Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM) Article (Faculty180)

cited authors

  • Lapidot, Moshe; Case, Abigail E; Weisberg, Ellen L; Meng, Chengcheng; Walker, Sarah R; Garg, Swati; Ni, Wei; Podar, Klaus; Hung, Yin P; Carrasco, Ruben D; Knott, Aine; Gokhale, Prafulla C; Sharma, Sunil; Pozhitkov, Alex; Kulkarni, Prakash; Frank, David A; Salgia, Ravi; Griffin, James D; Saladi, Srinivas V; Bueno, Raphael; Sattler, Martin

description

  • Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A (lysine-specific histone demethylase 4) was overexpressed in MPM.

authors

publication date

  • 2021

published in

start page

  • 582

end page

  • 592

volume

  • 125