Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome Article (Faculty180)

cited authors

  • Filbey, Willi A; Sanford, David T; Baghdoyan, Helen A; Koch, Lauren G; Britton, Steven L; Lydic, Ralph

description

  • Obesity alters the therapeutic window of sedative/hypnotic drugs and increases the probability of respiratory complications. The current experiments used an established rodent model of obesity to test the hypothesis that the sedative/hypnotic drugs eszopiclone and dexmedetomidine alter ventilation differentially in obese rats compared with lean/fit rats.

authors

publication date

  • 2014

published in

start page

  • 871

end page

  • 80

volume

  • 37