James Willey
- Director, Cancer Research Center, Medicine , College of Medicine and Life Sciences
Contact Info
Publications
selected publications
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Article (Faculty180)
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2021Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA. Cell Reports Methods. Cell Reports Methods, 1, 2021, https://doi.org/10.1016/j.crmeth.2021.100106 .
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2020Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis. Public Library of Sciences One. 15:e0236966.
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2019Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells. BMC Cancer. BMC Cancer. (2019) Nov 11;19(1):1081. https://doi:10.1186/s12885-019-6313-x PMID: 31711466.
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2018RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs. BMC Pulm Med. BMC Pulm Med., 2018 Mar 5;18(1):42. doi: 10.1186/s12890-018-0603-y, PMID: 29506519.
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Article (Web of Science)
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2021Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing. NATURE BIOTECHNOLOGY. 39:1141-+.Full Text via DOI: 10.1038/s41587-021-00994-5 PMID: 34504346
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2021Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions. GENOME BIOLOGY. 22.Full Text via DOI: 10.1186/s13059-021-02315-0 PMID: 33863344
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2021Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology. NATURE BIOTECHNOLOGY.Full Text via DOI: 10.1038/s41587-021-00857-z PMID: 33846644
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2020Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis. PLOS ONE. 15.Full Text via DOI: 10.1371/journal.pone.0236966 PMID: 32776968
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2019Survival with Parenchymal and Pleural Invasion of Non-Small Cell Lung Cancers Less than 30 mm. JOURNAL OF THORACIC ONCOLOGY. 14:890-902.Full Text via DOI: 10.1016/j.jtho.2019.01.013 PMID: 30685507
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2019BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. CANCER LETTERS. 457:10-19.Full Text via DOI: 10.1016/j.canlet.2019.04.036 PMID: 31059751
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2018A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer. CANCER LETTERS. 418:75-83.Full Text via DOI: 10.1016/j.canlet.2018.01.007
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2018RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs. BMC PULMONARY MEDICINE. 18.Full Text via DOI: 10.1186/s12890-018-0603-y
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2017A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. BMC CANCER. 17.Full Text via DOI: 10.1186/s12885-017-3287-4
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2016Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells. PHYSIOLOGICAL GENOMICS. 48:537-543.Full Text via DOI: 10.1152/physiolgenomics.00021.2016
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2016Lung cancer risk test trial: study design, participant baseline characteristics, bronchoscopy safety, and establishment of a biospecimen repository. BMC PULMONARY MEDICINE. 16.Full Text via DOI: 10.1186/s12890-016-0178-4
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2014A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. NATURE BIOTECHNOLOGY. 32:903-914.Full Text via DOI: 10.1038/nbt.2957
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2014A Multiplex Two-Color Real-Time PCR Method for Quality-Controlled Molecular Diagnostic Testing of FFPE Samples. PLOS ONE. 9.Full Text via DOI: 10.1371/journal.pone.0089395
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2013Targeted RNA-Sequencing with Competitive Multiplex-PCR Amplicon Libraries. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0079120
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2013Quality Control Methods for Optimal BCR-ABL1 Clinical Testing in Human Whole Blood Samples. JOURNAL OF MOLECULAR DIAGNOSTICS. 15:391-400.Full Text via DOI: 10.1016/j.jmoldx.2013.02.004
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2013A new StaRT-PCR approach to detect and quantify fish Viral Hemorrhagic Septicemia virus (VHSv): Enhanced quality control with internal standards. JOURNAL OF VIROLOGICAL METHODS. 189:129-142.Full Text via DOI: 10.1016/j.jviromet.2013.01.006
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2013Illicit narcotic injection masquerading as acute pulmonary embolism. VASCULAR MEDICINE. 18:92-94.Full Text via DOI: 10.1177/1358863X13480228
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2013CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells. Gene Regulation and Systems Biology. 7:GRSB.S11879.Full Text via DOI: 10.4137/grsb.s11879
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2013Illicit narcotic injection masquerading as acute pulmonary embolism. VASCULAR MEDICINE. 18:92-94.Full Text via DOI: 10.1177/1358863x13480228
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2010The MicroArray Quality Control (MAQC)-IIII study of common practices for the development and validation of microarray-based predictive models. NATURE BIOTECHNOLOGY. 28:827-U109.Full Text via DOI: 10.1038/nbt.1665
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2010Cis-acting genetic variation at an E2F1/YY1 response site and putative p53 site is associated with altered allele-specific expression of ERCC5 (XPG) transcript in normal human bronchial epithelium. CARCINOGENESIS. 31:1242-1250.Full Text via DOI: 10.1093/carcin/bgq057
