunology (Baltimore, Md. : 1950). 182:1061-8.
- 2009
  
  The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. Journal of immunology (Baltimore, Md. : 1950). 182:7009-18.
- 2008
  
  Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. The Journal of biological chemistry. 283:9475-87.
- 2007
  
  Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes. Blood. 110:2190-2.
- 2007
  
  Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. The Journal of biological chemistry. 282:18960-8.
- 2006
  
  Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. Journal of immunology (Baltimore, Md. : 1950). 177:6308-16.
- 2005
  
  An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis. Molecular and biochemical parasitology. 140:133-40.
- 2005
  
  F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement. Biological research. 38:187-95.
- 2004
  
  The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi. Journal of immunology (Baltimore, Md. : 1950). 172:3042-50.
- 2003
  
  An anti-human recombinant tumor necrosis factor alpha (TNF alpha) monoclonal antibody recognizes an epitope in feline TNF alpha. Veterinary research. 34:177-84.
- 2001
  
  Daily production of human tumor necrosis factor in lipopolysaccharide (LPS)-stimulated ex vivo blood culture assays. European cytokine network. 12:105-10.
- 1999
  
  Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice. Vaccine. 18:89-99.
- 1996
  
  Immunomodulation of LPS ability to induce the local Shwartzman reaction. Scandinavian journal of immunology. 44:551-5.
Article (Web of Science)
- 2021
  
  Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. CANCER IMMUNOLOGY RESEARCH. 9:790-810.
  Full Text via DOI: 10.1158/2326-6066.cir-20-0922
- 2020
  
  The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa. FRONTIERS IN IMMUNOLOGY. 11.
  Full Text via DOI: 10.3389/fimmu.2020.572562 PMID: 33240263
- 2020
  
  Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H. FRONTIERS IN IMMUNOLOGY. 11.
  Full Text via DOI: 10.3389/fimmu.2020.01728 PMID: 32849614
- 2020
  
  Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. FRONTIERS IN IMMUNOLOGY. 11.
  Full Text via DOI: 10.3389/fimmu.2020.01460 PMID: 32793201
- 2020
  
  Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 202:230-240.
  Full Text via DOI: 10.1164/rccm.201910-2083oc
- 2018
  
  Properdin: A multifaceted molecule involved in inflammation and diseases. MOLECULAR IMMUNOLOGY. 102:58-72.
  Full Text via DOI: 10.1016/j.molimm.2018.05.018
- 2017
  
  Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. FRONTIERS IN IMMUNOLOGY. 8.
  Full Text via DOI: 10.3389/fimmu.2017.01586
- 2016
  
  Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. JOURNAL OF IMMUNOLOGY. 196:4671-4680.
  Full Text via DOI: 10.4049/jimmunol.1600040
- 2016
  
  SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. SCIENTIFIC REPORTS. 6:19300.
  Full Text via DOI: 10.1038/srep19300
- 2014
  
  New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. MOLECULAR IMMUNOLOGY. 62:235-248.
  Full Text via DOI: 10.1016/j.molimm.2014.06.028
- 2014
  
  Delineating the Importance of Serum Opsonins and the Bacterial Capsule in Affecting the Uptake and Killing of Burkholderia pseudomallei by Murine Neutrophils and Macrophages. PLOS NEGLECTED TROPICAL DISEASES. 8.
  Full Text via DOI: 10.1371/journal.pntd.0002988
- 2014
  
  Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:5301-5306.
  Full Text via DOI: 10.1073/pnas.1401011111
- 2013
  
  Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 24:1849-1862.
  Full Text via DOI: 10.1681/ASN.2012111064
- 2013
  
  Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C-3(H2O). JOURNAL OF IMMUNOLOGY. 190:6457-6467.
  Full Text via DOI: 10.4049/jimmunol.1300610
- 2013
  
  Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex-Induced Arthritis. JOURNAL OF IMMUNOLOGY. 190:3560-3569.
  Full Text via DOI: 10.4049/jimmunol.1203271
- 2013
  
  Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 24:1849-1862.
  Full Text via DOI: 10.1681/asn.2012111064
- 2012
  
  The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation. JOURNAL OF IMMUNOLOGY. 188:661-667.
  Full Text via DOI: 10.4049/jimmunol.1101813
- 2011
  
  Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. KIDNEY INTERNATIONAL. 80:166-174.
  Full Text via DOI: 10.1038/ki.2011.115
- 2011
  
  Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation. INFECTION AND IMMUNITY. 79:724-731.
  Full Text via DOI: 10.1128/IAI.00980-10
- 2011
  
  Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity. IMMUNOBIOLOGY. 216:265-273.
  Full Text via DOI: 10.1016/j.imbio.2010.04.001
- 2011
  
  Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation. INFECTION AND IMMUNITY. 79:724-731.
  Full Text via DOI: 10.1128/iai.00980-10
- 2010
  
  Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. IMMUNOBIOLOGY. 215:932-940.
  Full Text via DOI: 10.1016/j.imbio.2010.02.002
- 2010
  
  The Complement Inhibitors Crry and Factor H Are Critical for Preventing Autologous Complement Activation on Renal Tubular Epithelial Cells. JOURNAL OF IMMUNOLOGY. 185:3086-3094.
  Full Text via DOI: 10.4049/jimmunol.1000111
- 2010
  
  Complement control protein factor H: The good, the bad, and the inadequate. MOLECULAR IMMUNOLOGY. 47:2187-2197.
  Full Text via DOI: 10.1016/j.molimm.2010.05.007
- 2010
  
  An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae. JOURNAL OF IMMUNOLOGY. 185:507-516.
  Full Text via DOI: 10.4049/jimmunol.0903598
- 2010
  
  Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin. MOLECULAR IMMUNOLOGY. 47:1516-1521.
  Full Text via DOI: 10.1016/j.molimm.2010.01.019
- 2009
  
  Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:16939-16947.
  Full Text via DOI: 10.1074/jbc.m808166200
- 2009
  
  Polyanion-Induced Self-Association of Complement Factor H. JOURNAL OF IMMUNOLOGY. 182:1061-1068.
  Full Text via DOI: 10.4049/jimmunol.182.2.1061
- 2009
  
  The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome. JOURNAL OF IMMUNOLOGY. 182:7009-7018.
  Full Text via DOI: 10.4049/jimmunol.0804031
- 2008
  
  Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:9475-9487.
  Full Text via DOI: 10.1074/jbc.m709587200
- 2007
  
  Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes. BLOOD. 110:2190-2192.
  Full Text via DOI: 10.1182/blood-2007-04-083170
- 2007
  
  Structure Shows That a Glycosaminoglycan and Protein Recognition Site in Factor H Is Perturbed by Age-related Macular Degeneration-linked Single Nucleotide Polymorphism. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:18960-18968.
  Full Text via DOI: 10.1074/jbc.m609636200
- 2006
  
  Critical Role of the C-Terminal Domains of Factor H in Regulating Complement Activation at Cell Surfaces. JOURNAL OF IMMUNOLOGY. 177:6308-6316.
  Full Text via DOI: 10.4049/jimmunol.177.9.6308
- 2005
  
  An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis. MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 140:133-140.
  Full Text via DOI: 10.1016/j.molbiopara.2004.12.014
- 2005
  
  Does Trypanosoma cruzi calreticulin modulate the complement system and angiogenesis?. TRENDS IN PARASITOLOGY. 21:169-174.
  Full Text via DOI: 10.1016/j.pt.2005.02.005
- 2004
  
  The Classical Activation Pathway of the Human Complement System Is Specifically Inhibited by Calreticulin fromTrypanosoma cruzi. JOURNAL OF IMMUNOLOGY. 172:3042-3050.
  Full Text via DOI: 10.4049/jimmunol.172.5.3042
- 2003
  
