Mandal, Juthika; Aryal, Sachin; Manandhar, Ishan; Chakraborty, Saroj; Mei, Xue; Yeoh, Beng Sa S; Mell, Blair; Kleinhenz, Andrew; Tummala, Ramakumar; Yang, Tao; Saha, Piu; Gunning, William T; Vijay-Kumar, Matam; Basrur, Venkatesha; de la Serna, Ivana; Joe, Bina
description
Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining whether the reno-protective effect of β-hydroxybutyrate is due to its known ability to epigenetically remodel chromatin via histone β-hydroxybutyrylation.
