Eda D Yildirim-Ayan
- Associate Professor , Bioengineering , College of Engineering
Contact Info
Overview
overview
-
Eda Yildirim-Ayan, PhD
Bibliography
Eda Yildirim-Ayan is an Associate Professor in the Bioengineering Department at the University of Toledo. Eda received her B.S. degree in Mechanical Engineering from the Ege University, Turkey, M.S. degree in Mechanical Engineering from the Izmir Institute of Technology, Turkey, and her Ph.D. in Mechanical Engineering (Computer-aided Tissue Engineering) from Drexel University, Philadelphia, PA in 2010. Eda joined UT in the Fall term of 2010.
The interdisciplinary nature of her background is providing a great niche in fabricating biomimetic and bioactive musculoskeletal tissue scaffolds and studying them under physiologically relevant mechanical loading conditions. Eda has published over 25 journal publications and has 2 patents in the field of scaffold-guided musculoskeletal tissue engineering. She is currently the director of Engineered Biosystems Laboratory (EBSL). The research at EBSL engages in the design, analysis, and fabrication of physiologically relevant three-dimensional (3D) in vitro platforms (scaffolds, mechanical stimulators, etc) to study musculoskeletal tissue regeneration, in particular, bone, tendon, and bone-tendon intersection. The EBSL is equipped with in-house developed 3D cell printer, Electro-Spinning system, in-house developed mechanical strain applicators, and conventional mammalian cell culture equipment and characterization devices. The detail about the EBSL and research trusts under EBSL can be found from the following link http://www.eng-biosystems-lab.org
Publications
selected publications
-
Article (Faculty180)
-
2021Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold. International Journal of Molecular Sciences. 22:1134.
-
2021Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.
-
2019Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization. Annals of biomedical engineering.
-
2019Miniature Non‑thermal Plasma Induced Cell Cycle Arrest and Apoptosis in Lung Carcinoma Cells. Plasma Chemistry and Plasma Processing. 1-19.
-
2017Design and validation of equiaxial mechanical strain platform, EQUicycler, for 3D Tissue Engineered Constructs. BioMed research international. 2017.
-
2017Effect of Uniaxial Tensile Cyclic Loading Regimes on Matrix Organization and Tenogenic Differentiation of Adipose-derived Stem Cells Encapsulated within 3D Collagen Scaffolds. Stem Cells International. DOI:10.1155/2017/6072406.
-
2017
-
2017Investigation of non-thermal plasma effects on lung cancer cells within 3D collagen matrices. Journal of Physics D Applied Physics. 50.
-
2017Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. BioMed research international. 2017.
-
2017Predicting cell viability within tissue scaffolds under equiaxial strain: multi-scale finite element model of collagen--cardiomyocytes constructs. Biomechanics and modeling in mechanobiology. 16:1049.
-
2016Mechanoresponsive musculoskeletal tissue differentiation of adipose-derived stem cells. Biomedical engineering online. 15:43.
-
2015Exogenous nitric oxide (NO) generated by NO-plasma treatment modulates osteoprogenitor cells early differentiation. Journal of Physics D: Applied Physics. 48:345401.
-
2015Nanofibrous yet injectable polycaprolactone-collagen bone tissue scaffold with osteoprogenitor cells and controlled release of bone morphogenetic protein-2. Materials Science and Engineering: C. 51:16.
-
2014In situ osteoblast mineralization mediates post-injection mechanical properties of osteoconductive material. Journal of the mechanical behavior of biomedical materials. 38:143.
-
2013Biomechanical evaluation of an endplate-conformed polycaprolactone-hydroxyapatite intervertebral fusion graft and its comparison with a typical nonconformed cortical graft. Journal of biomechanical engineering. 135:061005.
-
2013Polycaprolactone nanofiber interspersed collagen type-I scaffold for bone regeneration: a unique injectable osteogenic scaffold. Biomedical Materials. 8:045011.
-
2011DIMENSIONAL POLY (s-CAPROLACTONE) SCAFFOL FOR TISSUE ENGINEERING APPLICATION. Plasma Assisted Decontamination of Biological and Chemical Agents. 191.
-
2011Development of a cold atmospheric pressure microplasma jet for freeform cell printing. Applied Physics Letters. 99:111502.
-
2011Enhanced cellular functions on polycaprolactone tissue scaffolds by O2 plasma surface modification. Plasma Processes and Polymers. 8:256.
-
2008A numerical simulation study for the human passive thermal system. Energy and Buildings. 40:1117.
-
2008
-
2008Enhanced osteoblast function on bone tissue engineering scaffolds by plasma modification. Journal of Biotechnology. 136:S121.
-
2008Fabrication and plasma treatment of 3D polycaprolactane tissue scaffolds for enhanced cellular function. Virtual and Physical Prototyping. 3:199.
-
2008Fabrication, characterization, and biocompatibility of single-walled carbon nanotube-reinforced alginate composite scaffolds manufactured using freeform fabrication technique. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 87:406.
-
2007A tracer metric numerical model for predicting tortuosity factors in three-dimensional porous tissue scaffolds. Computer methods and programs in biomedicine. 87:21.
-
2005A mathematical model of the human thermal system. Izmir Institute of Technology, Urla Izmir Turkey.
