Contact Info
Overview
overview
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Education and Training
Degree
Field of Study
Institution
Year
B.Pharm
Pharmacy
University of Kerala (India)
1994
M.Pharm
Pharmacology
Panjab University (India)
1996
Ph.D
Pharmacology
Panjab University ((India)
2000
Publications
selected publications
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Article (Faculty180)
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2021Development-Dependent Plasticity in Vasoactive Intestinal Polypeptide Neurons in the Infralimbic Cortex. Cerebral cortex communications. 2:tgab007.
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2016Development- and experience-dependent plasticity in the dorsomedial habenula. Molecular and cellular neurosciences. 77:105-112.
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2016Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Science translational medicine. 8:344ra85.
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2014Synaptic regulation of affective behaviors; role of BDNF. Neuropharmacology. 76 Pt C:684-95.
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2014The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice. Molecular and cellular neurosciences. 58:76-84.
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2013
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2012Altered fear learning across development in both mouse and human. Proceedings of the National Academy of Sciences of the United States of America. 109:16318-23.
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2012BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 37:1297-304.
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2010
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2010Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. Journal of neuroscience research. 88:3447-56.
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2010Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nature medicine. 16:598-602, 1p following 602.
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2006BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature neuroscience. 9:1009-18.
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2006Early presynaptic changes during plasticity in cultured hippocampal neurons. The EMBO journal. 25:4361-71.
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2006Estimation of the mean from sums with unknown numbers of summands. Biometrics. 62:918-20.
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2004
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2004alpha-Synuclein produces a long-lasting increase in neurotransmitter release. The EMBO journal. 23:4506-16.
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2003Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence. The European journal of neuroscience. 17:1306-12.
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Article (Web of Science)
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2019Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron–Mediated Inhibition in the Infralimbic Cortex. BIOLOGICAL PSYCHIATRY. 86:682-692.Full Text via DOI: 10.1016/j.biopsych.2019.04.035
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2019Lack of experience‐dependent intrinsic plasticity in the adolescent infralimbic medial prefrontal cortex. SYNAPSE. 73:e22090.Full Text via DOI: 10.1002/syn.22090
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2019Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity. NEUROPSYCHOPHARMACOLOGY. 44:1828-1836.Full Text via DOI: 10.1038/s41386-019-0396-6
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2017A Cooperative Mechanism Involving Ca2+-Permeable AMPA Receptors and Retrograde Activation of GABAB Receptors in Interpeduncular Nucleus Plasticity. CELL REPORTS. 20:1111-1122.Full Text via DOI: 10.1016/j.celrep.2017.07.013
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2017The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity-dependent synaptic plasticity in the dorsolateral striatum. NEUROPHARMACOLOGY. 112:84-93.Full Text via DOI: 10.1016/j.neuropharm.2016.06.030
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2016Development- and experience-dependent plasticity in the dorsomedial habenula. MOLECULAR AND CELLULAR NEUROSCIENCE. 77:105-112.Full Text via DOI: 10.1016/j.mcn.2016.10.006
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2016Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. NATURE COMMUNICATIONS. 7:11475.Full Text via DOI: 10.1038/ncomms11475
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2016Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. SCIENCE TRANSLATIONAL MEDICINE. 8.Full Text via DOI: 10.1126/scitranslmed.aaf7151
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2016Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease. SCIENTIFIC REPORTS. 6:32553.Full Text via DOI: 10.1038/srep32553
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2015Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism. NEUROPSYCHOPHARMACOLOGY. 40:2269-2277.Full Text via DOI: 10.1038/npp.2015.76
