David Giovannucci
- Professor, Neurosciences , College of Medicine and Life Sciences
Contact Info
Publications
selected publications
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Article (Faculty180)
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2019CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats. Biochemical and Biophysical Research Communications.
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Article (Web of Science)
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2021Selection and characterization of structure-switching DNA aptamers for the salivary peptide histatin 3. JOURNAL OF BIOTECHNOLOGY. 327:9-17.Full Text via DOI: 10.1016/j.jbiotec.2020.12.018 PMID: 33387594
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2020Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos. JOURNAL OF NEUROCHEMISTRY. 598.Full Text via DOI: 10.1111/jnc.14986 PMID: 32058590
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2019CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 513:760-765.Full Text via DOI: 10.1016/j.bbrc.2019.03.215 PMID: 30992131
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2019Role of NAADP for calcium signaling in the salivary gland. CELL CALCIUM. 80:29-37.Full Text via DOI: 10.1016/j.ceca.2019.03.001 PMID: 30947088
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2018Arachidonic acid-induced Ca2+ entry and migration in a neuroendocrine cancer cell line. CANCER CELL INTERNATIONAL. 18.Full Text via DOI: 10.1186/s12935-018-0529-8
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2017Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules. JOURNAL OF GENERAL PHYSIOLOGY. 149:763-780.Full Text via DOI: 10.1085/jgp.201711757
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2017Salivary protein changes in response to acute stress in medical residents performing advanced clinical simulations: a pilot proteomics study. BIOMARKERS. 22:372-382.Full Text via DOI: 10.1080/1354750X.2017.1279215
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2017Salivary protein changes in response to acute stress in medical residents performing advanced clinical simulations: a pilot proteomics study. BIOMARKERS. 22:372-382.Full Text via DOI: 10.1080/1354750x.2017.1279215
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2016cAMP-dependent recruitment of acidic organelles for Ca2+ signaling in the salivary gland. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 311:C697-C709.Full Text via DOI: 10.1152/ajpcell.00010.2016
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2016Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.Full Text via DOI: 10.1074/jbc.M115.681833
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2016Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigenrelated Cell Adhesion Molecule 2 (CEACAM2). JOURNAL OF BIOLOGICAL CHEMISTRY. 291:980-988.Full Text via DOI: 10.1074/jbc.M115.692582
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2016Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). JOURNAL OF BIOLOGICAL CHEMISTRY. 291:980-988.Full Text via DOI: 10.1074/jbc.m115.692582
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2016Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:4503-4522.Full Text via DOI: 10.1074/jbc.m115.681833
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2015Crosstalk between purinergic receptors and canonical signaling pathways in the mouse salivary gland. CELL CALCIUM. 58:589-597.Full Text via DOI: 10.1016/j.ceca.2015.09.006
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2015Gastro-Enteropancreatic Neuroendocrine Tumor Cell Dynamics in Liver Microvasculature. MICROSCOPY AND MICROANALYSIS. 21:655-665.Full Text via DOI: 10.1017/S1431927615000392
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2015Gastro-Enteropancreatic Neuroendocrine Tumor Cell Dynamics in Liver Microvasculature. MICROSCOPY AND MICROANALYSIS. 21:655-665.Full Text via DOI: 10.1017/s1431927615000392
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2013Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 304:H427-H435.Full Text via DOI: 10.1152/ajpheart.00462.2012
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2012Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium signals in mouse parotid acinar cells. JOURNAL OF PHYSIOLOGY-LONDON. 590:2721-2737.Full Text via DOI: 10.1113/jphysiol.2012.228148
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2012Human Heat Shock Protein 105/110 kDa (Hsp105/110) Regulates Biogenesis and Quality Control of Misfolded Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Levels. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:19158-19170.Full Text via DOI: 10.1074/jbc.M111.297580
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2012Human Heat Shock Protein 105/110 kDa (Hsp105/110) Regulates Biogenesis and Quality Control of Misfolded Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Levels. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:19158-19170.Full Text via DOI: 10.1074/jbc.m111.297580
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2011FKBP38 Peptidylprolyl Isomerase Promotes the Folding of Cystic Fibrosis Transmembrane Conductance Regulator in the Endoplasmic Reticulum. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:43071-43080.Full Text via DOI: 10.1074/jbc.M111.269993
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2011FKBP38 Peptidylprolyl Isomerase Promotes the Folding of Cystic Fibrosis Transmembrane Conductance Regulator in the Endoplasmic Reticulum. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:43071-43080.Full Text via DOI: 10.1074/jbc.m111.269993
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2010Defining a rat blood pressure quantitative trait locus to a < 81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis. PHYSIOLOGICAL GENOMICS. 42A:153-161.Full Text via DOI: 10.1152/physiolgenomics.00122.2010
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2009The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 296:F922-F934.Full Text via DOI: 10.1152/ajprenal.90605.2008
