Tomer Avidor-Reiss
Overview
overview
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I am a Joan L. and Julius H. Jacobson II Endowed Professor in Biomedical Research at the University of Toledo. My lab studies how the subcellular organelles, the centriole, centrosome, and cilium are formed, function, and their involvement in reproductive diseases such as infertility and miscarriages. The lab is interested in basic and translational research and studying sperm biology in fruit flies, rabbits, bovines, and humans. The lab discoveries include: a new type of centriole – the sperm atypical centriole; that sperm centrioles must be modified to function in spermatozoon; that the cilia's transition zone migrates to form cytoplasmic sperm cilium; that tubulin functions as a switch protein in centrosome assembly; and that Asterless/Cep152 is essential for centriole duplication. Before joining the University of Toledo, I was at Harvard Medical School in Boston, where I was an Assistant Professor and studied the centrosome. My Post-doctorate studies were at the University of California San Diego, in the Howard Hughes Medical Institute lab of Dr. Charles Zuker, working on how the cilium is formed. I obtained my Ph. D. from the Weizmann Institute of Science in Rehovot, Israel, studying the mechanism of opiate addiction in the lab of Dr. Zvi Vogel. I received my M. Sc. and B. Sc. from Hebrew University, Jerusalem, Israel, where I studied how cells released neurotransmitters.
Publications
selected publications
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Article (Faculty180)
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2024CP110 and CEP135 Localize Near the Proximal Centriolar Remnants of Mice Spermatozoa. microPublication biology. 2024.
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2024Protamine 2 Deficiency Results In Septin 12 Abnormalities. bioRxiv : the preprint server for biology.
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2024Renaissance in sperm cytoplasmic contribution to infertility. Journal of assisted reproduction and genetics. 41:293-296.
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2024Structural Analysis of Sperm Centrioles Using N-STORM. Methods in molecular biology (Clifton, N.J.). 2725:103-119.
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2024Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations. The world journal of men's health. 42:202-215.
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2024The evolution of centriole degradation in mouse sperm. Nature communications. 15:117.
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2023Abnormal centriolar biomarker ratios correlate with unexplained bull artificial insemination subfertility: a pilot study. Scientific reports. 13:18338.
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2023Artificial Intelligence in Andrology: From Semen Analysis to Image Diagnostics. The world journal of men's health.
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2023CP110 and CEP135 localize near the proximal and distal centrioles of cattle and human spermatozoa. microPublication biology. 2023.
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2023Centrosome Formation in the Bovine Early Embryo. Cells. 12.
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2023Citation Errors in Scientific Research and Publications: Causes, Consequences, and Remedies. The world journal of men's health. 41:461-465.
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2023
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2023IgG antibodies label the spermatozoan centriole of Drosophila melanogaster. microPublication biology. 2023.
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2023Revisiting the mystery of centrioles at the beginning of mammalian embryogenesis. Journal of assisted reproduction and genetics. 40:2539-2543.
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2023The Renaissance of Male Infertility Management in the Golden Age of Andrology. The world journal of men's health. 41:237-254.
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2022On the Origin and Evolution of Sperm Cells. Cells. 12.
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2022Sperm centriole assessment identifies male factor infertility in couples with unexplained infertility - a pilot study. European journal of cell biology. 101:151243.
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2022The Centriole's Role in Miscarriages. Frontiers in cell and developmental biology. 10:864692.
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2022The Centrosome: Conclusions and Perspectives. Cells. 11.
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2022Tubulin posttranslational modifications modify the atypical spermatozoon centriole. microPublication biology. 2022.
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2021A dynamic basal complex modulates mammalian sperm movement. Nature communications. 12:3808.
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2021Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality. Frontiers in cell and developmental biology. 9:658891.
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2021Lack of trusted diagnostic tools for undetermined male infertility. Journal of assisted reproduction and genetics. 38:265-276.
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2020Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nature communications. 11:1862.
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2020Editorial: Sperm Differentiation and Spermatozoa Function: Mechanisms, Diagnostics, and Treatment. Frontiers in cell and developmental biology. 8:219.
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2020
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2020The sperm centrioles. Molecular and cellular endocrinology. 518:110987.
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2019It takes two (centrioles) to tango. Reproduction (Cambridge, England). 157:R33-R51.
