Deepak K Malhotra
- Chief, Division of Nephrology, Medicine , College of Medicine and Life Sciences
Contact Info
Publications
selected publications
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Article (Faculty180)
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Article (Web of Science)
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2022Age-related GSK3β overexpression drives podocyte senescence and glomerular aging. Journal of Clinical Investigation. 132.Full Text via DOI: 10.1172/jci141848
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2021The ketone body beta-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults. KIDNEY INTERNATIONAL. 100:1037-1053.Full Text via DOI: 10.1016/j.kint.2021.06.031 PMID: 34246657
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2021Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.Full Text via DOI: 10.3390/ijms22189939 PMID: 34576099
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2021Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes. ANTIOXIDANTS. 10.Full Text via DOI: 10.3390/antiox10010138 PMID: 33478120
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2020Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes. JOURNAL OF PERSONALIZED MEDICINE. 10.Full Text via DOI: 10.3390/jpm10040146 PMID: 32992731
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2020Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity. CHEMOSPHERE. 257.Full Text via DOI: 10.1016/j.chemosphere.2020.127111 PMID: 32485513
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2020CD40 Receptor Knockout Protects against Microcystin-LR (MC-LR) Prolongation and Exacerbation of Dextran Sulfate Sodium (DSS)-Induced Colitis. BIOMEDICINES. 8.Full Text via DOI: 10.3390/biomedicines8060149 PMID: 32498446
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2020Harmful Algal Bloom Toxicity inLithobates catesbeianaTadpoles. TOXINS. 12.Full Text via DOI: 10.3390/toxins12060378 PMID: 32521650
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2020Relapse of Nephrotic Syndrome after Adrenocorticotropic Hormone-Induced Remission: Implications of Adrenocorticotropic Hormone Antibodies. AMERICAN JOURNAL OF NEPHROLOGY. 51:390-394.Full Text via DOI: 10.1159/000506854 PMID: 32187600
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2020Glycogen synthase kinase 3 beta hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease. KIDNEY INTERNATIONAL. 97:175-192.Full Text via DOI: 10.1016/j.kint.2019.08.036 PMID: 31791666
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2020Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na + /K + ‐ATPase‐α‐1. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 9.Full Text via DOI: 10.1161/jaha.119.013933
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2020Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling. CLINICAL SCIENCE. 134:695-710.Full Text via DOI: 10.1042/cs20200016
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2020Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 9.Full Text via DOI: 10.1161/jaha.119.014072
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2019Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease. TOXINS. 11.Full Text via DOI: 10.3390/toxins11090486 PMID: 31450746
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2019GSK3 beta-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition. REDOX BIOLOGY. 26.Full Text via DOI: 10.1016/j.redox.2019.101275 PMID: 31349118
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2019Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20.Full Text via DOI: 10.3390/ijms20143495 PMID: 31315267
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2019Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease. JOURNAL OF CLINICAL MEDICINE. 8.Full Text via DOI: 10.3390/jcm8071034 PMID: 31311140
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2019Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis. TOXINS. 11.Full Text via DOI: 10.3390/toxins11060371 PMID: 31242640
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2019Brain natriuretic peptide mitigates TIMP2 induction and reinstates extracellular matrix catabolic activity via GSK3 beta inhibition in glomerular podocytes exposed to a profibrogenic milieu. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. 11:964-+.
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2019Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells. HYPERTENSION. 74:73-82.Full Text via DOI: 10.1161/hypertensionaha.118.12605
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2018Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma. NEPHROLOGY DIALYSIS TRANSPLANTATION. 33:1138-1149.Full Text via DOI: 10.1093/ndt/gfx334
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2018Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 49:1633-1645.Full Text via DOI: 10.1159/000493499
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2017Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease. SCIENTIFIC REPORTS. 7.Full Text via DOI: 10.1038/s41598-017-08426-8
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2016Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/JAHA.116.004106
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2016Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase alpha 1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/JAHA.116.003675
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2016Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac progenitor cells. STEM CELL RESEARCH. 16:795-806.Full Text via DOI: 10.1016/j.scr.2016.04.017
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2016Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/jaha.116.003675
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2016Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/jaha.116.004106
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2015Disequilibrium Syndrome and Prevention in Nonhemodialysis Patients. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 349:438-441.
