Saha, Piu; Mell, Blair; Golonka, Rachel M; Bovilla, Venugopal R; Abokor, Ahmed A A; Mei, Xue; Yeoh, Beng S; Doris, Peter A; Gewirtz, Andrew T; Joe, Bina; Vijay-Kumar, Matam
description
The spontaneously hypertensive rat (SHR) is extensively used to study hypertension. Gut microbiota dysbiosis is a notable feature in SHR for reasons unknown. Immunoglobulin A (IgA) is a major host factor required for gut microbiota homeostasis. We hypothesized that inadequate IgA contributes to gut microbiota dysbiosis in SHR.
