Raman, Dayanidhi

Dayanidhi Raman
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Positions

Biochemistry and Cancer Biology , College of Medicine and Life Sciences

Contact Info

Dayanidhi.Raman@utoledo.edu

http://www.utoledo.edu/med/depts/cancer-biology/faculty/Raman.html

selected publications

Article (Faculty180)
- 2023
  
  Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer reports (Hoboken, N.J.). e1779.
- 2022
  
  Editorial: Drug resistance in breast cancer - mechanisms and approaches to overcome chemoresistance. Frontiers in oncology. 12:1080684.
- 2021
  
  A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. Molecules (Basel, Switzerland). 26.
- 2021
  
  A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells. Cancers. 13.
- 2020
  
  CCR5 and responses to cocaine: Addiction is not just about the brain. Brain Behavior and Immunity. 84:8-9.
- 2020
  
  CCR5 and responses to cocaine: Addiction is not just about the brain. Brain, behavior, and immunity. 84:8-9.
- 2020
  
  Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes. Frontiers in oncology. 10:299.
- 2020
  
  Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells. Cancers. 12.
- 2020
  
  Role of eIF4A1 in triple-negative breast cancer stem-like cell-mediated drug resistance. Cancer reports (Hoboken, N.J.). e1299.
- 2020
  
  Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer. Cancers. 12.
- 2020
  
  The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer. Cancers. 12.
- 2019
  
  Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells. Cancers. 11.
- 2019
  
  Novel and Alternative Targets Against Breast Cancer Stemness to Combat Chemoresistance. Frontiers in oncology. 9:1003.
- 2019
  
  Novel and Alternative Targets against Breast Cancer Stemness to Combat Chemoresistance. Frontiers in Oncology.
- 2019
  
  Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness. Frontiers in oncology. 9:1311.
- 2019
  
  The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells. Frontiers in Oncology. 9:284.
- 2018
  
  New frontiers for the cytoskeletal protein LASP1. Frontiers in Oncology. 8.
- 2017
  
  MDM2 Antagonists Counteract Drug-Induced DNA Damage. EBioMedicine. 24:43.
- 2016
  
  Connecting the dots: therapy-induced senescence and a tumor-suppressive immune microenvironment. JNCI: Journal of the National Cancer Institute. 108.
- 2016
  
  LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene. 35:1122.
- 2014
  
  Adaptor Protein2 (AP2) Orchestrates CXCR2-Mediated Cell Migration. Traffic. 15:451.
- 2011
  
  Chemokines in health and disease. Experimental Cell Research. 317:575.
- 2011
  
  Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1$alpha$, suppress amyloid $beta$-induced neurotoxicity. Toxicology and Applied Pharmacology. 256:300.
- 2010
  
  LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. PLoS One. 5:e10050.
- 2009
  
  VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. Journal of cell science. 122:1882.
- 2008
  
  Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. Journal of Biological Chemistry. 283:26538.
- 2007
  
  Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. Journal of molecular biology. 368:375.
- 2007
  
  Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer research. 67:4244.
- 2007
  
  Regulation of arrestin binding by rhodopsin phosphorylation level. Journal of Biological Chemistry. 282:32075.
- 2007
  
  Role of chemokines in tumor growth. Cancer letters. 256:137.
- 2006
  
  Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells. Cancer research. 66:5665.
- 2006
  
  Visual and both non-visual arrestins in their “inactive” conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm. Journal of Biological Chemistry. 281:21491.
- 2005
  
  Crystal structure of cone arrestin at 2.3 AA: evolution of receptor specificity. Journal of molecular biology. 354:1069.
- 2003
  
  The interaction with the cytoplasmic loops of rhodopsin plays a crucial role in arrestin activation and binding. Journal of neurochemistry. 84:1040.
- 1999
  
  Binding of arrestin to cytoplasmic loop mutants of bovine rhodopsin. Biochemistry. 38:5117.
- 1998
  
  Rhodopsin arginine-135 mutants are phosphorylated by rhodopsin kinase and bind arrestin in the absence of 11-cis-retinal. Biochemistry. 37:4869.
- 1998
  
  The cloning of GRK7, a candidate cone opsin kinase, from cone-and rod-dominant mammalian retinas. Mol Vis. 4:865.
- 1993
  
  Detergent solubilization of the EGF receptor from A431 cells. Transactions of the Kansas Academy of Science. Kansas Academy of Science. 96:28-34.
Article (Web of Science)
- 2022
  
  IND-2, a Quinoline Derivative, Inhibits the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress, Apoptosis and Inhibiting Topoisomerase II. LIFE-BASEL. 12.
  Full Text via DOI: 10.3390/life12111879 PMID: 36431014
- 2021
  
  A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. MOLECULES. 26.
  Full Text via DOI: 10.3390/molecules26144214 PMID: 34299490
- 2021
  