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2015Disequilibrium Syndrome Prevention in Nonhemodialysis Patients. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 349:438-441.Full Text via DOI: 10.1097/maj.0000000000000445
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2014Early acute antibody-mediated rejection of a negative flow crossmatch, 3rd kidney transplant with exclusive disparity at HLA-DP. HUMAN IMMUNOLOGY. 75:703-708.Full Text via DOI: 10.1016/j.humimm.2014.04.001
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2014Passive Immunization Against Marinobufagenin Attenuates Renal Fibrosis and Improves Renal Function in Experimental Renal Disease. AMERICAN JOURNAL OF HYPERTENSION. 27:603-609.Full Text via DOI: 10.1093/ajh/hpt169
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2013Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:34249-34258.Full Text via DOI: 10.1074/jbc.M113.461020
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2013Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC NEPHROLOGY. 14.Full Text via DOI: 10.1186/1471-2369-14-209
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2013A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience. INTERNATIONAL UROLOGY AND NEPHROLOGY. 45:917-920.Full Text via DOI: 10.1007/s11255-012-0129-9
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2013Peroxisome Proliferator-Activated Receptor delta Agonist, HPP593, Prevents Renal Necrosis under Chronic Ischemia. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0064436
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2013Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:34249-34258.Full Text via DOI: 10.1074/jbc.m113.461020
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2012Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation. INTERNATIONAL UROLOGY AND NEPHROLOGY. 44:1907-1909.Full Text via DOI: 10.1007/s11255-011-9989-7
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2012Minimal change disease associated with MALT lymphoma. INTERNATIONAL UROLOGY AND NEPHROLOGY. 44:1911-1913.Full Text via DOI: 10.1007/s11255-011-9992-z
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2012Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. MOLECULAR AND CELLULAR BIOCHEMISTRY. 367:175-183.Full Text via DOI: 10.1007/s11010-012-1331-x
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2012Monoclonal Antibody Against Marinobufagenin Reverses Cardiac Fibrosis in Rats With Chronic Renal Failure. AMERICAN JOURNAL OF HYPERTENSION. 25:690-696.Full Text via DOI: 10.1038/ajh.2012.17
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2012Reduction of Na/K-ATPase Potentiates Marinobufagenin-induced Cardiac Dysfunction and Myocyte Apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:16390-16398.Full Text via DOI: 10.1074/jbc.M111.304451
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2012Ouabain and Insulin Induce Sodium Pump Endocytosis in Renal Epithelium. HYPERTENSION. 59:665-672.Full Text via DOI: 10.1161/HYPERTENSIONAHA.111.176727
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2012Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 10.Full Text via DOI: 10.1186/1477-7827-10-15
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2012Ouabain and Insulin Induce Sodium Pump Endocytosis in Renal Epithelium. HYPERTENSION. 59:665-672.Full Text via DOI: 10.1161/hypertensionaha.111.176727
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2012Reduction of Na/K-ATPase Potentiates Marinobufagenin-induced Cardiac Dysfunction and Myocyte Apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:16390-16398.Full Text via DOI: 10.1074/jbc.m111.304451
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2011Endogenous cardiotonic steroids in chronic renal failure. NEPHROLOGY DIALYSIS TRANSPLANTATION. 26:2912-U1511.Full Text via DOI: 10.1093/ndt/gfq772
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2011Impairment of Na/K-ATPase Signaling in Renal Proximal Tubule Contributes to Dahl Salt-sensitive Hypertension. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:22806-22813.Full Text via DOI: 10.1074/jbc.M111.246249
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2011Impairment of Na/K-ATPase Signaling in Renal Proximal Tubule Contributes to Dahl Salt-sensitive Hypertension. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:22806-22813.Full Text via DOI: 10.1074/jbc.m111.246249
