Viviana P Ferreira
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Associate Professor
Associate Professor, Medical Microbiology and Immunology , College of Medicine and Life Sciences
Contact Info
Overview
overview
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I am a tenured Associate Professor at UTCOMLS, where I hold dual appointments in the Departments of Medical Education and Medical Microbiology and Immunology. I joined UTCOMLS in 2009 and was promoted to tenured Associate Professor in 2015 within the Academic Basic Scientist Track. Recognizing my evolving professional interests and accomplishments, in late 2022, I requested a dual appointment in the Department of Medical Education and recently formally changed to the Basic Science Educator Track. My research laboratory focuses on understanding the regulation of the complement system and innate immune system. My research and educational work have resulted in 63 peer-reviewed publications, including four book chapters, 26 of which are since promotion to Associate Professor, overall contributing to approximately $3.4 million in basic research funding, with $1.6 million secured post-promotion. I currently collaborate with colleagues in both education and basic science research endeavors. In addition to research, I direct and teach within several critical courses, including the Immunology and the Infectious Diseases systems for first-year medical students, the Advanced Immunology course for graduate students, and serve as clerkship director for a Veterinary Medicine elective for fourth-year students. I have received awards in recognition of my teaching efforts. I have strived to make significant contributions to the academic community through additional leadership roles. I serve as Editor-in-Chief of Immunobiology and Associate Editor of the Journal of Immunology. I am also the Past-Treasurer of the International Complement Society and an active member of the American Association of Immunology Education Committee. At UTCOMLS, I carry out a variety of institutional service, chairing the Assessment Committee for UTCOMLS and serving on various other committees, including those focused on diversity and inclusion, curriculum development, research development, and student ethics. Some of my past roles include serving as a standing member of the NIH Innate Immunity and Inflammation study section, Vice Chair and Chair of the IACUC, Chair of the organizing committee for WISDOM (Women in STEM Day of Meetings) events on the UT Health Science Campus, and member of the American Association of Immunologists Program Committee.
Publications
selected publications
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Article (Faculty180)
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2024In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection. The Journal of infectious diseases. 230:209-220.
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2024Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement. Frontiers in immunology. 15:1152000.
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2023Factor H preserves alternative complement function during ARDS, linked to improved survival. ERJ open research. 9.
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2023In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection. bioRxiv : the preprint server for biology.
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2022
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2020Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. American journal of respiratory and critical care medicine. 202:230-240.
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2020The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa. Frontiers in immunology. 11:572562.
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2017Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. Frontiers in immunology. 8:1586.
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2014New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Molecular immunology. 62:235-48.
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2013Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. Journal of immunology (Baltimore, Md. : 1950). 190:3560-9.
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2011Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney international. 80:165-73.
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2010An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. Journal of immunology (Baltimore, Md. : 1950). 185:507-16.
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2010Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin. Molecular immunology. 47:1516-21.
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2009Polyanion-induced self-association of complement factor H. Journal of immunology (Baltimore, Md. : 1950). 182:1061-8.
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2009The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. Journal of immunology (Baltimore, Md. : 1950). 182:7009-18.
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2008Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. The Journal of biological chemistry. 283:9475-87.
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2007Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. The Journal of biological chemistry. 282:18960-8.
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2004The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi. Journal of immunology (Baltimore, Md. : 1950). 172:3042-50.
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1996Immunomodulation of LPS ability to induce the local Shwartzman reaction. Scandinavian journal of immunology. 44:551-5.
