Guillermo Vazquez
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Professor (with tenure)
Program Director MSBS-Medical Sciences
Associate Director, Center for Hypertension and Precision Medicine, Physiology and Pharmacology , College of Medicine and Life Sciences
Overview
overview
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Dr. Vazquez did his undergraduate work at the National University of the South in Argentina, where he also received his Ph.D. in Biochemistry in 1997. He completed a von Humboldt Visiting Fellowship in Pharmacology at the Freie Universitat in Berlin, Germany (1997) and a Visiting Postdoctoral Fellowship in the Signal Transduction Division at the National Institute of Environmental Health Sciences in North Carolina (2001-2006). Dr. Vazquez has been a faculty member of the College of Medicine and Life Sciences at University of Toledo (UT) since 2007 and is currently a tenured Professor in the Department of Physiology and Pharmacology within that College. He also serves as the Associate Director of the Center for Hypertension and Precision Medicine and Director of the MSBS in Medical Sciences program, both in this institution.
For the past 15 years, Dr. Vazquez has been teaching and mentoring graduate and medical students, while maintaining an independent, AHA- and NIH-funded research program on molecular and cellular basis of coronary heart disease. During his appointment at UT Dr. Vazquez has received numerous awards, among them the Dean’s New Investigator Award and the Dean's Mentor award from the College of Medicine and Life Sciences in recognition of his success as a scholar and mentor. Dr. Vazquez groundbreaking work on the role of TRPC channels in endothelial and macrophage biology led to seminal contributions to current knowledge of cellular mechanisms of coronary heart disease. His work has been published in several high impact factor scientific journals. Dr. Vazquez's contributions have been recognized by peers in the cardiovascular field by being elected Fellow of the American Heart Association.
Publications
selected publications
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Article (Faculty180)
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2019CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats. Biochemical and Biophysical Research Communications.
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2017Deep transcriptomic profiling of M1 macrophages lacking Trpc3. Scientific reports. 7:39867.
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2017Evidence for constitutive bone morphogenetic protein-2 secretion by m1 macrophages: constitutive auto/paracrine osteogenic signaling by bmp-2 in m1 macrophages. Biochemical and biophysical research communications. 491:154.
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2017
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2016
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2016Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis. PloS one. 11:e0153519.
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2016VASCULAR CALCIFICATION IN ATHEROSCLEROSIS: POTENTIAL ROLES OF MACROPHAGES AND NON-CODING MICRO-RNAs. ACTUALIZACIONES EN OSTEOLOGIA. 12:126.
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2015Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. Proceedings of the National Academy of Sciences. 112:E2201.
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2015Micro-RNAs and macrophage diversity in atherosclerosis: new players, new challenges⦠new opportunities for therapeutic intervention?. Biochemistry and biophysics reports. 3:202.
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2014
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2014Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages. American Journal of Physiology-Cell Physiology. 307:C521.
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2013
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2013Ceacam1 deletion causes vascular alterations in large vessels. American Journal of Physiology-Endocrinology and Metabolism. 305:E519.
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2013Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages. Physiological reports. 1:e00189.
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2013
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2012Alpha7 nicotinic acetylcholine receptor in macrophage apoptosis and efferocytosis. The FASEB Journal. 26:lb551.
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2012CAM/CAMKII-dependent survival signaling in bone marrow derived macrophages. The FASEB Journal. 26:lb548.
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2012Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages. Biochemical and biophysical research communications. 427:178.
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2012Macrophage function in atherosclerosis: potential roles of TRP channels. Channels. 6:141.
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2012On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease. Cardiovascular \& Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular \& Hematological Agents). 10:265.
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2012TRPC channels as prospective targets in atherosclerosis: terra incognita. Front Biosci (Schol Ed). 4:157.
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2011Evidence for operation of nicotinic and muscarinic acetylcholine receptor-dependent survival pathways in human coronary artery endothelial cells. Journal of cellular biochemistry. 112:1978.