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2019The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis. Results and problems in cell differentiation. 67:3-15.
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2019The Role of Sperm Centrioles in Human Reproduction - The Known and the Unknown. Frontiers in cell and developmental biology. 7:188.
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2018A novel atypical sperm centriole is functional during human fertilization. Nature communications. 9:2210.
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2018Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes. Cell reports. 25:3618-3630.e6.
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2017Atypical centrioles are present in Tribolium sperm. Open Biology. 7.
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2017Transition Zone Migration: A Mechanism for Cytoplasmic Ciliogenesis and Postaxonemal Centriole Elongation. Cold Spring Harbor perspectives in biology. a028142.
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2017Transition Zone Migration: A Mechanism for Cytoplasmic Ciliogenesis and Postaxonemal Centriole Elongation. Cold Spring Harbor perspectives in biology. 9.
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2016Centriole Remodeling during Spermiogenesis in Drosophila. Current biology : CB. 26:3183-3189.
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2015Asterless Reduction during Spermiogenesis Is Regulated by Plk4 and Is Essential for Zygote Development in Drosophila. Current biology : CB. 25:2956-63.
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2015Atypical centrioles during sexual reproduction. Frontiers in cell and developmental biology. 3.
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2015Drosophila Hook-Related Protein (Girdin) Is Essential for Sensory Dendrite Formation. Genetics. 200:1149-59.
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2015Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis. Current biology : CB. 25:R1143-50.
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2014A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Current Biology. 24:2622.
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2014Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. Proceedings of the National Academy of Sciences. 111:E354.
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2014From the cytoplasm into the cilium: bon voyage. Organogenesis. 10:138.
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2014The origin of the second centriole in the zygote of Drosophila melanogaster. Genetics. 197:199.
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2013Building a centriole. Current opinion in cell biology. 25:72.
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2013Cell cycle regulation of the centrosome and cilium. Drug Discovery Today: Disease Mechanisms. 10:e119.
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2013Imaging centrosomes in fly testes. Journal of visualized experiments: JoVE.
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2012Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. Nature Cell Biology.
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2011Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nature communications. 2:359.
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2010Self-assembling SAS-6 multimer is a core centriole building block. Journal of Biological Chemistry. 285:8759.
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2009Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Developmental biology. 329:386.
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2008
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2005Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase. Journal of molecular neuroscience. 27:195.
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2005Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. Biochemical Journal. 386:341.
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2000Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB1 cannabinoid receptor. Molecular Pharmacology. 57:746.
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1999Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs. Cellular and molecular neurobiology. 19:653.
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1998Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. Journal of neurochemistry. 71:1525.
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1998Differential modulation of adenylyl cyclases I and II by various G$\beta$ subunits. Journal of Biological Chemistry. 273:2273.
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1998Inhibition of adenylyl cyclase isoforms V and VI by various G$\beta$$\gamma$ subunits. The FASEB Journal. 12:1019.
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1998Opioid Modulation of Extracellular Signal-Regulated Protein Kinase Activity Is Ras-Dependent and Involves G$\beta$$\gamma$ Subunits. Journal of neurochemistry. 70:635.
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1998Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Molecular Pharmacology. 54:419.
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1997Differential coupling of D2-type dopamine receptors to the PTX-insensitive GZ GTP binding protein. Neuroscience Letters. 237:S37.
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1997Differential regulation of adenylyl cyclase isozymes upon chronic activation of inhibitory G protein-coupled receptors. Neuroscience Letters. 237:S37.
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1997Modulation of adenylyl cyclase isoforms I, II, V and VI by various G BG subunits. Neuroscience Letters. 237:S8.
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1997Opiate-induced adenylyl cyclase superactivation is isozyme-specific. Journal of Biological Chemistry. 272:5040.
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1996()--Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase. Journal of Biological Chemistry. 271:9902.
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1996Adenylyl cyclase inhibition and superactivation resulting from acute and chronic stimulation of inhibitory, seven-transmembrane domain receptors. ISRAEL JOURNAL OF MEDICAL SCIENCES. 32:S48.
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1996Chronic opioid treatment induces adenylyl cyclase v superactivation involvement of G$\beta$$\gamma$. Journal of Biological Chemistry. 271:21309.