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Article (Web of Science)
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2021Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. CANCER IMMUNOLOGY RESEARCH. 9:790-810.Full Text via DOI: 10.1158/2326-6066.cir-20-0922
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2020The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa. FRONTIERS IN IMMUNOLOGY. 11.Full Text via DOI: 10.3389/fimmu.2020.572562 PMID: 33240263
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2020Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H. FRONTIERS IN IMMUNOLOGY. 11.Full Text via DOI: 10.3389/fimmu.2020.01728 PMID: 32849614
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2020Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. FRONTIERS IN IMMUNOLOGY. 11.Full Text via DOI: 10.3389/fimmu.2020.01460 PMID: 32793201
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2020Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 202:230-240.Full Text via DOI: 10.1164/rccm.201910-2083oc
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2018Properdin: A multifaceted molecule involved in inflammation and diseases. MOLECULAR IMMUNOLOGY. 102:58-72.Full Text via DOI: 10.1016/j.molimm.2018.05.018
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2017Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. FRONTIERS IN IMMUNOLOGY. 8.Full Text via DOI: 10.3389/fimmu.2017.01586
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2016Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. JOURNAL OF IMMUNOLOGY. 196:4671-4680.Full Text via DOI: 10.4049/jimmunol.1600040
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2016SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. SCIENTIFIC REPORTS. 6:19300.Full Text via DOI: 10.1038/srep19300
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2014New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. MOLECULAR IMMUNOLOGY. 62:235-248.Full Text via DOI: 10.1016/j.molimm.2014.06.028
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2014Delineating the Importance of Serum Opsonins and the Bacterial Capsule in Affecting the Uptake and Killing of Burkholderia pseudomallei by Murine Neutrophils and Macrophages. PLOS NEGLECTED TROPICAL DISEASES. 8.Full Text via DOI: 10.1371/journal.pntd.0002988
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2014Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:5301-5306.Full Text via DOI: 10.1073/pnas.1401011111
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2013Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 24:1849-1862.Full Text via DOI: 10.1681/ASN.2012111064
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2013Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C-3(H2O). JOURNAL OF IMMUNOLOGY. 190:6457-6467.Full Text via DOI: 10.4049/jimmunol.1300610
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2013Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex-Induced Arthritis. JOURNAL OF IMMUNOLOGY. 190:3560-3569.Full Text via DOI: 10.4049/jimmunol.1203271
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2013Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 24:1849-1862.Full Text via DOI: 10.1681/asn.2012111064
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2012The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation. JOURNAL OF IMMUNOLOGY. 188:661-667.Full Text via DOI: 10.4049/jimmunol.1101813
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2011Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. KIDNEY INTERNATIONAL. 80:166-174.Full Text via DOI: 10.1038/ki.2011.115
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2011Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation. INFECTION AND IMMUNITY. 79:724-731.Full Text via DOI: 10.1128/IAI.00980-10
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2011Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity. IMMUNOBIOLOGY. 216:265-273.Full Text via DOI: 10.1016/j.imbio.2010.04.001
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2011Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation. INFECTION AND IMMUNITY. 79:724-731.Full Text via DOI: 10.1128/iai.00980-10
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2010Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. IMMUNOBIOLOGY. 215:932-940.Full Text via DOI: 10.1016/j.imbio.2010.02.002
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2010The Complement Inhibitors Crry and Factor H Are Critical for Preventing Autologous Complement Activation on Renal Tubular Epithelial Cells. JOURNAL OF IMMUNOLOGY. 185:3086-3094.Full Text via DOI: 10.4049/jimmunol.1000111
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2010Complement control protein factor H: The good, the bad, and the inadequate. MOLECULAR IMMUNOLOGY. 47:2187-2197.Full Text via DOI: 10.1016/j.molimm.2010.05.007
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2010An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae. JOURNAL OF IMMUNOLOGY. 185:507-516.Full Text via DOI: 10.4049/jimmunol.0903598
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2010Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin. MOLECULAR IMMUNOLOGY. 47:1516-1521.Full Text via DOI: 10.1016/j.molimm.2010.01.019
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2009Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:16939-16947.Full Text via DOI: 10.1074/jbc.m808166200