-
2004Exergy analysis and performance evaluation of Kizildere geothermal power plant, Turkey. International Journal of Exergy. 1:316.
-
-
Article (Web of Science)
-
2021Impact of Digestive Inflammatory Environment and Genipin Crosslinking on Immunomodulatory Capacity of Injectable Musculoskeletal Tissue Scaffold. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.Full Text via DOI: 10.3390/ijms22031134 PMID: 33498864
-
2019Miniature Non-thermal Plasma Induced Cell Cycle Arrest and Apoptosis in Lung Carcinoma Cells. PLASMA CHEMISTRY AND PLASMA PROCESSING. 40:99-117.Full Text via DOI: 10.1007/s11090-019-10037-2
-
2017Equiaxial Strain Modulates Adipose-derived Stem Cell Differentiation within 3D Biphasic Scaffolds towards Annulus Fibrosus. SCIENTIFIC REPORTS. 7.Full Text via DOI: 10.1038/s41598-017-13240-3
-
2017Investigation of non-thermal plasma effects on lung cancer cells within 3D collagen matrices. JOURNAL OF PHYSICS D-APPLIED PHYSICS. 50.Full Text via DOI: 10.1088/1361-6463/aa7b10
-
2017Creating homogenous strain distribution within 3D cell-encapsulated constructs using a simple and cost-effective uniaxial tensile bioreactor: Design and validation study. BIOTECHNOLOGY AND BIOENGINEERING. 114:1878-1887.Full Text via DOI: 10.1002/bit.26304
-
2017Predicting cell viability within tissue scaffolds under equiaxial strain: multi-scale finite element model of collagen-cardiomyocytes constructs. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY. 16:1049-1063.Full Text via DOI: 10.1007/s10237-017-0872-z
-
2017Design and Validation of Equiaxial Mechanical Strain Platform, EQUicycler, for 3D Tissue Engineered Constructs. BIOMED RESEARCH INTERNATIONAL.Full Text via DOI: 10.1155/2017/3609703
-
2017Effect of Uniaxial Tensile Cyclic Loading Regimes on Matrix Organization and Tenogenic Differentiation of Adipose-Derived Stem Cells Encapsulated within 3D Collagen Scaffolds. STEM CELLS INTERNATIONAL.Full Text via DOI: 10.1155/2017/6072406
-
2017Miniature Dielectric Barrier Discharge Nonthermal Plasma Induces Apoptosis in Lung Cancer Cells and Inhibits Cell Migration. BIOMED RESEARCH INTERNATIONAL.Full Text via DOI: 10.1155/2017/8058307
-
2015Exogenous nitric oxide (NO) generated by NO-plasma treatment modulates osteoprogenitor cells early differentiation. JOURNAL OF PHYSICS D-APPLIED PHYSICS. 48.Full Text via DOI: 10.1088/0022-3727/48/34/345401
-
2015Nanofibrous yet injectable polycaprolactone-collagen bone tissue scaffold with osteoprogenitor cells and controlled release of bone morphogenetic protein-2. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS. 51:16-27.Full Text via DOI: 10.1016/j.msec.2015.02.030
-
2014In situ osteoblast mineralization mediates post-injection mechanical properties of osteoconductive material. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. 38:143-153.Full Text via DOI: 10.1016/j.jmbbm.2014.06.018
-
2013Biomechanical Evaluation of an Endplate-Conformed Polycaprolactone-Hydroxyapatite Intervertebral Fusion Graft and Its Comparison With a Typical Nonconformed Cortical Graft. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 135.Full Text via DOI: 10.1115/1.4023988
-
2013Polycaprolactone nanofiber interspersed collagen type-I scaffold for bone regeneration: a unique injectable osteogenic scaffold. BIOMEDICAL MATERIALS. 8.Full Text via DOI: 10.1088/1748-6041/8/4/045011
-
-
Book (Faculty180)
-
Chapter (Faculty180)
-
2010Precision extruding deposition for freeform fabrication of PCL and PCL-HA tissue scaffolds. Printed Biomaterials. Springer New York. 91.
-
2008Plasma Surface Modification of Three Dimensional Poly ($\varepsilon$-Caprolactone) Scaffolds for Tissue Engineering Application. Plasma Assisted Decontamination of Biological and Chemical Agents. Springer, Dordrecht. 191.
-
-
Correction (Web of Science)
-
2019Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization (vol 47, pg 2213, 2019). ANNALS OF BIOMEDICAL ENGINEERING. 2341-2341.Full Text via DOI: 10.1007/s10439-019-02326-w PMID: 31388848
-
-
Other Scholarly Work (Faculty180)
-
Proceedings (Faculty180)
-
Review Article (Web of Science)
-
2019Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization. ANNALS OF BIOMEDICAL ENGINEERING. 2213-2231.Full Text via DOI: 10.1007/s10439-019-02302-4 PMID: 31218484
-
2016Mechanoresponsive musculoskeletal tissue differentiation of adipose-derived stem cells. BIOMEDICAL ENGINEERING ONLINE.Full Text via DOI: 10.1186/s12938-016-0150-9
-
Contact
full name
- Eda D Yildirim-Ayan