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2011Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. Biochemical and biophysical research communications. 410:643.
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2011Muscarinic-and Nicotinic-Acetylcholine Receptor dependent survival signaling in Human Coronary artery Endothelial Cells. The FASEB Journal. 25:lb450.
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2011Novel role of nicotinic acetylcholine receptor-dependent signaling in macrophage survival. The FASEB Journal. 25:lb446.
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2011Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling. Biochemical and biophysical research communications. 407:432.
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2010Endothelial TRPC3/6/7 proteins at the edge of cardiovascular disease. Cardiovascular \& Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular \& Hematological Agents). 8:76.
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2008Activation and regulation of TRPC cation channels. Cell Membranes and Free Radical Research. 1:51.
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2008Involvement of native TRPC3 proteins in ATP-dependent expression of VCAM-1 and monocyte adherence in coronary artery endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. 28:2049.
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2006Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C. Journal of Biological Chemistry. 281:11712.
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2006Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1763:1147.
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2006Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. Journal of Biological Chemistry. 281:25250.
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2006Role of Canonical Transient Receptor Potential (trpc) Channels in Receptor-dependent Regulation of Vascular Cell Adhesion Molecule-1 in Human Coronary Artery Endothelium: P229. Arteriosclerosis, Thrombosis, and Vascular Biology. 26:e.
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2005The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. Journal of Biological Chemistry. 280:35346.
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2004Evidence that TRPC3 is a molecular component of the 1$\alpha$, 25 (OH) 2D3-activated capacitative calcium entry (CCE) in muscle and osteoblast cells. The Journal of steroid biochemistry and molecular biology. 89:291.
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2004Mechanisms of phospholipase C-regulated calcium entry. Current molecular medicine. 4:291.
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2004Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels. Journal of Biological Chemistry. 279:40521.
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2004TRPC3-like protein and Vitamin D receptor mediate 1a, 25 (OH) 2D3-induced SOC influx in muscle cells. International Journal of Biochemistry and Cell Biology. 36:1920.
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2004The mammalian TRPC cation channels. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1742:21.
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2003A calmodulin/IP3 receptor binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process. Journal of Biological Chemistry.
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2003A calmodulin/inositol 1, 4, 5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process. Journal of Biological Chemistry. 278:25758.
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2003Capacitative calcium influx in human epithelial breast cancer and non-tumorigenic cells occurs through Ca2+ entry pathways with different permeabilities to divalent cations. Journal of cellular biochemistry. 88:1265.
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2003Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. Journal of Biological Chemistry. 278:21649.
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2003Modulation of cytosolic calcium levels in osteoblast-like osteosarcoma cells by olpadronate and its amino-derivative IG-9402. Calcified tissue international. 72:215.
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2003TRPC3-like protein is involved in the capacitative cation entry induced by 1$\alpha$, 25-dihydroxy-vitamin D3 in ROS 17/2.8 osteoblastic cells. Journal of cellular biochemistry. 90:197.
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2003The TRPC3/6/7 subfamily of cation channels. Cell calcium. 33:451.
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2002An inositol 1, 4, 5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes. The EMBO journal. 21:4531.
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2002Characterization of a 1, 25 (OH) 2-vitamin D3-responsive capacitative Ca2+ entry pathway in rat osteoblast-like cells. Journal of cellular biochemistry. 86:678.
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2001Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes. Proceedings of the National Academy of Sciences. 98:11777.
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2001Protein Kinase C $\alpha$ Modulates the Ca2+ Influx Phase of the Ca2+ Response to 1$\alpha$, 25-Dihydroxy-Vitamin-D3 in Skeletal Muscle Cells. Hormone and Metabolic Research. 33:201.
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2001
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2001The vitamin D receptor mediates rapid changes in muscle protein tyrosine phosphorylation induced by 1, 25 (OH) 2D3. Biochemical and biophysical research communications. 289:1150.