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2009Polyanion-Induced Self-Association of Complement Factor H. JOURNAL OF IMMUNOLOGY. 182:1061-1068.Full Text via DOI: 10.4049/jimmunol.182.2.1061
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2009The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome. JOURNAL OF IMMUNOLOGY. 182:7009-7018.Full Text via DOI: 10.4049/jimmunol.0804031
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2008Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:9475-9487.Full Text via DOI: 10.1074/jbc.m709587200
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2007Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes. BLOOD. 110:2190-2192.Full Text via DOI: 10.1182/blood-2007-04-083170
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2007Structure Shows That a Glycosaminoglycan and Protein Recognition Site in Factor H Is Perturbed by Age-related Macular Degeneration-linked Single Nucleotide Polymorphism. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:18960-18968.Full Text via DOI: 10.1074/jbc.m609636200
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2006Critical Role of the C-Terminal Domains of Factor H in Regulating Complement Activation at Cell Surfaces. JOURNAL OF IMMUNOLOGY. 177:6308-6316.Full Text via DOI: 10.4049/jimmunol.177.9.6308
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2005An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis. MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 140:133-140.Full Text via DOI: 10.1016/j.molbiopara.2004.12.014
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2005Does Trypanosoma cruzi calreticulin modulate the complement system and angiogenesis?. TRENDS IN PARASITOLOGY. 21:169-174.Full Text via DOI: 10.1016/j.pt.2005.02.005
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2004The Classical Activation Pathway of the Human Complement System Is Specifically Inhibited by Calreticulin fromTrypanosoma cruzi. JOURNAL OF IMMUNOLOGY. 172:3042-3050.Full Text via DOI: 10.4049/jimmunol.172.5.3042
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2003An anti-human recombinant tumor necrosis factor alpha (TNF?) monoclonal antibody recognizes an epitope in feline TNF?. Veterinary Research. 34:177-184.Full Text via DOI: 10.1051/vetres:2002064
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2000Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress. JOURNAL OF IMMUNOLOGY. 164:4292-4300.Full Text via DOI: 10.4049/jimmunol.164.8.4292
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2000Defective p56Lck activity in T cells from an adult patient with idiopathic CD4+ lymphocytopenia. International Immunology. 12:449-457.Full Text via DOI: 10.1093/intimm/12.4.449
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1999Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice. VACCINE. 18:89-99.Full Text via DOI: 10.1016/s0264-410x(99)00184-x
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1996Immunomodulation of LPS Ability to Induce the Local Shwartzman Reaction. Scandinavian Journal of Immunology. 44:551-555.Full Text via DOI: 10.1046/j.1365-3083.1996.d01-345.x
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Book Chapter (Web of Science)
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2010A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration. Advances in Experimental Medicine and Biology. 137-149.Full Text via DOI: 10.1007/978-1-4419-5635-4_10
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Chapter (Faculty180)
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2022The Complement System. Reference Module in Biomedical Sciences. Encyclopedia of Infection and Immunity.. Elsevier. 144-169.
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2022The role of properdin and Factor H in disease. Advances in Immunology. Elsevier. 1-90.
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2018Properdin. The Complement Facts Book. Elsevier Editorial. 283-293.
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2005"Sistema del Complemento" (The Complement System). Immunologia Basica y Clinica. Mediterraneo Editorial. 130-150.
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Meeting Abstract (Web of Science)
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2018Characterization of binding properties of individual functional sites of complement factor H. MOLECULAR IMMUNOLOGY. 148-148.Full Text via DOI: 10.1016/j.molimm.2018.06.062
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2018Novel assay measuring properdin function gives insights into functional differences between sera- and neutrophil-derived properdin. MOLECULAR IMMUNOLOGY. 148-148.Full Text via DOI: 10.1016/j.molimm.2018.06.063
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2018Properdin is a key player in lysis of red blood cells in aHUS and PNH. MOLECULAR IMMUNOLOGY. 139-140.Full Text via DOI: 10.1016/j.molimm.2018.06.043
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2016Role of factor H and effects of C-terminal mutations on control of human platelet/granulocyte aggregate formation. EUROPEAN JOURNAL OF IMMUNOLOGY. 366-367.
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2014
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2014
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2013Surface plasmon resonance indicates that complement factor H, C3b and native properdin bind to carboxyethylpyrrole-adducted BSA. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.
