Liu, Ruihua; Su, Shang; Xing, Jing; Liu, Ke; Zhao, Yawei; Stangis, Mary; Jacho, Diego P; Yildirim-Ayan, Eda D; Gatto-Weis, Cara M; Chen, Bin; Li, Xiaohong
description
Disseminated tumor cells (DTCs) can enter a dormant state and cause no symptoms in cancer patients. On the other hand, the dormant DTCs can reactivate and cause metastases progression and lethal relapses. In prostate cancer (PCa), relapse can happen after curative treatments such as primary tumor removal. The impact of surgical removal on PCa dissemination and dormancy remains elusive. Furthermore, as dormant DTCs are asymptomatic, dormancy-induction can be an operational cure for preventing metastases and relapse of PCa patients.
