Chadee, Deborah N

Deborah N Chadee
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Positions

Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

Deborah.Chadee@utoledo.edu

selected publications

Article (Faculty180)
- 2022
  
  Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division. The Journal of biological chemistry. 298:102263.
- 2021
  
  A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. Molecular biology of the cell. 32:1446-1458.
- 2021
  
  LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells. Molecular and Cellular Biology. 41:e0007821.
- 2020
  
  Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells. Experimental cell research. 394:112167.
- 2019
  
  G protein αq exerts expression level-dependent distinct signaling paradigms. Cellular signalling. 58:34-43.
- 2018
  
  MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. Oncogene. 37:1031.
- 2017
  
  Osmotic and heat stress-dependent regulation of MLK4$beta$ and MLK3 by the CHIP E3 ligase in ovarian cancer cells. Cellular signalling. 39:66.
- 2015
  
  Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis. Experimental cell research. 331:292.
- 2014
  
  The E3 ligase CHIP Mediates Ubiquitination and Degradation of Mixed Lineage Kinase 3. Molecular and Cellular Biology. MCB.
- 2012
  
  Involvement of mixed lineage kinase 3 in cancer. Canadian journal of physiology and pharmacology. 91:268.
- 2012
  
  MLK4$beta$ functions as a negative regulator of MAPK signaling and cell invasion. Oncogenesis. 1:e6.
- 2012
  
  Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Experimental cell research. 318:1641.
- 2011
  
  Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. Oncogene. 30:781.
- 2010
  
  Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin. Small GTPases. 1:781.
- 2009
  
  Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cellular signalling. 21:1620.
- 2009
  
  Investigating the role of Aurora kinases in RAS signaling. Journal of cellular biochemistry. 106:33.
- 2009
  
  Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1793:1811.
- 2006
  
  Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proceedings of the National Academy of Sciences. 103:4463.
- 2004
  
  A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation. Cell Cycle. 3:1227.
- 2004
  
  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nature cell biology. 6:770.
- 2003
  
  Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-$beta$-induced nuclear accumulation. American Journal of Physiology-Cell Physiology. 285:C823.
- 2003
  
  RECEPTORS AND SIGNAL TRANSDUCTION-Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-b-induced nuclear accumulation. American Journal of Physiology-Regulatory Integrative Comparative Physiology. 54:C823.
- 2002
  
  Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Molecular and cellular biology. 22:737.
- 2002
  
  Histone H1 S-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. Oncogene. 21:8397.
- 2002
  
  Role of signal transduction pathways altering chromatin structure and function. Biochemistry and Cell Biology. 80:389.
- 1999
  
  Histone modifications, gene expression, and the nuclear matrix. Biochemistry and Cell Biology. 77:390.
- 1999
  
  Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts. Journal of Biological Chemistry. 274:24914.
- 1999
  
  Involvement of histone H1 and H3 phosphorylation in oncogene-mediated cellular transformation
- 1999
  
  Organization of chromatin in cancer cells: role of signalling pathways. Biochemistry and cell biology. 77:265.
- 1998
  
  Chromatin, nuclear matrix and the cytoskeleton: role of cell structure in neoplastic transformation. International journal of oncology. 13:827.
- 1998
  
  Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. Journal of cellular biochemistry. 70:130.
- 1998
  
  Regulation and regulatory parameters of histone modifications. Journal of cellular biochemistry. 72:203.
- 1997
  
  Histone H1b phosphorylation is dependent upon ongoing transcription and replication in normal and ras-transformed mouse fibroblasts. Journal of Biological Chemistry. 272:8113.
- 1995
  
  Fibroblasts transformed by combinations of ras, myc and mutant p53 exhibit increased phosphorylation of histone H1 that is independent of metastatic potential. FEBS letters. 377:51.
- 1995
  
  Increased phosphorylation of histone H1 in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase kinase. Journal of Biological Chemistry. 270:20098.
Article (Web of Science)
- 2021
  
  A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. MOLECULAR BIOLOGY OF THE CELL. mbc.E20-11-0750.
  Full Text via DOI: 10.1091/mbc.e20-11-0750
- 2020
  
  Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells. EXPERIMENTAL CELL RESEARCH. 394.
  Full Text via DOI: 10.1016/j.yexcr.2020.112167 PMID: 32649943
- 2019
  
  G protein alpha q exerts expression level-dependent distinct signaling paradigms. CELLULAR SIGNALLING. 58:34-43.
  Full Text via DOI: 10.1016/j.cellsig.2019.02.006 PMID: 30849518
- 2018
  
  MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. ONCOGENE. 37:1031-1040.
  Full Text via DOI: 10.1038/onc.2017.396
- 2017
  
  Osmotic and heat stress-dependent regulation of MLK4 beta and MLK3 by the CHIP E3 ligase in ovarian cancer cells. CELLULAR SIGNALLING. 39:66-73.
  Full Text via DOI: 10.1016/j.cellsig.2017.07.021
- 2015
  