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2012Endothelial cells injured by the thrombotic microangiopathy-inducing drug cyclosporin release complement-activating microparticles. IMMUNOBIOLOGY. 1167-1167.Full Text via DOI: 10.1016/j.imbio.2012.08.110
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2012Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. IMMUNOBIOLOGY. 1168-1168.Full Text via DOI: 10.1016/j.imbio.2012.08.113
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2012Identification of a novel mode of complement activation on stimulated platelets mediated by properdin. IMMUNOBIOLOGY. 1175-1176.Full Text via DOI: 10.1016/j.imbio.2012.08.135
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2012LJM19, a salivary protein from the sand fly vector that transmits leishmaniasis, is a novel inhibitor of the classical pathway of complement. IMMUNOBIOLOGY. 1182-1182.Full Text via DOI: 10.1016/j.imbio.2012.08.153
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2012Properdin binding to the surface of leptospira promotes complement activation and controls proliferation of non-pathogenic bacteria in vitro. IMMUNOBIOLOGY. 1195-1195.Full Text via DOI: 10.1016/j.imbio.2012.08.190
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2012Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis.. ARTHRITIS AND RHEUMATISM. S458-S458.
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2010Complement activation on Chlamydia pneumoniae is promoted by direct binding of native properdin to its surface. MOLECULAR IMMUNOLOGY. 2240-2240.Full Text via DOI: 10.1016/j.molimm.2010.05.132
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2010Trypanosoma cruzi calreticulin, a virulence factor that binds C1/C1q on the parasite surface. MOLECULAR IMMUNOLOGY. 2246-2247.Full Text via DOI: 10.1016/j.molimm.2010.05.150
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2010
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2009Factor H controls spontaneous complement activation on mouse endothelial cells. MOLECULAR IMMUNOLOGY. 2851.Full Text via DOI: 10.1016/j.molimm.2009.05.277
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2009Factor H plays an essential role in the control of airway hyperresponsiveness and eosinophilic pulmonary inflammation in experimental asthma. MOLECULAR IMMUNOLOGY. 2826.Full Text via DOI: 10.1016/j.molimm.2009.05.208
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2008Analysis of the complement functions of human properdin requires separation of native polymeric forms from non-physiological aggregates. MOLECULAR IMMUNOLOGY. 4103.Full Text via DOI: 10.1016/j.molimm.2008.08.025
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2008Expression of the protein Annexin A2 in the kidney after ischaemia/reperfusion enhances binding of factor H and inhibition of the alternative complement pathway. MOLECULAR IMMUNOLOGY. 4111.Full Text via DOI: 10.1016/j.molimm.2008.08.049
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2008The binding of factor H to a complex of the physiological polyanion and C3b on the cell surface is disrupted in atypical haemolytic uraemic syndrome. MOLECULAR IMMUNOLOGY. 4099.Full Text via DOI: 10.1016/j.molimm.2008.08.014
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2007Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. MOLECULAR IMMUNOLOGY. 169.Full Text via DOI: 10.1016/j.molimm.2006.07.055
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2007Structure of the complement regulatory N-terminal region of factor H: Implications for disease. MOLECULAR IMMUNOLOGY. 3929.Full Text via DOI: 10.1016/j.molimm.2007.06.052
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2007Unravelling the complexities of factor H action on self-surfaces. MOLECULAR IMMUNOLOGY. 3987-3988.Full Text via DOI: 10.1016/j.molimm.2007.06.204
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Review (Faculty180)
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Review Article (Web of Science)
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2021Hijacking Factor H for Complement Immune Evasion. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2021.602277 PMID: 33717083
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2020The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2020.01561 PMID: 32793217
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2020Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis. TRENDS IN PARASITOLOGY. 368-381.Full Text via DOI: 10.1016/j.pt.2020.01.007 PMID: 32191851
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2016Properdin: a tightly regulated critical inflammatory modulator. IMMUNOLOGICAL REVIEWS. 172-190.Full Text via DOI: 10.1111/imr.12466
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2013Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2012.00412
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2011Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay. TRENDS IN PARASITOLOGY. 115-122.Full Text via DOI: 10.1016/j.pt.2010.12.007
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2008Discrimination between host and pathogens by the complement system. VACCINE. I15-I21.Full Text via DOI: 10.1016/j.vaccine.2008.11.023
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2004Role of calreticulin from parasites in its interaction with vertebrate hosts. MOLECULAR IMMUNOLOGY. 1279-1291.Full Text via DOI: 10.1016/j.molimm.2003.11.018
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Contact
full name
- Viviana P Ferreira