  A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells. CANCERS. 13.
  Full Text via DOI: 10.3390/cancers13081954 PMID: 33919653
- 2020
  
  Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer. CANCERS. 12.
  Full Text via DOI: 10.3390/cancers12092372 PMID: 32825729
- 2020
  
  The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer. CANCERS. 12.
  Full Text via DOI: 10.3390/cancers12092455 PMID: 32872485
- 2020
  
  Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells. CANCERS. 12.
  Full Text via DOI: 10.3390/cancers12082169 PMID: 32759815
- 2019
  
  Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness. FRONTIERS IN ONCOLOGY. 9.
  Full Text via DOI: 10.3389/fonc.2019.01311 PMID: 31867270
- 2019
  
  Novel Thienopyrimidine Derivative, RP-010, Induces beta-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells. CANCERS. 11.
  Full Text via DOI: 10.3390/cancers11050711 PMID: 31126091
- 2019
  
  The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells. FRONTIERS IN ONCOLOGY. 9.
  Full Text via DOI: 10.3389/fonc.2019.00284 PMID: 31106142
- 2017
  
  MDM2 Antagonists Counteract Drug-Induced DNA Damage. EBIOMEDICINE. 24:43-55.
  Full Text via DOI: 10.1016/j.ebiom.2017.09.016
- 2016
  
  Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 108.
  Full Text via DOI: 10.1093/jnci/djv406
- 2016
  
  LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. ONCOGENE. 35:1122-1133.
  Full Text via DOI: 10.1038/onc.2015.166
- 2014
  
  Adaptor Protein2 (AP2) Orchestrates CXCR2-Mediated Cell Migration. Traffic. 15:451-469.
  Full Text via DOI: 10.1111/tra.12154
- 2011
  
  Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY. 256:300-313.
  Full Text via DOI: 10.1016/j.taap.2011.06.006
- 2010
  
  LIM and SH3 Protein -1 Modulates CXCR2-Mediated Cell Migration. PLOS ONE. 5:e10050.
  Full Text via DOI: 10.1371/journal.pone.0010050
- 2009
  
  VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. JOURNAL OF CELL SCIENCE. 122:1882-1894.
  Full Text via DOI: 10.1242/jcs.039057
- 2008
  
  Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:26538-26547.
  Full Text via DOI: 10.1074/jbc.m805611200
- 2007
  
  Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity. JOURNAL OF MOLECULAR BIOLOGY. 368:375-387.
  Full Text via DOI: 10.1016/j.jmb.2007.02.053
- 2007
  
  Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium. CANCER RESEARCH. 67:4244-4253.
  Full Text via DOI: 10.1158/0008-5472.can-06-3946
- 2007
  
  Regulation of Arrestin Binding by Rhodopsin Phosphorylation Level. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:32075-32083.
  Full Text via DOI: 10.1074/jbc.m706057200
- 2006
  
  Deletion of the COOH-Terminal Domain of CXC Chemokine Receptor 4 Leads to the Down-regulation of Cell-to-Cell Contact, Enhanced Motility and Proliferation in Breast Carcinoma Cells. CANCER RESEARCH. 66:5665-5675.
  Full Text via DOI: 10.1158/0008-5472.can-05-3579
- 2006
  
  Visual and Both Non-visual Arrestins in Their “Inactive” Conformation Bind JNK3 and Mdm2 and Relocalize Them from the Nucleus to the Cytoplasm. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:21491-21499.
  Full Text via DOI: 10.1074/jbc.m603659200
Book (Faculty180)
- 2021
  
  Chemokine Receptors. Encyclopedia of Biological Chemistry 3rd ed. Pandey S, editor, Elsevier Inc.,.
- 2020
  
  CXCR4 Signaling and its Impact on Tumor Progression and Metastasis in Breast Cancer. Recent Advances in Signal Transduction and Therapy, Manoj. K. Pandey, editor, Bentham Science Publishers.
- 2013
  
  Chemokine Receptors
- 2009
  
  Characterization of chemokine receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 “chemosynapse”
- 2000
  
  Heterologous expression and reconstitution of rhodopsin with rhodopsin kinase and arrestin. Methods in Enzymology.
Book Chapter (Web of Science)
- 2021
  
  Alternative approaches to overcome chemoresistance to apoptosis in cancer. APOPTOSIS IN HEALTH AND DISEASE, PT B. 91-122.
  Full Text via DOI: 10.1016/bs.apcsb.2021.01.005 PMID: 34090621
- 2009
  
  Chapter 15 Characterization of Chemokine Receptor CXCR2 Interacting Proteins Using a Proteomics Approach to Define the CXCR2 “Chemosynapse”. 315-330.
  Full Text via DOI: 10.1016/s0076-6879(09)05215-x
Chapter (Faculty180)
- 2021
  
