Hill, Jennifer W

Jennifer W Hill
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Positions

Associate Professor, Physiology and Pharmacology , College of Medicine and Life Sciences

Contact Info

JenniferW.Hill@utoledo.edu

https://www.utoledo.edu/med/depts/physpharm/faculty/hill.html

selected publications

Article (Faculty180)
- 2022
  
  Spexin modulates molecular thermogenic profile of adipose tissue and thermoregulatory behaviors in female C57BL/6 mice. Hormones and behavior. 143:105195.
- 2021
  
  Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. CURRENT HYPERTENSION REPORTS. 23.
- 2021
  
  Role of insulin in the neuroendocrine control of reproduction. JOURNAL OF NEUROENDOCRINOLOGY. 33:e12930.
- 2020
  
  Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation. JOURNAL OF ENDOCRINOLOGY. 247:39-52.
- 2020
  
  Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder 2019 Harriet Dustan Award. HYPERTENSION. 75:1386-1396.
- 2020
  
  Microbial Reconstitution Reverses Early Female Puberty Induced by Maternal High-fat Diet During Lactation. ENDOCRINOLOGY. 161:bqz041.
- 2020
  
  The role of non-neuronal cells in hypogonadotropic hypogonadism. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 518:110996.
- 2019
  
  Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice. PLOS BIOLOGY. 17:e3000189.
- 2019
  
  Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis. METABOLISM-CLINICAL AND EXPERIMENTAL. 93:33-43.
- 2019
  
  Oxytocin Neurons Enable Melanocortin Regulation of Male Sexual Function in Mice. MOLECULAR NEUROBIOLOGY. 56:6310-6323.
- 2018
  
  Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats. LIFE SCIENCES. 207:105-109.
- 2018
  
  NEUROANATOMICAL FRAMEWORK OF THE METABOLIC CONTROL OF REPRODUCTION. PHYSIOLOGICAL REVIEWS. 98:2349-2380.
- 2018
  
  Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. GUT MICROBES. 9:400-421.
- 2018
  
  Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice. ENDOCRINOLOGY. 159:439-449.
- 2017
  
  Alteration in follistatin gene expression detected in prenatally androgenized rats. GYNECOLOGICAL ENDOCRINOLOGY. 33:433-437.
- 2017
  
  PI3K alpha inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction. JCI INSIGHT. 2:e96728.
- 2017
  
  The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances. NEUROENDOCRINOLOGY. 104:330-346.
- 2016
  
  Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:11124-11132.
- 2016
  
  The Efficacy of GnRHa Alone or in Combination with rhGH for the Treatment of Chinese Children with Central Precocious Puberty. SCIENTIFIC REPORTS. 6:24259.
- 2015
  
  Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. PLOS ONE. 10:e0121974.
- 2015
  
  Reduced Melanocortin Production Causes Sexual Dysfunction in Male Mice With POMC Neuronal Insulin and Leptin Insensitivity. ENDOCRINOLOGY. 156:1372-1385.
- 2014
  
  Glucocorticoid Receptor beta Stimulates Akt1 Growth Pathway by Attenuation of PTEN. JOURNAL OF BIOLOGICAL CHEMISTRY. 289:17885-17894.
- 2013
  
  Annexin A1 Complex Mediates Oxytocin Vesicle Transport. JOURNAL OF NEUROENDOCRINOLOGY. 25:1241-1254.
- 2013
  
  Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells. ENDOCRINOLOGY. 154:1337-1348.
- 2013
  
  From precocious puberty to infertility: metabolic control of the reproductive function. Frontiers in endocrinology. 4:43.
- 2013
  
  Genetic Factors Modulate the Impact of Pubertal Androgen Excess on Insulin Sensitivity and Fertility. PLOS ONE. 8:e79849.
- 2013
  
  Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation. BMC CELL BIOLOGY. 14.
- 2012
  
  Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence of Adipocyte Hypertrophy and Tissue-Specific Inflammation. PLOS ONE. 7:e48643.
- 2012
  
  ApoA-1 mimetic restores adiponectin expression and insulin sensitivity independent of changes in body weight in female obese mice. NUTRITION & DIABETES. 2:e33.
- 2012
  
  Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. DIABETOLOGIA. 55:763-772.
- 2012
  
  PVN pathways controlling energy homeostasis. Indian journal of endocrinology and metabolism. 16:S627-36.
- 2011
  
  Central insulin and leptin-mediated autonomic control of glucose homeostasis. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 22:275-285.
- 2011
  
  Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons. Frontiers in endocrinology. 2:98.
- 2010
  
  Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility. CELL METABOLISM. 11:286-297.
- 2010
  
  Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons. Open neuroendocrinology journal (Online). 3:21-27.
- 2010
  
  PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis. CELL METABOLISM. 12:88-95.
- 2009
  
  Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis. ENDOCRINOLOGY. 150:4874-4882.
- 2008
  
  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. JOURNAL OF CLINICAL INVESTIGATION. 118:1796-1805.
- 2008
  
  Hypothalamic pathways linking energy balance and reproduction. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 294:E827-E832.
- 2008
  
