Charles K Thodeti
Contact Info
Publications
selected publications
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Article (Faculty180)
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202437th Annual Meeting of the Ohio Physiological Society: October 6-7, 2023, The University of Toledo, Toledo, Ohio. Advances in physiology education. 48:547-549.
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2024A TRP to Pathological Angiogenesis and Vascular Normalization. Comprehensive Physiology. 14:5389-5406.
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2023Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels. Journal of molecular and cellular cardiology plus. 6.
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2023Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload-Induced Hypertrophy. Hypertension (Dallas, Tex. : 1979). 80:2345-2356.
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2018AMP-activated kinase "Keaps" ischemia/reperfusion-induced necroptosis under control. International journal of cardiology. 259:168-169.
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2017Changing the Channels: Nature's Remote Controlling in Health and Disease. Circulation research. 120:599-601.
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2017Mechanosensitive transient receptor potential vanilloid 4 regulates -induced airway remodeling 2 distinct pathways modulating matrix synthesis and degradation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:1556-1570.
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20164-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling. Free radical biology & medicine. 101:10-19.
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2016
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2016Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction. Basic research in cardiology. 111:21.
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2016Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. The Journal of allergy and clinical immunology. 137:289-298.
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2016TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway. Oncotarget. 7:25849-61.
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2015A bouquet for a broken heart: can flowers repair a damaged heart?. Circulation research. 116:1729-31.
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2015Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions. Journal of cellular physiology. 230:595-602.
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2015TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation. Scientific reports. 5:14257.
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2014Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts. Canadian journal of physiology and pharmacology. 92:598-604.
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2014TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. The Journal of clinical investigation. 124:5225-38.
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20132.5D constructs for characterizing phase separated polymer blend surface morphology in tissue engineering scaffolds. Journal of biomedical materials research. Part A. 101:1502-10.
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2013A TRP to cardiac fibroblast differentiation. Channels (Austin, Tex.). 7:211-4.
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2013
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2013Injury models to study cardiac remodeling in the mouse: myocardial infarction and ischemia-reperfusion. Methods in molecular biology (Clifton, N.J.). 1037:325-42.
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2013TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. Journal of molecular and cellular cardiology. 54:45-52.
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2012Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction. Circulation research. 110:851-6.
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2012Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. American journal of physiology. Heart and circulatory physiology. 303:H216-23.
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2012Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways. American journal of physiology. Cell physiology. 303:C179-91.
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2011Endothelin-mediated in vivo pressor responses following TRPV1 activation. American journal of physiology. Heart and circulatory physiology. 301:H1135-42.
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2011PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells. American journal of physiology. Heart and circulatory physiology. 301:H757-65.
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2010Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integrative biology : quantitative biosciences from nano to macro. 2:435-42.
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2009Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. Journal of cellular biochemistry. 106:529-38.
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2009TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circulation research. 104:1123-30.
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2008Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22:1649-59.
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2008Investigating complexity of protein-protein interactions in focal adhesions. Biochemical and biophysical research communications. 369:929-34.
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2008Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proceedings of the National Academy of Sciences of the United States of America. 105:11305-10.
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2006Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. Journal of cellular biochemistry. 97:1175-83.
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2005ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. FEBS letters. 579:5589-95.
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2005Hierarchy of ADAM12 binding to integrins in tumor cells. Experimental cell research. 309:438-50.
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2004Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. The Journal of biological chemistry. 279:51601-11.
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2003ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. Journal of cell science. 116:3893-904.
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2003ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. The Journal of biological chemistry. 278:9576-84.
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2002Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. The Biochemical journal. 365:157-63.
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2002Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. Advances in experimental medicine and biology. 507:187-91.
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2001The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. Experimental cell research. 262:95-103.
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2000Differential formation of octadecadienoic acid and octadecatrienoic acid products in control and injured/infected potato tubers. Biochimica et biophysica acta. 1483:294-300.
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2000Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. The Journal of biological chemistry. 275:9849-53.
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2000Purification and characterization of rat testicular glutathione S-transferases: role in the synthesis of eicosanoids. Asian journal of andrology. 2:277-82.
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1998Pulmonary lipid peroxidation and antioxidant defenses during exhaustive physical exercise: the role of vitamin E and selenium. Nutrition (Burbank, Los Angeles County, Calif.). 14:448-51.
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1997Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise. Biochemistry and molecular biology international. 41:641-6.
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1995Induction of Ya1 subunit of rat hepatic glutathione S-transferases by exercise-induced oxidative stress. Archives of biochemistry and biophysics. 323:6-10.
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1992Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Molecular and cellular biochemistry. 111:109-15.
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1992Exercise-induced oxidant stress in the lung tissue: role of dietary supplementation of vitamin E and selenium. Biochemistry international. 26:863-71.
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Contact
full name
- Charles K Thodeti
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Cumulative publications in Scholars@UToledo