JOURNAL OF MEDICINAL CHEMISTRY Journal
Overview
publication venue for
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Immunogenic Sulfated
l -Idose Homo Oligosaccharides Elicit Neutralizing Antibody against Native Heparan Sulfate with Biomarker and Therapeutic Possibilities 2024 - CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes. 67:16107-16127. 2024
- Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective. 66:16515-16545. 2023
- Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence 2022
- Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity 2022
- First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids 2022
- Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. 65:13681-13691. 2022
- Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis 2022
- A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-D-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials. 65:3706-3728. 2022
- Synthesis and Evaluation of PPAR delta Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis. 64:6996-7032. 2021
- Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. 63:12290-12358. 2020
- Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network. 63:8867-8875. 2020
- Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. 63:7243-7251. 2020
- Furoxans (Oxadiazole-4N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. 61:4593-4607. 2018
- Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. 59:10642-10660. 2016
- Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on Receptor Mediated Ca2+ Release. 58:3593-3610. 2015
- Synthesis and Biological Evaluation of Indolyl-Pyridinyl-Propenones Having Either Methuosis or Microtubule Disruption Activity. 58:2489-2512. 2015
- Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase. 58:778-784. 2015
- Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors. 56:6054-6068. 2013
- Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death. 55:1940-1956. 2012
- Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents. 55:3076-3087. 2012
- Hypoxia Activated Prodrugs of a 9-Aza-anthrapyrazole Derivative That Has Promising Anticancer Activity. 54:8224-8227. 2011
- Biomimetic Syntheses and Antiproliferative Activities of Racemic, Natural (-), and Unnnatural (+) Glyceollin I. 54:3506-3523. 2011
- Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates. 54:2293-2306. 2011
- Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation. 54:7453-7463. 2011
- Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Containing Substituted Nicotinic Acid: Effect of Modification on Ca2+ Release. 53:7599-7612. 2010
- Design and Synthesis of Novel Derivatives of the Muscarinic Agonist Tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-Methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] Ether (CDD-0304): Effects of Structural Modifications on the Binding and Activity at Muscarinic Receptor Subtypes and Chimeras. 49:7518-7531. 2006
- Cyclic ADP-Ribose Analogues Containing the Methylenebisphosphonate Linkage: Effect of Pyrophosphate Modifications on Ca2+ Release Activity. 48:4177-4181. 2005
- SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase. 46:4322-4332. 2003
- Synthesis and Biological Characterization of 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Muscarinic Agonists for the Treatment of Neurological Disorders. 46:4273-4286. 2003
- Design, Synthesis, and Biological Characterization of Bivalent 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Selective Muscarinic Agonists. 44:4563-4576. 2001
- Synthesis and Biological Characterization of 1,4,5,6-Tetrahydropyrimidine and 2-Amino-3,4,5,6-tetrahydropyridine Derivatives as Selective m1 Agonists. 40:1230-1246. 1997
- Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle. 38:2119-2129. 1995
- Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists. 37:2774-2782. 1994
- (Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase. 36:1041-1047. 1993
- Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. 36:842-847. 1993
- Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs. 36:1893-1901. 1993
- Cardiotonic agents. 7. Prodrug derivatives of 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one. 35:1267-1272. 1992
- Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogs. 34:2671-2677. 1991
- Synthesis and biological activity of angiotensin II analog containing a Val-His replacement, Val.psi.[CH(CONH2)HN]His. 34:2402-2410. 1991
- An approach to trapping .gamma.-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: .alpha.,.beta.-methyleneglutamic acid. 33:824-832. 1990
- Cardiotonic agents. 6. Histamine analogs as potential cardiovascular selective H2 agonists. 33:1688-1697. 1990
- Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore. 32:1173-1176. 1989
- Heterocyclic analogs of benzamide antiarrhythmic agents. 32:688-693. 1989
- Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations. 32:1164-1172. 1989
- Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents. 31:814-823. 1988
- Cardiotonic agents. 1. Novel 8-aryl substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents. 30:1337-1342. 1987
- Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. 30:1342-1347. 1987
- In search of the digitalis replacement. 30:231-237. 1987
- Ultra-short-acting .beta.-adrenergic receptor blocking agents. 3. Ethylenediamine derivatives of (aryloxy)propanolamines having esters on the aryl function. 26:1109-1112. 1983
- Ultra-short-acting .beta.-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent. 25:1402-1407. 1982
- Ultra-short-acting .beta.-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function. 25:1408-1412. 1982
- Correction to Furoxans (Oxadiazole-N-oxides) with Attenuated Reactivity Are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory 2018
- Additions and Corrections - In Search of the Digitalis Replacement 1987
- Mechanism of Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol 1995
- Specific Inhibition of Poly(ADP-ribose) Glycohydrolase by Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol 1995
Research
category
- CHEMISTRY, MEDICINAL Category
Identity
International Standard Serial Number (ISSN)
- 0022-2623
Electronic International Standard Serial Number (EISSN)
- 1520-4804
Other
journal abbreviation
- J MED CHEM