  Alternative Approaches to Overcome Chemoresistance to Apoptosis in Cancer. Advances in Protein Chemistry & Structural Biology. Advances in Protein Chemistry and Structural Biology, Donev R, editor, Elsevier, Inc.,. 1-32.
Early Access (Web of Science)
- 2023
  
  Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. CANCER REPORTS.
  Full Text via DOI: 10.1002/cnr2.1779 PMID: 36632988
- 2020
  
  Role of eIF4A1 in triple-negative breast cancer stem-likecell-mediateddrug resistance. CANCER REPORTS.
  Full Text via DOI: 10.1002/cnr2.1299 PMID: 33053607
Editorial Material (Web of Science)
- 2023
  
  Editorial: Drug resistance in breast cancer – mechanisms and approaches to overcome chemoresistance. FRONTIERS IN ONCOLOGY.
  Full Text via DOI: 10.3389/fonc.2022.1080684
- 2020
  
  Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes. FRONTIERS IN ONCOLOGY.
  Full Text via DOI: 10.3389/fonc.2020.00299 PMID: 32211328
- 2020
  
  CCR5 and responses to cocaine: Addiction is not just about the brain. BRAIN BEHAVIOR AND IMMUNITY. 8-9.
  Full Text via DOI: 10.1016/j.bbi.2019.12.008 PMID: 31843646
Meeting Abstract (Web of Science)
- 2023
  
  Abstract 2846: The mitochondrial dynamics of breast cancer regulate P-glycoprotein expression. Cancer Research. 2846-2846.
  Full Text via DOI: 10.1158/1538-7445.am2023-2846
- 2023
  
  Abstract 4479: Targeting of eIF4A1 curtails lung metastases in triple-negative breast cancer. Cancer Research. 4479-4479.
  Full Text via DOI: 10.1158/1538-7445.am2023-4479
- 2023
  
  Abstract P1-13-12: Targeting Dynamin-related protein 1 for the management of taxane-resistant triple-negative breast cancer. Cancer Research. P1-13-12-P1-13-12.
  Full Text via DOI: 10.1158/1538-7445.sabcs22-p1-13-12
- 2023
  
  Abstract P4-08-03: Operation of eIF4A1-PD-L1 axis in therapy-naïve and drug-resistant TNBC. Cancer Research. P4-08-03-P4-08-03.
  Full Text via DOI: 10.1158/1538-7445.sabcs22-p4-08-03
- 2023
  
  Abstract PD2-08: Targeting of eIF4A1 along with anti-PD-L1 therapy limits lung metastases efficaciously in triple-negative breast cancer. Cancer Research. PD2-08-PD2-08.
  Full Text via DOI: 10.1158/1538-7445.sabcs22-pd2-08
- 2020
  
  Abstract 4959: Targeting of the eukaryotic translation initiation factor 4A against breast cancer stemness
  Full Text via DOI: 10.1158/1538-7445.am2020-4959
- 2017
  
  Abstract 513: The link between polyploidy and replication stress in melanoma
  Full Text via DOI: 10.1158/1538-7445.am2017-513
- 2012
  
  Abstract P1-05-01: Chemokine-mediated nuclear translocation and novel nuclear role for LIM and SH3 Protein-1(LASP-1) in breast cancer
  Full Text via DOI: 10.1158/0008-5472.sabcs12-p1-05-01
Presentation (Faculty180)
- 2022
  
  Development of novel unconventional cell death inducers against triple negative breast cancer
- 2022
  
  Targeting mitochondrial dynamics for the management of multidrug resistant cancer
Review Article (Web of Science)
- 2023
  
  Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints. CANCERS.
  Full Text via DOI: 10.3390/cancers15102774 PMID: 37345111
- 2022
  
  LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator. CELLS.
  Full Text via DOI: 10.3390/cells11233817 PMID: 36497077
- 2019
  
  Novel and Alternative Targets Against Breast Cancer Stemness to Combat Chemoresistance. FRONTIERS IN ONCOLOGY.
  Full Text via DOI: 10.3389/fonc.2019.01003 PMID: 31681564
- 2018
  
  New Frontiers for the Cytoskeletal Protein LASP1. FRONTIERS IN ONCOLOGY.
  Full Text via DOI: 10.3389/fonc.2018.00391
- 2011
  
  Chemokines in health and disease. EXPERIMENTAL CELL RESEARCH. 575-589.
  Full Text via DOI: 10.1016/j.yexcr.2011.01.005
- 2007
  
  Role of chemokines in tumor growth. CANCER LETTERS. 137-165.
  Full Text via DOI: 10.1016/j.canlet.2007.05.013

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Dayanidhi Raman

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Cumulative publications in Scholars@UToledo

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