Tomer Avidor-Reiss
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Professor
Adjunct Professor, Urology, Molecular Cellular and Dev Bio , College of Natural Sciences and Mathematics
Overview
overview
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I am a Joan L. and Julius H. Jacobson II Endowed Professor in Biomedical Research at the University of Toledo. My lab studies how the subcellular organelles, the centriole, centrosome, and cilium are formed, function, and their involvement in reproductive diseases such as infertility and miscarriages. The lab is interested in basic and translational research and studying sperm biology in fruit flies, rabbits, bovines, and humans. The lab discoveries include: a new type of centriole – the sperm atypical centriole; that sperm centrioles must be modified to function in spermatozoon; that the cilia's transition zone migrates to form cytoplasmic sperm cilium; that tubulin functions as a switch protein in centrosome assembly; and that Asterless/Cep152 is essential for centriole duplication. Before joining the University of Toledo, I was at Harvard Medical School in Boston, where I was an Assistant Professor and studied the centrosome. My Post-doctorate studies were at the University of California San Diego, in the Howard Hughes Medical Institute lab of Dr. Charles Zuker, working on how the cilium is formed. I obtained my Ph. D. from the Weizmann Institute of Science in Rehovot, Israel, studying the mechanism of opiate addiction in the lab of Dr. Zvi Vogel. I received my M. Sc. and B. Sc. from Hebrew University, Jerusalem, Israel, where I studied how cells released neurotransmitters.
Publications
selected publications
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Article (Faculty180)
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2022
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Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. Proceedings of the National Academy of Sciences.
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Article (Web of Science)
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2021Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 9.Full Text via DOI: 10.3389/fcell.2021.658891 PMID: 33968935
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2019Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster. CELLS. 8.Full Text via DOI: 10.3390/cells8080841 PMID: 31387336
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2019The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis. GOLGI APPARATUS AND CENTRIOLE: FUNCTIONS, INTERACTIONS AND ROLE IN DISEASE. 67:3-15.Full Text via DOI: 10.1007/978-3-030-23173-6_1 PMID: 31435789
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2018Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes. CELL REPORTS. 25:3618-+.Full Text via DOI: 10.1016/j.celrep.2018.11.102
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2018A novel atypical sperm centriole is functional during human fertilization. NATURE COMMUNICATIONS. 9.Full Text via DOI: 10.1038/s41467-018-04678-8
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2017Transition Zone Migration: A Mechanism for Cytoplasmic Ciliogenesis and Postaxonemal Centriole Elongation. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 9.Full Text via DOI: 10.1101/cshperspect.a028142
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2017Atypical centrioles are present in Tribolium sperm. OPEN BIOLOGY. 7.Full Text via DOI: 10.1098/rsob.160334
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2016Centriole Remodeling during Spermiogenesis in Drosophila. CURRENT BIOLOGY. 26:3183-3189.Full Text via DOI: 10.1016/j.cub.2016.07.006
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2015Aster less Reduction during Spermiogenesis Is Regulated by Plk4 and Is Essential for Zygote Development in Drosophila. CURRENT BIOLOGY. 25:2956-2963.Full Text via DOI: 10.1016/j.cub.2015.09.045
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2015Drosophila Hook-Related Protein (Girdin) Is Essential for Sensory Dendrite Formation. GENETICS. 200:1149-+.Full Text via DOI: 10.1534/genetics.115.178954
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2014A Migrating Ciliary Gate Compartmentalizes the Site of Axoneme Assembly in Drosophila Spermatids. CURRENT BIOLOGY. 24:2622-2631.Full Text via DOI: 10.1016/j.cub.2014.09.047
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2014Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:E354-E363.Full Text via DOI: 10.1073/pnas.1317535111
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2014The Origin of the Second Centriole in the Zygote of Drosophila melanogaster. Genetics. 197:199-205.Full Text via DOI: 10.1534/genetics.113.160523
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2013Imaging Centrosomes in Fly Testes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/50938
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2013Building a centriole. CURRENT OPINION IN CELL BIOLOGY. 25:72-77.Full Text via DOI: 10.1016/j.ceb.2012.10.016
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2012Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. NATURE CELL BIOLOGY. 14:865-873.Full Text via DOI: 10.1038/ncb2527
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2011Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. NATURE COMMUNICATIONS. 2:359.Full Text via DOI: 10.1038/ncomms1367
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2010Self-assembling SAS-6 Multimer Is a Core Centriole Building Block. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:8759-8770.Full Text via DOI: 10.1074/jbc.m109.092627
