Ninan, Ipe

Ipe Ninan
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Positions

Neurosciences , College of Medicine and Life Sciences

Contact Info

Ipe.Ninan@UToledo.Edu

selected publications

Article (Web of Science)
- 2019
  
  Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron–Mediated Inhibition in the Infralimbic Cortex. BIOLOGICAL PSYCHIATRY. 86:682-692.
  Full Text via DOI: 10.1016/j.biopsych.2019.04.035
- 2019
  
  Lack of experience‐dependent intrinsic plasticity in the adolescent infralimbic medial prefrontal cortex. SYNAPSE. 73:e22090.
  Full Text via DOI: 10.1002/syn.22090
- 2019
  
  Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity. NEUROPSYCHOPHARMACOLOGY. 44:1828-1836.
  Full Text via DOI: 10.1038/s41386-019-0396-6
- 2017
  
  A Cooperative Mechanism Involving Ca2+-Permeable AMPA Receptors and Retrograde Activation of GABAB Receptors in Interpeduncular Nucleus Plasticity. CELL REPORTS. 20:1111-1122.
  Full Text via DOI: 10.1016/j.celrep.2017.07.013
- 2017
  
  The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity-dependent synaptic plasticity in the dorsolateral striatum. NEUROPHARMACOLOGY. 112:84-93.
  Full Text via DOI: 10.1016/j.neuropharm.2016.06.030
- 2016
  
  Development- and experience-dependent plasticity in the dorsomedial habenula. MOLECULAR AND CELLULAR NEUROSCIENCE. 77:105-112.
  Full Text via DOI: 10.1016/j.mcn.2016.10.006
- 2016
  
  Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. NATURE COMMUNICATIONS. 7:11475.
  Full Text via DOI: 10.1038/ncomms11475
- 2016
  
  Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. ELIFE. 5.
  Full Text via DOI: 10.7554/elife.15092
- 2016
  
  Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. SCIENCE TRANSLATIONAL MEDICINE. 8.
  Full Text via DOI: 10.1126/scitranslmed.aaf7151
- 2016
  
  Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease. SCIENTIFIC REPORTS. 6:32553.
  Full Text via DOI: 10.1038/srep32553
- 2015
  
  Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism. NEUROPSYCHOPHARMACOLOGY. 40:2269-2277.
  Full Text via DOI: 10.1038/npp.2015.76
- 2015
  
  Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. CELL REPORTS. 13:1747-1756.
  Full Text via DOI: 10.1016/j.celrep.2015.10.064
- 2014
  
  Regulation of the Mouse Medial Prefrontal Cortical Synapses by Endogenous Estradiol. NEUROPSYCHOPHARMACOLOGY. 39:2086-2094.
  Full Text via DOI: 10.1038/npp.2014.56
- 2014
  
  The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice. MOLECULAR AND CELLULAR NEUROSCIENCE. 58:76-84.
  Full Text via DOI: 10.1016/j.mcn.2013.12.003
- 2013
  
  Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor. CELL. 155:1596-1609.
  Full Text via DOI: 10.1016/j.cell.2013.11.030
- 2013
  
  Sucrose Ingestion Induces Rapid AMPA Receptor Trafficking. JOURNAL OF NEUROSCIENCE. 33:6123-6132.
  Full Text via DOI: 10.1523/jneurosci.4806-12.2013
- 2012
  
  Altered fear learning across development in both mouse and human. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:16318-16323.
  Full Text via DOI: 10.1073/pnas.1206834109
- 2012
  
  BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity. NEUROPSYCHOPHARMACOLOGY. 37:1297-1304.
  Full Text via DOI: 10.1038/npp.2011.318
- 2012
  
  The BDNF Val66Met Polymorphism Impairs Synaptic Transmission and Plasticity in the Infralimbic Medial Prefrontal Cortex. JOURNAL OF NEUROSCIENCE. 32:2410-2421.
  Full Text via DOI: 10.1523/jneurosci.5205-11.2012
- 2011
  
  Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. JOURNAL OF NEUROCHEMISTRY. 119:324-331.
  Full Text via DOI: 10.1111/j.1471-4159.2011.07430.x
- 2011
  
  Selective early-acquired fear memories undergo temporary suppression during adolescence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:1182-1187.
  Full Text via DOI: 10.1073/pnas.1012975108
- 2011
  
  Synaptic Autoregulation by Metalloproteases and -Secretase. JOURNAL OF NEUROSCIENCE. 31:12083-12093.
  Full Text via DOI: 10.1523/jneurosci.2513-11.2011
- 2010
  
  Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development. PLOS ONE. 5:e12486.
  Full Text via DOI: 10.1371/journal.pone.0012486
- 2010
  
  Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. JOURNAL OF NEUROSCIENCE RESEARCH. 88:3447-3456.
  Full Text via DOI: 10.1002/jnr.22513
- 2010
  
  Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice. Nature Medicine. 16:598-602.
  Full Text via DOI: 10.1038/nm.2125
- 2010
  
  The ARMS/Kidins220 scaffold protein modulates synaptic transmission. MOLECULAR AND CELLULAR NEUROSCIENCE. 45:92-100.
  Full Text via DOI: 10.1016/j.mcn.2010.06.002
- 2010
  
  The BDNF Val66Met Polymorphism Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Hippocampus. JOURNAL OF NEUROSCIENCE. 30:8866-8870.
  Full Text via DOI: 10.1523/jneurosci.1405-10.2010
- 2009
  
  A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity. NEUROSCIENCE RESEARCH. 65:S29.
  Full Text via DOI: 10.1016/j.neures.2009.09.1657
- 2008
  
  Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. JOURNAL OF NEUROCHEMISTRY.
  Full Text via DOI: 10.1111/j.1471-4159.2008.05685.x
- 2007
  
  A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking. Neuron. 56:670-688.
  Full Text via DOI: 10.1016/j.neuron.2007.09.016
- 2006
  
  BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature Neuroscience. 9:1009-1018.
  Full Text via DOI: 10.1038/nn1730
- 2006
  
  Early presynaptic changes during plasticity in cultured hippocampal neurons. EMBO JOURNAL. 25:4361-4371.
  Full Text via DOI: 10.1038/sj.emboj.7601318
- 2006
  
  Estimation of the Mean from Sums with Unknown Numbers of Summands. BIOMETRICS. 62:918-920.
  Full Text via DOI: 10.1111/j.1541-0420.2005.00518.x
- 2004
  
  P3-323 Alzheimer Aβ increases neuro-transmitter release and blocks synaptic plasticity in hippocampal cultures. Neurobiology of Aging. 25:S447.
  Full Text via DOI: 10.1016/s0197-4580(04)81473-8
- 2004
  
  Presynaptic CaMKII Is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons. Neuron. 42:129-141.
  Full Text via DOI: 10.1016/s0896-6273(04)00143-6
- 2004
  
  α-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO JOURNAL. 23:4506-4516.
  Full Text via DOI: 10.1038/sj.emboj.7600451
- 2003
  
  Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells. SYNAPSE. 47:285-294.
  Full Text via DOI: 10.1002/syn.10175
- 2003
  
  Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex. SYNAPSE. 48:66-79.
  Full Text via DOI: 10.1002/syn.10189
- 2003
  
  Dopamine depletion and D1 receptor blockade abolish facilitatory effect of clozapine on NMDA- and electrically-evoked responses in pyramidal cells of the rat medial prefrontal cortex. Schizophrenia Research. 60:113.
  Full Text via DOI: 10.1016/s0920-9964(03)80863-0
- 2003
  
  Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence. European Journal of Neuroscience. 17:1306-1312.
  Full Text via DOI: 10.1046/j.1460-9568.2003.02549.x
- 2003
  
  Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex. NEUROPHARMACOLOGY. 44:462-472.
  Full Text via DOI: 10.1016/s0028-3908(03)00033-9
- 2003
  
