Yeo, Jiyoun; Morales, Diego A; Chen, Tian; Crawford, Erin L; Zhang, Xiaolu; Blomquist, Tho M; Levin, Albert M; Massion, Pierre P P; Arenberg, Dougl A; Midthun, David E; Mazzone, Peter J; Nathan, Steven D; Wainz, Ronald J; Nana-Sinkam, Patrick; Willey, Paige F S; Arend, Taylor J; Padda, Karanbir; Qiu, Shuhao; Federov, Alexei; Hernandez, Dawn-Alita R; Hammersley, Jeff R; Yoon, Youngsook; Safi, Fadi; Khuder, S A; Willey, James C
description
There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression patterns associated with COPD.