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1995ADENYLATE CYCLASE INHIBITION BY THE PERIPHERAL CANNABINOID RECEPTOR. Analgesia. 1:286.
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1995Adenylylcyclase supersensitization in $\mu$-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment. Journal of Biological Chemistry. 270:29732.
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1995Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment. Molecular brain research. 34:221.
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1995The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS letters. 375:143.
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1994Caffeine-induced transmitter release is mediated via ryanodine-sensitive channel. Neuroscience letters. 165:133.
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1994Cardiac L-type Ca2+ channel triggers transmitter release in PC 12 cells. FEBS letters. 342:209.
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Article (Web of Science)
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2021Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC) Finds Patient Age and Sperm Morphology Are Associated With Centriole Quality. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 9.Full Text via DOI: 10.3389/fcell.2021.658891 PMID: 33968935
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2019Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster. CELLS. 8.Full Text via DOI: 10.3390/cells8080841 PMID: 31387336
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2019The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis. GOLGI APPARATUS AND CENTRIOLE: FUNCTIONS, INTERACTIONS AND ROLE IN DISEASE. 67:3-15.Full Text via DOI: 10.1007/978-3-030-23173-6_1 PMID: 31435789
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2018Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes. CELL REPORTS. 25:3618-+.Full Text via DOI: 10.1016/j.celrep.2018.11.102
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2018A novel atypical sperm centriole is functional during human fertilization. NATURE COMMUNICATIONS. 9.Full Text via DOI: 10.1038/s41467-018-04678-8
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2017Transition Zone Migration: A Mechanism for Cytoplasmic Ciliogenesis and Postaxonemal Centriole Elongation. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 9.Full Text via DOI: 10.1101/cshperspect.a028142
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2017Atypical centrioles are present in Tribolium sperm. OPEN BIOLOGY. 7.Full Text via DOI: 10.1098/rsob.160334
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2016Centriole Remodeling during Spermiogenesis in Drosophila. CURRENT BIOLOGY. 26:3183-3189.Full Text via DOI: 10.1016/j.cub.2016.07.006
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2015Aster less Reduction during Spermiogenesis Is Regulated by Plk4 and Is Essential for Zygote Development in Drosophila. CURRENT BIOLOGY. 25:2956-2963.Full Text via DOI: 10.1016/j.cub.2015.09.045
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2015Drosophila Hook-Related Protein (Girdin) Is Essential for Sensory Dendrite Formation. GENETICS. 200:1149-+.Full Text via DOI: 10.1534/genetics.115.178954
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2014A Migrating Ciliary Gate Compartmentalizes the Site of Axoneme Assembly in Drosophila Spermatids. CURRENT BIOLOGY. 24:2622-2631.Full Text via DOI: 10.1016/j.cub.2014.09.047
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2014Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:E354-E363.Full Text via DOI: 10.1073/pnas.1317535111
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2014The Origin of the Second Centriole in the Zygote of Drosophila melanogaster. Genetics. 197:199-205.Full Text via DOI: 10.1534/genetics.113.160523
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2013Imaging Centrosomes in Fly Testes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/50938
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2013Building a centriole. CURRENT OPINION IN CELL BIOLOGY. 25:72-77.Full Text via DOI: 10.1016/j.ceb.2012.10.016
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2012Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. NATURE CELL BIOLOGY. 14:865-873.Full Text via DOI: 10.1038/ncb2527
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2011Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. NATURE COMMUNICATIONS. 2:359.Full Text via DOI: 10.1038/ncomms1367
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2010Self-assembling SAS-6 Multimer Is a Core Centriole Building Block. JOURNAL OF BIOLOGICAL CHEMISTRY. 285:8759-8770.Full Text via DOI: 10.1074/jbc.m109.092627
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2009A Proximal Centriole-Like Structure Is Present in Drosophila Spermatids and Can Serve as a Model to Study Centriole Duplication. Genetics. 182:133-144.Full Text via DOI: 10.1534/genetics.109.101709
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2009Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. DEVELOPMENTAL BIOLOGY. 329:386-399.Full Text via DOI: 10.1016/j.ydbio.2009.02.009
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2008Drosophila asterless and Vertebrate Cep152 Are Orthologs Essential for Centriole Duplication. Genetics. 180:2081-2094.Full Text via DOI: 10.1534/genetics.108.095141
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2005Inhibition and Superactivation of the Calcium-Stimulated Isoforms of Adenylyl Cyclase: Role of Gβγ Dimers. JOURNAL OF MOLECULAR NEUROSCIENCE. 27:195-204.Full Text via DOI: 10.1385/jmn:27:2:195
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2005Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. BIOCHEMICAL JOURNAL. 386:341-348.Full Text via DOI: 10.1042/bj20041670
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2000Acute and chronic activation of the μ-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes. NEUROPHARMACOLOGY. 39:364-371.Full Text via DOI: 10.1016/s0028-3908(99)00155-0
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1998Differential Modulation of Adenylyl Cyclases I and II by Various Gβ Subunits. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:2273-2276.Full Text via DOI: 10.1074/jbc.273.4.2273
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Chapter (Faculty180)
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2012Centriole duplication and inheritance in Drosophila melanogaster. The Centrosome. Humana Press. 3.
