Alasmari, Mohammed S; Almohammed, Omar A; Hammad, Alaa M; Altulayhi, Khalid A; Alkadi, Bader K; Alasmari, Abdullah F; Alqahtani, Faleh; Sari, Youssef; Alasmari, Fawaz
description
Preclinical studies demonstrated that beta-lactams have neuroprotective effects in conditions involving glutamate neuroexcitotoxicity, including substance use disorders (SUDs). This meta-analysis aims to analyze the existing evidences on the effects of beta-lactams as glutamate transporter 1 (GLT-1) upregulators in animal models of SUDs, identification of gaps in the literature, and setting the stage for potential translation into clinical phases.