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2010Neural Network Analysis to Predict Mortality in End-Stage Renal Disease: Application to United States Renal Data System. NEPHRON CLINICAL PRACTICE. 116:C148-C158.Full Text via DOI: 10.1159/000315884
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2009Spironolactone Attenuates Experimental Uremic Cardiomyopathy by Antagonizing Marinobufagenin. HYPERTENSION. 54:1313-+.Full Text via DOI: 10.1161/HYPERTENSIONAHA.109.140038
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2009Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 296:F1219-F1226.Full Text via DOI: 10.1152/ajprenal.90710.2008
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2009The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 296:F922-F934.Full Text via DOI: 10.1152/ajprenal.90605.2008
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2009Spironolactone Attenuates Experimental Uremic Cardiomyopathy by Antagonizing Marinobufagenin. HYPERTENSION. 54:1313-1320.Full Text via DOI: 10.1161/hypertensionaha.109.140038
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2008Effects of cardiotonic steroids on dermal collagen synthesis and wound healing. JOURNAL OF APPLIED PHYSIOLOGY. 105:30-36.Full Text via DOI: 10.1152/japplphysiol.00119.2008
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2008Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 294:F450-F454.Full Text via DOI: 10.1152/ajprenal.00472.2007
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2008Regulation of apical NHE3 trafficking by ouabain-induced activation of the basolateral Na+-K+-ATPase receptor complex. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 294:C555-C563.Full Text via DOI: 10.1152/ajpcell.00475.2007
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2007Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. HYPERTENSION. 49:215-224.Full Text via DOI: 10.1161/01.HYP.0000252409.36927.05
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2007Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy. HYPERTENSION. 49:215-224.Full Text via DOI: 10.1161/01.hyp.0000252409.36927.05
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2007Renal Vein Thrombosis: A Case Report. Angiology. 58:640-643.Full Text via DOI: 10.1177/0003319707303646
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2006Clearance of linezolid via continuous venovenous hemodiafiltration. AMERICAN JOURNAL OF KIDNEY DISEASES. 47:E83-E86.Full Text via DOI: 10.1053/j.ajkd.2006.03.037
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2006HEMATOLOGY: ISSUES IN THE DIALYSIS PATIENT: Platelet Dysfunction and End-Stage Renal Disease. SEMINARS IN DIALYSIS. 19:317-322.Full Text via DOI: 10.1111/j.1525-139x.2006.00179.x
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2006Ouabain decreases sarco(endo)plasmic reticulum calcium ATPase activity in rat hearts by a process involving protein oxidation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 291:H3003-H3011.Full Text via DOI: 10.1152/ajpheart.00603.2006
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Conference Poster (Faculty180)
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Letter (Web of Science)
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2017Measuring creatinine excretion and clearance for diagnosing and staging chronic kidney disease. INTERNATIONAL UROLOGY AND NEPHROLOGY. 551-552.Full Text via DOI: 10.1007/s11255-016-1468-8
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2011Leclercia adecarboxylata, an unusual hemodialysis catheter-related infection. INTERNATIONAL UROLOGY AND NEPHROLOGY. 1257-1258.Full Text via DOI: 10.1007/s11255-011-0002-2
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Meeting Abstract (Web of Science)
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2020Paraoxonase-1 regulation of Na/K-ATPase alpha-1 Src signaling in Chronic Kidney Disease. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.06643
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2019TARGETED DISRUPTION OF NA/K-ATPASE- SRC SIGNALING CASCADE SIGNIFICANTLY REDUCES RENAL INFLAMMATION AND OXIDATIVE STRESS FOLLOWING 5/6TH PARTIAL NEPHRECTOMY. JOURNAL OF INVESTIGATIVE MEDICINE. 920-920.Full Text via DOI: 10.1136/jim-2019-midwestern2019.91
