Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus Article (Faculty180)

cited authors

  • Mäkinen, Elina; Lensu, Sanna; Honkanen, Markus; Laitinen, Paavo; Wikgren, Jan; Koch, Lauren G; Britton, Steven L; Kainulainen, Heikki; Pekkala, Satu; Nokia, Miriam S


  • Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats.

publication date

  • 2021

published in

start page

  • 250

end page

  • 259


  • 97