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2009Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis. CANCER RESEARCH. 69:8629-8635.Full Text via DOI: 10.1158/0008-5472.CAN-09-1568
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2009Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis. CANCER RESEARCH. 69:8629-8635.Full Text via DOI: 10.1158/0008-5472.can-09-1568
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2008The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC BIOINFORMATICS. 9.Full Text via DOI: 10.1186/1471-2105-9-S9-S10
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2008The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC BIOINFORMATICS. 9:S10.Full Text via DOI: 10.1186/1471-2105-9-s9-s10
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2006Evaluation of DNA microarray results with quantitative gene expression platforms. NATURE BIOTECHNOLOGY. 24:1115-1122.Full Text via DOI: 10.1038/nbt1236
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2006Using RNA sample titrations to assess microarray platform performance and normalization techniques. NATURE BIOTECHNOLOGY. 24:1123-1131.Full Text via DOI: 10.1038/nbt1241
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Meeting Abstract (Web of Science)
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2018Abstract 2222: Using rare variants to characterize lung cancer riskFull Text via DOI: 10.1158/1538-7445.am2018-2222
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2017Accuracy Of Fdg-Pet To Diagnose Lung Cancer In Northwest Ohio. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2017Bronchial Anthracofibrosis In An East Indian Immigrant Living In Northwest Ohio. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2017Computed Tomography (ct) And Photon Emission Tomography (pet) Findings And Endobronchial Ultrasound (ebus) Fine Needle Aspiration (fna) Results In An Area With Endemic Histoplasmosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2017Genome Maintenance Gene Regulation In Normal Bronchial Epithelial Cells By Cebp And Tp53 Transcription Factor Families Is Different In COPD Subjects. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2017Strategies To Identify Common Low Effect COPD Risk Variants. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2016Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing analysis of KRAS actionable mutations. JOURNAL OF THORACIC ONCOLOGY. S53-S54.
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2016Accuracy Of Self-Reporting In Diagnosis Of COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2015Conversion of the Lung Cancer Risk Test (LCRT) to a next generation sequencing (NGS) platform. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4259
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2015Genetic variation at a cis-acting C/EBPG binding site is associated with allele-specific ERCC5 transcript expression. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-2084
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2015Identification of transcript abundance difference at lung cancer and COPD risk genes in normal bronchial epithelial cells. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-2205
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2015Methods for accurate reporting of confidence intervals in clinical applications of next generation sequencing (NGS). CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4892
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2014Identification of expression quantitative trait loci at lung cancer and COPD risk genes in normal bronchial epithelial cells. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-4251
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2014Inter-individual variation in MUC5B allele specific expression in normal bronchial epithelial cells and relationship to lung cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3401
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2014Investigation of C/EBPG transcription factor role in regulation of ERCC4 and ERCC5 in human lung cancer cells. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3381
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2014Safety Of Bronchoscopic Brush Biopsy In Subjects Recruited For Lung Cancer And COPD Risk Test Validation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2013Demographic Characteristics Of Subjects Recruited For Lung Cancer And COPD Risk Test Validation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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2012Development of RNA quality control methods to improve BCR-ABL measurement in whole blood samples. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2012-5538
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2012Molecular diagnostic tests to augment cytomorphologic diagnosis of lung cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2012-5541
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2012Normal bronchial epithelial cells (NBEC) sample RNA quality characteristics that will yield reliable measurement of lung cancer risk test. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2012-5549
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2011An antioxidant and DNA repair gene expression pattern associated with lung cancer risk is also associated with COPD risk. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2011-3168
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2009A multi-gene test for lung cancer risk. CANCER RESEARCH.
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2009
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2009
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Presentation (Faculty180)
Contact
full name
- James Willey
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Cumulative publications in Scholars@UToledo
