Tideglusib enhances ALP activity and upregulates RANKL expression in Osteoblast-macrophage Co-cultures within a 3D collagen scaffold Article (Faculty180)

cited authors

  • Toledano, Raquel; Osorio, María T; Osorio, Raquel; Toledano, Manuel; Jacho, Diego; Yildirim-Ayan, Eda

description

  • Tideglusib (Tx) is known for its osteogenic potential, yet its effects on the interplay between osteoblasts and M1 macrophages remain underexplored. This in vitro study aimed to isolate and evaluate both the individual and combined roles of M1 macrophages and osteoblasts in macrophage differentiation and osteoblast function, specifically focusing on how these interactions influence protein expression of osteogenesis and osteoclastogenesis in the presence or absence of Tx.

authors

publication date

  • 2025

published in

start page

  • 105509

volume

  • 153