Morris, E M; Whaley-Connell, Adam T; Thyfault, John P; Britton, Steven L; Koch, Lauren G; Wei, Yongzhong; Ibdah, J A; Sowers, James R
description
Insulin receptor (IR-alpha and IR-beta) is reduced in the kidney of insulin-resistant rodents. It is unknown if there are also reductions in insulin receptor substrate (IRS)-1 or if these effects are due to metabolic injury. Thereby, we hypothesized intrinsically high aerobic fitness would protect against high-fat diet (HFD)-induced reactive oxygen species (ROS) and IRS-1 degradation.