  Intercellular adhesion molecule-1 expression by skeletal muscle cells augments myogenesis. EXPERIMENTAL CELL RESEARCH. 331:292-308.
  Full Text via DOI: 10.1016/j.yexcr.2014.09.032
- 2014
  
  The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3. MOLECULAR AND CELLULAR BIOLOGY. 34:3132-3143.
  Full Text via DOI: 10.1128/MCB.00296-14
- 2014
  
  The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3. MOLECULAR AND CELLULAR BIOLOGY. 34:3132-3143.
  Full Text via DOI: 10.1128/mcb.00296-14
- 2012
  
  Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. EXPERIMENTAL CELL RESEARCH. 318:1641-1648.
  Full Text via DOI: 10.1016/j.yexcr.2012.05.002
- 2012
  
  MLK4 beta functions as a negative regulator of MAPK signaling and cell invasion. ONCOGENESIS. 1.
  Full Text via DOI: 10.1038/oncsis.2012.6
- 2011
  
  Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. ONCOGENE. 30:781-789.
  Full Text via DOI: 10.1038/onc.2010.453
- 2009
  
  Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1793:1811-1818.
  Full Text via DOI: 10.1016/j.bbamcr.2009.09.014
- 2009
  
  Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. CELLULAR SIGNALLING. 21:1620-1625.
  Full Text via DOI: 10.1016/j.cellsig.2009.06.008
- 2009
  
  Investigating the role of Aurora Kinases in RAS signaling. JOURNAL OF CELLULAR BIOCHEMISTRY. 106:33-41.
  Full Text via DOI: 10.1002/jcb.21974
- 2006
  
  Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103:4463-4468.
  Full Text via DOI: 10.1073/pnas.0510651103
- 2004
  
  A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation. CELL CYCLE. 3:1227-1229.
  Full Text via DOI: 10.4161/cc.3.10.1187
- 2004
  
  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. NATURE CELL BIOLOGY. 6:770-776.
  Full Text via DOI: 10.1038/ncb1152
- 2003
  
  Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 285:C823-C830.
  Full Text via DOI: 10.1152/ajpcell.00053.2003
- 2002
  
  Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2. MOLECULAR AND CELLULAR BIOLOGY. 22:737-749.
  Full Text via DOI: 10.1128/mcb.22.3.737-749.2002
- 2002
  
  Histone H1S-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. ONCOGENE. 21:8397-8403.
  Full Text via DOI: 10.1038/sj.onc.1206029
- 1999
  
  Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:24914-24920.
  Full Text via DOI: 10.1074/jbc.274.35.24914
- 1998
  
  Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. JOURNAL OF CELLULAR BIOCHEMISTRY. 70:130-140.
  Full Text via DOI: 10.1002/(sici)1097-4644(19980701)70:1<130::aid-jcb13>3.0.co;2-t
- 1997
  
  Histone H1b Phosphorylation Is Dependent upon Ongoing Transcription and Replication in Normal and ras-transformed Mouse Fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY. 272:8113-8116.
  Full Text via DOI: 10.1074/jbc.272.13.8113
- 1995
  
  Fibroblasts transformed by combinations ofras,mycand mutant p53 exhibit increased phosphorylation of histone H1 that is independent of metastatic potential. FEBS LETTERS. 377:51-53.
  Full Text via DOI: 10.1016/0014-5793(95)01314-8
- 1995
  
  Increased Phosphorylation of Histone H1 in Mouse Fibroblasts Transformed with Oncogenes or Constitutively Active Mitogen-activated Protein Kinase Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY. 270:20098-20105.
  Full Text via DOI: 10.1074/jbc.270.34.20098
- 1994
  
  Roles for the yeast RAD18 and RAD52 DNA repair genes in UV mutagenesis. Mutation Research/DNA Repair. 315:281-293.
  Full Text via DOI: 10.1016/0921-8777(94)90039-6
Book Chapter (Web of Science)
- 2010
  
  Activation of SAPK/JNKs In Vitro. MAP Kinase Signaling Protocols. 59-73.
  Full Text via DOI: 10.1007/978-1-60761-795-2_3
Chapter (Faculty180)
- 2010
  
  Activation of SAPK/JNKs in vitro. MAP Kinase Signaling Protocols. Humana Press, Totowa, NJ. 59.
- 2004
  
  Activation of SAPKs/JNKs and p38s in vitro. MAP Kinase Signaling Protocols. Humana Press. 61.
Editorial Material (Web of Science)
- 2013
  
  Made in Canada. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. V-V.
  Full Text via DOI: 10.1139/cjpp-2013-0116
Meeting Abstract (Web of Science)
- 2013
  
  Regulation of MLK3 by the E3 Ligase CHIP. MOLECULAR BIOLOGY OF THE CELL.
Proceedings (Faculty180)
- 2013
  
  Regulation of MLK3 by the E3 Ligase CHIP
- 2003
  
  Functions of apoptosis signal-regulating kinase-1 revealed by RNA interference.
Review Article (Web of Science)
- 2013
  
  Involvement of mixed lineage kinase 3 in cancer. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 268-274.
  Full Text via DOI: 10.1139/cjpp-2012-0258

full name

Deborah N Chadee

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