TRPV4 deletion remodels the gut microbiota and increases colonic ammonia levels Article (Faculty180)

cited authors

  • Tummala, Ramakumar; Kondapalli, Narendra Bab B; Katari, Venkatesh; Manandhar, Ishan; Dalal, Kesha; Adapala, Ravi; Paruchuri, Sailaja; Joe, Bina; Thodeti, Charles

description

  • The transient receptor potential vanilloid 4 ion channel (TRPV4) is widely expressed in the gastrointestinal tract and contributes to epithelial barrier regulation, mechanosensation and innate immune signaling. However, its role in shaping gut microbiota composition and intestinal metabolic homeostasis remains unclear. This study aimed to determine whether deletion of TRPV4 influences gut microbial composition and intestinal ammonia levels.

authors

publication date

  • 2026

published in

start page

  • 124671

volume

  • 405