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2008Chronic Benzodiazepine Administration Potentiates High Voltage-Activated Calcium Currents in Hippocampal CA1 Neurons. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 327:872-883.Full Text via DOI: 10.1124/jpet.108.144444
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2008Visualizing form and function in organotypic slices of the adult mouse parotid gland. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 295:G629-G640.Full Text via DOI: 10.1152/ajpgi.90217.2008
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2008Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia. JOURNAL OF COMPARATIVE NEUROLOGY. 508:867-878.Full Text via DOI: 10.1002/ene.21719
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2008Regulation of inositol 1,4,5-trisphosphate receptor-mediated calcium release by the Na/K-ATPase in cultured renal epithelial cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:1128-1136.Full Text via DOI: 10.1074/jbc.M708025200
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2008Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia. JOURNAL OF COMPARATIVE NEUROLOGY. 508:867-878.Full Text via DOI: 10.1002/cne.21719
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2008Regulation of Inositol 1,4,5-Trisphosphate Receptor-mediated Calcium Release by the Na/K-ATPase in Cultured Renal Epithelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:1128-1136.Full Text via DOI: 10.1074/jbc.m708025200
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2007Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system. Developmental Dynamics. 236:93-105.Full Text via DOI: 10.1002/dvdy.20989
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2005Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells. JOURNAL OF CELL SCIENCE. 118:5615-5623.Full Text via DOI: 10.1242/jcs.02663
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2005Na/K-ATPase Tethers Phospholipase C and IP3 Receptor into a Calcium-regulatory Complex. MOLECULAR BIOLOGY OF THE CELL. 16:4034-4045.Full Text via DOI: 10.1091/mbc.e05-04-0295
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2005Spatiotemporal analysis of exocytosis in mouse parotid acinar cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 289:C1209-C1219.Full Text via DOI: 10.1152/ajpcell.00159.2005
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2004Ca2+and frequency dependence of exocytosis in isolated somata of magnocellular supraoptic neurones of the rat hypothalamus. JOURNAL OF PHYSIOLOGY-LONDON. 555:699-711.Full Text via DOI: 10.1113/jphysiol.2003.051136
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2004Modulation of [Ca2+] Signaling Dynamics and Metabolism by Perinuclear Mitochondria in Mouse Parotid Acinar Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:12909-12917.Full Text via DOI: 10.1074/jbc.m309070200
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2003A Model of Calcium Waves in Pancreatic and Parotid Acinar Cells. BIOPHYSICAL JOURNAL. 85:1392-1405.Full Text via DOI: 10.1016/s0006-3495(03)74572-x
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2002A Role for Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Defining Calcium Signals Induced by Peptide Agonists in Pancreatic Acinar Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:31949-31956.Full Text via DOI: 10.1074/jbc.m204318200
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2002Cytosolic Ca2+and Ca2+‐activated Cl−current dynamics: insights from two functionally distinct mouse exocrine cells. JOURNAL OF PHYSIOLOGY-LONDON. 540:469-484.Full Text via DOI: 10.1113/jphysiol.2001.013453
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2002Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors in Parotid Acinar Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:1340-1348.Full Text via DOI: 10.1074/jbc.m106609200
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2001Identification of a Ryanodine Receptor in Rat Heart Mitochondria. JOURNAL OF BIOLOGICAL CHEMISTRY. 276:21482-21488.Full Text via DOI: 10.1074/jbc.m101486200
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2000Calcium Wave Propagation in Pancreatic Acinar Cells. JOURNAL OF GENERAL PHYSIOLOGY. 116:547-560.Full Text via DOI: 10.1085/jgp.116.4.547
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2000Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells. Journal of Korean Medical Science. 15:S55.Full Text via DOI: 10.3346/jkms.2000.15.s.s55
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2000Targeted Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors Selectively Inhibits Localized Ca2+ Release and Shapes Oscillatory Ca2+ Signals. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:33704-33711.Full Text via DOI: 10.1074/jbc.m004278200
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1999Identification and distribution of dietary precursors of the Drosophila visual pigment chromophore: analysis of carotenoids in wild type and ninaD mutants by HPLC. Vision Research. 39:219-229.Full Text via DOI: 10.1016/s0042-6989(98)00184-9
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1999Regulation of Exocytosis by Cyclin-dependent Kinase 5 via Phosphorylation of Munc18. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:4027-4035.Full Text via DOI: 10.1074/jbc.274.7.4027
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1998Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 275:C732-C739.Full Text via DOI: 10.1152/ajpcell.1998.275.3.c732
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1997Regulation of secretory granule recruitment and exocytosis at rat neurohypophysial nerve endings.. JOURNAL OF PHYSIOLOGY-LONDON. 498:735-751.Full Text via DOI: 10.1113/jphysiol.1997.sp021898
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1995Glutamate Receptor Agonists Modulate [Ca2+]i in Isolated Rat Melanotropes. NEUROENDOCRINOLOGY. 62:111-122.Full Text via DOI: 10.1159/000126995
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Meeting Abstract (Web of Science)
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2019Synaptotagmin-7 Endows a Subpopulation of Chromaffin Granules with Distinct Calcium Sensing and Fusion Properties. BIOPHYSICAL JOURNAL. 525A-526A.