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2000
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2000
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2000Involvement of calmodulin in 1$\alpha$, 25-dihydroxyvitamin D3 stimulation of store-operated Ca2+ influx in skeletal muscle cells. Journal of Biological Chemistry. 275:16134.
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2000Involvement of tyrosine kinase activity in 1$\alpha$, 25 (OH) 2-vitamin D3 signal transduction in skeletal muscle cells. Journal of Biological Chemistry. 275:36021.
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2000Role of protein kinase C in 1, 25 (OH) 2-vitamin D3 modulation of intracellular calcium during development of skeletal muscle cells in culture. Journal of cellular biochemistry. 77:200.
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199917$\beta$-Oestradiol increases intracellular Ca2+ concentration in rat enterocytes. Biochemical Journal. 339:71.
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1999Activation of a$\beta$-adrenergic-sensitive Signal Transduction Pathway by the Secosteroid Hormone 1, 25-(OH) 2-Vitamin D3in Chick Heart. Journal of molecular and cellular cardiology. 31:1095.
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1999Rapid actions of calcitriol and its side chain analogues CB1093 and GS1500 on intracellular calcium levels in skeletal muscle cells: a comparative study. British journal of pharmacology. 126:1815.
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1998
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19971$\alpha$, 25-(OH) 2-Vitamin D3Stimulates the Adenylyl Cyclase Pathway in Muscle Cells by a GTP-Dependent Mechanism Which Presumably Involves Phosphorylation of G$\alpha$i. Biochemical and biophysical research communications. 234:125.
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1997Stimulation of Ca2+ release-activated Ca2+ channels as a potential mechanism involved in non-genomic 1, 25 (OH) 2-vitamin D3-induced Ca2+ entry in skeletal muscle cells. Biochemical and biophysical research communications. 239:562.
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1996Involvement of protein kinase C in the modulation of 1$\alpha$, 25-dihydroxy-vitamin D3-induced 45Ca2+ uptake in rat and chick cultured myoblasts. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1310:157.
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1995Avian muscle cells as targets for the secosteroid hormone 1, 25-dihydroxy-vitamin D3. Molecular and cellular endocrinology. 114:1.
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1995Modulation by 1, 25 (OH) 2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1269:91.
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1993" Stimulation of dihydropyridine-sensitive Ca2+ influx in cultured myoblasts by 1, 25 (OH) 2-vitamin D3".. Biochemistry and molecular biology international. 31:677.
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Article (Web of Science)
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2020Loss of Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Links Nonalcoholic Steatohepatitis to Atherosclerosis. HEPATOLOGY COMMUNICATIONS.Full Text via DOI: 10.1002/hep4.1590
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2019CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 513:760-765.Full Text via DOI: 10.1016/j.bbrc.2019.03.215 PMID: 30992131
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2018Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. HYPERTENSION. 72:1125-1132.Full Text via DOI: 10.1161/HYPERTENSIONAHA.118.11175
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2018Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene. MOLECULAR METABOLISM. 9:98-113.Full Text via DOI: 10.1016/j.molmet.2018.01.009
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2018Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3. ATHEROSCLEROSIS. 270:199-204.Full Text via DOI: 10.1016/j.atherosclerosis.2017.12.025
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2018Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. HYPERTENSION. 72:1125-1132.Full Text via DOI: 10.1161/hypertensionaha.118.11175
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2017Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 491:154-158.Full Text via DOI: 10.1016/j.bbrc.2017.07.065
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2017Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3. SCIENTIFIC REPORTS. 7.Full Text via DOI: 10.1038/srep42526
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2017Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3. SCIENTIFIC REPORTS. 7.Full Text via DOI: 10.1038/srep39867
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2016Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. PHYSIOLOGICAL GENOMICS. 48:644-649.Full Text via DOI: 10.1152/physiolgenomics.00067.2016
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2016Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis. PLOS ONE. 11.Full Text via DOI: 10.1371/journal.pone.0153519
