Trumbly, Robert

Robert Trumbly
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Positions

Director of Block 1/Med. Curriculum, Medical Education , College of Medicine and Life Sciences

Contact Info

Robert.Trumbly@utoledo.edu

http://www.utoledo.edu/med/depts/cancer-biology/faculty/trumbly.html

selected publications

Article (Faculty180)
- 2020
  
  Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation. Epigenetics & chromatin. 13:14.
- 2019
  
  Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells. PloS one. 14:e0204387.
- 2016
  
  Correction: RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. Oncotarget. 7:26925.
- 2015
  
  Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells. Biochemical and biophysical research communications. 457:404-11.
- 2015
  
  RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. PloS one. 10:e0134494.
- 2015
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. Oncotarget. 6:39050-61.
- 2014
  
  Genetic and epigenetic control of RKIP transcription. Critical reviews in oncogenesis. 19:417-30.
- 2013
  
  The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells. The Journal of biological chemistry. 288:11047-65.
- 2011
  
  During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein. Breast cancer research : BCR. 13:R18.
- 2011
  
  Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements. Molecular endocrinology (Baltimore, Md.). 25:621-34.
- 2010
  
  C/EBPalpha redirects androgen receptor signaling through a unique bimodal interaction. Oncogene. 29:723-38.
- 2010
  
  RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS letters. 584:662-8.
- 2006
  
  In vitro characterization of the Mig1 repressor from Saccharomyces cerevisiae reveals evidence for monomeric and higher molecular weight forms. Yeast (Chichester, England). 23:1151-66.
- 2002
  
  Functional dissection of the global repressor Tup1 in yeast: dominant role of the C-terminal repression domain. Genetics. 161:957-69.
- 2002
  
  Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo. Molecular and cellular biology. 22:693-703.
- 2002
  
  Mutations of the WD repeats that compromise Tup1 repression function maintain structural integrity of the WD domain trypsin-resistant core. Archives of biochemistry and biophysics. 406:47-54.
- 2000
  
  Sds22p is a subunit of a stable isolatable form of protein phosphatase 1 (Glc7p) from Saccharomyces cerevisiae. Archives of biochemistry and biophysics. 376:288-98.
- 1998
  
  Multiple regulatory proteins mediate repression and activation by interaction with the yeast Mig1 binding site. Yeast (Chichester, England). 14:985-1000.
- 1998
  
  Purification and characterization of type 1 protein phosphatase from Saccharomyces cerevisiae: effect of the R73C mutation. Archives of biochemistry and biophysics. 357:58-66.
- 1996
  
  The Cyc8 (Ssn6)-Tup1 corepressor complex is composed of one Cyc8 and four Tup1 subunits. Molecular and cellular biology. 16:6707-14.
- 1994
  
  Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae. Biochimica et biophysica acta. 1193:107-17.
- 1993
  
  On the regulation of Na+/H+ and K+/H+ antiport in yeast mitochondria: evidence for the absence of an Na(+)-selective Na+/H+ antiporter. Biochimica et biophysica acta. 1144:367-73.
- 1992
  
  Glucose repression in the yeast Saccharomyces cerevisiae. Molecular microbiology. 6:15-21.
- 1991
  
  Identification of a glycogen synthase phosphatase from yeast Saccharomyces cerevisiae as protein phosphatase 2A. The Journal of biological chemistry. 266:10925-32.
- 1991
  
  The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Molecular and cellular biology. 11:3307-16.
- 1991
  
  The yeast GLC7 gene required for glycogen accumulation encodes a type 1 protein phosphatase. The Journal of biological chemistry. 266:23796-801.
- 1990
  
  Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae. Molecular and cellular biology. 10:6500-11.
- 1990
  
  Purification and characterization of glycogen synthase from a glycogen-deficient strain of Saccharomyces cerevisiae. The Journal of biological chemistry. 265:13871-7.
- 1988
  
  Cloning and characterization of the CYC8 gene mediating glucose repression in yeast. Gene. 73:97-111.
- 1987
  
  Endo-beta-N-acetylglucosaminidase H from Streptomyces plicatus. Methods in enzymology. 138:763-70.
- 1986
  
  Isolation of Saccharomyces cerevisiae mutants constitutive for invertase synthesis. Journal of bacteriology. 166:1123-7.
- 1985
  
  Amplified expression of streptomyces endo-beta-N-acetylglucosaminidase H in Escherichia coli and characterization of the enzyme product. The Journal of biological chemistry. 260:5683-90.
- 1985
  
  Comparative properties of amplified external and internal invertase from the yeast SUC2 gene. The Journal of biological chemistry. 260:13334-41.
- 1983
  
  Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae. Journal of bacteriology. 156:36-48.
- 1983
  
  Stage-specific protein synthesis during early embryogenesis in Drosophila melanogaster. The EMBO journal. 2:1281-90.
Article (Web of Science)
- 2015
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. ONCOTARGET. 6:39050-39061.
- 2015
  
  RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. PLOS ONE. 10.
  Full Text via DOI: 10.1371/journal.pone.0134494
- 2013
  
  The ETS Domain Transcription Factor ELK1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:11047-11065.
  Full Text via DOI: 10.1074/jbc.M112.438473
- 2010
  
  RKIP inhibits NF-kappa B in cancer cells by regulating upstream signaling components of the I kappa B kinase complex. FEBS LETTERS. 584:662-668.
  Full Text via DOI: 10.1016/j.febslet.2009.12.051
Chapter (Faculty180)
- 2020
  
  RKIP Regulation and Crosstalks Regulation of RKIP Expression in Breast Cancer Cells by miRNA. Prognostic and Therapeutic Applications of RKIP in Cancer. Academic Press. 139-146.
Correction (Web of Science)
- 2016
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration (vol 6, pg 39050, 2015). ONCOTARGET. 26925-26925.
  Full Text via DOI: 10.18632/oncotarget.9139
Meeting Abstract (Web of Science)
- 2014
  
  Role of gene repression by estrogen in invasiveness of breast cancer cells. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2014-2111
- 2013
  
  RAR alpha 1 as a novel drug target to improve conventional hormonal adjuvant therapy of breast cancer. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2013-4757

full name

Robert Trumbly

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