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2019Synaptotagmin-7 Endows a Subpopulation of Chromaffin Granules with Distinct Calcium Sensing and Fusion Properties. BIOPHYSICAL JOURNAL. 525a-526a.Full Text via DOI: 10.1016/j.bpj.2018.11.2832
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2018Gabaergic Innervation of the Salivary Gland. BIOPHYSICAL JOURNAL. 156A-156A.
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2018Role of NAADP for Calcium Signaling in the Salivary Gland. BIOPHYSICAL JOURNAL. 468A-468A.
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2017
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2017Chromaffin Cell Synaptotagmin Isoforms form Functionally and Spatially Separable Granule Pools. BIOPHYSICAL JOURNAL. 473A-473A.
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2017Chromaffin Cell Synaptotagmin Isoforms form Functionally and Spatially Separable Granule Pools. BIOPHYSICAL JOURNAL. 473a.Full Text via DOI: 10.1016/j.bpj.2016.11.2538
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2016
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2016Chromaffin cell synaptotagmin isoforms belong to spatially and functionally vesicle granule pools. MOLECULAR BIOLOGY OF THE CELL.
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2015Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104A-104A.
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2015Synaptotagmin-1 and Synaptotagmin-7 Differ in their Stimulus and Ca2+-Dependence of Activation. BIOPHYSICAL JOURNAL. 103A-103A.
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2015Acidic Calcium Stores Contribute to Secretory Activity Following Elevation of Camp in the Salivary Gland. BIOPHYSICAL JOURNAL. 104a.Full Text via DOI: 10.1016/j.bpj.2014.11.594
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2015Synaptotagmin-1 and Synaptotagmin-7 Differ in their Stimulus and Ca2+-Dependence of Activation. BIOPHYSICAL JOURNAL. 103a.Full Text via DOI: 10.1016/j.bpj.2014.11.586
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2014Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530A-530A.
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2014The Contribution of Store Operated and Store Independent Calcium Entry to Migration in a Model of Neuroendocrine Cancer. BIOPHYSICAL JOURNAL. 762A-762A.
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2014Calcium Release from Acidic Stores Modulate Fluid and Protein Secretion in the Salivary Gland. BIOPHYSICAL JOURNAL. 530a.Full Text via DOI: 10.1016/j.bpj.2013.11.2958
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2014The Contribution of Store Operated and Store Independent Calcium Entry to Migration in a Model of Neuroendocrine Cancer. BIOPHYSICAL JOURNAL. 762a.Full Text via DOI: 10.1016/j.bpj.2013.11.4193
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2013Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation.. ARTHRITIS AND RHEUMATISM. S286-S286.
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2011
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2010Development of an arganotypic System to Image Metastasis of Carcinoid Tumors in Situ. BIOPHYSICAL JOURNAL. 745A-745A.
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2010Development of an arganotypic System to Image Metastasis of Carcinoid Tumors in Situ. BIOPHYSICAL JOURNAL. 745a.Full Text via DOI: 10.1016/j.bpj.2009.12.4087
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2008ALLOPREGNANOLONE AND GABA EVOKE CALCIUM CURRENTS IN CORTICAL NEURONS. EPILEPSIA. 343-343.
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Note (Web of Science)
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1995An NMDA receptor on isolated secretory nerve endings. BRAIN RESEARCH. 246-250.Full Text via DOI: 10.1016/0006-8993(95)00567-1
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Contact
full name
- David Giovannucci
visualizations
Cumulative publications in Scholars@UToledo
research areas
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cardiovascular System & Cardiology
- Cell Biology
- Gastroenterology & Hepatology
- Immunology
- Life Sciences & Biomedicine - Other Topics
- Materials Science
- Microscopy
- Neurosciences & Neurology
- Oncology
- Pharmacology & Pharmacy
- Physiology
- Toxicology
- Urology & Nephrology
- Zoology