Bindu Menon
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Assistant Professor
Assistant Dean for Admissions, COMLS programs, Medical Education , College of Medicine and Life Sciences
Contact Info
Overview
overview
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After getting my Ph.D. in biochemistry, I spent the next one and a half decades on scholarly research. I worked in various prestigious institutions in India and the USA. For ten years (2008-2018), I worked as a research track faculty at the University of Michigan, Ann Arbor. My research interest was in the regulation of gonadotropin receptors. The work was highly productive resulting in several publications in high impact factor journals, review articles, and book chapters. The major breakthrough during this period was the discovery of a microRNA in the ovary, until then known to be expressed solely in liver, which functions as an intermediate in the regulation of a very crucial gonadotropin receptor and thereby plays a significant role in the female reproductive process. This microRNA, miR-122 is by now widely established to be involved in the regulation of cholesterol synthesis thereby making it a critical link between cholesterol metabolism and female reproduction.
While my research work was interesting, at one point I decided to give it a rest and chase my passion for teaching. I was provided with a valuable opportunity for that in my current position as an Assistant Professor at UT Medical School. I find my work as an instructor of Medical Education highly rewarding and personally motivating and empowering. I look forward to more fruitful years being a dedicated teacher, sincere career advisor, trusted student mentor, and endearing colleague.
Publications
selected publications
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Article (Faculty180)
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2022Assessing knowledge in medical school: Implementation of an item review committee to increase assessment item quality. Emergcing Dialogues {Association for the Assessment of Learning in Higher Education).
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2022Assessing knowledge in medical school: Implementation of an item review committee to increase assessment item quality. Emerging Dialogues (Association for the Assessment of Learning in Higher Education).
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2022The holy basil administration diminishes the NF-kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma. Phytotherapy research . 36:1822-1835.
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2021
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2021Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. Current hypertension reports. 23:28.
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2021Integration of E-learning into the Physiology Education of Medical Students in their Pre-clinical Curriculum: E-learning in Medical Physiology Education. Translation: The University of Toledo Journal of Medical Sciences. 9.
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2021
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2020Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model. Reproduction (Cambridge, England). 160:239-245.
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2019SREBP Plays a Regulatory Role in LH/hCG Receptor mRNA Expression in Human Granulosa-Lutein cells. The Journal of clinical endocrinology and metabolism.
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2018miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA. Endocrinology. 159:2075-2082.
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2017A novel method for immobilization of proteins via entrapment of magnetic nanoparticles through epoxy cross-linking. Analytical biochemistry. 519:42-50.
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2017
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2017Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary. Molecular and cellular endocrinology. 442:81-89.
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2016
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2015Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary. Molecular and cellular endocrinology. 413:90-5.
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2015miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries. Endocrinology. 156:3370-80.
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2014Eukaryotic initiation factor 5A plays an essential role in luteinizing hormone receptor regulation. Molecular endocrinology (Baltimore, Md.). 28:1796-806.
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2014Regulation of luteinizing hormone receptor expression by an RNA binding protein: role of ERK signaling. The Indian journal of medical research. 140 Suppl:S112-9.
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2013Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. Biochimica et biophysica acta. 1833:1173-9.
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2013Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway. Molecular and cellular endocrinology. 366:81-9.
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2012Structure, function and regulation of gonadotropin receptors - a perspective. Molecular and cellular endocrinology. 356:88-97.
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2011Luteinizing hormone receptor mRNA down-regulation is mediated through ERK-dependent induction of RNA binding protein. Molecular endocrinology (Baltimore, Md.). 25:282-90.
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2010Extracellular ubiquitin inhibits beta-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3beta and mitochondrial pathways. Cardiovascular research. 86:20-8.
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2010Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism. Molecular and cellular endocrinology. 329:26-32.
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2009Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation. Biochimica et biophysica acta. 1793:1787-94.
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2008Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats. Investigative ophthalmology & visual science. 49:1645-51.
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2008The extracellular domain of luteinizing hormone receptor dictates its efficiency of maturation. Biochemical and biophysical research communications. 377:307-11.
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2007Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. Journal of molecular and cellular cardiology. 42:653-61.
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2007Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs. American journal of physiology. Cell physiology. 292:C867-75.
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2006
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2006beta-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway. American journal of physiology. Cell physiology. 290:C254-61.
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2005Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. American journal of physiology. Cell physiology. 289:C168-76.
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Article (Web of Science)
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2022The holy basil administration diminishes the NF-kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma. PHYTOTHERAPY RESEARCH.Full Text via DOI: 10.1002/ptr.7428 PMID: 35233841
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2020Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model. REPRODUCTION. 160:239-245.Full Text via DOI: 10.1530/rep-20-0058
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2019SREBP Plays a Regulatory Role in LH/hCG Receptor mRNA Expression in Human Granulosa-Lutein Cells. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 104:4783-4792.Full Text via DOI: 10.1210/jc.2019-00913 PMID: 31150065
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2018miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA. Endocrinology. 159:2075-2082.Full Text via DOI: 10.1210/en.2017-03270
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2017A novel method for immobilization of proteins via entrapment of magnetic nanoparticles through epoxy cross-linking. ANALYTICAL BIOCHEMISTRY. 519:42-50.Full Text via DOI: 10.1016/j.ab.2016.12.007
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2017LHCGR Expression During Follicle Stimulating Hormone–Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A. ENDOCRINOLOGY. 158:2672-2679.Full Text via DOI: 10.1210/en.2017-00113
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2017Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 442:81-89.Full Text via DOI: 10.1016/j.mce.2016.12.002
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2016HCG-mediated activation of mTORC1 signaling plays a crucial role in steroidogenesis in human granulosa lutein cells. ENDOCRINE. 54:217-224.Full Text via DOI: 10.1007/s12020-016-1065-8
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2013Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1833:1173-1179.Full Text via DOI: 10.1016/j.bbamcr.2013.01.024
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2008Beneficial Effect of Zeaxanthin on Retinal Metabolic Abnormalities in Diabetic Rats. Investigative Opthalmology & Visual Science. 49:1645.Full Text via DOI: 10.1167/iovs.07-0764
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Book (Faculty180)
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Conference Poster (Faculty180)
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Lecture or Panel Discussion (Faculty180)
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20183rd International Workshop "Effects of Melatonin on the Female Reproductive System" . University of Sao Paulo.
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Presentation (Faculty180)
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Review Article (Web of Science)
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2021Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. CURRENT HYPERTENSION REPORTS.Full Text via DOI: 10.1007/s11906-021-01142-9 PMID: 33961141
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2018Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary: The Role of miR-122. 67-87.Full Text via DOI: 10.1016/bs.vh.2018.01.010
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2014Regulation of luteinizing hormone receptor expression by an RNA binding protein: role of ERK signaling.. The Indian journal of medical research. S112-9.PMID: 25673531
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Contact
full name
- Bindu Menon