  Protein kinase c is involved in clozapine’s facilitation of n-methyl-d-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. NEUROSCIENCE. 118:501-512.
  Full Text via DOI: 10.1016/s0306-4522(02)00976-4
- 2001
  
  Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug. SYNAPSE. 41:294-300.
  Full Text via DOI: 10.1002/syn.1086
- 2000
  
  Ketanserin reverses dizocilpine-suppression of morphine dependence but not tolerance in mice. BRAIN RESEARCH. 876:215-219.
  Full Text via DOI: 10.1016/s0006-8993(00)02660-3
- 1999
  
  Antagonism by pimozide of olanzapine-induced hypothermia. Fundamental & Clinical Pharmacology. 13:541-546.
  Full Text via DOI: 10.1111/j.1472-8206.1999.tb00359.x
- 1999
  
  Differential effects of olanzapine at dopamine D 1 and D 2 receptors in dopamine depleted animals. PSYCHOPHARMACOLOGY. 142:175-181.
  Full Text via DOI: 10.1007/s002130050877
- 1999
  
  Effect of olanzapine on behavioural changes induced by FG 7142 and dizocilpine on active avoidance and plus maze tasks. BRAIN RESEARCH. 830:337-344.
  Full Text via DOI: 10.1016/s0006-8993(99)01422-5
- 1999
  
  Preferential inhibition of dizocilpine-induced hyperlocomotion by olanzapine. EUROPEAN JOURNAL OF PHARMACOLOGY. 368:1-7.
  Full Text via DOI: 10.1016/s0014-2999(98)00982-0
- 1999
  
  Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.. Methods and findings in experimental and clinical pharmacology. 21:603-8.
  PMID: 10669905
- 1998
  
  5-HT2A receptor antagonists block MK-801-induced stereotypy and hyperlocomotion. EUROPEAN JOURNAL OF PHARMACOLOGY. 358:111-116.
  Full Text via DOI: 10.1016/s0014-2999(98)00591-3
- 1998
  
  Dopamine receptor sensitive effect of dizocilpine on feeding behaviour. BRAIN RESEARCH. 812:157-163.
  Full Text via DOI: 10.1016/s0006-8993(98)00990-1
- 1998
  
  Partial agonistic action of clozapine at dopamine D 2 receptors in dopamine depleted animals. PSYCHOPHARMACOLOGY. 135:311-317.
  Full Text via DOI: 10.1007/s002130050515
- 1997
  
  Inhibition of morphine tolerance and dependence by Withania somnifera in mice. JOURNAL OF ETHNOPHARMACOLOGY. 57:213-217.
  Full Text via DOI: 10.1016/s0378-8741(97)00064-0
- 1996
  
  Clozapine-induced cognitive dysfunction in mice.. Methods and findings in experimental and clinical pharmacology. 18:367-72.
  PMID: 8892266
Letter (Web of Science)
- 1998
  
  Clozapine: partial agonist at dopamine D 2 receptors!. PSYCHOPHARMACOLOGY. 215-216.
  Full Text via DOI: 10.1007/s002130050666
Review Article (Web of Science)
- 2014
  
  Synaptic regulation of affective behaviors; role of BDNF. NEUROPHARMACOLOGY. 684-695.
  Full Text via DOI: 10.1016/j.neuropharm.2013.04.011
- 2007
  
  ?-Synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. European Journal of Neuroscience. 3583-3596.
  Full Text via DOI: 10.1111/j.1460-9568.2007.05569.x
- 2000
  
  Dopamine D₄receptors and development of newer antipsychotic drugs. Fundamental & Clinical Pharmacology. 529-539.
  Full Text via DOI: 10.1111/j.1472-8206.2000.tb00437.x
- 1996
  
  Current concepts in the molecular diversity and pharmacology of dopamine receptors.. Methods and findings in experimental and clinical pharmacology. 599-613.
  PMID: 9010835

full name

Ipe Ninan

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