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Correction (Web of Science)
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2020Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. NATURE COMMUNICATIONS. 1862.Full Text via DOI: 10.1038/s41467-020-14938-1
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2018A novel atypical sperm centriole is functional during human fertilization (vol 9, 2018). NATURE COMMUNICATIONS.Full Text via DOI: 10.1038/s41467-018-05324-z
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Early Access (Web of Science)
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2021Lack of trusted diagnostic tools for undetermined male infertility. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.Full Text via DOI: 10.1007/s10815-020-02037-5 PMID: 33389378
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Editorial Material (Web of Science)
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2020Editorial: Sperm Differentiation and Spermatozoa Function: Mechanisms, Diagnostics, and Treatment. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2020.00219 PMID: 32318570
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2010The cellular and developmental program connecting the centrosome and cilium duplication cycle. Seminars in Cell & Developmental Biology. 139-141.Full Text via DOI: 10.1016/j.semcdb.2010.01.014
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Meeting Abstract (Web of Science)
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2014A Novel Proximal Centriole-Like (PCL) Structure Becomes the Second Centriole in the Zygote of Drosophila melanogaster. MOLECULAR BIOLOGY OF THE CELL.
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2014Paternal Poc1 is Essential for the Function of the Zygote Centrosome.. MOLECULAR BIOLOGY OF THE CELL.
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2013MKS Proteins form a Migrating Ciliary Gate. MOLECULAR BIOLOGY OF THE CELL.
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2012Drosophila mecH is Required for Cilium Formation.. MOLECULAR BIOLOGY OF THE CELL.
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2012Sas-4-mediated PCM assembly is regulated by Tubulin Dimers.. MOLECULAR BIOLOGY OF THE CELL.
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Other Scholarly Work (Faculty180)
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Presentation (Faculty180)
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Proceedings (Faculty180)
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Review Article (Web of Science)
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2020The sperm centrioles. MOLECULAR AND CELLULAR ENDOCRINOLOGY.Full Text via DOI: 10.1016/j.mce.2020.110987 PMID: 32810575
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2020Principal Postulates of Centrosomal Biology. Version 2020. CELLS.Full Text via DOI: 10.3390/cells9102156 PMID: 32987651
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2020Male Infertility is a Women's Health Issue-Research and Clinical Evaluation of Male Infertility Is Needed. CELLS.Full Text via DOI: 10.3390/cells9040990 PMID: 32316195
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2019The Role of Sperm Centrioles in Human Reproduction - The Known and the Unknown. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2019.00188 PMID: 31632960
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2019It takes two (centrioles) to tango. REPRODUCTION. R33-R51.Full Text via DOI: 10.1530/REP-18-0350
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2019It takes two (centrioles) to tango. REPRODUCTION. R33-R51.Full Text via DOI: 10.1530/rep-18-0350
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2015Shared and Distinct Mechanisms of Compartmentalized and Cytosolic Ciliogenesis. CURRENT BIOLOGY. R1143-R1150.Full Text via DOI: 10.1016/j.cub.2015.11.001
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2015Atypical centrioles during sexual reproduction. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2015.00021
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2014From the cytoplasm into the cilium: Bon voyage. ORGANOGENESIS. 138-157.Full Text via DOI: 10.4161/org.29055
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Contact
full name
- Tomer Avidor-Reiss