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2009A Proximal Centriole-Like Structure Is Present in Drosophila Spermatids and Can Serve as a Model to Study Centriole Duplication. Genetics. 182:133-144.Full Text via DOI: 10.1534/genetics.109.101709
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2009Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. DEVELOPMENTAL BIOLOGY. 329:386-399.Full Text via DOI: 10.1016/j.ydbio.2009.02.009
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2008Drosophila asterless and Vertebrate Cep152 Are Orthologs Essential for Centriole Duplication. Genetics. 180:2081-2094.Full Text via DOI: 10.1534/genetics.108.095141
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2005Inhibition and Superactivation of the Calcium-Stimulated Isoforms of Adenylyl Cyclase: Role of Gβγ Dimers. JOURNAL OF MOLECULAR NEUROSCIENCE. 27:195-204.Full Text via DOI: 10.1385/jmn:27:2:195
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2005Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. BIOCHEMICAL JOURNAL. 386:341-348.Full Text via DOI: 10.1042/bj20041670
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2000Acute and chronic activation of the μ-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes. NEUROPHARMACOLOGY. 39:364-371.Full Text via DOI: 10.1016/s0028-3908(99)00155-0
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1998Differential Modulation of Adenylyl Cyclases I and II by Various Gβ Subunits. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:2273-2276.Full Text via DOI: 10.1074/jbc.273.4.2273
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Correction (Web of Science)
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2020Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. NATURE COMMUNICATIONS. 1862.Full Text via DOI: 10.1038/s41467-020-14938-1
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2018A novel atypical sperm centriole is functional during human fertilization (vol 9, 2018). NATURE COMMUNICATIONS.Full Text via DOI: 10.1038/s41467-018-05324-z
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Early Access (Web of Science)
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2021Lack of trusted diagnostic tools for undetermined male infertility. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.Full Text via DOI: 10.1007/s10815-020-02037-5 PMID: 33389378
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Editorial Material (Web of Science)
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2020Editorial: Sperm Differentiation and Spermatozoa Function: Mechanisms, Diagnostics, and Treatment. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2020.00219 PMID: 32318570
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2010The cellular and developmental program connecting the centrosome and cilium duplication cycle. Seminars in Cell & Developmental Biology. 139-141.Full Text via DOI: 10.1016/j.semcdb.2010.01.014
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Meeting Abstract (Web of Science)
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2014A Novel Proximal Centriole-Like (PCL) Structure Becomes the Second Centriole in the Zygote of Drosophila melanogaster. MOLECULAR BIOLOGY OF THE CELL.
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2014Paternal Poc1 is Essential for the Function of the Zygote Centrosome.. MOLECULAR BIOLOGY OF THE CELL.
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2013MKS Proteins form a Migrating Ciliary Gate. MOLECULAR BIOLOGY OF THE CELL.
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2012Drosophila mecH is Required for Cilium Formation.. MOLECULAR BIOLOGY OF THE CELL.
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2012Sas-4-mediated PCM assembly is regulated by Tubulin Dimers.. MOLECULAR BIOLOGY OF THE CELL.
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Presentation (Faculty180)
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Review Article (Web of Science)
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2020The sperm centrioles. MOLECULAR AND CELLULAR ENDOCRINOLOGY.Full Text via DOI: 10.1016/j.mce.2020.110987 PMID: 32810575
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2020Principal Postulates of Centrosomal Biology. Version 2020. CELLS.Full Text via DOI: 10.3390/cells9102156 PMID: 32987651
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2020Male Infertility is a Women's Health Issue-Research and Clinical Evaluation of Male Infertility Is Needed. CELLS.Full Text via DOI: 10.3390/cells9040990 PMID: 32316195
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2019The Role of Sperm Centrioles in Human Reproduction - The Known and the Unknown. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2019.00188 PMID: 31632960
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2019It takes two (centrioles) to tango. REPRODUCTION. R33-R51.Full Text via DOI: 10.1530/REP-18-0350
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2019It takes two (centrioles) to tango. REPRODUCTION. R33-R51.Full Text via DOI: 10.1530/rep-18-0350
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2015Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis. CURRENT BIOLOGY. R1143-R1150.Full Text via DOI: 10.1016/j.cub.2015.11.001
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2015Atypical centrioles during sexual reproduction. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2015.00021
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2014From the cytoplasm into the cilium: Bon voyage. ORGANOGENESIS. 138-157.Full Text via DOI: 10.4161/org.29055
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Contact
full name
- Tomer Avidor-Reiss