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2015Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. CELL REPORTS. 13:1747-1756.Full Text via DOI: 10.1016/j.celrep.2015.10.064
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2014Regulation of the Mouse Medial Prefrontal Cortical Synapses by Endogenous Estradiol. NEUROPSYCHOPHARMACOLOGY. 39:2086-2094.Full Text via DOI: 10.1038/npp.2014.56
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2014The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice. MOLECULAR AND CELLULAR NEUROSCIENCE. 58:76-84.Full Text via DOI: 10.1016/j.mcn.2013.12.003
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2013Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor. CELL. 155:1596-1609.Full Text via DOI: 10.1016/j.cell.2013.11.030
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2013Sucrose Ingestion Induces Rapid AMPA Receptor Trafficking. JOURNAL OF NEUROSCIENCE. 33:6123-6132.Full Text via DOI: 10.1523/jneurosci.4806-12.2013
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2012Altered fear learning across development in both mouse and human. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:16318-16323.Full Text via DOI: 10.1073/pnas.1206834109
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2012BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity. NEUROPSYCHOPHARMACOLOGY. 37:1297-1304.Full Text via DOI: 10.1038/npp.2011.318
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2012The BDNF Val66Met Polymorphism Impairs Synaptic Transmission and Plasticity in the Infralimbic Medial Prefrontal Cortex. JOURNAL OF NEUROSCIENCE. 32:2410-2421.Full Text via DOI: 10.1523/jneurosci.5205-11.2012
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2011Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. JOURNAL OF NEUROCHEMISTRY. 119:324-331.Full Text via DOI: 10.1111/j.1471-4159.2011.07430.x
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2011Selective early-acquired fear memories undergo temporary suppression during adolescence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:1182-1187.Full Text via DOI: 10.1073/pnas.1012975108
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2011Synaptic Autoregulation by Metalloproteases and -Secretase. JOURNAL OF NEUROSCIENCE. 31:12083-12093.Full Text via DOI: 10.1523/jneurosci.2513-11.2011
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2010Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development. PLOS ONE. 5:e12486.Full Text via DOI: 10.1371/journal.pone.0012486
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2010Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. JOURNAL OF NEUROSCIENCE RESEARCH. 88:3447-3456.Full Text via DOI: 10.1002/jnr.22513
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2010Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice. Nature Medicine. 16:598-602.Full Text via DOI: 10.1038/nm.2125
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2010The ARMS/Kidins220 scaffold protein modulates synaptic transmission. MOLECULAR AND CELLULAR NEUROSCIENCE. 45:92-100.Full Text via DOI: 10.1016/j.mcn.2010.06.002
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2010The BDNF Val66Met Polymorphism Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Hippocampus. JOURNAL OF NEUROSCIENCE. 30:8866-8870.Full Text via DOI: 10.1523/jneurosci.1405-10.2010
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2009A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity. NEUROSCIENCE RESEARCH. 65:S29.Full Text via DOI: 10.1016/j.neures.2009.09.1657
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2008Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. JOURNAL OF NEUROCHEMISTRY.Full Text via DOI: 10.1111/j.1471-4159.2008.05685.x
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2007A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking. Neuron. 56:670-688.Full Text via DOI: 10.1016/j.neuron.2007.09.016
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2006BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature Neuroscience. 9:1009-1018.Full Text via DOI: 10.1038/nn1730
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2006Early presynaptic changes during plasticity in cultured hippocampal neurons. EMBO JOURNAL. 25:4361-4371.Full Text via DOI: 10.1038/sj.emboj.7601318
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2006Estimation of the Mean from Sums with Unknown Numbers of Summands. BIOMETRICS. 62:918-920.Full Text via DOI: 10.1111/j.1541-0420.2005.00518.x
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2004P3-323 Alzheimer Aβ increases neuro-transmitter release and blocks synaptic plasticity in hippocampal cultures. Neurobiology of Aging. 25:S447.Full Text via DOI: 10.1016/s0197-4580(04)81473-8
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2004Presynaptic CaMKII Is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons. Neuron. 42:129-141.Full Text via DOI: 10.1016/s0896-6273(04)00143-6
