Adapala, Ravi K; Katari, Venkatesh; Kanugula, Anantha K; Ohanyan, Vahagn; Paruchuri, Sailaja; Thodeti, Charles K
description
Left ventricular hypertrophy is a bipolar response, starting as an adaptive response to the hemodynamic challenge, but over time develops maladaptive pathology partly due to microvascular rarefaction and impaired coronary angiogenesis. Despite the profound influence on cardiac function, the mechanotransduction mechanisms that regulate coronary angiogenesis, leading to heart failure, are not well known.