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2018CARDIOTONIC STEROID SIGNALING THROUGH NA/ K-ATPASE-A-1 AND SRC KINASE ENHANCE FUNCTIONAL INTERACTIONS BETWEEN IMMUNE CELLS AND ENDO/EPITHELIAL CELLS. JOURNAL OF INVESTIGATIVE MEDICINE. 859-859.Full Text via DOI: 10.1136/jim-2018-000745.140
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2018EVIDENCE OF HEPATOTOXICITY FOLLOWING CHRONIC LOW DOSE EXPOSURE TO MICROCYSTIN-LR IN A MURINE MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 824-824.Full Text via DOI: 10.1136/jim-2018-000745.75
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2018PARAOXONASE REGULATION OF CARDIOTONIC STEROIDS IN CHRONIC KIDNEY DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 865-865.Full Text via DOI: 10.1136/jim-2018-000745.149
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2017CARDTIOTONIC STEROIDS MEDIATE INFLAMMATION IN RENAL EPITHELIUM VIA THE NA/K-ATPASE ALPHA-1-SRC KINASE SIGNALING PATHWAY. JOURNAL OF INVESTIGATIVE MEDICINE. 851-852.Full Text via DOI: 10.1136/jim-2017-000448.99
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2017NA/K-ATPASE SIGNALING STIMULATES CD40 EXPRESSION IN RENAL PROXIMAL TUBULAR EPITHELIAL CELLS. JOURNAL OF INVESTIGATIVE MEDICINE. 855-856.Full Text via DOI: 10.1136/jim-2017-000448.106
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2017TARGETED DISRUPTION OF CD40 SIGNIFICANTLY REDUCES RENAL FIBROSIS FOLLOWING RENAL TRANSPLANTATION IN EXPERIMENTAL RENAL ISCHEMIA. JOURNAL OF INVESTIGATIVE MEDICINE. 853-854.Full Text via DOI: 10.1136/jim-2017-000448.102
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2011RISE IN SERUM SODIUM CONCENTRATION AFTER SALINE INFUSION IN HYPONATREMIA. JOURNAL OF INVESTIGATIVE MEDICINE. 174-174.
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Review Article (Web of Science)
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2021Therapeutic Targeting of SGLT2: A New Era in the Treatment of Diabetes and Diabetic Kidney Disease. FRONTIERS IN ENDOCRINOLOGY.Full Text via DOI: 10.3389/fendo.2021.749010 PMID: 34790170
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2021Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall. BIOMEDICINES.Full Text via DOI: 10.3390/biomedicines9040404 PMID: 33917965
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2019Serum Sodium Concentration and Tonicity in Hyperglycemic Crises: Major Influences and Treatment Implications. JOURNAL OF THE AMERICAN HEART ASSOCIATION.Full Text via DOI: 10.1161/jaha.118.011786
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2018Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms19092576
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2018Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. INTERNATIONAL UROLOGY AND NEPHROLOGY. 1263-1270.Full Text via DOI: 10.1007/s11255-018-1822-0
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2018Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives. KIDNEY DISEASES. 205-213.Full Text via DOI: 10.1159/000490703 PMID: 30574497
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2014Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 432-439.
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2014Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 432-439.Full Text via DOI: 10.1097/maj.0000000000000331
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2013Principles of Management of Severe Hyponatremia. JOURNAL OF THE AMERICAN HEART ASSOCIATION.Full Text via DOI: 10.1161/JAHA.112.005199
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2013Principles of Management of Severe Hyponatremia. JOURNAL OF THE AMERICAN HEART ASSOCIATION.Full Text via DOI: 10.1161/jaha.112.005199
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Contact
full name
- Deepak K Malhotra
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Cumulative publications in Scholars@UToledo
research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Gastroenterology & Hepatology
- General & Internal Medicine
- Immunology
- Oncology
- Physiology
- Reproductive Biology
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Sport Sciences
- Transplantation
- Urology & Nephrology