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2016On the Roles of the Transient Receptor Potential Canonical 3 (TRPC3) Channel in Endothelium and Macrophages: Implications in Atherosclerosis. CALCIUM ENTRY PATHWAYS IN NON-EXCITABLE CELLS. 898:185-199.Full Text via DOI: 10.1007/978-3-319-26974-0_9
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2016Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells. VASCULAR PHARMACOLOGY. 76:42-52.Full Text via DOI: 10.1016/j.vph.2015.07.011
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2015Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112:E2201-E2206.Full Text via DOI: 10.1073/pnas.1505410112
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2014Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 307:C521-C531.Full Text via DOI: 10.1152/ajpcell.00369.2013
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2014Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis. CARDIOVASCULAR RESEARCH. 101:138-144.Full Text via DOI: 10.1093/cvr/cvt231
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2013Ceacam1 deletion causes vascular alterations in large vessels. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 305:E519-E529.Full Text via DOI: 10.1152/ajpendo.00266.2013
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2013Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages. PHYSIOLOGICAL REPORTS. 1:e00189.Full Text via DOI: 10.1002/phy2.189
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2012Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 427:178-184.Full Text via DOI: 10.1016/j.bbrc.2012.09.038
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2011Evidence for Operation of Nicotinic and Muscarinic Acetylcholine Receptor-Dependent Survival Pathways in Human Coronary Artery Endothelial Cells. JOURNAL OF CELLULAR BIOCHEMISTRY. 112:1978-1984.Full Text via DOI: 10.1002/jcb.23169
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2011Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 410:643-647.Full Text via DOI: 10.1016/j.bbrc.2011.06.045
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2011Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 407:432-437.Full Text via DOI: 10.1016/j.bbrc.2011.03.048
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2010The Constitutive Function of Native TRPC3 Channels Modulates Vascular Cell Adhesion Molecule-1 Expression in Coronary Endothelial Cells Through Nuclear Factor kappa B Signaling. CIRCULATION RESEARCH. 106:1479-1488.Full Text via DOI: 10.1161/CIRCRESAHA.109.213314
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2010The Constitutive Function of Native TRPC3 Channels Modulates Vascular Cell Adhesion Molecule-1 Expression in Coronary Endothelial Cells Through Nuclear Factor κB Signaling. CIRCULATION RESEARCH. 106:1479-1488.Full Text via DOI: 10.1161/circresaha.109.213314
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2008Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 28:2049-2055.Full Text via DOI: 10.1161/ATVBAHA.108.175356
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2008Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 28:2049-2055.Full Text via DOI: 10.1161/atvbaha.108.175356
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Chapter (Faculty180)
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2016On the roles of the transient receptor potential canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis. Calcium Entry Pathways in Non-excitable Cells. Springer. 185.
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2012Molecular and cellular aspects of atherosclerosis: emerging roles of TRPC channels. Coronary Artery Disease-New Insights and Novel Approaches. InTech.
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2007Phospholipase C-coupled receptors and activation of TRPC channels. Transient Receptor Potential (TRP) Channels. Springer. 593.
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Meeting Abstract (Web of Science)
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2009Upregulated Expression of Constitutively Active Transient Receptor Potential Canonical 3 Channels in Coronary Endothelial Cells Modulates Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. E111-E111.
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Other Scholarly Work (Faculty180)
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Proceedings (Faculty180)
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Review Article (Web of Science)
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2012Macrophage function in atherosclerosis Potential roles of TRP channels. CHANNELS. 141-148.Full Text via DOI: 10.4161/chan.20292
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2010On the potential role of source and species of diacylglycerol in phospholipase-dependent regulation of TRPC3 channels. CHANNELS. 232-240.Full Text via DOI: 10.4161/chan.4.3.12058
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Contact
full name
- Guillermo Vazquez