During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein Article (Faculty180)

cited authors

  • Salazar, Marcela D; Ratnam, Maya; Patki, Mugdha; Kisovic, Ivana; Trumbly, Robert; Iman, Mohamed; Ratnam, Manohar


  • Current hormonal adjuvant therapies for breast cancer including tamoxifen treatment and estrogen depletion are overall tumoristatic and are severely limited by the frequent recurrence of the tumors. Regardless of the resistance mechanism, development and progression of the resistant tumors requires the persistence of a basal level of cycling cells during the treatment for which the underlying causes are unclear.


publication date

  • 2011

published in

start page

  • R18


  • 13