Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways

Article (Faculty180)

cited authors

  • Rafiqi, Shafiya Imtia I; Aldasouqi, Ahmad; Paparodis, Rodis D; Dewan, Sandesh; Farooqi, Aneeba; Faisal, Sarah; Nemat, Yousuf; Salim, Nancy; Qureshi, Salauddin; Mahmood, Asif; Tovar, Yara; Jun, John Y; Kalinoski, Andrea L; Mirmira, Raghavendra G; Jaume, Juan Carlo C; Imam, Shahnawaz

description

  • <p>The generation of functionally active, stable T regulatory cells (Tregs) is a crucial target of type 1 diabetes (T1D) immunotherapy. This study investigated therapeutic intervention for T1D/Latent autoimmune diabetes in adults (LADA), wherein the diabetogenic proinflammatory Treg (intermediate) cell subset was characterized and driven to a Treg phenotype (CD4CD25FOXP3). This involved simultaneous inhibition of the eukaryotic initiation factor 5a (eIF5a) and Notch pathways using GC7 (N1-Guanyl-1,7-diaminoheptane) and Anti-DLL4 (Delta-like-ligand-4).</p>

authors

publication date

  • 2025

published in

start page

  • 205

end page

  • 226

volume

  • 14