  An anti-human recombinant tumor necrosis factor alpha (TNF?) monoclonal antibody recognizes an epitope in feline TNF?. Veterinary Research. 34:177-184.
  Full Text via DOI: 10.1051/vetres:2002064
- 2000
  
  Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress. JOURNAL OF IMMUNOLOGY. 164:4292-4300.
  Full Text via DOI: 10.4049/jimmunol.164.8.4292
- 2000
  
  Defective p56Lck activity in T cells from an adult patient with idiopathic CD4+ lymphocytopenia. International Immunology. 12:449-457.
  Full Text via DOI: 10.1093/intimm/12.4.449
- 1999
  
  Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice. VACCINE. 18:89-99.
  Full Text via DOI: 10.1016/s0264-410x(99)00184-x
- 1996
  
  Immunomodulation of LPS Ability to Induce the Local Shwartzman Reaction. Scandinavian Journal of Immunology. 44:551-555.
  Full Text via DOI: 10.1046/j.1365-3083.1996.d01-345.x
Book Chapter (Web of Science)
- 2010
  
  A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration. Advances in Experimental Medicine and Biology. 137-149.
  Full Text via DOI: 10.1007/978-1-4419-5635-4_10
Chapter (Faculty180)
- 2022
  
  The role of Factor H and properdin in disease. Advances in Immunology. 1-90.
- 2021
  
  The Complement System. Reference Module in Biomedical Sciences. Encyclopedia of Infection and Immunity..
- 2018
  
  Properdin. The Complement Facts Book. Elsevier Editorial. 283-293.
- 2005
  
  "Sistema del Complemento" (The Complement System). Immunologia Basica y Clinica. Mediterraneo Editorial. 130-150.
Meeting Abstract (Web of Science)
- 2018
  
  Characterization of binding properties of individual functional sites of complement factor H. MOLECULAR IMMUNOLOGY. 148-148.
  Full Text via DOI: 10.1016/j.molimm.2018.06.062
- 2018
  
  Novel assay measuring properdin function gives insights into functional differences between sera- and neutrophil-derived properdin. MOLECULAR IMMUNOLOGY. 148-148.
  Full Text via DOI: 10.1016/j.molimm.2018.06.063
- 2018
  
  Properdin is a key player in lysis of red blood cells in aHUS and PNH. MOLECULAR IMMUNOLOGY. 139-140.
  Full Text via DOI: 10.1016/j.molimm.2018.06.043
- 2016
  
  Role of factor H and effects of C-terminal mutations on control of human platelet/granulocyte aggregate formation. EUROPEAN JOURNAL OF IMMUNOLOGY. 366-367.
- 2014
  
  Critical role of alternative pathway complement regulatory proteins properdin and factor H in platelet/leukocyte aggregate formation. MOLECULAR IMMUNOLOGY. 241-241.
- 2014
  
  Evaluation of the role of regulatory proteins factor H and properdin in regulating alternative pathway activation on Trypanosoma cruzi. MOLECULAR IMMUNOLOGY. 270-271.
- 2014
  
  Essential regulatory role for factor H and properdin in the formation of platelet/granulocyte aggregates in human whole blood. JOURNAL OF IMMUNOLOGY.
- 2014
  
  Factor H binds to Trypanosoma cruzi trypomastigotes via its C-terminus and contributes to parasite resistance against the alternative pathway of complement. JOURNAL OF IMMUNOLOGY.
- 2013
  
  Surface plasmon resonance indicates that complement factor H, C3b and native properdin bind to carboxyethylpyrrole-adducted BSA. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.
- 2013
  
  Complement regulatory protein properdin promotes complement activation on platelets and increases platelet-leukocyte aggregate formation. JOURNAL OF IMMUNOLOGY.
- 2012
  
