Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron-Mediated Inhibition in the Infralimbic Cortex

Article (Faculty180)

cited authors

  • Koppensteiner, Peter; Von Itter, Richard; Melani, Riccardo; Galvin, Christopher; Lee, Francis S; Ninan, Ipe

description

  • <p>Rodents and humans show an attenuation of fear extinction during adolescence, which coincides with the onset of several psychiatric disorders. Although the ethological relevance and the underlying mechanism are largely unknown, the suppression of fear extinction during adolescence is associated with a diminished plasticity in the glutamatergic neurons of the infralimbic medial prefrontal cortex, a brain region critical for fear extinction. Given the putative effect of synaptic inhibition on glutamatergic neuron activity, we studied whether gamma-aminobutyric acidergic neurons in the infralimbic medial prefrontal cortex are involved in the suppression of fear extinction during adolescence.</p>

authors

publication date

  • 2019

published in

start page

  • 682

end page

  • 692

volume

  • 86