Deborah N Chadee
Contact Info
Publications
selected publications
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Article (Faculty180)
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2021A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. Molecular biology of the cell. 32:1446-1458.
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2021LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells. Molecular and Cellular Biology. 41:e0007821.
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2019G protein αq exerts expression level-dependent distinct signaling paradigms. Cellular signalling. 58:34-43.
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2017Osmotic and heat stress-dependent regulation of MLK4$beta$ and MLK3 by the CHIP E3 ligase in ovarian cancer cells. Cellular signalling. 39:66.
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2015Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis. Experimental cell research. 331:292.
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2012MLK4$beta$ functions as a negative regulator of MAPK signaling and cell invasion. Oncogenesis. 1:e6.
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2012Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Experimental cell research. 318:1641.
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2009Investigating the role of Aurora kinases in RAS signaling. Journal of cellular biochemistry. 106:33.
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2009Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1793:1811.
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2004
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2003Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-$beta$-induced nuclear accumulation. American Journal of Physiology-Cell Physiology. 285:C823.
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2003RECEPTORS AND SIGNAL TRANSDUCTION-Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-b-induced nuclear accumulation. American Journal of Physiology-Regulatory Integrative Comparative Physiology. 54:C823.
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2002Histone H1 S-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. Oncogene. 21:8397.
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Article (Web of Science)
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2021A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. MOLECULAR BIOLOGY OF THE CELL. mbc.E20-11-0750.Full Text via DOI: 10.1091/mbc.e20-11-0750
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2020Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells. EXPERIMENTAL CELL RESEARCH. 394.Full Text via DOI: 10.1016/j.yexcr.2020.112167 PMID: 32649943
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2019G protein alpha q exerts expression level-dependent distinct signaling paradigms. CELLULAR SIGNALLING. 58:34-43.Full Text via DOI: 10.1016/j.cellsig.2019.02.006 PMID: 30849518
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2018MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. ONCOGENE. 37:1031-1040.Full Text via DOI: 10.1038/onc.2017.396
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2017Osmotic and heat stress-dependent regulation of MLK4 beta and MLK3 by the CHIP E3 ligase in ovarian cancer cells. CELLULAR SIGNALLING. 39:66-73.Full Text via DOI: 10.1016/j.cellsig.2017.07.021
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2015Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis. EXPERIMENTAL CELL RESEARCH. 331:292-308.Full Text via DOI: 10.1016/j.yexcr.2014.09.032
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2014The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3. MOLECULAR AND CELLULAR BIOLOGY. 34:3132-3143.Full Text via DOI: 10.1128/MCB.00296-14
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2014The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3. MOLECULAR AND CELLULAR BIOLOGY. 34:3132-3143.Full Text via DOI: 10.1128/mcb.00296-14
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2012Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. EXPERIMENTAL CELL RESEARCH. 318:1641-1648.Full Text via DOI: 10.1016/j.yexcr.2012.05.002
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2012MLK4 beta functions as a negative regulator of MAPK signaling and cell invasion. ONCOGENESIS. 1.Full Text via DOI: 10.1038/oncsis.2012.6
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2011Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. ONCOGENE. 30:781-789.Full Text via DOI: 10.1038/onc.2010.453
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2009Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1793:1811-1818.Full Text via DOI: 10.1016/j.bbamcr.2009.09.014
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2009Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. CELLULAR SIGNALLING. 21:1620-1625.Full Text via DOI: 10.1016/j.cellsig.2009.06.008
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2009Investigating the role of Aurora Kinases in RAS signaling. JOURNAL OF CELLULAR BIOCHEMISTRY. 106:33-41.Full Text via DOI: 10.1002/jcb.21974
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2006Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103:4463-4468.Full Text via DOI: 10.1073/pnas.0510651103
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2004A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation. CELL CYCLE. 3:1227-1229.Full Text via DOI: 10.4161/cc.3.10.1187
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2004MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. NATURE CELL BIOLOGY. 6:770-776.Full Text via DOI: 10.1038/ncb1152
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2003Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 285:C823-C830.Full Text via DOI: 10.1152/ajpcell.00053.2003
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2002Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2. MOLECULAR AND CELLULAR BIOLOGY. 22:737-749.Full Text via DOI: 10.1128/mcb.22.3.737-749.2002
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2002Histone H1S-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. ONCOGENE. 21:8397-8403.Full Text via DOI: 10.1038/sj.onc.1206029
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1999Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:24914-24920.Full Text via DOI: 10.1074/jbc.274.35.24914
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1998Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. JOURNAL OF CELLULAR BIOCHEMISTRY. 70:130-140.Full Text via DOI: 10.1002/(sici)1097-4644(19980701)70:1<130::aid-jcb13>3.0.co;2-t
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1997Histone H1b Phosphorylation Is Dependent upon Ongoing Transcription and Replication in Normal and ras-transformed Mouse Fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY. 272:8113-8116.Full Text via DOI: 10.1074/jbc.272.13.8113
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1995Fibroblasts transformed by combinations ofras,mycand mutant p53 exhibit increased phosphorylation of histone H1 that is independent of metastatic potential. FEBS LETTERS. 377:51-53.Full Text via DOI: 10.1016/0014-5793(95)01314-8
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1995Increased Phosphorylation of Histone H1 in Mouse Fibroblasts Transformed with Oncogenes or Constitutively Active Mitogen-activated Protein Kinase Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY. 270:20098-20105.Full Text via DOI: 10.1074/jbc.270.34.20098
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1994Roles for the yeast RAD18 and RAD52 DNA repair genes in UV mutagenesis. Mutation Research/DNA Repair. 315:281-293.Full Text via DOI: 10.1016/0921-8777(94)90039-6
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Book Chapter (Web of Science)
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2010Activation of SAPK/JNKs In Vitro. MAP Kinase Signaling Protocols. 59-73.Full Text via DOI: 10.1007/978-1-60761-795-2_3
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Chapter (Faculty180)
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2004Activation of SAPKs/JNKs and p38s in vitro. MAP Kinase Signaling Protocols. Humana Press. 61.
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Editorial Material (Web of Science)
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2013Made in Canada. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. V-V.Full Text via DOI: 10.1139/cjpp-2013-0116
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Meeting Abstract (Web of Science)
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2013Regulation of MLK3 by the E3 Ligase CHIP. MOLECULAR BIOLOGY OF THE CELL.
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Proceedings (Faculty180)
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Review Article (Web of Science)
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2013Involvement of mixed lineage kinase 3 in cancer. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 268-274.Full Text via DOI: 10.1139/cjpp-2012-0258
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Contact
full name
- Deborah N Chadee
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Cumulative publications in Scholars@UToledo