  Endothelial cells injured by the thrombotic microangiopathy-inducing drug cyclosporin release complement-activating microparticles. IMMUNOBIOLOGY. 1167-1167.
  Full Text via DOI: 10.1016/j.imbio.2012.08.110
- 2012
  
  Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. IMMUNOBIOLOGY. 1168-1168.
  Full Text via DOI: 10.1016/j.imbio.2012.08.113
- 2012
  
  Identification of a novel mode of complement activation on stimulated platelets mediated by properdin. IMMUNOBIOLOGY. 1175-1176.
  Full Text via DOI: 10.1016/j.imbio.2012.08.135
- 2012
  
  LJM19, a salivary protein from the sand fly vector that transmits leishmaniasis, is a novel inhibitor of the classical pathway of complement. IMMUNOBIOLOGY. 1182-1182.
  Full Text via DOI: 10.1016/j.imbio.2012.08.153
- 2012
  
  Properdin binding to the surface of leptospira promotes complement activation and controls proliferation of non-pathogenic bacteria in vitro. IMMUNOBIOLOGY. 1195-1195.
  Full Text via DOI: 10.1016/j.imbio.2012.08.190
- 2012
  
  Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis.. ARTHRITIS AND RHEUMATISM. S458-S458.
- 2010
  
  Complement activation on Chlamydia pneumoniae is promoted by direct binding of native properdin to its surface. MOLECULAR IMMUNOLOGY. 2240-2240.
  Full Text via DOI: 10.1016/j.molimm.2010.05.132
- 2010
  
  Trypanosoma cruzi calreticulin, a virulence factor that binds C1/C1q on the parasite surface. MOLECULAR IMMUNOLOGY. 2246-2247.
  Full Text via DOI: 10.1016/j.molimm.2010.05.150
- 2010
  
  Complement activation on Chlamydia pneumoniae is accelerated by direct binding of native properdin to its surface. JOURNAL OF IMMUNOLOGY.
- 2009
  
  Factor H controls spontaneous complement activation on mouse endothelial cells. MOLECULAR IMMUNOLOGY. 2851.
  Full Text via DOI: 10.1016/j.molimm.2009.05.277
- 2009
  
  Factor H plays an essential role in the control of airway hyperresponsiveness and eosinophilic pulmonary inflammation in experimental asthma. MOLECULAR IMMUNOLOGY. 2826.
  Full Text via DOI: 10.1016/j.molimm.2009.05.208
- 2008
  
  A novel concept for the treatment of paroxysmal nocturnal haemoglobinuria (PNH): Complement depletion with a human C3 derivative with cobra venom factor-like activity prevents lysis of PNH erythrocytes. MOLECULAR IMMUNOLOGY. 4177.
  Full Text via DOI: 10.1016/j.molimm.2008.08.245
- 2008
  
  Analysis of the complement functions of human properdin requires separation of native polymeric forms from non-physiological aggregates. MOLECULAR IMMUNOLOGY. 4103.
  Full Text via DOI: 10.1016/j.molimm.2008.08.025
- 2008
  
  Expression of the protein Annexin A2 in the kidney after ischaemia/reperfusion enhances binding of factor H and inhibition of the alternative complement pathway. MOLECULAR IMMUNOLOGY. 4111.
  Full Text via DOI: 10.1016/j.molimm.2008.08.049
- 2008
  
  The binding of factor H to a complex of the physiological polyanion and C3b on the cell surface is disrupted in atypical haemolytic uraemic syndrome. MOLECULAR IMMUNOLOGY. 4099.
  Full Text via DOI: 10.1016/j.molimm.2008.08.014
- 2007
  
  Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. MOLECULAR IMMUNOLOGY. 169.
  Full Text via DOI: 10.1016/j.molimm.2006.07.055
- 2007
  
  Structure of the complement regulatory N-terminal region of factor H: Implications for disease. MOLECULAR IMMUNOLOGY. 3929.
  Full Text via DOI: 10.1016/j.molimm.2007.06.052
- 2007
  