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2004α-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO JOURNAL. 23:4506-4516.Full Text via DOI: 10.1038/sj.emboj.7600451
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2003Dopamine depletion and D1 receptor blockade abolish facilitatory effect of clozapine on NMDA- and electrically-evoked responses in pyramidal cells of the rat medial prefrontal cortex. Schizophrenia Research. 60:113.Full Text via DOI: 10.1016/s0920-9964(03)80863-0
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2003Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence. European Journal of Neuroscience. 17:1306-1312.Full Text via DOI: 10.1046/j.1460-9568.2003.02549.x
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2003Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex. NEUROPHARMACOLOGY. 44:462-472.Full Text via DOI: 10.1016/s0028-3908(03)00033-9
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2003Protein kinase c is involved in clozapine’s facilitation of n-methyl-d-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. NEUROSCIENCE. 118:501-512.Full Text via DOI: 10.1016/s0306-4522(02)00976-4
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2001Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug. SYNAPSE. 41:294-300.Full Text via DOI: 10.1002/syn.1086
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2000Ketanserin reverses dizocilpine-suppression of morphine dependence but not tolerance in mice. BRAIN RESEARCH. 876:215-219.Full Text via DOI: 10.1016/s0006-8993(00)02660-3
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1999Antagonism by pimozide of olanzapine-induced hypothermia. Fundamental & Clinical Pharmacology. 13:541-546.Full Text via DOI: 10.1111/j.1472-8206.1999.tb00359.x
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1999Differential effects of olanzapine at dopamine D 1 and D 2 receptors in dopamine depleted animals. PSYCHOPHARMACOLOGY. 142:175-181.Full Text via DOI: 10.1007/s002130050877
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1999Effect of olanzapine on behavioural changes induced by FG 7142 and dizocilpine on active avoidance and plus maze tasks. BRAIN RESEARCH. 830:337-344.Full Text via DOI: 10.1016/s0006-8993(99)01422-5
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1999Preferential inhibition of dizocilpine-induced hyperlocomotion by olanzapine. EUROPEAN JOURNAL OF PHARMACOLOGY. 368:1-7.Full Text via DOI: 10.1016/s0014-2999(98)00982-0
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1999Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.. Methods and findings in experimental and clinical pharmacology. 21:603-8.PMID: 10669905
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19985-HT2A receptor antagonists block MK-801-induced stereotypy and hyperlocomotion. EUROPEAN JOURNAL OF PHARMACOLOGY. 358:111-116.Full Text via DOI: 10.1016/s0014-2999(98)00591-3
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1998Dopamine receptor sensitive effect of dizocilpine on feeding behaviour. BRAIN RESEARCH. 812:157-163.Full Text via DOI: 10.1016/s0006-8993(98)00990-1
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1998Partial agonistic action of clozapine at dopamine D 2 receptors in dopamine depleted animals. PSYCHOPHARMACOLOGY. 135:311-317.Full Text via DOI: 10.1007/s002130050515
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1997Inhibition of morphine tolerance and dependence by Withania somnifera in mice. JOURNAL OF ETHNOPHARMACOLOGY. 57:213-217.Full Text via DOI: 10.1016/s0378-8741(97)00064-0
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1996Clozapine-induced cognitive dysfunction in mice.. Methods and findings in experimental and clinical pharmacology. 18:367-72.PMID: 8892266
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Letter (Web of Science)
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1998Clozapine: partial agonist at dopamine D 2 receptors!. PSYCHOPHARMACOLOGY. 215-216.Full Text via DOI: 10.1007/s002130050666
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Review Article (Web of Science)
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2014Synaptic regulation of affective behaviors; role of BDNF. NEUROPHARMACOLOGY. 684-695.Full Text via DOI: 10.1016/j.neuropharm.2013.04.011
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2007?-Synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. European Journal of Neuroscience. 3583-3596.Full Text via DOI: 10.1111/j.1460-9568.2007.05569.x
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2000Dopamine D4receptors and development of newer antipsychotic drugs. Fundamental & Clinical Pharmacology. 529-539.Full Text via DOI: 10.1111/j.1472-8206.2000.tb00437.x
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1996Current concepts in the molecular diversity and pharmacology of dopamine receptors.. Methods and findings in experimental and clinical pharmacology. 599-613.PMID: 9010835
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Contact
full name
- Ipe Ninan
visualizations
Cumulative publications in Scholars@UToledo
