Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats Article (Faculty180)

cited authors

  • Smyers, Mark E; Koch, Lauren G; Britton, Steven L; Wagner, Jacob G; Novak, Colleen M


  • Intermittent fasting (IF) strategies have emerged as viable alternatives to traditional calorie-restricted diets. A key predictor of metabolic health and response to diet is cardiometabolic fitness, including intrinsic aerobic capacity. In a contrasting rat model of aerobic capacity-high- and low-capacity runners (HCR, LCR)-we found that the lean and physically active HCR were also more responsive to a standard calorie-restricted diet. Here, we assessed the ability of IF to induce weight loss on a background of high and low aerobic fitness accompanied by different levels of daily physical activity.

publication date

  • 2021

published in

start page

  • 113280


  • 230