  Unravelling the complexities of factor H action on self-surfaces. MOLECULAR IMMUNOLOGY. 3987-3988.
  Full Text via DOI: 10.1016/j.molimm.2007.06.204
Other Scholarly Work (Faculty180)
- 2022
  
  Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement.. American Association of Immunology meeting 2022.
- 2018
  
  Characterization of binding properties of individual functional sites of complement factor H.. Published abstract in "Molecular Immunology".
- 2018
  
  Novel assay measuring properdin function gives insights into functional differences between sera- and neutrophil-derived properdin.. Published abstract in "Molecular Immunology".
- 2018
  
  Properdin is a key player in lysis of red blood cells in aHUS and PNH.. Published abstract in "Molecular Immunology".
- 2017
  
  Inhibition of properdin is more effective than other inhibitors of the complement system at preventing cell lysis in an in vitro model of atypical hemolytic uremic syndrome.. Published abstract in "The Journal of Immunology".
- 2016
  
  Role of factor H and effects of C-terminal mutations on control of human platelet/granulocyte aggregate formation.. Published abstract in "European Journal of Immunology".
- 2014
  
  Essential regulatory role for factor H and properdin in the formation of platelet/leukocyte aggregates in human whole blood.. Published abstract in "The Journal of Immunology".
- 2014
  
  Essential regulatory roles for properdin and factor H in platelet-leukocyte aggregate formation.. Published abstract in "Molecular Immunology".
- 2014
  
  Evaluation of the role of regulatory proteins factor H and properdin in regulating alternative pathway activation on Trypanosoma cruzi.. Published abstract in "Molecular Immunology".
- 2014
  
  Factor H binds to Trypanosoma cruzi trypomastigotes via its C-terminus and contributes to parasite resistance against the alternative pathway of complement.. Published abstract in "The Journal of Immunology".
- 2013
  
  Complement regulatory protein properdin promotes complement activation on platelets and increases platelet-leukocyte aggregate formation.. Published abstract in "The Journal of Immunology".
- 2012
  
  Endothelial cells injured by the thrombotic microangiopathy-inducing drug cyclosporin release complement-activating microparticles.. Published abstract in "Immunobiology".
- 2012
  
  Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.. Published abstract in "Immunobiology".
- 2012
  
  Identification of a novel mode of complement activation on stimulated platelets mediated by properdin.. Published abstract in "Immunobiology".
- 2012
  
  LJM19, a salivary protein from the sand fly vector that transmits leishmaniasis, is a novel inhibitor of the classical pathway of complement.. Published abstract in "Immunobiology".
- 2012
  
  Properdin binding to the surface of leptospira promotes complement activation and controls proliferation of non-pathogenic bacteria in vitro.. Published abstract in "Immunobiology".
- 2010
  
  Complement activation on Chlamydia pneumoniae is promoted by direct binding of native properdin to its surface.. Published abstract in "Molecular Immunology".
- 2010
  
  Trypanosoma cruzi calreticulin, a virulence factor that binds C1/C1q on the parasite surface.. Published abstract in "Molecular Immunology".
- 2009
  
  Factor H plays an essential role in the control of airway hyperresponsiveness and eosinophilic pulmonary inflammation in experimental asthma.. Published abstract in "Molecular Immunology".
- 2008
  
  A novel concept for the treatment of PNH: Complement depletion with a human C3 derivative with cobra venom factor-like activity prevents lysis of PNH erythrocytes.. Published abstract in "Molecular Immunology".
- 2008
  
  Analysis of the complement functions of human properdin requires separation of native polymeric forms from non-physiological aggregates.. Published abstract in "Molecular Immunology".
- 2008
  
  Expression of the protein annexin A2 in the kidney after ischemia/reperfusion enhances binding of factor H and inhibition of the alternative complement pathway.. Published abstract in "Molecular Immunology".
- 2008
  