  Monitoring FoxO1 Localization in Chemically Identified Neurons. JOURNAL OF NEUROSCIENCE. 28:13640-13648.
- 2006
  
  Leptin, Insulin, and PTEN: Divergent effects on hypothalamic neurons explained? . Cellscience Reviews. 3:42-51.
- 2004
  
  Estrogen induces neuropeptide Y (NPY) Y1 receptor gene expression and responsiveness to NPY in gonadotrope-enriched pituitary cell cultures. ENDOCRINOLOGY. 145:2283-2290.
- 2003
  
  Abnormal response of the neuropeptide Y-deficient mouse reproductive axis to food deprivation but not lactation. Endocrinology. 144:1780-6.
- 2003
  
  Testosterone decreases the potential for song plasticity in adult male zebra finches. Hormones and behavior. 44:402-12.
- 2002
  
  Revisiting the reproductive functions of neuropeptide Y. Current Opinion in Endocrinology, Diabetes and Obesity. 9:203-214.
- 2000
  
  Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice. NEUROENDOCRINOLOGY. 72:263-271.
- 2000
  
  Regulation of hypothalamic neuropeptide YY1 receptor gene expression during the estrous cycle: Role of progesterone receptors. ENDOCRINOLOGY. 141:3319-3327.
Article (Web of Science)
- 2020
  
  Microbial Reconstitution Reverses Early Female Puberty Induced by Maternal High-fat Diet During Lactation. ENDOCRINOLOGY. 161.
  Full Text via DOI: 10.1210/endocr/bqz041 PMID: 31912132
- 2020
  
  Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation. JOURNAL OF ENDOCRINOLOGY. 247:39-52.
  Full Text via DOI: 10.1530/joe-20-0052
- 2019
  
  Oxytocin Neurons Enable Melanocortin Regulation of Male Sexual Function in Mice. MOLECULAR NEUROBIOLOGY. 56:6310-6323.
  Full Text via DOI: 10.1007/s12035-019-1514-5 PMID: 30756300
- 2019
  
  Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis. METABOLISM-CLINICAL AND EXPERIMENTAL. 93:33-43.
  Full Text via DOI: 10.1016/j.metabol.2019.01.008 PMID: 30664851
- 2019
  
  Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice. PLOS BIOLOGY. 17.
  Full Text via DOI: 10.1371/journal.pbio.3000189 PMID: 30893295
- 2018
  
  Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats. LIFE SCIENCES. 207:105-109.
  Full Text via DOI: 10.1016/j.lfs.2018.05.052
- 2018
  
  Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. GUT MICROBES. 9:400-421.
  Full Text via DOI: 10.1080/19490976.2018.1441664
- 2018
  
  Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice. ENDOCRINOLOGY. 159:439-449.
  Full Text via DOI: 10.1210/en.2017-00488
- 2017
  
  PI3K alpha inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction. JCI INSIGHT. 2.
  Full Text via DOI: 10.1172/jci.insight.96728
- 2017
  
  Alteration in follistatin gene expression detected in prenatally androgenized rats. GYNECOLOGICAL ENDOCRINOLOGY. 33:433-437.
  Full Text via DOI: 10.1080/09513590.2017.1290067
- 2017
  
  The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances. NEUROENDOCRINOLOGY. 104:330-346.
  Full Text via DOI: 10.1159/000450649
- 2016
  
  The Efficacy of GnRHa Alone or in Combination with rhGH for the Treatment of Chinese Children with Central Precocious Puberty. SCIENTIFIC REPORTS. 6.
  Full Text via DOI: 10.1038/srep24259
- 2016
  
  Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1. JOURNAL OF BIOLOGICAL CHEMISTRY. 291:11124-11132.
  Full Text via DOI: 10.1074/jbc.m116.716431
- 2015
  
  Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. PLOS ONE. 10.
  Full Text via DOI: 10.1371/journal.pone.0121974
- 2015
  
  Reduced Melanocortin Production Causes Sexual Dysfunction in Male Mice With POMC Neuronal Insulin and Leptin Insensitivity. ENDOCRINOLOGY. 156:1372-1385.
  Full Text via DOI: 10.1210/en.2014-1788
- 2014
  
  Glucocorticoid Receptor beta Stimulates Akt1 Growth Pathway by Attenuation of PTEN. JOURNAL OF BIOLOGICAL CHEMISTRY. 289:17885-17894.
  Full Text via DOI: 10.1074/jbc.M113.544072
- 2014
  
  Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN. JOURNAL OF BIOLOGICAL CHEMISTRY. 289:17885-17894.
  Full Text via DOI: 10.1074/jbc.m113.544072
- 2013
  
  Annexin A1 Complex Mediates Oxytocin Vesicle Transport. JOURNAL OF NEUROENDOCRINOLOGY. 25:1241-1254.
  Full Text via DOI: 10.1111/jne.12112
- 2013
  
  Genetic Factors Modulate the Impact of Pubertal Androgen Excess on Insulin Sensitivity and Fertility. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0079849
- 2013
  
  Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation. BMC CELL BIOLOGY. 14.
  Full Text via DOI: 10.1186/1471-2121-14-39
- 2013
  
  Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells. ENDOCRINOLOGY. 154:1337-1348.
  Full Text via DOI: 10.1210/en.2012-2056
- 2012
  
  Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence of Adipocyte Hypertrophy and Tissue-Specific Inflammation. PLOS ONE. 7.
  Full Text via DOI: 10.1371/journal.pone.0048643
- 2012
  
  ApoA-1 mimetic restores adiponectin expression and insulin sensitivity independent of changes in body weight in female obese mice. NUTRITION & DIABETES. 2.
  Full Text via DOI: 10.1038/nutd.2012.4
- 2012
  
  Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2. DIABETOLOGIA. 55:763-772.
  Full Text via DOI: 10.1007/s00125-011-2388-x
- 2010
  
  PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis. CELL METABOLISM. 12:88-95.
  Full Text via DOI: 10.1016/j.cmet.2010.05.002
- 2010
  
  Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility. CELL METABOLISM. 11:286-297.
  Full Text via DOI: 10.1016/j.cmet.2010.03.002
- 2009
  
  Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis. ENDOCRINOLOGY. 150:4874-4882.
  Full Text via DOI: 10.1210/en.2009-0454
- 2008
  
  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. JOURNAL OF CLINICAL INVESTIGATION. 118:1796-1805.
  Full Text via DOI: 10.1172/jci32964
- 2008
  
  Monitoring FoxO1 Localization in Chemically Identified Neurons. JOURNAL OF NEUROSCIENCE. 28:13640-13648.
  Full Text via DOI: 10.1523/jneurosci.4023-08.2008
Chapter (Faculty180)
- 2021
  
  Bremelanotide. Encyclopedia of Molecular Pharmacology. Springer International. 1-6.
- 2021
  
  Current Genetic Techniques Available for Investigating Feeding Behavior and the Control of Energy Balance. Neuron Signaling in Metabolic Regulation . Taylor &Francis. 121-141.
- 2018
  
  Obesity and Stress: The Melanocortin Connection. Obesity and Stress: The Melanocortin Connection. Springer International Publishing. 271-319.
Conference Poster (Faculty180)
Correction (Web of Science)
- 2012
  
  Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2 (vol 55, pg 763, 2012). DIABETOLOGIA. 861-861.
  Full Text via DOI: 10.1007/s00125-012-2453-0
Early Access (Web of Science)
- 2021
  
  Role of insulin in the neuroendocrine control of reproduction. JOURNAL OF NEUROENDOCRINOLOGY.
  Full Text via DOI: 10.1111/jne.12930 PMID: 33523515
Lecture or Panel Discussion (Faculty180)
- 2022
  
  Lab Management and Organization. Annual Meeting of the Society for Behavioral Neuroendocrinology.
Meeting Abstract (Web of Science)
- 2017
  
  Prenatal Androgen Exposure of Single-Injection of Testosterone Induces Cardiovascular and Metabolic Dysfunction in Adult Female Wistar Rats.. FASEB JOURNAL.
- 2017
  
  The Effects of Glutamate on Oxytocin Release. FASEB JOURNAL.
- 2014
  
  Disrupted Melanocortin Signaling Facilitates Type 2 Diabetes Associated Erectile Dysfunction. ENDOCRINE REVIEWS.
- 2013
  
  PKCtheta Contributes to Myotube Formation by Regulating Protein Synthesis. FASEB JOURNAL.
- 2011
  
  Apo-Lipoprotein-A1 Mimetic Restores Insulin Sensitivity and Attenuates Systemic Inflammation in Female-Obese Mice Independent of Effects on Body Weight. HYPERTENSION. E169-E169.
- 2010
  
  L-4F Treatment Increases Adiponectin and Normalizes Both Blood Pressure and Abnormal Steroid Hormone Ratios in Male and Female Mice. HYPERTENSION. E77-E77.
- 2010
  
  The Metabolic Syndrome and Ovarian Dysfunction in Mice.. BIOLOGY OF REPRODUCTION. 176-176.
Presentation (Faculty180)
Proceedings (Faculty180)
Review Article (Web of Science)
- 2021
  
  Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. CURRENT HYPERTENSION REPORTS.
  Full Text via DOI: 10.1007/s11906-021-01142-9 PMID: 33961141
- 2020
  
  The role of non-neuronal cells in hypogonadotropic hypogonadism. MOLECULAR AND CELLULAR ENDOCRINOLOGY.
  Full Text via DOI: 10.1016/j.mce.2020.110996 PMID: 32860862
- 2018
  
  Neuroanatomical Framework of the Metabolic Control of Reproduction. PHYSIOLOGICAL REVIEWS. 2349-2380.
  Full Text via DOI: 10.1152/physrev.00033.2017
- 2011
  
  Central insulin and leptin-mediated autonomic control of glucose homeostasis. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 275-285.
  Full Text via DOI: 10.1016/j.tem.2011.03.001
- 2008
  
  Hypothalamic pathways linking energy balance and reproduction. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. E827-E832.
  Full Text via DOI: 10.1152/ajpendo.00670.2007

full name

Jennifer W Hill

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Cumulative publications in Scholars@UToledo

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