  Factor H controls spontaneous complement activation on mouse endothelial cells.. Published abstract in "Molecular Immunology".
- 2008
  
  Relative contribution of membrane-bound complement regulatory proteins CD55, CD59, CD46, and soluble factor H to resistance of human B lymphoma cells to complement.. Published abstract in "The FASEB Journal".
- 2008
  
  The binding of factor H to a complex of the physiological polyanion and C3b on the cell surface is disrupted in atypical haemolytic uraemic syndrome.. Published abstract in "Molecular Immunolgy".
- 2007
  
  Cell surface complement regulatory functions of factor H are essential for the survival of normal and paroxysmal nocturnal hemoglobinuric (PNH) red blood cells.. Published abstract in "The Journal of Immunology".
- 2007
  
  Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.. Published abstract in "Molecular Immunology".
- 2007
  
  Polyanion-induced self-association of complement factor H: Possible mechanism of host protection from an innate immune system.. Published abstract in "The Journal of Immunology".
- 2007
  
  Structure of the complement regulatory N-terminal region of factor H: Implications for disease.. Published abstract in "Molecular Immunology".
- 2007
  
  Unravelling the complexities of factor H action on self-surfaces.. Published abstract in "Molecular Immunology".
- 2006
  
  A combinatorial use of binding sites allows factor H to distinguish host from target.. Published abstract in "Molecular Immunology".
- 2003
  
  Purification, by immunoaffinity, of native calreticulin de Trypanosoma cruzi.. Published abstract in "Biological Research".
- 2003
  
  The S domain of Trypanosoma cruzi calreticulin binds the collagenous portion of C1q and inhibits human complement. Published abstract in "Biological research".
- 2003
  
  Trypanosoma cruzi calreticulin: modulation by F(ab’)2 fragments, of its capacity to inhibit the human complement system.. Published abstract in "Biological Research".
Review (Faculty180)
- 2020
  
  Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis. 368-381.
- 2018
  
  Properdin: A multifaceted molecule involved in inflammation and diseases. 58-72.
- 2016
  
  Properdin: a tightly regulated critical inflammatory modulator. 172-190.
- 2013
  
  Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement. 412.
- 2011
  
  Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay. 115-22.
- 2010
  
  A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. 137-49.
- 2010
  
  Complement control protein factor H: the good, the bad, and the inadequate. 2187-97.
- 2008
  
  Discrimination between host and pathogens by the complement system. I15-21.
- 2005
  
  Does Trypanosoma cruzi calreticulin modulate the complement system and angiogenesis?. 169-74.
- 2004
  
  Role of calreticulin from parasites in its interaction with vertebrate hosts. 1279-91.
- 2002
  
  Parasite calreticulin: possible roles in the parasite / host interface.. 156-168.
Review Article (Web of Science)
- 2021
  
  Hijacking Factor H for Complement Immune Evasion. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2021.602277 PMID: 33717083
- 2020
  
  The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2020.01561 PMID: 32793217
- 2020
  
  Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis. TRENDS IN PARASITOLOGY. 368-381.
  Full Text via DOI: 10.1016/j.pt.2020.01.007 PMID: 32191851
- 2016
  
  Properdin: a tightly regulated critical inflammatory modulator. IMMUNOLOGICAL REVIEWS. 172-190.
  Full Text via DOI: 10.1111/imr.12466
- 2013
  
  Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2012.00412
- 2011
  
  Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay. TRENDS IN PARASITOLOGY. 115-122.
  Full Text via DOI: 10.1016/j.pt.2010.12.007
- 2008
  
  Discrimination between host and pathogens by the complement system. VACCINE. I15-I21.
  Full Text via DOI: 10.1016/j.vaccine.2008.11.023
- 2004
  
  Role of calreticulin from parasites in its interaction with vertebrate hosts. MOLECULAR IMMUNOLOGY. 1279-1291.
  Full Text via DOI: 10.1016/j.molimm.2003.11.018

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Viviana P Ferreira

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